|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 2 | Review on observational studies of western tropical Pacific Ocean circulation and climate显示文摘The Western Tropical Pacific(WTP) Ocean holds the largest area of warm water(>28℃) in the world ocean referred to as the Western Pacific Warm Pool(WPWP),which modulates the regional and global climate through strong atmospheric convection and its variability.The WTP is unique in terms of its complex 3-D ocean circulation system and intensive multiscale variability,making it crucial in the water and energy cycle of the global ocean.Great advances have been made in understanding the complexity of the WTP ocean circulation and associated climate impact by the international scientific community since the 1960 s through field experiments.In this study,we review the evolving insight to the 3-D structure and multi-scale variability of the ocean circulation in the WTP and their climatic impacts based on in-situ ocean observations in the past decades,with emphasis on the achievements since 2000.The challenges and open que stions remaining are reviewed as well as future plan for international study of the WTP ocean circulation and climate. | HU Dunxin WANG Fan SPRINTALL Janet WU Lixin RISER Stephen CRAVATTE Sophie GORDON Arnold ZHANG Linlin CHEN Dake ZHOU Hui ANDO Kentaro WANG Jianing LEE Jae-Hak HU Shijian WANG Jing ZHANG Dongxiao FENG Junqiao LIU Lingling VILLANOY Cesar KALUWIN Chalapan QU Tangdong MA Yixin | 2020 | Journal of Oceanology and Limnology2020，38，4： | 3 |
| 3 | Iron deficiency anmia, cigarette smoking and risk of abruptio placentae 显示文摘 | Arnold DL Williams MA Miller RS | 2009 | J Obstet Gynaecol Res2009，35，3： | 1 |
| 4 | Systematic review: efficacy and safety of rituximab for adult with idiopathic thrombocytopenic purpura显示文摘 | ARNOLD DM DENTALI F CROWTHER MA | 2007 | Ann Intern Med2007，146，： | 1 |
| 5 | Iron deficiency anemia,cigarette smoking and risk of abruptio placentae显示文摘 | Arnold DL Williams MA Miller RS | 2009 | J Obstet Gynaecol Res2009，35，3： | 1 |
| 6 | Histonedeacetylase degradation andMEF2 activationpromote the formation of slow-twitch myofi-bers显示文摘 | Potthoff MJ Wu H Arnold MA | 2007 | J Clin Invest2007，117，9： | 1 |
| 7 | Calcito- nin: a drug of the past or for the future7 Physiologic inhibition of bone resorption while sustaining osteoclast numbers imp roves bone quality 显示文摘 | Karsdal MA Henriksen K Arnold M | 2008 | BioDrugs2008，22，3： | 1 |
| 8 | Systematic review: efficacy and safety of rituximah for adults with idiopathic thrombocytopenic purpur显示文摘 | Arnold DM Dentali F Crowther MA | 2007 | Ann Intern Med2007，146，1： | 1 |
| 9 | Immunotherapy of Experimental Bladder Cancer with Recombinant BCG Expressing Interferon-gamma显示文摘 | Arnold J De Boer EC O'Donnell MA | 2004 | J Immunother2004，27，2： | 1 |
| 10 | Iron deficiency anmia,cigarette smoking and risk of abruptio placentae显示文摘 | Arnold DL Williams MA Miller RS | 2009 | J Obstet GynaecolRes2009，35，3： | 1 |
| 11 | The effects of early and repeated prone positioning in pediatric patients with acute lung injury显示文摘 | Curley MA Thompson JE Arnold JH | 2000 | Chest2000，118，1： | 1 |
| 12 | Iron deficiency anemia,cigarette smoking and risk of abruption plancentae 显示文摘 | Arnold DL Wiliiams MA Miller RS | 2009 | J Obstet Gynaecol Res2009，35，3： | 1 |
| 13 | Recent advances in the development and analytical applications of biosensing probes 显示文摘 | ARNOLD MA MEYERHOFF ME | 1988 | Crit Rev Anal Chem1988，20，3： | 1 |
| 14 | Systematic review:efficacy and safety of rituximab for adults with idiopathic thrombocytopenic purpura显示文摘 | Arnold DM Dentali F Crowther MA | 2007 | Ann Intern Med2007，146，： | 1 |
| 15 | Systematic review: efficacy and safety of dtuximab for adults with idiopathic thrombocytopenic purpura显示文摘 | Arnold DM Dentali F Crowther MA | 2007 | Ann Intern Med2007，146，1： | 1 |
| 16 | Five-year clinical and economic outcomes among patients with medically managed severe aortic stenosis: results from a Medicare claims analysis 显示文摘 | Clark MA Arnold SV Duhay FG | 2012 | Circ Carcliovasc Qua] Outcomes2012，5，5： | 1 |
| 17 | Immunotherapy of experimental bladder cancer with recombinant BCG expressing interferon-gamma显示文摘 | Arnold J de Boer EC O'Donnell MA | | 0，，2： | 1 |
| 18 | The 6-min walk test:a quick measure of functional status in elderly adults显示文摘 | Enright PL McBurnie MA Bittner V Tracy RP.McNamara R Arnold A | | 0，，： | 1 |
| 19 | Clinical trial design--effect of prone positioning on clinical outcomes in infants and children with acute respiratory distress syndrome 显示文摘 | Curley MA Arnold JH Thompson JE | 2006 | J Crit Care2006，21，： | 1 |
| 20 | Passive transfer of peanut hypersensitivity by fresh frozen plasma显示文摘 | Arnold DM Blajchman MA Ditomasso J | 2007 | Arch Intern Med2007，167，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员