|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Spontaneous bacterial peritonitis显示文摘Since its initial description in 1964,research hastransformed spontaneous bacterial peritonitis (SBP)from a feared disease (with reported mortality of 90%)to a treatable complication of decompensated cirrhosis,albeit with steady prevalence and a high recurrencerate. Bacterial translocation,the key mechanism in thepathogenesis of SBP,is only possible because of theconcurrent failure of defensive mechanisms in cirrhosis.Variants of SBP should be treated. Leucocyte esterasereagent strips have managed to shorten the 'tap-to-shot' time,while future studies should look into theircombined use with ascitic fluid pH. Third generationcephalosporins are the antibiotic of choice becausethey have a number of advantages. Renal dysfunctionhas been shown to be an independent predictor ofmortality in patients with SBP. Albumin is felt to reducethe risk of renal impairment by improving effectiveintravascular volume,and by helping to bind pro-inflammatory molecules. Following a single episodeof SBP,patients should have long-term antibioticprophylaxis and be considered for liver transplantation. | Anastasios Koulaouzidis Shivaram Bhat Athar A Saeed | 2009 | World Journal of Gastroenterology2009，15，9： | 31 |
| 2 | Adrenal G protein-coupled receptor kinase-2 in regulation of sympathetic nervous system activity in heart failure显示文摘Heart failure(HF), the number one cause of death in the western world, is caused by the insufficient performance of the heart leading to tissue underperfusion in response to an injury or insult. It comprises complex interactions between important neurohormonal mechanisms that try but ultimately fail to sustain cardiac output. The most prominent such mechanism is the sympathetic(adrenergic) nervous system(SNS), whose activity and outflow are greatly elevated in HF. SNS hyperactivity confers significant toxicity to the failing heart and markedly increases HF morbidity and mortality via excessive activation of adrenergic receptors, which are G protein-coupled receptors. Thus, ligand binding induces their coupling to heterotrimeric G proteins that transduce intracellular signals. G protein signaling is turned-off by the agonist-bound receptor phosphorylation courtesy of G protein-coupled receptor kinases(GRKs), followed by βarrestin binding, which prevents the GRK-phosphorylated receptor from further interaction with the G proteins and simultaneously leads it inside the cell(receptor sequestration). Recent evidence indicates that adrenal GRK2 and βarrestins can regulate adrenal catecholamine secretion, thereby modulating SNS activity in HF. The present review gives an account of all these studies on adrenal GRKs and βarrestins in HF and discusses the exciting new therapeutic possibilities for chronic HF offered by targeting these proteins pharmacologically. | Katie A Mc Crink Ava Brill Anastasios Lymperopoulos | 2015 | World Journal of Cardiology2015，7，9： | 4 |
| 3 | A preliminary investigation on the topology of Chinese climate networks显示文摘Complex networks have been studied across many fields of science in recent years.In this paper,we give a brief introduction of networks,then follow the original works by Tsonis et al (2004,2006) starting with data of the surface temperature from 160 Chinese weather observations to investigate the topology of Chinese climate networks.Results show that the Chinese climate network exhibits a characteristic of regular,almost fully connected networks,which means that most nodes in this case have the same number of links,and so-called super nodes with a very large number of links do not exist there.In other words,though former results show that nodes in the extratropical region provide a property of scale-free networks,they still have other different local fine structures inside.We also detect the community of the Chinese climate network by using a Bayesian technique;the effective number of communities of the Chinese climate network is about four in this network.More importantly,this technique approaches results in divisions which have connections with physics and dynamics;the division into communities may highlight the aspects of the dynamics of climate variability. | 王革丽 Anastasios A Tsonis | 2009 | Chinese Physics B2009，18，11： | 2 |
| 4 | The application of bioflocculant for the removal of humic acids from stabilized landfill leachates显示文摘 | Anastasios I Zouboulis Xiao-Li Chai Ioannis A Katsoyiannis | 2004 | Journal of Environmental Management2004，，1： | 2 |
| 5 | Role of autophagy in gastric carcinogenesis显示文摘Gastric cancer represents a common and highly fatal malignancy,and thus a pathophysiology-based reconsideration is necessary,given the absence of efficient therapeutic regimens.In this regard,emerging data reveal a significant role of autophagy in gastric oncogenesis,progression,metastasis and chemoresistance.Although autophagy comprises a normal primordial process,ensuring cellular homeostasis under energy depletion and stress conditions,alterations at any stage of the complex regulatory system could stimulate a tumorigenic and promoting cascade.Among others,Helicobacter pylori infection induces a variety of signaling molecules modifying autophagy,during acute infection or after chronic autophagy degeneration.Subsequently,defective autophagy allows malignant transformation and upon cancer establishment,an overactive autophagy is stimulated.This overexpressed autophagy provides energy supplies and resistance mechanisms to gastric cancer cells against hosts defenses and anticancer treatment.This review interprets the implicated autophagic pathways in normal cells and in gastric cancer to illuminate the potential preventive,therapeutic and prognostic benefits of understanding and intervening autophagy. | Apostolis Papaefthymiou Gregory Christodoulidis Apostolos Koffas Michael Doulberis Stergios A Polyzos Anastasios Manolakis Spyros Potamianos Andreas Kapsoritakis Jannis Kountouras | 2021 | World Journal of Gastrointestinal Oncology2021，13，10： | 2 |
