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| 1 | Vitamin D deficiency: Correlation to interleukin-17, interleukin-23 and PⅢNP in hepatitis C virus genotype 4显示文摘AIM: To assess vitamin D (Vit D) abnormalities in hepatitis C infected patients and their relationship with interleukin (IL)-17, IL-23 and N-terminal propeptide of type Ⅲ pro-collagen (PⅢNP) as immune response mediators. METHODS: The study was conducted on 50 Egyptian patients (36 male, 14 female) with hepatitis C virus (HCV) infection, who visited the Hepatology Outpatient Clinic in the Endemic Disease Hospital at Cairo University. Patients were compared with 25 ageand sexmatched healthy individuals. Inclusion criteria were based on a history of liver disease with HCV genotype 4 (HCV-4) infection (as new patients or under followup). Based on ultrasonography, patients were classified into four subgroups; 14 with bright hepatomegaly; 11 with perihepatic fibrosis; 11 with hepatic cirrhosis; and 14 with cirrhosis and hepatocellular carcinoma (HCC).Total Vit D (i.e., 25-OH-Vit D) and active Vit D [i.e., 1,25-(OH) 2 -Vit D] assays were carried out using commercial kits. IL-17, IL-23 and PⅢNP levels were assayed using enzyme linked immunosorbent assay kits, while HCV virus was measured by quantitative and qualitative polymerase chain reaction. RESULTS: Levels of Vit D and its active form were significantly lower in advanced liver disease (hepatic cirrhosis and/or carcinoma) patients, compared to those with bright hepatomegaly and perihepatic fibrosis. IL-17, IL-23 and PⅢNP levels were markedly increased in HCV patients and correlated with the progression of hepatic damage. The decrease in Vit D and active Vit D was concomitant with an increase in viral load, as well as levels of IL-17, IL-23 and PⅢNP among all subgroups of HCV-infected patients, compared to normal healthy controls. A significant negative correlation was evident between active Vit D and each of IL-17, IL-23 and PⅢNP (r = -0.679, -0.801 and -0.920 at P < 0.001, respectively). HCV-infected men and women showed no differences with respect to Vit D levels. The viral load was negatively correlated with Vit D and active Vit D (r = -0.084 and -0.846 at P < 0.001, respectively), and positively correlated with IL-17, IL-23 and PⅢNP (r = 0.951, 0.922 and 0.94 at P < 0.001, respectively). Whether the deficiency in Vit D was related to HCVinduced chronic liver disease or was a predisposing factor for a higher viral load remains to be elucidated. CONCLUSION: The negative correlations between Vit D and IL-17, IL-23 and PⅢNP highlight their involvement in the immune response in patients with HCV-4related liver diseases in Egypt. | Mona F Schaalan Waleed A Mohamed Hesham H Amin | 2012 | World Journal of Gastroenterology2012，18，28： | 12 |
| 2 | Standardized measurement of the future liver remnant prior to extended liver resection: Methodology and clinical associations显示文摘 | Jean-Nicolas Vauthey Amin Chaoui Kim-Anh Do Malcolm M Bilimoria Marc J Fenstermacher Chuslip Charnsangavej Marshall Hicks Guido Alsfasser Gregory Lauwers Irvin F Hawkins James Caridi | 2000 | Surgery2000，，5： | 2 |
| 3 | F/A-18A Inlet-Engine Compatibility Flight Test Results显示文摘 | Amin N F Hollweger D J | | AIAA-91-13930，，： | 2 |
| 4 | The impact of workplace spirituality di- mensions on organisational citizenship behaviour among nurses with the mediating effect of affective organisational commitment 显示文摘 | Kazemipour F Mohd Amin S | 2012 | J Nurs Manag2012，20，8： | 1 |
