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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Determination of food authenticity by enzyme-linked immunosorbent assay (ELISA)显示文摘 | ASENSIO L GONZALEZ I GARCIA T | 2008 | Food Control2008，19，1： | 1 |
| 3 | Cytokines and chemokines as mediators of protection and injury in the central nervous system assessed in transgenic mice 显示文摘 | Wang J Asensio V C Campbell I L | 2002 | Curr Top Microbiol Immunol2002，265，： | 1 |
| 4 | Use of heat-shocked mesophilic lactic acid bacteria in low-fat goat's milk cheesemaking 显示文摘 | Asensio C Parra L Pelaez C | 1996 | Journal of Agricultural and Food Chemistry1996，44，9： | 1 |
| 5 | Nanage ment of duodenal injuries显示文摘 | ASENSIO J A FELICIANO D V BRIT L D | 1993 | Our Prob In Surg1993，30，： | 1 |
| 6 | Tree vegetation and waste amendments to improve the physical condition of copper mine soils显示文摘 | ASENSIO V VEGA F A ANDRADE M L COVELO E F | 2013 | Chemosphere2013，90，2： | 1 |
| 7 | Complementary roles of tumor necrosis factor alpha and interferon gamma in inducible microglial nitric oxide generation 显示文摘 | Mir M Tolosa L Asensio V J | 2008 | J Neuroimmunol2008，204，12： | 1 |
| 8 | NMR Investigations of Protein-carbohydrate Interactions Binding Studies and Refined Three-dimensional Solution Structure of the Complex Between the B Domain of Wheat Germ Agglutinin and N,N',N'-triacetylchitotriose显示文摘 | Espinosa J F Asensio J L García J L | 2000 | Eur J Biochem2000，267，： | 1 |
| 9 | Evaluation of a modified QuEChERS method for the extraction of pesticides from agricultural, ornamental and forestal soils 显示文摘 | Asensio - Ramos M Hem6ndez - Borges J Ravelo - Parez L M | 2010 | Anal Bioanal Chem2010，396，： | 1 |
| 10 | Reliable variables in the exsanguinated patient which indicate damage control and predict outcome显示文摘 | Asensio JA McDuffie L Petrone P | 2001 | Am J Surg2001，182，6： | 1 |
| 11 | Determination of food authenticity by enzyme-linked immunosorbent assay (ELISA)显示文摘 | Asensio L Gonz~tlez I Garcia T | 2008 | Food Control2008，19，： | 1 |
| 12 | Determination of food authenticity by enzyme-linked immunosorbent assay ( ELISA ) 显示文摘 | Asensio L Gonzlez I Garcia T | 2008 | Food Control2008，19，： | 1 |
| 13 | A unified approach to the surgical exposure of pancreatic and duodenal injuries 显示文摘 | Asensio J Demetriades D Berne J e t a l | 1997 | Am J Surg1997，174，1： | 1 |
| 14 | Determination of food authenticity by enzyme-linked immunosorbent assay (ELISA) 显示文摘 | Asensio L Gonzalez I Garcia T | 2008 | Food Control2008，19，： | 1 |
| 15 | Vascular endotheli- al growth factor protects spinal cord motoneurons against glutamate-induced excitotoxicity via phosphatidylinositol 3-kinase 显示文摘 | Tolosa L Mir M Asensio V J | 2008 | J N eurochem2008，105，4： | 1 |
| 16 | Reliable variables in the exsanguinated patient which indicate damage control and predict outcome显示文摘 | Asensio JA McDuffie L Petrone P | 2001 | Am J Surg2001，182，6： | 1 |
| 17 | Reliable variables in the exsanguinated patient which indicate damage control and predict outcome显示文摘 | Asensio JA Mcduffie L Petrone P | 2001 | Am J Surg2001，182，6： | 1 |
| 18 | Evaluation of a modified Qu ECh ERS method for the extraction of pesticides from agricultural,ornamental and forestal soils显示文摘 | Asensio Ramos M Hernández Borges J Ravelo Pérez L M | 2010 | Anal Bioanal Chem2010，396，6： | 1 |
| 19 | Thermodynamics, Kinetics, and Dynamics of the Two Alternative Aniomesolytic Fragmentations of C-O Bonds: An Electrochemical and Theoretical Study显示文摘 | Pisano L Farriol M Asensio X | 2002 | J Am Chem Soc2002，124，： | 1 |
| 20 | Helical Ctcholangiography in the evaluation of the biliary tract: application to the diagnosis of choledocholithiasis显示文摘 | Giadas TC Sarria Octavio de Toledo L Martinez-Berganza Asensio MT | 2002 | Abdom Imaging2002，27，1： | 1 |
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