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| 1 | The immune tolerant phase of chronic HBV infection: new perspectives on an old concept显示文摘长期的肝炎 B 病毒(HBV ) 感染通过强烈与耐心的年龄被联系的不同疾病阶段进行。所谓的免疫者容忍(信息技术) 阶段代表感染的古典早阶段;它与 HBV 复制的高水平和肝发炎的临床的符号的缺乏被联系。HBV 感染的这个阶段是否也与免疫学的被联系, “ 展示; tolerance' 最近被质问了。这里,我们考察数据那争论有免疫力的忍耐的这个概念然后建议发生在 CHB 感染的这个早阶段期间的 immunopathological 事件的其他的解释。 | Antonio Bertoletti Patrick T Kennedy | 2015 | Cellular & Molecular Immunology2015，12，3： | 36 |
| 2 | A systematic review and meta-analysis to determine the effect of sperm DNA damage on in vitro fertilization and intracytoplasmic sperm injection outcome显示文摘精子 DNA 损坏在不肥沃的人之中是流行的并且被知道影响自然复制。然而,帮助繁殖结果上的精子 DNA 损坏的影响仍然保持争论。这里,我们在精子 DNA 损坏上进行了研究的元分析(由 SCSA, TUNEL, SCD,或彗星试金估计了) 并且在从 MEDLINE, EMBASE,和 PUBMED 数据库的 IVF 或 ICSI 处理以后的临床的怀孕寻找这分析。我们识别了 41 篇文章(与 56 研究的一个总数) 包括 16, IVF 学习, 24 ICSI 研究,并且 16 混合了(IVF + ICSI ) 学习。这些研究测量了 DNA 损坏(由四试金之一:23 SCSA, 18 TUNEL, 8 SCD,和 7 彗星) 并且包括了 8068 个处理周期(3734 IVF, 2282 ICSI,和 2052 混合 IVF + ICSI ) 的一个总数。联合或 1.68 (95% CI:1.49-1.89;P <0.0001 ) 显示那精子 DNA 损坏影响临床的怀孕追随者 IVF 或 ICSI 处理。另外,联合或 IVF 的估计(16 估计,或 = 1.65;95% CI:1.34-2.04;P <0.0001 ) , ICSI (24 估计,或 = 1.31;95% CI:1.08-1.59;P = 0.0068 ) ,并且混合 IVF + ICSI 学习(16 估计,或 = 2.37;95% CI:1.89-2.97;P <0.0001 ) 也是统计上重要的。在建议精子 DNA 损坏在临床的怀孕追随者 IVF 或 ICSI 处理上有否定效果的存在文学有足够的证据。 | Luke Simon Armand Zini Alina Dyachenko Antonio Ciampi Douglas T Carrell | 2017 | Asian Journal of Andrology2017，19，1： | 38 |
| 3 | Use of antibiotics in broiler production:Global impacts and alternatives显示文摘Antibiotics are used to fight bacterial infections.However, a selective pressure gave rise to bacteria resistant to antibiotics.This leaves scientists worried about the danger to human and animal health.Some strategies can be borrowed to reduce the use of antibiotics in chicken farms.Much research has been carried out to look for natural agents with similar beneficial effects of growth promoters.The aim of these alternatives is to maintain a low mortality rate, a good level of animal yield while preserving environment and consumer health.Among these, the most popular are probiotics, prebiotics, enzymes,organic acids, immunostimulants, bacteriocins, bacteriophages, phytogenic feed additives, phytoncides,nanoparticles and essential oils. | Youcef Mehdi Marie-Pierre Létourneau-Montminy Marie-Lou Gaucher Younes Chorfi Gayatri Suresh Tarek Rouissi Satinder Kaur Brar Caroline Cté Antonio Avalos Ramirez Stéphane Godbout | 2018 | Animal Nutrition2018，，2： | 19 |
| 4 | Endoscopic ultrasound-guided vs endoscopic retrograde cholangiopancreatography biliary drainage for obstructed distal malignant biliary strictures: A systematic review and meta-analysis显示文摘BACKGROUND For palliation of malignant biliary obstruction(MBO), the gold-standard method of biliary drainage is endoscopic retrograde cholangiopancreatography(ERCP)with the placement of metallic stents. Endoscopic ultrasound(EUS)-guided drainage is an alternative that is typically reserved for cases of ERCP failure.Recently, however, there have been robust randomized clinical trials(RCTs)comparing EUS-guided drainage and ERCP as primary approaches to MBO.AIM To compare EUS guidance and ERCP in terms of their effectiveness and safety in palliative biliary drainage for MBO.METHODS This was a systematic review and meta-analysis, in which we searched the