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| 1 | Embolization of splenorenal shunt associated to portal vein thrombosis and hepatic encephalopathy显示文摘Hepatic encephalopathy(HE)is a cognitive disturbance characterized by neuropsychiatric alterations.It occurs in acute and chronic hepatic disease and also in patients with portosystemic shunts.The presence of these portosystemic shunts allows the passage of nitrogenous substances from the intestines through systemic veins without liver depuration.Therefore,the embolization of these shunts has been performed tocontrol HE manifestations,but the presence of portal vein thrombosis is considered a contraindication.In this presentation we show a cirrhotic patient with severe HE and portal vein thrombosis who was submitted to embolization of a large portosystemic shunt.Case report:a 57 years-old cirrhotic patient who had been hospitalized many times for persistent HE and hepatic coma,even without precipitant factors.She had a wide portosystemic shunt and also portal vein thrombosis.The abdominal angiography confirmed the splenorenal shunt and showed other shunts.The larger shunt was embolized through placement of microcoils,and the patient had no recurrence of overt HE.There was a little increase of esophageal and gastric varices,but no endoscopic treatment was needed.Since portosystemic shunts are frequent causes of recurrent HE in cirrhotic patients,portal vein thrombosis should be considered a relative contraindication to perform a shunt embolization.However,in particular cases with many shunts and severe HE,we found that one of these shunts can be safely embolized and this procedure can be sufficient to obtain a good HE recovery.In conclusion,we reported a case of persistent HE due to a wide portosystemic shunt associated with portal vein thrombosis.As the patient had other shunts,she was successfully treated by embolization of the larger shunt. | Letícia de Campos Franzoni Fábio Cardoso de Carvalho Rafael Gomes de Almeida Garzon Fábio da Silva Yamashiro Laís Augusti Lívia Alves Amaral Santos Mariana de Souza Dorna Júlio Pinheiro Baima Talles Bazeia Lima Carlos Antonio Caramori Giovanni Faria Silva Fernando Gomes Romeiro | 2014 | World Journal of Gastroenterology2014，20，42： | 6 |
| 2 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 3 | 25 Gbps low-voltage hetero-structured silicongermanium waveguide pin photodetectors for monolithic on-chip nanophotonic architectures显示文摘Near-infrared germanium(Ge) photodetectors monolithically integrated on top of silicon-on-insulator substrates are universally regarded as key enablers towards chip-scale nanophotonics, with applications ranging from sensing and health monitoring to object recognition and optical communications. In this work, we report on the highdata-rate performance pin waveguide photodetectors made of a lateral hetero-structured silicon-Ge-silicon(Si-Ge-Si) junction operating under low reverse bias at 1.55 μm. The pin photodetector integration scheme considerably eases device manufacturing and is fully compatible with complementary metal-oxide-semiconductor technology. In particular, the hetero-structured Si-Ge-Si photodetectors show efficiency-bandwidth products of^9 GHz at-1 V and ~30 GHz at-3 V, with a leakage dark current as low as ~150 nA, allowing superior signal detection of high-speed data traffic. A bit-error rate of 10-9 is achieved for conventional 10 Gbps, 20 Gbps, and25 Gbps data rates, yielding optical power sensitivities of-13.85 dBm,-12.70 dBm, and-11.25 dBm, respectively. This demonstration opens up new horizons towards cost-effective Ge pin waveguide photodetectors that combine fast device operation at low voltages with standard semiconductor fabrication processes, as desired for reliable on-chip architectures in next-generation nanophotonics integrated circuits. | DANIEL BENEDIKOVIC LéOPOLD VIROT GUY AUBIN FARAH AMAR BERTRAND SZELAG BAYRAM KARAKUS JEAN-MICHEL HARTMANN CARLOS ALONSO-RAMOS XAVIER LE ROUX PAUL CROZAT ERIC CASSAN DELPHINE MARRIS-MORINI CHARLES BAUDOT FRéDéRIC BOEUF JEAN-MARC FéDéLI CHRISTOPHE KOPP LAURENT VIVIEN | 2019 | Photonics Research2019，7，4： | 2 |
| 4 | The web of human sexual contact显示文摘 | Rdling C R Amaral L A N | 2001 | Nature2001，411，6840： | 1 |
| 5 | Characterization and electrochemical performance of the spinel LiMn2O4 prepared from a- MnO2显示文摘 | FERRACIN L C AMARAL F A BOCCHI N | 2000 | Solid State Ionics2000，130，34： | 1 |
| 6 | Neuronal death in cytokine - activated primary human brain cell culture: role of tumor neerosis factor - alpha显示文摘 | DOWNEN M AMARAL TI) HUA L L | 1999 | Glia1999，28，2： | 1 |
| 7 | Scaling behaviour in the growth of companies显示文摘 | Stanley M H R Amaral L A N Buldyrev S V Havlin S Leschhorn H Maass P Salinger M A Stanley H E | 1996 | Nature1996，379，： | 1 |
| 8 | Classes of small-world networks 显示文摘 | Amaral L A N | 2000 | National Acad Sciences2000，97，11： | 1 |
| 9 | Virtual round table on ten leading questions for network 显示文摘 | AMARAL L BARRAT A CALDARELLI G | 2004 | The European Physical Journal B2004，38，2： | 1 |
| 10 | Palhogenesis and pharmacological strategies for mitigating secondary damage in acute spinal cord injury 显示文摘 | Amar A P Levy M L | 1999 | Neurosurgery1999，44，5： | 1 |
| 11 | Quantitative detection of poultry meat adulteration with pork by a duplex PCR assay 显示文摘 | Soares S Amaral JS M afra l | 2010 | Meat Sci2010，85，3： | 1 |
| 12 | Physiobank,physiotoolkit and physionet:Components of a newresearch resource for complex physiologic signals显示文摘 | Goldberger A L Amaral L A Glass L | 2000 | Circulation2000，101，23： | 1 |
| 13 | Evaluation of landfill leachate treatment by advanced oxidative process by Fenton's reagent combined with membrane separation system显示文摘 | Moravia W G Amaral M Lange L C | 2013 | Waste Management2013，33，1： | 1 |
| 14 | Classes of Complex Networks Defined by Role-to-role Connectivi- ty Profiles显示文摘 | Guimera R Sales-Pardo M Amaral L A N | 2007 | Nature physics2007，3，1： | 1 |
| 15 | A model for the growth dynamics of economic organizations显示文摘 | Amaral L A N Gopikrishnan P Plerou V Stanley H E | 2001 | Physica A2001，299，： | 1 |
| 16 | Numerical analysis of adsorptive temperature wave regenerative heat pump显示文摘 | Amar N B Sun L M Meunier F | 1996 | Applied Thermal Engineering1996，16，5： | 1 |
| 17 | PhysioBank,PhysioToolkit,and PhysioNet:components of a new research resource for complex physiologic signals显示文摘 | Goldberger AL Amaral LA Glass L | 2000 | Circulation2000，101，： | 1 |
| 18 | Classes of small-world net- works显示文摘 | Amaral L Scala A Barth616my M | 2000 | PNAS2000，97，11： | 1 |
| 19 | Microglial stress induc-ible protein 1 promotes proliferation and migration in human glioblas-toma cells显示文摘 | Fonseca AC Romao L Amaral RF | | 0，，01： | 1 |
| 20 | Resveratrol attenuates cisplatin-induced nephrotoxicity in rats显示文摘 | do AMARAL C L FRANCESCATO H D C COIMBRA T M | 2008 | Archives of Toxicology2008，82，6： | 1 |
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