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| 1 | A practical approach to the diagnosis of autoimmune pancreatitis显示文摘Autoimmune pancreatitis is a disease characterized by specific pathological features,different from those of other forms of pancreatitis,that responds dramatically to steroid therapy.The pancreatic parenchyma may be diffusely or focally involved with the possibility of a low-density mass being present at imaging,mimicking pancreatic cancer.Clinically,the most relevant problems lie in the diagnosis of autoimmune pancreatitis and in distinguishing autoimmune pancreatitis from pancreatic cancer.Since in the presence of a pancreatic mass the probability of tumour is much higher than that of pancreatitis,the physician should be aware that in focal autoimmune pancreatitis the first step before using steroids is to exclude pancreatic adenocarcinoma.In this review,we briefly analyse the strategies to be followed for a correct diagnosis of autoimmune pancreatitis. | Luca Frulloni Antonio Amodio Anna Maria Katsotourchi Italo Vantini | 2011 | World Journal of Gastroenterology2011,17,16: | 8 |
| 2 | Covert hepatic encephalopathy: Agreement and predictive validity of different indices显示文摘AIM:To investigate the agreement and prognosticvalue of different measures of covert hepatic encephalopathy(CHE).METHODS:One-hundred-and-thirty-two cirrhotic outpatients underwent electroencephalography(EEG),paper-and-pencil psychometry(PHES)and critical flicker frequency,scored on the original/modified(CFFo/CFFm)thresholds.Eighty-four patients underwent Dopplerultrasound to diagnose/exclude portal-systemic shunt.Seventy-nine were followed-up for 11±7 mo in relation to the occurrence of hepatic encephalopathy(HE)-related hospitalisations.RESULTS:On the day of study,36%had gradeⅠHE,42%abnormal EEG,33%abnormal PHES and 31/21%abnormal CFFo/CFFm.Significant associations were observed between combinations of test abnormalities;however,agreement was poor(Cohen’sκ<0.4).The prevalence of EEG,PHES and CFFo/CFFm abnormalities was significantly higher in patients with gradeⅠovert HE.The prevalence of EEG and CFFm abnormalities was higher in patients with shunt.The prevalence of EEG abnormalities was significantly higher in patients with a history of HE.During follow-up,10 patients died,10were transplanted and 29 had HE-related hospitalisations.GradeⅠHE(P=0.004),abnormal EEG(P=0.008)and abnormal PHES(P=0.04)at baseline all predicted the subsequent occurrence of HE;CFF did not.CONCLUSION:CHE diagnosis probably requires a combination of clinical,neurophysiological and neuropsychological indices. | Sara Montagnese Esmeralda Balistreri Sami Schiff Michele De Rui Paolo Angeli Giacomo Zanus Umberto Cillo Giancarlo Bombonato Massimo Bolognesi David Sacerdoti Angelo Gatta Carlo Merkel Piero Amodio | 2014 | World Journal of Gastroenterology2014,20,42: | 6 |
| 3 | Comparison of imaging-based and pathological dimensions in pancreatic neuroendocrine tumors显示文摘AIM To establish the ability of magnetic resonance(MR) and computer tomography(CT) to predict pathologic dimensions of pancreatic neuroendocrine tumors(Pan NET) in a caseload of a tertiary referral center.METHODS Patients submitted to surgery for Pan NET at the Surgical Unit of the Pancreas Institute with at least 1 preoperative imaging examination(MR or CT scan) from January 2005 to December 2015 were included and data retrospectively collected. Exclusion criteria were: multifocal lesions, genetic syndromes, microadenomas or mixed tumors, metastatic disease and neoadjuvant therapy. Bland-Altman(BA) and Mountain-Plot(MP) statistics were used to compare size measured by each modality with the pathology