MEDLINE, Excerpta Medica, and Cochrane Central Register of Controlled Trials databases. Only RCTs comparing EUS and ERCP for primary drainage of MBO were eligible. All of the studies selected provided data regarding the rates of technical and clinical success, as well as the duration of the procedure, adverse events, and stent patency. We assessed the risk of biases using the Jadad score and the quality of evidence using the Grading of Recommendations Assessment,Development and Evaluation criteria.RESULTS The database searches yielded 5920 records, from which we selected 3 RCTs involving a total of 222 patients(112 submitted to EUS and 110 submitted to ERCP). In the EUS and ERCP groups, the rate of technical success was 91.96%n and 91.81%, respectively, with a risk difference(RD) of 0.00%(95%CI:-0.07, 0.07;P = 0.97; I^2 = 0%). The clinical success was 84.81% and 85.53% in the EUS and ERCP groups, respectively, with an RD of-0.01%(95%CI:-0.12, 0.10; P = 0.90; I^2 =0%). The mean difference(MD) for the duration of the procedure was-0.12%(95%CI:-8.20, 7.97; P = 0.98; I^2 = 84%). In the EUS and ERCP groups, there were14 and 25 adverse events, respectively, with an RD of-0.06%(95%CI:-0.23, 0.12; P= 0.54; I^2 = 77%). The MD for stent patency was 9.32%(95%CI:-4.53, 23.18; P =0.19; I^2 = 44%). The stent dysfunction rate was significantly lower in the EUS t group(MD =-0.22%; 95 CI:-0.35,-0.08; P = 0.001; I^2 = 0%).CONCLUSION EUS represents an interesting alternative to ERCP for MBO drainage,demonstrating lower stent dysfunction rates compared with ERCP. Technical and clinical success, duration, adverse events and patency rates were similar. | Fernanda P Logiudice Wanderlei M Bernardo Facundo Galetti Vitor M Sagae Carolina O Matsubayashi Antonio C Madruga Neto Vitor O Brunaldi Diogo T H de Moura Tomazo Franzini Spencer Cheng Sergio E Matuguma Eduardo G H de Moura | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，4： | 6 |
| 5 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 6 | 在 7T 的多原子的磁性的回声光谱学的应用显示文摘 AIM: To discuss the advantages of ultra-high field (7T) for 1H and 13C magnetic resonance spectroscopy (MRS) studies of metabolism.made at both 3 and 7T using 1H MRS. Measurements of glycogen and lipids in muscle were measured using 13C and 1H MRS respectively. RESULTS: In the brain, increased signal-to-noise ratio (SNR) and dispersion allows spectral separation of the amino-acids glutamate, glutamine and γ-aminobutyric acid (GABA), without the need for sophisticated editing sequences. Improved quantification of these me-tabolites is demonstrated at 7T relative to 3T. SNR was 36% higher, and measurement repeatability (% coefficients of variation) was 4%, 10% and 10% at 7T, vs 8%, 29% and 21% at 3T for glutamate, glutamine and GABA respectively. Measurements at 7T were used to compare metabolite levels in the anterior cingulate cortex (ACC) and insula. Creatine and glutamate levels were found to be significantly higher in the insula compared to the ACC (P < 0.05). In muscle, the increased SNR and spectral resolution at 7T enables interleaved studies of glycogen (13C) and intra-myocellular lipid (IMCL) and extra-myocellular lipid (EMCL) (1H) following exercise and refeeding. Glycogen levels were sig-nificantly decreased following exercise (-28% at 50% VO2 max; -58% at 75% VO2 max). Interestingly, levels of glycogen