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| 1 | Vascular endothelial growth factor and tryptase changes after chemoembolization in hepatocarcinoma patients显示文摘AIM: To evaluate vascular endothelial growth factor(VEGF) and tryptase in hepatocellular cancer(HCC)before and after trans-arterial chemoembolization(TACE).METHODS: VEGF and tryptase serum concentrations were assessed from 71 unresectable HCC patients before and after hepatic TACE performed by binding DC-Beads?to doxorubicin. VEGF levels were examined for each serum sample using the Quantikine Human VEGF-enzyme-linked immuno-absorbent assay(ELISA),whereas tryptase serum concentrations were assessed for each serum sample by means of fluoro-enzyme immunoassay(FEIA) using the Uni-CAP100 tool.Differences between serum VEGF and tryptase values before and after TACE were evaluated using Student t test. Person's correlation was used to assess the degree of association between the two variables.RESULTS: VEGF levels and serum tryptase in HCCpatients before TACE had a mean value and standard deviation(SD) of 114.31 ± 79.58 pg/mL and 8.13± 3.61 μg/L, respectively. The mean levels and SD of VEGF levels and serum tryptase in HCC patients after TACE were 238.14 ± 109.41 pg/mL and 4.02 ±3.03 μg/L. The changes between the mean values of concentration of VEGF and tryptase before treatment and after treatment was statistically significant(P <0.000231 and P < 0.00124, by Wilcoxon-Mann-Whitney respectively). A significant correlation between VEGF levels before and after TACE and between tryptase levels before and after TACE was demonstrated(r =0.68, P = 0.003; r = 0.84, P = 0.000 respectively).CONCLUSION: Our pilot results suggest that the higher serum VEGF levels and the lower tryptase levels following TACE may be potential biomarkers changing in response to therapy. | Girolamo Ranieri Michele Ammendola Ilaria Marech Annamaria Laterza Ines Abbate Caroline Oakley Angelo Vacca Rosario Sacco Cosmo Damiano Gadaleta | 2015 | World Journal of Gastroenterology2015，21，19： | 13 |
| 2 | Targeting mast cells in gastric cancer with special reference to bone metastases显示文摘Bone metastases from gastric cancer(GC) are considered a relatively uncommon finding; however, they are related to poorer prognosis. Both primary GC and its metastatic progression rely on angiogenesis. Several lines of evidence from GC patients strongly support the involvement of mast cells(MCs) positive to tryptase(MCPT) in primary gastric tumor angiogenesis. Recently,we analyzed infiltrating MCs and neovascularization in bone tissue metastases from primary GC patients, and observed a significant correlation between infiltrating MCPT and angiogenesis. Such a finding suggested the involvement of peritumoral MCPT by infiltrating surrounding tumor cells, and in bone metastasis angiogenesis from primary GC. Thus, an MCPT-stimulated angiogenic process could support the development of metastases in bone tissue. From this perspective, we aim to review the hypothetical involvement of tumorinfiltrating,peritumoral MCPT in angiogenesis-mediated GC cell growth in the bone microenvironment and in tumor-induced osteoclastic bone resorption. We also focus on the potential use of MCPT targeting agents,such as MCs tryptase inhibitors(gabexate mesylate,nafamostat mesylate) or c-KitR tyrosine kinase inhibitors(imatinib, masitinib), as possible new anti-angiogenic and anti-resorptive strategies for the treatment of GC patientsaffected by bone metastases. | Christian Leporini Michele Ammendola Ilaria Marech Giuseppe Sammarco Rosario Sacco Cosmo Damiano Gadaleta Caroline Oakley Emilio Russo Giovambattista De Sarro Girolamo Ranieri | 2015 | World Journal of Gastroenterology2015，21，37： | 5 |
