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| 1 | Autoantibody profiles in autoimmune hepatitis and chronic hepatitis C identifies similarities in patients with severe disease显示文摘AIM To determine how the auto-antibodies(Abs) profiles overlap in chronic hepatitis C infection(CHC) and autoimmune hepatitis(AIH) and correlate to liver disease.METHODS Levels of antinuclear Ab, smooth muscle antibody(SMA) and liver/kidney microsomal-1(LKM-1) Ab and markers of liver damage were determined in the sera of 50 patients with CHC infection, 20 AIH patients and 20 healthy controls using enzyme linked immunosorbent assay and other immune assays. RESULTS We found that AIH patients had more severe liver disease as determined by elevation of total Ig G, alkaline phosphatase, total serum bilirubin and serum transaminases and significantly higher prevalence of the three non-organ-specific autoantibodies(auto-Abs) than CHC patients. Antinuclear Ab, SMA and LKM-1 Ab were also present in 36% of CHC patients and related to disease severity. CHC cases positive for auto-Abs were directly comparable to AIH in respect of most markers of liver damage and total Ig G. These cases had longer disease duration compared with auto-Ab negative cases, but there was no difference in gender, age or viral load. KLM-1+ Ab CHC cases showed best overlap with AIH. CONCLUSION Auto-Ab levels in CHC may be important markers of disease severity and positive cases have a disease similar to AIH. Auto-Abs might have a pathogenic role as indicated by elevated markers of liver damage. Future studies will unravel any novel associations between these two diseases, whether genetic or other. | Kawa Amin Aram H Rasool Ali Hattem Taha AM Al-Karboly Taher E Taher Jonas Bystrom | 2017 | World Journal of Gastroenterology2017，23，8： | 5 |
| 2 | Urothelial neoplasms of the urinary bladder occurring in young adult and pediatric patients:a comprehensive review of literature with implications for patient management显示文摘 | Paner GP Zehnder P Amin AM | 2011 | Adv Anat Pathol2011，18，： | 1 |
| 3 | Ultrasound registration of the bonesurface for surgical navigation显示文摘 | Amin DV Kanade T DiGoia AM ⅢJ | 2003 | Comput Aided Surg2003，61，8： | 1 |
| 4 | Naloxone and spontaneous reversal of depressed ventilatory responses to hypoxia during and after continuous infusion of remifentanil or alfentanil显示文摘 | Amin HM Sopchak AM Esposito BF | 1995 | J Pharmacol Exp Ther1995，274，1： | 1 |
| 5 | Laparoscopic Management of Paratubal and Paraovarian Cysts显示文摘 | Darwish AM Amin AF | 2006 | Eur Snrg Res2006，38，3： | 1 |
| 6 | Comparative study of neuro- muscular blocking and hemodynamic effects of recurenium and cisatra- curium under sevoflurane or total intravenous anesthesia 显示文摘 | Amin AM Mohammad MY Ibrahim MF | 2009 | Middle East J Anesthesiol2009，20，1： | 1 |
| 7 | Laparoscopic management of paratubal and paraovarian cysts显示文摘 | Darwish AM Amin AF | 2006 | Eur Surg Res2006，38，3： | 1 |
| 8 | Dieulafoys lesson:an ob scure cause of GI bleeding显示文摘 | Al-Mishlab T Amin AM Ellul JP | 1999 | JR Call Surg Edinb1999，44，： | 1 |
| 9 | Evaluaion of the impact of laparoscopie ovarian drilling on Doppler indices of ovarian stromal blood flow,serum vascular endothelial growth factor,and insulinlike growth faetor-I in women with polycystie ovary syndrome 显示文摘 | Amin AF Abd el-Aal DE Darwish AM | 2003 | Fertil Steril2003，79，4： | 1 |
| 10 | Evaluation of the impact of laparoscopic ovarian drilling on Doppler indices of ovarian stromal blood flow, serum vascular endothelial growth factor, and insulin-like growth factor-1 in women with polycystic ovary syndrome 显示文摘 | Amin AF Abdel-Aal DE Darwish AM | 2003 | Fertil Steril2003，79，4： | 1 |
| 11 | Acute mes-enteric ischaemia显示文摘 | Menon NJ Amin AM Mohammed A | 2005 | Acta Chir Belg2005，105，4： | 1 |
| 12 | Evaluation of the impact of laparoscopic ovarian drilling on Doppler indices of ovarian stromal blood flow, serum vascular endothelial growth factor, and Insulin-like growth factor I in women with the polycystic ovarian syndrome 显示文摘 | Amin AF Aal DM Darwish AM | 2003 | Fertil Steril2003，79，4： | 1 |
| 13 | Effects of preoperative It-blocker on Dmoa Joss anu blood transfusion during spinal stlrgeries with sodium nitroprusside-con- trolled hypotension显示文摘 | Am YM Amin SM | 2012 | Saudi J Anzesth2012，6，3： | 1 |
| 14 | Comparative study of neuromuscular blocking and hemodynamic effects of rocuronium and cisatracurium under sevoflarane or total intravenous anesthesia显示文摘 | Amin AM Mohammed MY Ibrahim MF | 2009 | Middle East J Anaesthesiol2009，20，1： | 1 |
| 15 | The nature of the interfacebetween polymethyl methacrylate denture base materials and softlining materials显示文摘 | Amin WM Fletcher AM Ritchie GM | 1981 | J Dent1981，9，4： | 1 |
| 16 | Naloxoneinduced and spontaneous reversal of depressed ventilatoryresponses to hypoxia during and after continuous infusion of remifentanil or alfentanil 显示文摘 | Amin HM Sopchak AM Esposito BF | 1995 | J Pharmacol Exp Ther1995，274，1： | 1 |
| 17 | Dieulafoy's lesion: an obscure cause of GI bleeding显示文摘 | AL-MISHLAB T AMIN AM ELLUL JP | 1999 | J R Coil Surg Edinb1999，44，： | 1 |
| 18 | Naloxone induced and spontaneous reversal of depressed ventilatory responses to hypoxia during and after continuous infusion of remifentanil or alfentanil显示文摘 | Amin HM Sopchak AM Espositeo BF | 1995 | J Pharmacol Exp Ther1995，274，1： | 1 |
| 19 | Urothelial neoplasms of the urinary bladder occurring in young adult and pediatric patients:a comprehensive review of literature with implications for patient management显示文摘 | Paner GP Zehnder P Amin AM | | 0，，01： | 1 |
| 20 | Naloxone-induced and spontaneous reversal of depressed ventilatory responses to hypoxia during and after continuous infusion of remifentanil or alfentanil显示文摘 | Sopchak AM Esposito BF | 1995 | J Pharmacol Exp Ther1995，274，1： | 1 |
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