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| 1 | Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease显示文摘AIM: To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease. METHODS: Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men, 26 (51%) had villous atrophy, and 25 (49%) used B-vitamin supplements] and 50 healthy control individuals matched for age and sex. Finally, the C677T polymorphism of 5,10-methylene tetrahydrofolate reductase (MTHFR) was evaluated in 46 patients with celiac disease and all control individuals. RESULTS: Patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003),folate (P < 0.001), and vitamin B12 (P = 0.012) levels than patients who did not or healthy controls (P = 0.035, P < 0.001, P = 0.007, for vitamin B6, folate, and vitamin B12, respectively). Lower plasma homocysteine levels were found in patients using vitamin supplements than in patients who did not (P = 0.001) or healthy controls (P = 0.003). However, vitamin B6 and folate, not vitamin B12, were significantly and independently associated with homocysteine levels. Twenty-four (48%) of 50 controls and 23 (50%) of 46 patients with celiac disease carried the MTHFR thermolabile variant T-allele (P = 0.89). CONCLUSION: Homocysteine levels are dependent on Marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management. | Muhammed Hadithi Chris JJ Mulder Frank Stam Joshan Azizi J Bart A Crusius Amado Salvador Pea Coen DA Stehouwer Yvo M Smulders | 2009 | World Journal of Gastroenterology2009，15，8： | 3 |
| 2 | One decade of salivary proteomics: Currentapproaches and outstanding challenges显示文摘 | AMADO F M L FERREIRA R P VITORINAR | 2013 | ClinicalBiochemistry2013，46，6： | 1 |
| 3 | Wild - type KRAS is required for panitumumab efficacy in patients with meta- static colorectal cancer显示文摘 | Amado RG Wolf M Peeters M | 2008 | J Clin 0ncol2008，26，： | 1 |
| 4 | Impairment of Predictive Saccades in Schizophrenia 显示文摘 | Krebs M O Gut - Fayand A Amado I | 2001 | Neuroreport2001，12，3： | 1 |
| 5 | Squamous cell carcinoma arising in inverted papilloma显示文摘 | LFSPERANCE M M ESCL AMADO R M | 1995 | Laryngoscope1995，105，2： | 1 |
| 6 | DCT-domain watermarking techniques for still images:Detector performance analysis and a new structure显示文摘 | J R Hernández M Amado Femando Pérez-González | 2000 | IEEE Trans on Image-Processing2000，9，1： | 1 |
| 7 | Wild - type KRAS is required for panitumumab effcacy in patients with metastatic colorectal cancer 显示文摘 | Amado RG Wolf M Peeters M | 2008 | J Clin Oncol2008，26，： | 1 |
| 8 | Morphology and characterization of laser clad composite NiCrBSi-WC coatings on stainless steel显示文摘 | TOBAR M J ALVAREZ C AMADO J M RODRIGUEZ G YANEZ A | 2006 | Surface & Coatings Technology2006，200，： | 1 |
| 9 | Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer 显示文摘 | Amado RG Wolf M Peeters M | 2008 | J Clin Oncol2008，26，10： | 1 |
| 10 | Delayed ACTH response to human cortieotropin reseasing hormone during eardiopulmonary bypass under diazepam-high dose fentanyl anaesthesia显示文摘 | Amado J A Diago M C | 1994 | Anaesthesia1994，49，： | 1 |
| 11 | Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer 显示文摘 | Amado RG Wolf M Peeter M | 2008 | J Clin Oncol2008，26，： | 1 |
| 12 | Wild- type K-RAS is required for panitumumab efficacy in patients with metastatic colorectal cancer显示文摘 | AMADO R G WOLF M PEETERS M | 2008 | J Clin Oncol2008，26，10： | 1 |
| 13 | Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer显示文摘 | Amado RG Wolf M Peeters M | 2008 | J Clin Oncol2008，26，10： | 1 |
| 14 | Crack free tungsten carbide reinforced Ni (Cr) layers obtained by laser cladding 显示文摘 | Amado J M Tobar M J Y6f:ez A | 2011 | Phys Procedia2011，12，338： | 1 |
| 15 | Wild-type KRAS isrequired for panitumumab efficacy in patients withmetastatic colorectal cancer显示文摘 | Amado RG Wolf M Peeters M | 2008 | J Clin Oncol2008，26，10： | 1 |
| 16 | Influence of natural extracts on the shelf life of modified atmosphere-pack- aged pork patties显示文摘 | LORENZO J M SINEIRO J AMADO I R | 2014 | Meat science2014，96，1： | 1 |
| 17 | Double versus single renal allografts from agel donors 显示文摘 | Amado A jose mara M Juan Carlos H | 2000 | Transplantation2000，69，10： | 1 |
| 18 | Evidence-based allergy diagnostic tests显示文摘 | Portnoy JM Amado M | 2006 | Curr Allergy Asthma Rep2006，6，6： | 1 |
| 19 | Regulation of muscle hydration upon hypo-or hyper-osmotic shocks:Differences related to invasion of the freshwater habitat by decapod crustaceans显示文摘 | FREIRE C A SOUZA-BASTOS L R AMADO E M | 2013 | J Exp Zool A Ecol Genet Physiol2013，319，6： | 1 |
| 20 | Crack free tungsten carbide reinforced Ni(Cr) layers obtained by laser cladding显示文摘 | AMADO J M TOBAR M J YANEZ A | 2011 | Phys Proc2011，，12： | 1 |
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