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| 1 | 氧化磷酸化与糖酵解:精子以何种途径获取能量?显示文摘精子为高度特异性的细胞,提供精子重要功能的主要能源一一三磷酸腺苷(ATP)主要通过两种代谢途径形成,即糖酵解和氧化磷酸化(OXPHOS)。ATP除了在精子的头部和鞭毛的主段通过糖酵解的方式产生外,在线粒体主要通过OXPHOS的方式产生。然而,在精子成功受精的过程中主要以何种方式产生ATP具有很大的差异性。与糖酵解相比,线粒体呼吸被认为是一种更有效的ATP合成代谢过程。然而,研究表明ATP从线粒体到精子鞭毛末端的扩散电位不足以支持精子的运动,这表明糖酵解是精子尾部区域主要的获能方式。多项研究表明虽然糖酵解是鞭毛产生ATP的主要方式,但是,精子运动所需要的能量主要还是来自于线粒体的呼吸。有些研究表明当糖酵解受到抑制的时候,精子仍能维持其正常的运动和功能,虽然目前尚未明确这种运动是否能持续足够长的时间,是否能够达到有效受精。本文主要目的是对哺乳动物精子能量的代谢进行综述,分析人类精子在受精的过程中以何种ATP代谢途径作为主要的能量供应方式。 | Stefan S du Plessis Ashok Agarwal Gayatri Mohanty Michelle van der Linde | 2015 | Asian Journal of Andrology2015，17，2： | 19 |
| 2 | Response of blood pressure after percutaneous transluminal renal artery angioplasty and stenting显示文摘AIM: To evaluate the short and intermediate term out-come of percutaneous transluminal renal artery angioplasty (PTRA) and stenting particularly on blood pressure (BP) control and renal function and to evaluate predictors of poor BP response after successful PTRA and stenting. METHODS: We conducted a prospective analysis of all patients who underwent PTRA and stenting in our institute between August 2010 to September 2012. A total number of 86 patients were underwent PTRA and renal stenting. Selective angiography was done to confirm at least 70% angiographic stenosis. The predilatation done except few cases with critical stenosis, direct stenting was done in the rest of cases. All patients received aspirin 325 mg orally, and clopidogrel 300 mg orally within 24 h before the procedure. Heparin was used as the procedural anticoagulant agent. Optimal results with TIMI-Ⅲ flow obtained in all cases. Following stent placement, aspirin 150 mg orally once daily was continued for a minimum of 12 mo and clopidogrel 75 mg orally once daily for at least 4 wk. The clinical, radiological, electrocardiography, echocardiography and treatment data of all patients were recorded. The BP measurement, serum creatinine and glomerular filtration rate (GFR) were recorded before the procedure and 1 and 6 mo after PTRA. RESULTS: A total of 86 patients were included in the study. The mean age of study population was 55.87±11.85 years old and 67 (77.9%) of patients were male. There was a significant reduction in both systolic and diastolic BP at 1 mo after the procedure: 170.15±20.10 mmHg vs 146.60±17.32 mmHg and 98.38±10.55 mmHg vs 89.88±9.22 mmHg respectively (P=0.0000). The reduction in BP was constant throughout the follow-up period and was evident 6 mo after the procedure: 144.23±18.19 and 88.26±9.79 mmHg respectively (P=0.0000). However, no improvement in renal function was observed at any time during the follow-up period. After multivariate analysis, we found male sex, low GFR (<60 mL/min) and higher baseline mean BP as a poor predictors of successful outcome on BP response after PTRA and stenting. CONCLUSION: The PTRA and stenting can be considered as an effective therapeutic intervention for improving BP control with minimal effect on renal function. The male sex, higher baseline BP and low GFR are associated with poor BP response after successful PTRA and stenting. | Jayesh S Prajapati Sharad R Jain Hasit Joshi Shaurin Shah Kamal Sharma Sibasis Sahoo Kapil Virparia Ashok Thakkar | 2013 | World Journal of Cardiology2013，5，7： | 3 |