| 6 | Data redundancy and reduced-scan reconstruction in reflectivity tomography显示文摘 | Pan X Zou Y Anastasio M A | 2003 | IEEE Transactions on Image Processing2003，12，7： | 1 |
| 7 | Improving efficiency and robustness of the doubly robust estimator for a popu- lation mean with incomplete data显示文摘 | CAO Weihua ANASTASIOS A T MARIE D | 2009 | Biometdka2009，96，3： | 1 |
| 8 | Application of biological processes for the removal of arsenic from groundwaters显示文摘 | IOANNIS A KATSOYIANNIS ANASTASIOS I ZOUBOULIS | 2004 | Water Rerch2004，38，1： | 1 |
| 9 | High temperature laminating resins based on maleimide end -capped pyromellitimide显示文摘 | Jone A Mikroyannidis Anastasios P | 1988 | Journal of Applied Polymer Science1988，36，： | 1 |
| 10 | Comments on the filter back projection algorithm, range condition, and the pseudo reverse solmion 显示文摘 | Anastasio M A Pan X C Clarkson E | 2001 | IEEE Trans Med Imag2001，20，6： | 1 |
| 11 | Effects ofheat treatment on atmospheric composition and color of peeled whiteasparagus in modified atmosphere packaging显示文摘 | ANASTASIOS S S DIMITRIOS G B PAVLOS T A | 2010 | Innovative FoodScience and Emerging Technologies2010，11，1： | 1 |
| 12 | 查看详情显示文摘 | Anastasios E Helen B Spyros A Despina T | | 0，，31： | 1 |
| 13 | Fate of eprinomectin in goat milk and cheeses with different ripening times following pour - on administration 显示文摘 | Anastasio A Veneziano V Capurro E | 2005 | Journal of Food Protection2005，68，5： | 1 |
| 14 | Blockade of N-methyl-D-aspartate receptors by phencyclidine causes the loss of corticostriatal neurons 显示文摘 | Wang C Anastasio N Popov V Leday A Johnson KM | 2004 | Neuroscience2004，125，2： | 1 |
| 15 | Applying DPSIR Analysis as A Decision Support Tool for Fostering Industrial Symbiosis Concept 显示文摘 | Ioannis S A Anastasios I Z Avraam K Petros S | 2013 | Fresenius Enviromnental Bulletin2013，22，12： | 1 |
| 16 | Not all arrestins are created equal: Therapeutic implications of the functional diversity of the β-arrestins in the heart显示文摘The two ubiquitous, outside the retina, G protein-coupled receptor(GPCR)adapter proteins, β-arrestin-1 and-2(also known as arrestin-2 and-3,respectively), have three major functions in cells: GPCR desensitization, i.e.,receptor decoupling from G-proteins; GPCR internalization via clathrin-coated pits; and signal transduction independently of or in parallel to G-proteins. Bothβ-arrestins are expressed in the heart and regulate a large number of cardiac GPCRs. The latter constitute the single most commonly targeted receptor class by Food and Drug Administration-approved cardiovascular drugs, with about onethird of all currently used in the clinic medications affecting GPCR function.Since β-arrestin-1 and-2 play important roles in signaling and function of several GPCRs, in particular of adrenergic receptors and angiotensin II type 1 receptors,in cardiac myocytes, they have been a major focus of cardiac biology research in recent years. Perhaps the most significant realization coming out of their studies is that these two GPCR adapter proteins, initially thought of as functionally interchangeable, actually exert diametrically opposite effects in the mammalian myocardium. Specifically, the most abundant of the two β-arrestin-1 exerts overall detrimental effects on the heart, such as negative inotropy and promotion of adverse remodeling post-myocardial infarction(MI). In contrast, β-arrestin-2 is overall beneficial for the myocardium, as it has anti-apoptotic and antiinflammatory effects that result in attenuation of post-MI adverse remodeling,while promoting cardiac contractile function. Thus, design of novel cardiac GPCRligands that preferentially activate β-arrestin-2 over β-arrestin-1 has the potential of generating novel cardiovascular therapeutics for heart failure and other heart diseases. | Anastasios Lymperopoulos Shelby L Wertz Celina M Pollard Victoria L Desimine Jennifer Maning Katie A McCrink | 2019 | World Journal of Cardiology2019，11，2： | 1 |
| 17 | Mixed transition-metal-lanthanide complexes at higher oxidation states:Heteronuclear ceⅣ-MnⅣclusters显示文摘 | Anastasios J Tasiopoulos A T Brien O | 2004 | Angew Chem Int Ed Engl2004，43，： | 1 |
| 18 | High Temperature Laminating Resins Based on Maleimide End-capped Pyromellitimide显示文摘 | Jone A Mikroyannidis Anastasios P | 1988 | Journal of Applied Polymer Science1988，36，： | 1 |
| 19 | The application of bioflocculant for the removal of humic acids from stabilized landfill leachates显示文摘 | Anastasios I Z Chai Xiao-Li Ioannis A K | 2004 | Journal of Environmental Management2004，70，2： | 1 |
| 20 | Sevelamer worsens meta- bolic acidosis in hemodialysis patients 显示文摘 | De Santo NG Frangiosa A Anastasio P | 2006 | J Nephro12006，199，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员