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| 1 | Microstructure and mechanical properties of Ti-6Al-4V-5% hydroxyapatite composite fabricated using electron beam powder bed fusion显示文摘A novel, Ti-6 Al-4 V(Ti64)/Hydroxyapatite(HA at 5% by weight concentration) metal/ceramic composite has been fabricated using electron beam powder bed fusion(EPBF) additive manufacturing(AM): specifically, the commercial electron beam melting(EBM?) process. In addition to solid Ti64 and Ti64/5% HA samples, four different unit cell(model) open-cellular mesh structures for the Ti64/5% HA composite were fabricated having densities ranging from 0.68 to 1.12 g/cm^3, and corresponding Young's moduli ranging from 2.9 to 8.0 GPa, and compressive strengths ranging from ~3 to 11 MPa. The solid Ti64/5%HA composite exhibited an optimal tensile strength of 123 MPa, and elongation of 5.5% in contrast to a maximum compressive strength of 875 MPa. Both the solid composite and mesh samples deformed primarily by brittle deformation, with the mesh samples exhibiting erratic, brittle crushing. Solid, EPBF-fabricated Ti64 samples had a Vickers microindentation hardness of 4.1 GPa while the Ti64/5%HA solid composite exhibited a Vickers microindentation hardness of 6.8 GPa. The lowest density Ti64/5%HA composite mesh strut sections had a Vickers microindentation hardness of 7.1 GPa. Optical metallography(OM) and scanning electron microscopy(SEM) analysis showed the HA dispersoids to be highly segregated along domain or grain boundaries, but homogeneously distributed along alpha(hcp) platelet boundaries within these domains in the Ti64 matrix for both the solid and mesh composites. The alpha platelet width varied from ~5 μm in the EPBF-fabricated Ti64 to ~1.1 m for the Ti64/5%HA mesh strut. The precursor HA powder diameter averaged 5 μm, in contrast to the dispersed HA particle diameters in the Ti64/5%HA composite which averaged 0.5 m. This work highlights the use of EPBF AM as a novel process for fabrication of a true composite structure, consisting of a Ti64 matrix and interspersed and exposed HA domains, which to the authors' knowledge has not been reported before. The results also illustrate the prospects not only for fabricating specialized, novel composite bone replacement scaffolds and implants, through the combination of Ti64 and HA, but also prospects for producing a variety of related metal/ceramic composites using EPBF AM. | César A.Terrazas Lawrence E.Murr Diego Bermudez Edel Arrieta David A.Roberson Ryan B.Wicker | 2019 | Journal of Materials Science & Technology2019，35，2： | 4 |
| 2 | Con- current chemo-radiotherapy following neoadjuvant chemotherapy in locally advanced breast cancer显示文摘 | Alvarado-Mirandal A Arrieta O Gamboa-Vignolle C | 2009 | Radiat Oncol2009，4，： | 1 |
| 3 | The human Ng gene homolog,NRGN contains a thyroid hormone-responsive elementlocated inthefirstintron显示文摘 | Martinez de Arrieta C Morte B Coloma A | 1999 | Endocrinology1999，140，1： | 1 |
| 4 | Identification of a cis-acting elementthat interferes withthyroid hormone induction of the neurogranin(NRGN)gene显示文摘 | Morte B Martinez de Arrieta C Manzano J | 1999 | FEBS Lett1999，464，3： | 1 |
| 5 | Role of periph- erally inserted central catheters (PICC) in home and in-hospital parenteral nutrition显示文摘 | Botella-Carretero Carrero C Arrieta F | 2009 | Nutrition al Therapy Metabolism2009，27，2： | 1 |
| 6 | Association of depression and anxiety on quality of life,treatment adherence,and prognosis in patients with advanced non-small cell lung cancer显示文摘 | Arrieta O Angulo LP Nú?ez-Valencia C | 2013 | Ann Surg Oncol2013，20，6： | 1 |
| 7 | Marine biodiversity and gene patents显示文摘 | ARNAUD-HAOND S ARRIETA J M DAURTE C M | 2011 | Science2011，，331： | 1 |
| 8 | Reducing small intestinal permeability attenuates colitis in the IL-10 gene deficient mice显示文摘 | Arrieta M C Madsen K Doyle J | 2009 | Gut2009，58，1： | 1 |
| 9 | Useful-ness of Serum Careinoembryonic Antigen ( CEA ) in evaluating response to chemotherapy in patients with advanced non small-cell lung cancer: a prospective cohort study显示文摘 | Arrieta Rodriguez O G Villarreal-Garza C Martinez-Barrera L | 2013 | BMC Cancer2013，13，6： | 1 |
| 10 | Association between AT1 and AT2 angiotensin II receptor expression with cell proliferation and angiogenesis in operable breast cancer 显示文摘 | Arrieta O Villarreal-Garza C Vizcal no G | 2015 | Tumour Biol2015，36，7： | 1 |
| 11 | Useful- ness of serum carcinoembryonic antigen (CEA) in evaluating re- sponse to chemotherapy in patients with advanced non small-cell lung cancer: a prospective cohort study 显示文摘 | Arrieta O Villarreal-Garza C Martinez-Barrera L | 2013 | BMC Cancer2013，13，： | 1 |
| 12 | Long-term survival in patients with non-small cell lung cancer and synchronous brain metastasis treated with whole-brain radiotherapy and thoracic chemoradiation显示文摘 | Arrieta O Villarreal-Garza C Zamora J | 2011 | Radiat Oncol2011，6，： | 1 |
| 13 | Safety, tolerability, and pharmacokinetics of micafungin (FK463) in febrile neutropenic pediatric patients显示文摘 | SEIBEL NL SCHWARTZ C ARRIETA A | 2005 | Antimicrob Agents Chemo- ther2005，49，8： | 1 |
| 14 | Whole-brain irradiation with concomitant daily fixed-dose Temozolomide for brain metastases treatment : A randomised phase II trial 显示文摘 | Gamboa-Vignolle C Ferrari-Carballo T Arrieta O | 2012 | Radiother Oncol2012，102，2： | 1 |
| 15 | X-ray dif- fraction, Raman, and differential thermal analyses of the thermal aging of a Kevlar { extregistered} -PBI blend fabric 显示文摘 | ARRIETA C DAVID E DOLEZ P | 2011 | Polymer Composites2011，，6： | 1 |
| 16 | Terminal-restriction fragment length polymorphism(T-RFLP)screening of a marine archaeal clone library to determine the different phylotypes显示文摘 | MOESENEDER M M WINTER C ARRIETA J M | 2001 | Journal of Microbiological Metbods2001，44，2： | 1 |
| 17 | Chemokine control of lymphocyte trafficking: a general overview 显示文摘 | Stein JV Nombela - Arrieta C | 2005 | Immunology2005，116，1： | 1 |
| 18 | Usefulness of serum carcinoembryonic antigen (CEA) in evaluating response to chemotherapy in patients with advanced non small-cell lung cancer: A prospective cohort study显示文摘 | Arrieta O Villarreal-Garza C Marttnez-Barrera L | 2013 | BMC Cancer2013，13，： | 1 |
| 19 | Kiwi spirits with stronger floral and fruity characters were obtained with a packed column distillation system显示文摘 | Arrieta G Y Lopez- Vazquez C Blanco P | 2013 | Chemistry & Food Science2013，117，9： | 1 |
| 20 | Effect of lead acetate on the in vitro engulfment and killing capability of toad(Bufo arenarum)neutrophils显示文摘 | ROSENBERG C E FINK N E ARRIETA M A | 2003 | Comp Biochem Physiol C Toxicol Pharmacol2003，136，3： | 1 |
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