| 3 | Meeting report:a hard look at the state of enamel research显示文摘The Encouraging Novel Amelogenesis Models and Ex vivo cell Lines(ENAMEL) Development workshop was held on 23 June 2017 at the Bethesda headquarters of the National Institute of Dental and Craniofacial Research(NIDCR). Discussion topics included model organisms, stem cells/cell lines, and tissues/3 D cell culture/organoids. Scientists from a number of disciplines,representing institutions from across the United States, gathered to discuss advances in our understanding of enamel, as well as future directions for the field. | ophir d klein olivier duverger wendy shaw rodrigo s lacruz derk joester janet moradian-oldak megan k pugach j timothy wright sarah e millar ashok b kulkarni john d bartlett thomas gh diekwisch pamela den besten james p simmer | 2017 | International Journal of Oral Science2017，9，4： | 3 |
| 4 | Effectiveness and safety of loop electrosurgieal excision procedure for cervical neoplasia in rural India显示文摘 | Rengaswamy S Vijay K Ashok K | 2009 | International Journal of Gynecology and Obstetrics2009，104，： | 1 |
| 5 | Exposure to As, Cd and Pb-mixture impairs myelin and axon development in rat brain,optic nerve and retina显示文摘 | Rai N K Ashok A Rai A Tripathi S Nagar G K Mitra K | 2013 | Toxicology and Applied Pharmacology2013，273，2： | 1 |
| 6 | Recent advances in biologicalproduction of 3-hydroxypropionic acid 显示文摘 | KUMAR V ASHOK S PARIC S | 2013 | BiotechnologyAdvances2013，31，6： | 1 |
| 7 | Heat management in aluminium/air batteries: sources of heat显示文摘 | Patnaik R S M Ganesh S Ashok G | 1994 | Power Sources1994，50，3： | 1 |
| 8 | Chemical effects of anodic contact glow discharge electrolysis in aqueous formic acid solutions: Formation of oxalic acid显示文摘 | SUSANTA K S G RAJESHWAR S ASHOK K S | 1995 | Indian Journal of Chemistry1995，34，： | 1 |
| 9 | A system for recognizing a large class of engineering drawings显示文摘 | YU Y ASHOK S | 1997 | IEEE Transactions on Pattern Analysis and Machine Intelligence1997，19，8： | 1 |
| 10 | Synthesis and antimicrobial activity of ethyl-2-chloro-4-substituted 6-(4-methoxybenzoyl)-4H-thieno[3,2-b]pyrrole-5-carboxylates显示文摘 | Ashok D Goud P S Shravani D | | 0，，： | 1 |
| 11 | Recent advances in biological production of 3-hydroxypropionic acid显示文摘 | KUMAR V ASHOK S PARK S | 2013 | Biotechnology Advances2013，31，6： | 1 |
| 12 | Assessment of serum interleukin - 8 as a sensitive serological marker in monito- ring the therapeutic effect of levamisole in recurrent aph- thous ulcers: A randomized control study 显示文摘 | GUPTA P ASHOK L NAIK S R | 2014 | Indian Journal of Dental Research2014，25，3： | 1 |
| 13 | Changes in tissue defence system in white spot syndrome virus (WSSV) infected Penaeus monodon 显示文摘 | Mathew S Ashok Kumar K Anandan R etal | 2007 | Comp Biochem Physioi C2007，145，3： | 1 |
| 14 | Transient crack growth behavior in aluminum alloys C415·T8 显示文摘 | CATER H B DAVID H E ASHOK S | 1999 | Engineering Fracture Mechanics1999，62，1： | 1 |
| 15 | Performance of aluminium anodes under heat treatment显示文摘 | ASHOK S R VENKATARAMANI A PARTHIBAN G T SRINWASAN S PALANISWAMY N MANI A RAGHAVAN M | 2002 | Corrosion on Prevention & Control2002，49，2： | 1 |
| 16 | Synthesis and characterization of nano-hydroxyapatite at ambient temperature using cationic surfactant显示文摘 | Shanthi P M S Ashok M Balasubramanian T | 2009 | Materials Letters2009，63，2425： | 1 |
| 17 | Expression profiling of various genes during the fruit development and ripening of mango显示文摘 | Sagar S P Ram S K Ashok P G | 2010 | Plant Physiol Biochem2010，48，6： | 1 |
| 18 | An optimization mode for industrial load management显示文摘 | Ashok S Banerjee R | 2001 | IEEE Trans on Power Systems2001，16，4： | 1 |
| 19 | Transient crack growth behavior in aluminum alloys C415-T8 and 2519-T87显示文摘 | CARTER H B DAVID H E ASHOK S | 1999 | Engineering Fracture Mechanics1999，62，1： | 1 |
| 20 | E1 Nifio Modoki and its possible teleconnection 显示文摘 | Ashok K Behera S K Rao S A | 2007 | Joumal of Geophysical Research2007，112，11： | 1 |
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