size. Passing-Bablok(PB) regression analysis was used to check the agreement between MR and CT.RESULTS Our study population consisted of 292 patients. Seventy-nine(27.1%) were functioning Pan NET. The mean biases were 0.17 ± 7.99 mm, 1 ± 8.51 mm and 0.23 ± 9 mm, 1.2 ± 9.8 mm for MR and CT, considering the overall population and the subgroup of non-functioning-Pan NET, respectively. Limits of agreement(LOA) included the vast majority of observations, indicating a good agreement between imaging and pathology. The MP further confirmed this finding and showed that the two methods are unbiased with respect to each other. Considering ≤ 2 cm non-functioning-Pan NET, no statistical significance was found in the size estimation rate of MR and CT(P = 0.433). PBR analysis did not reveal significant differences between MR, CT and pathology.CONCLUSION MR and CT scan are accurate and interchangeable imaging techniques in predicting pathologic dimensions of Pan NET. | Salvatore Paiella Harmony Impellizzeri Elisabetta Zanolin Giovanni Marchegiani Marco Miotto Anna Malpaga Riccardo De Robertis Mirko D'Onofrio Borislav Rusev Paola Capelli Sara Cingarlini Giovanni Butturini Maria Vittoria Davì Antonio Amodio Claudio BassiAldo Scarpa Roberto Salvia Luca Landoni | 2017 | World Journal of Gastroenterology2017,23,17: | 4 |
| 4 | Diagnostic yield of EUS-FNA of small(≤15 mm) solid pancreatic lesions using a 25-gauge needle显示文摘Background: Early detection of small solid pancreatic lesions is increasingly common. To date, few and contradictory data have been published about the relationship between lesion size and endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) diagnostic yield. The aim of this study was to assess the relation between the size of solid pancreatic lesions and the diagnostic yield of EUS-FNA using a 25-gauge needle in a center without available rapid on-site evaluation.Methods: In the retrospective cohort study, we selected patients who underwent EUS-FNA for solid pancreatic lesions with a 25-gauge needle from October 2014 to October 2015. Patients were divided into three groups(≤15 mm, 16–25 mm and >25 mm), and the outcomes were compared.Results: We analyzed 163 patients. Overall adequacy, sensitivity, specificity and accuracy were 85.2%,81.8%, 93.7%, and 80.4%, respectively. When stratified by size, the sensitivity and accuracy correlated with size(P = 0.016 and P = 0.042, respectively). Multivariate analysis showed that lesion size was the only independent factor(P = 0.019, OR = 4.76) affecting accuracy. The role of size as an independent factor affecting accuracy was confirmed in a separate multivariate analysis, where size was included in the model as a covariate(P = 0.018, OR = 1.08).Conclusion: Our study demonstrates that, in the absence of rapid on-site evaluation, mass size affects the accuracy of EUS-FNA of solid pancreatic lesions. | Stefano Francesco Crinò Maria Cristina Conti Bellocchi Laura Bernardoni Erminia Manfrin Alice Parisi Antonio Amodio Nicolò De Pretis Luca Frulloni Armando Gabbrielli | 2018 | Hepatobiliary & Pancreatic Diseases International2018,17,1: | 4 |
| 5 | Hepatitis C virus infection and health-related quality of life显示文摘Hepatitis C virus(HCV) hepatitis and other diseases related to HCV,such as cryoglobulinemia,lymphoma and renal failure,impair health-related quality of life(HRQoL).In addition,HCV per se might directly influence HRQoL via colonization of microglia in the brain or,indirectly,via the effect of systemic inflammatory cytokines which,in turn,can trigger brain interleukin production.The treatment of HCV-related disorders with interferon(IFN) has an effect on HRQoL.Initially,IFN causes a transient