| 5 | No Significant Association of 14 Candidate Genes With Schizophrenia in a Large European Ancestry Sample: Implications for Psychiatric Genetics显示文摘 | Sanders Alan R Duan Jubao Levinson Douglas F Shi Jianxin He Deli Hou Cuiping Burrell Gregory J Rice John P Nertney Deborah A Olincy Ann Rozic Pablo Vinogradov Sophia Buccola Nancy G Mowry Bryan J Freedman Robert Amin Farooq Black Donald W | 2008 | The American Journal of Psychiatry2008，，4： | 1 |
| 6 | A noncoherent radar system approach for through-the-wall imaging 显示文摘 | Ahmad F Amin MG | 2005 | Proceedings of SPIE2005，5778，： | 1 |
| 7 | Preventing blackouts:Building a smarter power Grid显示文摘 | Amin M Schewe P F | 2008 | Scientific American2008，，： | 1 |
| 8 | Toward a smart grid: power delivery for the 21st century显示文摘 | AMIN M WOLL ENBERG B F | 2005 | IEEE Power and Energy Magazine2005，3，5： | 1 |
| 9 | Aortic stiffness and left ventricu-lar mass in a rat model of isolated systolic hypertention显示文摘 | Tatehum-Talom R Niederhoffer N Amin F | 1995 | Hypertention1995，26，61： | 1 |
| 10 | Nonlinear dependence of viscosity in modeling the rate-dependent response of natural and high damping rubbers in compression and shear: experimental identification and numerical verification 显示文摘 | AMIN A F M S LION A SEKITA S | 2006 | Int J Plasticity2006，22，9： | 1 |
| 11 | Identification of putative gene based markers of renal toxicity 显示文摘 | Amin RP Vickers AE Sistare F | | Environ Health Perspect0，112，4： | 1 |
| 12 | A New Adaptive Merging and Growing Algorithm for Designing Artificial Neural Networks显示文摘 | Islam M M Sattar M A Amin F | 2009 | IEEE Trans on Systems Man and Cybernetics-Part B: Cybernetics2009，39，3： | 1 |
| 13 | Wideband synthetic aperture beamforming for through-the-wall imaging显示文摘 | AMIN M G AHMAD F | 2008 | IEEE Signal Processing Magazine2008，25，4： | 1 |
| 14 | A subspaceprojection approach for wall clutter mitigation in through -the-wall radar imaging显示文摘 | TIVIVE F H C BOUZERDOUM A AMIN M G | 2015 | IEEE Transactions on Geoscienceand Remote Sensing2015，53，4： | 1 |
| 15 | Effects of ventral hippocarnpal lesion on thermal and mechanical nociception in neonates and adult rats显示文摘 | Al Amin H A Atweh S F Jabbur S J | 2004 | Eur J Neurosei2004，20，11： | 1 |
| 16 | Association between use of bleeding avoidance strategies and risk of periprocedural bleeding among patients undergoing percutaneous coronary intervention 显示文摘 | Marso S P Amin A P House J A Kennedy K F Spertus J A Rao S V | 2010 | JAMA2010，303，： | 1 |
| 17 | Effectiveness of uncoated WC - Co and PCD inserts in end milling of titanium alloy - Ti - 6Al- 4V显示文摘 | A K M Nurul Amin Ahmad F Ismail M K Nor Khairusshima | 2007 | Journal of Materials Processing Technology2007，，： | 1 |
| 18 | Preventing blackouts : building a smarter power grid 显示文摘 | Amin M Schewe P F | 2008 | Scientific American2008，，8： | 1 |
| 19 | Through-the-Wall HumanMotion Indication Using Sparsity-Driven Change De-tection显示文摘 | AHMAD F AMIN M G | 2013 | IEEE Trans on Geoscience and RemoteSensing2013，51，2： | 1 |
| 20 | Autofo- cusing of Through-the-Wall Radar Imagery Under Un- known Wall Characteristics显示文摘 | AHMAD F AMIN M G MANDAPATI G | 2007 | IEEE Trans on Image Processing2007，16，7： | 1 |
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