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    题名 作者 年代 出处 被引量
1Signal integrity consoderations in high-reliability designs显示文摘Tarun Amla and Sean Mirshafiei 2007Circuitree2007,3,:1
2Cardiomyocyte apoptosis in experimental coxsackievirus 133 myocarditis显示文摘Saraste A Amla R Avuorinen T 2003Cardiovasc Pathol2003,12,:1
3Expression of modified gene encoding functional human α-1-antitrypsin protein in transgenic tomato plants显示文摘Saurabh Agarwal Rahul Singh Indraneel Sanyal D. V. Amla 2008Transgenic Research2008,,5:1
4The Effect of Piperine on Pharmacokinetics of Phenytoin in Healthy Volunteers显示文摘Bano G Amla V Raina RK 1987Planta med1987,53,6:1
5The mitochondrial genome of the blowfly Chrysomya chloropyga (Diptera:Calliphoridae)显示文摘Junqueira AC Lessinger AC Torres TT Silva FR da Vettore AL Arruda P Espin AMLA 0,,:1
6Pharmacokinetics of vasicine in healthy Indian volunteers显示文摘Amla V Bano G Johri RK 1987Acta Pharmacol Sin1987,8,2:1
7The effect of piperine on pharmacokinetics of phenytoin in healthy volunteers 显示文摘Bano C- Amla V Raina RK 1987Planta Med1987,53,6:1
8The effect of piperine on pharmacokinetics of phenytoin in healthy volunteeers显示文摘Bano G Amla V Raina RK 1987Planta Med1987,53,:1
9Skin as an immune organ and the site of biomimetic,non-invasive vaccination显示文摘A vaccine must be sufficiently stable and cause no discernible discomfort or organ damage both during administration and at the injection site. To achieve these aims, the skin offers a viable platform, provided, antigens mustpenetrate the skin barrier and then exit the skin through deformable yet stable vesicular carriers to enter thelymphatic system. Even after such antigen delivery into the body, the intended immune response can only beattained if the following immune response has previously been correctly understood at the cellular and molecularlevels. Here we review, the underlying immunological decision tree that has several branching points to generatean optimal immune response. The tolerance versus immunity decision during and after the delivery of an antigen viaskin depends on i) antigen/pathogen application effects on the cutaneous microenvironment, ii) the variousinvolved cells type (skin resident cells or directly the lymph node resident cells), and regulatory molecules. Theskin microenvironment alters due to skin perturbation. The skin is perturbed directly by the antigens/pathogenswhich activate the release of mediators and cytokines and thus trigger an autocrine and paracrine effect, or,indirectly via the antigen/pathogen influence on the commensal microorganisms on the skin (which helpmaintain skin homeostasis). The skin microenvironment changes by the mode of antigen delivery.The cue from cutaneous immunology in vaccine delivery across intact skin may provide insight for future noninvasive vaccination suggesting a possible shift in the vaccination protocols and the essential paradigmrefinement.Amla Chopra Archi Gupta 2022Medicine in Novel Technology and Devices2022,,4:0
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