deterioration of HRQoL,due to the induction of depression and other side effects of treatment.Subsequently,the subjects who obtain a sustained virologic response experience an improvement in HRQoL.Only rarely does interferon treatment causes permanent detrimental effects on HRQoL,due to residual psychiatric or neurologic side effects.Liver transplantation is the only treatment for end-stage HCV-related liver disease.HRQoL generally improves massively a few months after transplantation,except in the case of serious complications of the transplant procedure.Furthermore,high levels of anxiety and neuroticism pre-transplant are associated with lower HRQoL one year after transplant.Additionally,six months after transplant,patients with HCV who experience virologic recurrence show significantly greater depression,anxiety,phobic anxiety,and paranoid ideation than anti-HCV-negative patients.In conclusion,optimal care for the overall well-being of patients with HCV infection requires adequate knowledge of their neurological and psychological status. | Piero Amodio Laura Salari Sara Montagnese Sami Schiff Daniele Neri Tonino Bianco Lina Minazzato | 2012 | World Journal of Gastroenterology2012,18,19: | 3 |
| 6 | Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study Of Liver Diseases and the European Association for the Study of the Liver显示文摘 | Hendrik Vilstrup Piero Amodio Jasmohan Bajaj Juan Cordoba Peter Ferenci Kevin D. Mullen Karin Weissenborn Philip Wong | 2014 | Hepatology2014,,2: | 2 |
| 7 | Hemoperitoneum from a spontaneous rupture of a giant hemangioma of the liver: report of a case 显示文摘 | Corigliano N Mercantini P Amodio PM | 2003 | Surg Today2003,33,6: | 1 |
| 8 | Nutrition and survival in patients with liver cirrhosis显示文摘 | Alberino F Gatta A Amodio P | 2001 | Nutrition2001,17,6: | 1 |
| 9 | Cardiac biomarkers in acute coro- nary syndromes :a review 显示文摘 | Amodio G Antonelli G Diserio F | 2010 | J Curr Vasc Pharmacol2010,8,3: | 1 |
| 10 | miR-29s : a family of epi- miRNAs with therapeutic implications in hematologic malignancies 显示文摘 | Amodio N Rossi M Raimondi L | 2015 | Oncotarget2015,6,12: | 1 |
| 11 | Nutrition and survival in patients with liver cirrhosis显示文摘 | Alberino F Gatta A Amodio P | 2001 | Nutrition2001,17,6: | 1 |
| 12 | The parallel QR factorization algorithm for tridiagonal linear systems显示文摘 | Amodio P Brugnano L | 1995 | Parallel Computing1995,,21: | 1 |
| 13 | The laparoscopic ap- prach with anti-reflux surgery is superior to the thoracoscopic approach for the treatment of esophageal achalasia 显示文摘 | Ramaeciato G MereantiniP Amodio PM | 2002 | Surg Endosc2002,16,10: | 1 |
| 14 | The Conditioning of Toeplitz Band Matrices显示文摘 | Brugnano L | 1996 | Mathl Comput Modelling1996,23,10: | 1 |
| 15 | Nutrition and survival in patients with liver cirrhosis显示文摘 | Alberino F Gatta A Amodio P | 2001 | Nutrition2001,17,6: | 1 |
| 16 | Delayed-type hyper-sensitivity in classic Kaposi sarcoma patients and controls显示文摘 | Valenti RM Amodio E Nam JM | 2011 | Br J Cancer2011,104,3: | 1 |
| 17 | Nutrition and survival in patients with liver cirrhosis显示文摘 | Alberino F Gatta A Amodio P | 2012 | Nutrition2012,17,6: | 1 |
| 18 | Atmospheric depo- sition: sampling procedures, analytical methods, and main re- cent findings from the scientific literature显示文摘 | Amodio M Catino S Dambruoso P R | 2014 | Advances in Me- teorology2014,2014,: | 1 |
| 19 | New insights into HLA-G mediated tolerance显示文摘 | Amodio G Sales De Albuquerque R Gregori S | 2014 | Tissue Antigens2014,84,3: | 1 |
| 20 | Hemoperitoneum from a spontaneous rupture of a giant hemangioma of the liver:report of a case显示文摘 | Mercantini P Amodio PM | 2003 | Surg Today2003,33,6: | 1 |