in the hamstrings followed those in the quadriceps, despite reduce exercise loading. No changes in IMCL and EMCL were found in the study. CONCLUSION: The demonstrated improvements in brain and muscle MRS measurements at 7T will increase the potential for use in investigating human metabolism and changes due to pathologies. | Mary C Stephenson Frances Gunner Antonio Napolitano Paul L Greenhaff Ian A MacDonald Nadeem Saeed William Vennart Susan T Francis Peter G Morris | 2011 | World Journal of Radiology2011，3，4： | 2 |
| 7 | Environmental im- pacts of intensive aquacuhure in marine water 显示文摘 | ANTONIO T CARLOS M MANUEL P M | 2000 | Water Re- search2000，34，1： | 1 |
| 8 | Cholecystoc- holedocholithiasis: a case-control study comparing the short and long-term outcomes for a 'laparoseopy-first' attitude with the outcome for sequential treatment 显示文摘 | RENATO C ANTONIO M FRANCESCO T | 2010 | Surg Endosc2010，24，1： | 1 |
| 9 | Analysis of the porgnostic signficance of cytosoilc determination of CA125,CEA,SCC-AG in patients with NSCLC显示文摘 | Antonio LP Manuel D Antonio T | 1996 | Cancer1996，77，6： | 1 |
| 10 | A comparative study on the determi nation of lactic acid in silage by colorimetric, high performance liquid ehoromatography and enzymatic methods 显示文摘 | Josefa M Antonio M T | 1999 | Journal of the Science of Food and Agriculture1999，79，： | 1 |
| 11 | The use of carbon paste electrode in the direct voltammetric determination of tryptophan in pharmaceutical formulations显示文摘 | Antonio R F Eder T Cavalheiro G | 2002 | Journal of Pharmaceutical and Biomedical Analysis2002，28，5： | 1 |
| 12 | Nutritive value and performance of growing rabbits fed rations containing extruded corn显示文摘 | Furlan Antonio C Renilda T | 2003 | R Bras Zootec2003，32，5： | 1 |
| 13 | Addit,on ol teicoplanin or vancomycin for the treatment of documented bacteremia due to gram-positive cocci in neutropenic patients with hematological malignancies: microbiological, clinical and economic evaluation显示文摘 | D'Antonio D Staniscia T Piccolomini R | 2004 | Chemotherapy2004，50，2： | 1 |
| 14 | A Risk-return measure of hedging effectiveness显示文摘 | Howard C T Antonio L J D | 1984 | Journal of Financial and Quantitative Analysis1984，19，3： | 1 |
| 15 | Antiplatelet therapy: thrombin receptor antagonists 显示文摘 | ANTONIO T M SALVATORE D T MASAFUMI U D | 2011 | Br J Clin Pharmacol2011，72，4： | 1 |
| 16 | Thin -section CT of severe acute respiratory syndrome: evaluation of 74 patients exposed to or with the disease显示文摘 | Wong K T Antonio G E Hui D S | 2003 | Radiology2003，8，： | 1 |
| 17 | Modeling and simulation of lithium-ion batteries 显示文摘 | ERNESTO M R RUBEN V M ANTONIO F T | 2011 | Computers and Chemical Engineering2011，35，1： | 1 |
| 18 | A risk-return measure of hedging effectiveness显示文摘 | Howard C T D' Antonio L J | 1984 | Journal of Financial and Quantitative Analysis1984，19，1： | 1 |
| 19 | Comparison of linear and non-linear sweep rate regimes in variable frequency microwave technique for uniform heating in materials processing显示文摘 | Antonio C Deam R T | 2005 | Journal of Materials Processing Technology2005，169，： | 1 |
| 20 | Insulin resistance and insulin secretary dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development 显示文摘 | Christian W Antonio T Clifton B | 2001 | Diabetes Care2001，24，1： | 1 |
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