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| 1 | Response of blood pressure after percutaneous transluminal renal artery angioplasty and stenting显示文摘AIM: To evaluate the short and intermediate term out-come of percutaneous transluminal renal artery angioplasty (PTRA) and stenting particularly on blood pressure (BP) control and renal function and to evaluate predictors of poor BP response after successful PTRA and stenting. METHODS: We conducted a prospective analysis of all patients who underwent PTRA and stenting in our institute between August 2010 to September 2012. A total number of 86 patients were underwent PTRA and renal stenting. Selective angiography was done to confirm at least 70% angiographic stenosis. The predilatation done except few cases with critical stenosis, direct stenting was done in the rest of cases. All patients received aspirin 325 mg orally, and clopidogrel 300 mg orally within 24 h before the procedure. Heparin was used as the procedural anticoagulant agent. Optimal results with TIMI-Ⅲ flow obtained in all cases. Following stent placement, aspirin 150 mg orally once daily was continued for a minimum of 12 mo and clopidogrel 75 mg orally once daily for at least 4 wk. The clinical, radiological, electrocardiography, echocardiography and treatment data of all patients were recorded. The BP measurement, serum creatinine and glomerular filtration rate (GFR) were recorded before the procedure and 1 and 6 mo after PTRA. RESULTS: A total of 86 patients were included in the study. The mean age of study population was 55.87±11.85 years old and 67 (77.9%) of patients were male. There was a significant reduction in both systolic and diastolic BP at 1 mo after the procedure: 170.15±20.10 mmHg vs 146.60±17.32 mmHg and 98.38±10.55 mmHg vs 89.88±9.22 mmHg respectively (P=0.0000). The reduction in BP was constant throughout the follow-up period and was evident 6 mo after the procedure: 144.23±18.19 and 88.26±9.79 mmHg respectively (P=0.0000). However, no improvement in renal function was observed at any time during the follow-up period. After multivariate analysis, we found male sex, low GFR (<60 mL/min) and higher baseline mean BP as a poor predictors of successful outcome on BP response after PTRA and stenting. CONCLUSION: The PTRA and stenting can be considered as an effective therapeutic intervention for improving BP control with minimal effect on renal function. The male sex, higher baseline BP and low GFR are associated with poor BP response after successful PTRA and stenting. | Jayesh S Prajapati Sharad R Jain Hasit Joshi Shaurin Shah Kamal Sharma Sibasis Sahoo Kapil Virparia Ashok Thakkar | 2013 | World Journal of Cardiology2013，5，7： | 3 |
| 2 | Reduced semen quality in patients with testicular cancer seminoma is associated with alterations in the expression of sperm proteins显示文摘Testicular cancer seminoma is one of the most common types of cancer among men of reproductive age.Patients with this condition usually present reduced semen quality,even before initiating cancer therapy.However,the underlying mechanisms by which testicular cancer seminoma affects male fertility are largely unknown.The aim of this study was to investigate alterations in the sperm proteome of men with seminoma undergoing sperm banking before starting cancer therapy,in comparison to healthy proven fertile men(control group).A routine semen analysis was conducted before cryopreservation of the samples(n=15 per group).Men with seminoma showed a decrease in sperm motility(P=0.019),total motile count(P=0.001),concentration(P=0.003),and total sperm count(P=0.001).Quantitative proteomic analysis identified 393 differentially expressed proteins between the study groups.Ten proteins involved in spermatogenesis,sperm function,binding of sperm to the oocyte,and fertilization were selected for validation by western blot.We confirmed the underexpression of heat shock-related 70 kDa protein 2(P=0.041),ubiquinol-cytochrome C reductase core protein 2(P=0.026),and testis-specific sodium/potassium-transporting ATPase subunit alpha-4(P=0.016),as well as the overexpression of angiotensin I converting enzyme(P=0.005)in the seminoma group.The altered expression levels of these proteins are associated with spermatogenesis dysfunction,reduced sperm kinematics and motility,failure in capacitation and fertilization.The findings of this study may explain the decrease in the fertilizing ability of men with seminoma before starting cancer therapy. | Tania R Dias Ashok Agarwal Peter N Pushparaj Gulfam Ahmad Rakesh Sharma | 2020 | Asian Journal of Andrology2020，22，1： | 2 |
