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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Effect of antibiotic prophylaxis on the risk of surgical site infection in orthotopie liver transplant显示文摘 | Asensio A Ramos A Cuervas-Mons V | 2008 | Liver Transpl2008，14，6： | 1 |
| 3 | Cytokines and chemokines as mediators of protection and injury in the central nervous system assessed in transgenic mice 显示文摘 | Wang J Asensio V C Campbell I L | 2002 | Curr Top Microbiol Immunol2002，265，： | 1 |
| 4 | Effect of soil recla- mation process on soil C fractions显示文摘 | ASENSIO V VEGA F A COVELO E F | 2014 | Chemosphere2014，95，10： | 1 |
| 5 | Effects of atrazine on hepatic metabolism and endocrine homeostasis in rainbow trout (Oncorhynchus mykiss)显示文摘 | SALABERRIA I HANSEN B H ASENSIO V et a1 | 2009 | Toxicology and Applied Pharmacology2009，234，1： | 1 |
| 6 | Effects of atrazineon hepatic metabolism and endocrine homeostasis in rain-bow trout(Oncorhynchus mykiss)显示文摘 | Salaberria I Hansen B H Asensio V | 2009 | Toxicol Appl Pharma-col2009，234，1： | 1 |
| 7 | Nanage ment of duodenal injuries显示文摘 | ASENSIO J A FELICIANO D V BRIT L D | 1993 | Our Prob In Surg1993，30，： | 1 |
| 8 | Tree vegetation and waste amendments to improve the physical condition of copper mine soils显示文摘 | ASENSIO V VEGA F A ANDRADE M L COVELO E F | 2013 | Chemosphere2013，90，2： | 1 |
| 9 | Sensory and chemical changes of young white wines stored under oxygen, an assessment of the role played by aldehydes and some other important odorants显示文摘 | ESCUDERO E ASENSIO J CACHO V | 2002 | Food Chemistry2002，77，3： | 1 |
| 10 | Complementary roles of tumor necrosis factor alpha and interferon gamma in inducible microglial nitric oxide generation 显示文摘 | Mir M Tolosa L Asensio V J | 2008 | J Neuroimmunol2008，204，12： | 1 |
| 11 | Ocular surfacealteration after long-term treatment with an anti glaucomatousdmg显示文摘 | Herreras JM Pastor JC Calonge M Asensio V | 1992 | Ophthalmology1992，99，7： | 1 |
| 12 | Effects of tree vegetation and waste amendments on the fractionation of Cr, Cu, Ni, Pb and Zn in polluted mine soils显示文摘 | Asensio V Vega F A Singh B R | 2013 | Science of the Total Environment2013，443，： | 1 |
| 13 | Effects of tree vegetation and waste amendments on the fractionation of Cr, Cu, Ni, Pb and Znin polluted mine soils显示文摘 | ASENSIO V VEGA FA SINGH B R | 2013 | Sci Total Environ2013，443，44： | 1 |
| 14 | Ontologies:giving semantics to network management models显示文摘 | Lopez J E Vergara de Villagra V A Asensio J I Berrocal J | 2003 | IEEE Network2003，17，3： | 1 |
| 15 | Effect of soil reclamation process on soil C fractions显示文摘 | Asensio V Vega F A Covelo E F | 2014 | Chemosphere2014，95，： | 1 |
| 16 | Vascular endotheli- al growth factor protects spinal cord motoneurons against glutamate-induced excitotoxicity via phosphatidylinositol 3-kinase 显示文摘 | Tolosa L Mir M Asensio V J | 2008 | J N eurochem2008，105，4： | 1 |
| 17 | Insulin-like growth factors I and II in the sole Solea senegalensis: cDNA cloning and quantitation of gene expression in tissues and during larval development显示文摘 | Funes V Asensio E Ponce M | 2006 | Gen Comp Endocrinol2006，149，16： | 1 |
| 18 | Ontologies: Giving semantics to network management models 显示文摘 | de VERGARA J E L VILLAGRA V A ASENSIO J I | 2003 | IEEE Network2003，17，3： | 1 |
| 19 | Ferritic steels optimization of hot-rolled textures through cold rolling and annealing显示文摘 | Asensio J Romano G Martinez V J | 2001 | Materials Characterization2001，47，2： | 1 |
| 20 | Ferritie Steels Optimization of Hot-Rolled Textures Through Cold Rolling and Annealing 显示文摘 | Asensio J Romano G Martinez V J | 2001 | Materials Characterization2001，47，： | 1 |
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