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| 1 | Pancreatic stellate cell: Pandora's box for pancreatic disease biology显示文摘Pancreatic stellate cells(PSCs) were identified in the early 1980 s, but received much attention after 1998 when the methods to isolate and culture them from murine and human sources were developed. PSCs contribute to a small proportion of all pancreatic cells under physiological condition, but are essential for maintaining the normal pancreatic architecture. Quiescent PSCs are characterized by the presence of vitamin A laden lipid droplets. Upon PSC activation, these perinuclear lipid droplets disappear from the cytosol, attain a myofibroblast like phenotype and expresses the activation marker, alpha smooth muscle actin. PSCs maintain their activated phenotype via an autocrine loop involving different cytokines and contribute to progressive fibrosis in chronic pancreatitis(CP) and pancreatic ductal adenocarcinoma(PDAC). Several pathways(e.g., JAK-STAT, Smad, Wnt signaling, Hedgehog etc.), transcription factors and mi RNAs have been implicated in the inflammatory and profibrogenic function of PSCs. The role of PSCs goes much beyond fibrosis/desmoplasia in PDAC. It is now shown that PSCs are involved in significant crosstalk between the pancreatic cancer cells and the cancer stroma. These interactions result in tumour progression, metastasis, tumour hypoxia, immune evasion and drug resistance. This is the rationale for therapeutic preclinical and clinical trials that have targeted PSCs and the cancer stroma. | Ratnakar R Bynigeri Aparna Jakkampudi Ramaiah Jangala Chivukula Subramanyam Mitnala Sasikala G Venkat Rao D Nageshwar Reddy Rupjyoti Talukdar | 2017 | World Journal of Gastroenterology2017，23，3： | 25 |
| 2 | Split liver transplantation:What's unique?显示文摘The intraoperative management of split liver transplantation(SLT) has some unique features as compared to routine whole liver transplantations. Only the liver has this special ability to regenerate that confers benefits in survival and quality of life for two instead of one by splitting livers. Primary graft dysfunction may result from small for size syndrome. Graft weight to recipient body weight ratio is significant for both trisegmental and hemiliver grafts. Intraoperative surgical techniques aim to reduce portal hyperperfusion and decrease venous portal pressure. Ischemic preconditioning can be instituted to protect against ischemic reperfusion injury which impacts graft regeneration. Advancement of the technique of SLT is essential as use of split cadaveric grafts expands the donor pool and potentially has an excellent future. | Aparna R Dalal | 2015 | World Journal of Transplantation2015，5，3： | 2 |
| 3 | Surgical stress and the small intestine: role of Oxygen free radicals显示文摘 | Anup R Aparna V Pttlimood A | 1999 | Surgery1999，125，5： | 1 |
| 4 | Three-dimensional quantitative structure (3-D QSAR)activity relationship studies on imidazolyl and N-pyrrolyl heptenoates as 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibitors by comparative molecular similarity indices analysis (CoMSIA)显示文摘 | THILAGAVATHI R KUMAR R APARNA V | 2005 | Bioorg Med Chem Lett2005，15，4： | 1 |
| 5 | Failure of 220 kV double circuit transmission line tower due to lightning显示文摘 | NAIR Z APARNA K M KHANDAGALE R S | 2005 | Journal of Performance of Constructed Facilities2005，19，2： | 1 |
| 6 | Photodegradation of direct yellow-12 using UV/H2O2/Fe2+显示文摘 | APARNA R HAMENT K R RAKESH K S | 2003 | Journal of Hazardous Materials2003，2003，102： | 1 |
| 7 | Deshpande Molecular and Biotechnological Aspects of Microbial Proteases 显示文摘 | MALA B R APARNA M T MOHINI S G | 1998 | Microbiology and Molecular Biology Reviews1998，62，3： | 1 |
| 8 | Blending chitosan with polycaprolactone: Effects on physicochemical and antibacterial properties 显示文摘 | Aparna R Sarasam Raj K Krishnaswamy Sundararajan V Madihally | 2006 | Biomacromolecules2006，，7： | 1 |
| 9 | Surgical stress and the small intestine: Role of oxygen free radicals 显示文摘 | Anup R Aparna V Pulimood A | 1999 | Surgery1999，125，5： | 1 |
| 10 | Three-dimensional quantitative structure (3-D QSAR) activity relationship studies on imidazolyl and N-pyrrolyl heptenoates as 3-hydroxy-3-methyl- glutaryl-CoA reductase (HMGR)inhibition by comparative molecular similarity indices analysis (CoMSIA)显示文摘 | THILAGAVATHI R KUMAR R APARNA V | 2005 | Bioorg Med Chem Lett2005，15，4： | 1 |
| 11 | In vitro antibacterial activity of Bougainvillea spectabilis leaves extracts 显示文摘 | Umamaheswari A Shreevidya R Aparna N | 2008 | Adv Biol Res2008，2，12： | 1 |
| 12 | In Vitro Antibacterial Activity of Bougainvillea Spectabilis Leaves Extract显示文摘 | Umamaheswari A Shreevidya R Aparna Nuni | 2008 | Nationalism and Ethnic Politics2008，2，12： | 1 |
| 13 | Three-phase partitioning for simultaneous renaturation and partial purification of Aspergillus niger xylanase显示文摘 | Ipsita R Aparna S Munishwar NG | 2004 | Biochimica biophysica acta (BBA)-Proteins & Proteomics2004，1698，1： | 1 |
| 14 | Multi-sender multi-receiver authentication for dynamic secure group communication显示文摘 | APARNA R AMBERKER B B | 2007 | IJCSNS International Journal of Computer Science and Network Security2007，7，10： | 1 |
| 15 | Dynamic authenticated secure group communication显示文摘 | APARNA R AMBERKER B B | 2007 | Proceedings of World Academy of Science Engineering And Technology2007，25，： | 1 |
| 16 | Theoretical Prediction of Shape Memory Behavior and Ferrimagnetism in Mn2NiIn显示文摘 | Aparna Chakrabarti Barman S R | 2009 | Appl Phys Lett2009，94，16： | 1 |
| 17 | Liquisolid technology:An overview显示文摘 | Sambasiva R A Naga Aparna T | 2011 | Int J Res Pharm Biomed Sci2011，2，2： | 1 |
| 18 | Photocatalytie effect of TiO2 and the effect of dopants on degradation of brilliant green 显示文摘 | MUNUSAMY S APARNA R PRASAD R | 2013 | Sustainable Chemical Processes2013，，1： | 1 |
| 19 | An effective route to produce few-layer graphene using combinatorial ball milling and strong aqueous exfoliants显示文摘 | APARNA R SIVAKUMAR N BALAKRISHNAN A | 2013 | J Renew Sustain Ener2013，5，03： | 1 |
| 20 | Surgical stress and the small intestine: role of oxygen free radicals显示文摘 | Anup R Aparna V Pulimood A | 1999 | Surgery1999，125，： | 1 |
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