| 3 | Pain management in mice using methanol extracts of three plants belongs to family Amaranthaceae显示文摘Objective:To investigate the analgesic activity of methanolic extract of Amaranthus viridis(A. viridis),Amaranthus caudatus(A.caudatus) and Amaranthus spinosus(A.spinosus).Methods:In this study,the analgesic activity of methanol extracts of all three plants at doses of 200 and 400 mg/kg were investigated by acetic acid-induced writhings test,hot plate test and tail immersion test for mice.Results:It was found that all the three plants showed significant pain management effect(P<0.01) at a dose of 400 mg/kg,but showed a less significant effect at a dose of 20 mg/kg in the entire tests used for evaluation of analgesic activities(P<0.05).Conclusions:Methanol extracts of A.viridis,A.caudatus and A.spinosus show potent analgesic activities,and this study provides the scientific proof for their traditional claims. | Ashok Kumar BS Lakshman K Jayaveera KN Vel Murgan C Arun Kumar PA Vinod Kumar R Meghda Hegade Sridhar SM | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，7： | 2 |
| 4 | The realm of microbial lipases in biotechnology显示文摘 | Pandey Ashok Benjamin Sailas Soccol Carlos R | 1999 | Biotechnol Appl Biochem1999，29，： | 1 |
| 5 | Color duplex ultrasonography is insensitive for the detection of endoleak after aortic endografting:A systematic review显示文摘 | Ashoke R Brown LC Rodway A | | 0，，： | 1 |
| 6 | Intensity Correlation Properties of High-order Optical Vortices Passing Through a Rotation Ground-glass Plate 显示文摘 | Ashok Kumar Banerji J Singh R P | 2010 | Optics Letters(S0146-9592)2010，35，22： | 1 |
| 7 | Heat management in aluminium/air batteries: sources of heat显示文摘 | Patnaik R S M Ganesh S Ashok G | 1994 | Power Sources1994，50，3： | 1 |
| 8 | Rao Studieson thermal and morphologyical behavior of silieonized epoxy bismaleimide matrices 显示文摘 | A Ashok Kumar M Alagar R M V G K | 2001 | J Appl Polym Sci2001，81，： | 1 |
| 9 | A novel Kalman filter for frequency estimation of distorted signals in powersystems显示文摘 | Aurobinda R Ashok K P Rao K P | 2002 | IEEE Transactions on Instrumentation and Measurement2002，51，3： | 1 |
| 10 | Solid-state fermentation for the production of Monascus pig-mentsfrom jackfruit seed 显示文摘 | Sumathy Babitha Carlos R Soccol Ashok Pandey | 2007 | Bioresource Technology2007，，98： | 1 |
| 11 | Assessment of serum interleukin - 8 as a sensitive serological marker in monito- ring the therapeutic effect of levamisole in recurrent aph- thous ulcers: A randomized control study 显示文摘 | GUPTA P ASHOK L NAIK S R | 2014 | Indian Journal of Dental Research2014，25，3： | 1 |
| 12 | Changes in tissue defence system in white spot syndrome virus (WSSV) infected Penaeus monodon 显示文摘 | Mathew S Ashok Kumar K Anandan R etal | 2007 | Comp Biochem Physioi C2007，145，3： | 1 |
| 13 | Performance of aluminium anodes under heat treatment显示文摘 | ASHOK S R VENKATARAMANI A PARTHIBAN G T SRINWASAN S PALANISWAMY N MANI A RAGHAVAN M | 2002 | Corrosion on Prevention & Control2002，49，2： | 1 |
| 14 | Triterpenoids 显示文摘 | Shashi B M Ashoke K N Gita R | 1992 | Phyto-chemistry1992，31，7： | 1 |
| 15 | An optimization mode for industrial load management显示文摘 | Ashok S Banerjee R | 2001 | IEEE Trans on Power Systems2001，16，4： | 1 |
| 16 | New developments in solid state fermentation:Ⅰ-bioprocesses and products显示文摘 | Ashok Pandey Carlos R Soccol David Mitchell | 2000 | Process Biochemistry2000，35，： | 1 |
| 17 | The aging paradox: free radical theory of aging 显示文摘 | Ashok B T Ali R | 1999 | Exp Gerontol1999，34，3： | 1 |
| 18 | Differences in glycosylation patterns of heat shock protein, gp96: implications for prostate cancer prevention 显示文摘 | Suriano R Ghosh SK Ashok BT | 2005 | Cancer Res2005，65，14： | 1 |
| 19 | Production, purification and properties of microbial phytases 显示文摘 | Ashok Pandey George Szakacs Carlos R Soccol | 2001 | Bioresourse Technoiogy2001，，： | 1 |
| 20 | Changes in tissue defence system in white spot syndrome virus (WSSV) infected Penaeus monodon显示文摘 | Mathew S Ashok Kumar K Anandan R | 2007 | Comp Biochem Physiol C2007，145，3： | 1 |
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