| 3 | Possible biological and translational significance of mast cells density in colorectal cancer显示文摘Mast cells(MCs), located ubiquitously near blood vessels, are descended from CD34+ hematopoietic stem cells. Initially, although their role has been well defined in hypersensitivity reactions, the discovery of their sharing in both innate and adaptive immunity has allowed to redefine their crucial interplay on the regulatory function between inflammatory and tumor cells through the release of mediators granule-associated(mainly tryptase and vascular endothelial growth factor). In particular, in several animal and human malignancies it has been well demonstrated that activated c-Kit receptor(c-KitR) and tryptase(an agonist of the proteinase-activated receptor-2) take pivotal part in tumor angiogenesis after the MCs activation, contributing to tumor cells invasion and metastasis. In this review, we focused on crucial MCs density(MCD) role in colorectal cancer(CRC) development and progression angiogenesis-mediated; then, we will analyze the principal studies that have focused on MCD as possible prognostic factor. Finally, we will consider a possible role of MCD as novel therapeutic target mainly by c-KitR tyrosine kinase inhibitors(imatinib, masitinib) and tryptase inhibitors(gabexate and nafamostat mesylate) with the aim to prevent CRC progression. | Ilaria Marech Michele Ammendola Claudia Gadaleta Nicola Zizzo Caroline Oakley Cosmo Damiano Gadaleta Girolamo Ranieri | 2014 | World Journal of Gastroenterology2014，20，27： | 3 |
| 4 | Nerve growth factor inhibits apoptoais in memory B lymphocytes via inactivation p38 MAPK, prevention of Bcl-2 phosphorylation, and cytochrome C release显示文摘 | Torcia M de Chiara G Nencioni L Ammendola S Labardi D Lucibello M | 2001 | J Biol Chem2001，276，39： | 1 |
| 5 | Investigation ofthe catalytic activity of Rh-LaCoO3 catalyst in theconversion of tar from biomass devolatilization products显示文摘 | Ammendola P Chirone R Lisi L | 2010 | Applied Catalysis a-General2010，385，12： | 1 |
| 6 | Rh-perovskitecatalysts for conversion of tar from biomass pyrolysis显示文摘 | Ammendola P Lisi L Piriou B | 2009 | Chemical Engineering Journal2009，154，13： | 1 |
| 7 | Molecular and biochemical characterization of the recombinant amidase from hyperthermophilic archaeon Sulfolobus solfataricus显示文摘 | Scotto d'Abusco A Ammendola S Scandurra R | 2001 | Extremophiles2001，59，3： | 1 |
| 8 | Association of elevated levels of prothrombin fragment 1+2 and Arg506 to Gln mutation in patients with a history of ischemic stroke显示文摘 | Papa ML Ammendola F | 1999 | J Neurosurg Sci1999，43，： | 1 |
| 9 | Nonpremixed catalytic combustion of methane in a fluidized bed reactor显示文摘 | Iamarino M Ammendola P | 2006 | Industrial and Engineering Chemistry Research2006，45，3： | 1 |
| 10 | Hirayama disease: three cases assessed by F-wave, somatosensory and motor evoked potentials and magnetic resonance imaging not supporting flexior myelopathy 显示文摘 | Ammendola A Gallo A Iannaccone T | 2008 | Neurol Sci2008，29，5： | 1 |
| 11 | Severe Obesity and P-Wave Dispersion: The Effect of Surgically Induced Weight Loss显示文摘 | Vincenzo Russo Ernesto Ammendola Ilaria Crescenzo Ludovico Docimo Lucio Santangelo Raffaele Calabrò | 2007 | Obesity Surgery2007，，1： | 1 |
| 12 | High-affinityZn2+ uptakesystemZnuABCisrequiredforbacterialzinchomeostasisinintracellularenvironmentsandcontributestothevirulenceofSalmonellaenteric显示文摘 | AMMENDOLAS PASQUALIP PISTOIA C etal | 2007 | InfectImmun2007，75，12： | 1 |
| 13 | Rising behind NO:cGMP-dependent protein kinases显示文摘 | Hofmann F Ammendola A Schlossmann J | 2000 | J Cell Sci2000，113，10： | 1 |
| 14 | Use of green fluorescent protein as a marker for ecological studies of activated sludge communities 显示文摘 | Eberl L Schulze R Ammendola A | 1997 | FEMS Microbiol Lett1997，149，1： | 1 |
| 15 | Effects of some excita- tory amino acid antagonists on imipenem-induced seizures in DBA/2 mice显示文摘 | De Sarro G Ammendola D Nava F | 1995 | Brain Res1995，671，1： | 1 |
| 16 | Redox control of signal transduction, gene expression and cellular senescence显示文摘 | ESPOSITO F AMMENDOLA R FARAONIO R | 2004 | Neurochem Res2004，29，3： | 1 |
| 17 | The DNA-binding efficiency of Spl is affected by redox changes显示文摘 | AMMENDOLA R MESURACA M RUSSO T | 1994 | Eur J Biochem1994，225，： | 1 |
| 18 | Tlyptase- positive mast cells correlate with angiogenesis in early breast cancer patients显示文摘 | Ranieri G Ammendola M Patruno R | 2009 | Int J Oncol2009，35，1： | 1 |
| 19 | Breast cancer tissuetryptase expression as a new possible antiangiogenic target显示文摘 | Ammendola M Misino A Patruno R | 2011 | Breast2011，20，1： | 1 |
| 20 | Efficacy and safety of bevacizumab in glioblastomas 显示文摘 | DE FAZIO S RUSSO E AMMENDOLA M | 2012 | Curt Med Chem2012，，7： | 1 |
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