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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Role of AXL in invasion and drug resistance of colon and breast cancer cells and its association with p53 alterations显示文摘AIM To characterize AXL receptor tyrosine kinase(AXL)expression in relationship to tumor protein P53(TP53gene,p53 protein)and its role in tumor invasion and response to therapy.METHODS We used 14 cell lines,including 3 isogenic pairs carrying mutant/knockout p53,to gain insight into the relationship between AXL and TP53.These included HCT116,HCT116.p53 mutant,RKO,and RKO.p53-/-lines(all from colon cancers)as well as breast cancer cell lines MCF7 and 1001(MCF7-p53 mutant clone).He La cell line was used as a positive control for epithelial to mesenchymal transition(EMT).AXL expression was determined by Western blotting using rabbit monoclonal antibody clone C89E7.AXL si RNA silencing was performed and followed by collagen invasion assay.Cell viability analysis using the sulforhodamine B assay and the invasion assay were performed after exposure to chemotherapeutic agents(doxorubicin for breast cancer cells;5FU or irinotecan for colon cancer cells).RESULTS We showed that the introduction of p53 mutations or knockout increased expression levels of AXL in isogenic cells compared to the matching p53 wild-type parental cells.Overall,we found a trend for correlation between the potential EMT candidate AXL,p53 alterations,and EMT markers in colorectal and breast cancers.The expression of AXL in RKO cells,a rare colon cancer cell line with inactive Wnt signaling,suggests that the AXL oncogene might provide an alternative genetic pathway for colorectal carcinogenesis in the absence of Wnt signaling activation and TP53 mutation.AXL silencing in the TP53 mutant isogenic cell lines 1001,HCT116.p53 mutant and RKO.P53-/-was>95%efficient and the silenced cells were less invasive compared to the parental TP53 wild-type cells.AXL silencing showed a subtle trend to restore colon cancer cell sensitivity to5FU or irinotecan.Importantly,AXL expressing cells developed more invasive potential after exposure to chemotherapy compared to the AXL-silenced cells.CONCLUSION AXL is influenced by p53 status and could cause the emergence of aggressive clones after exposure to chemotherapy.These findings could have applications in cancer management. | Wael M Abdel-Rahman Noura A Al-khayyal Vidhya A Nair S R Aravind Maha Saber-Ayad | 2017 | World Journal of Gastroenterology2017，23，19： | 7 |
| 3 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 4 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 5 | Effect of Aging Time and Concentration of Aging Solution on the Porosity Characteristics of Subcritically Dried Silica Aerogels显示文摘 | Smitha S Shaiesh P Aravind P R | 2006 | Microporous Mesoporous Mater2006，91，： | 1 |
| 6 | Evaluation of antioxidant, antitumor and immunmodulatory properties of polysaccharide isolated from fruit rind of Punica granatum显示文摘 | Joseph M M Aravind S R Vargese S | 2011 | Mol Med Report2011，5，2： | 1 |
| 7 | Genome of the extremely radiation-resistant bacterium Deinococcus radiodurans viewed from the perspective of comparative genomics显示文摘 | Makarova K S Aravind L Wolf Y I Tatusov R L Minton K W Koonin E V Daly M J | 2001 | Microbiology and Molecular Biology Reviews2001，65，1： | 1 |
| 8 | Mesoporous silica- alumina aerogels with high thermal pore stability through hybrid sol -gel route followed by subcritical drying 显示文摘 | Aravind P R Mukundan P Pillai P K | 2006 | Microporous and Mesoporous Materials2006，96，123： | 1 |
| 9 | System study on hydrothermal gasification combined with a hybrid solid oxide fuel cell gas turbine显示文摘 | Toonssen R Aravind P V Smit G | 2010 | Fuel Cell2010，10，： | 1 |
| 10 | Bioaccumulation of chromium from tannery wastewater: An approach for chrome recovery and reuse 显示文摘 | ARAVIND HAN R MADHAN B RAO J R NAIR B U RAMASAMI T | 2004 | Environment Science and Technology2004，38，： | 1 |
| 11 | AS1411 aptamer tagged PLGA-lecithin-PEG nanoparticles for tumor cell targeting and drug delivery 显示文摘 | Aravind A Jeyamohan P Nair R | 2012 | Biotechnol Bioeng2012，109，11： | 1 |
| 12 | Genome sequence of the radioresistant bacteriumDeinococcus radiodurans R显示文摘 | White O Eisen J A Heidelberg J F Hickey E K Peterson J D Dodson R J Haft D H Gwinn M L Nelson W C Richardson D L Moffat K S Qin H Jiang L Pamphile W Crosby M Shen M Vamathevan J J Lam P McDonald L Utterback T Zalewski C Makarova K S Aravind L Daly M J Minton K W Fleischmann R D Ketchum K A Nelson K E Salzberg S Smith H O Venter J C Fraser C M | 1999 | Science1999，286，5444： | 1 |
| 13 | Interleaving-based cyclic delay diversity OFDM systems over spatially corre- lated channels 显示文摘 | Senthil B Aravind R Prabhu K M M | 2013 | Circuits Systems and Signal Pro- cessing2013，32，1： | 1 |
| 14 | Conserved domains in DNA repair proteins and evolution of repair systems显示文摘 | Aravind L Walker D R Koonin E V | 1999 | Nucleic Acids Res1999，27，5： | 1 |
| 15 | Patient compliance and supportive periodontal therapy:Study among young adults of Namakkal district显示文摘 | Gokulanathan S Balan N Aravind R J | 2014 | J Pharm Bioallied Sci2014，6，1： | 1 |
| 16 | Blends of nylon 6/66 and acrylonitrile-butadiene rubber: effects of blend atio and dynamic vulcanization on morphology and properties 显示文摘 | KUMAR C R ARAVIND I STEPHAN R | 2005 | Prog Rubber Plast Recycl Technol2005，21，4： | 1 |
| 17 | Motion-compensated video coding with adaptive perceptual quantization 显示文摘 | PURI A ARAVIND R | 1991 | IEEE Transaction on Circuits and Systems for Video Technology1991，1，4： | 1 |
| 18 | Modeling and Filter Design through Analysis of Conducted EMI in Switching PowerConverters 显示文摘 | Vimala R Baskaran K Aravind Britto K R | 2012 | Journal of Power Electronics2012，12，4： | 1 |
| 19 | , Muhifunctional gold coated thermo-sensitive liposomes for multimodal imaging and photo-thermal therapy of breast cancer cells 显示文摘 | Aravind Kumar R Madhura J Abhijit D | 2014 | Nanoscale2014，6，2： | 1 |
| 20 | A galactomannan polysaccharide from Punica granatum imparts in vitro and in vivo anticancer activity 显示文摘 | Joseph M M Aravind S R George S K | 2013 | Carbohydr Polym2013，98，： | 1 |
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