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| 1 | ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy显示文摘响应滋养的应力,房间开始能导致改编或死亡的一个 autophagy 节目。位于从饥饿发信号到 autophagy 的开始下面的机制充分没被理解。在当前的学习,我们证明 PARP-1 的缺席或 inactivation 强烈推迟导致饥饿的 autophagy。我们发现了那 DNA 损坏是由 γ 测量了的导致饥饿的 autophagy 的一个早事件; -H2AX 累积和彗星试金,与在两个参数显示减小的 PARP-1 猛烈房间。在饥饿期间,导致 ROS 的 DNA 损坏激活 PARP-1,导致 ATP 弄空(在滋养的剥夺以后的一个早事件) 。PARP-1 的缺席弄钝 AMPK 激活并且阻止了 mTOR 活动的完全的损失,导致在 autophagy 的延期。PARP-1 弄空在饥饿的房间赞成 apoptosis,建议在滋养的剥夺以后的 autophagy 和 PARP-1 激活的一个支持幸存的角色。在 PARP-1 变异的老鼠的出生不满一月的婴儿使遭到了到尖锐饥饿的 vivo 结果表演,也显示缺乏的肝 autophagy,暗示为在导致饥饿的 autophagy 的 PARP-1 的一个生理的角色。因此,表明小径的 PARP 是 autophagy 承诺追随者饥饿的起始的步骤的一个关键管理者。 | Jose Manuel Rodriguez-Vargas Maria Jose Ruiz-Magana Carmen Ruiz-Ruiz Jara Majuelos-Melguizo Andreina Peralta-Lea Maria Isabel Rodriguez Jose Antonio Munoz-Gaimez Mariano Ruiz de Almodovar Eva Siles Abelardo Lopez Rivas Marja Jaattela F Javier Oliver | 2012 | Cell Research2012，22，7： | 8 |
| 2 | Observing the stages of bystander intervention in virtual reality simulation显示文摘BACKGROUND: Understanding bystander reactions to an emergency is an important component of effective training. Four stages of bystander intervention (BI) have been previously described: noticing the situation as a problem, interpreting when it is appropriate to intervene, recognizing personal responsibility to intervene, and knowing how to intervene. Using virtual reality (VR) to simulate emergencies such as sudden cardiac arrest (SCA) can be used to study these stages. METHODS: In a secondary analysis of an observational cohort study, we analyzed bystander self-effi cacy for stages of BI before and after simulated SCA. Each subject participated in a singleplayer, immersive, VR SCA scenario. Subjects interacted with simulated bystanders through voice commands (“call 911”,“get an AED”). Actions taken in scenario, like performing CPR, were documented. Scenario BI actions were compared based on dichotomized comfort/discomfort. RESULTS: From June 2016 to June 2017, 119 subjects participated. Average age was 37±14 years, 44% were female and 46% reported CPR training within 2 years. During the scenario, 98%“noticed the event” and “interpreted it as a problem”, 78%“took responsibility”, and 54%“possessed the necessary skills”. Self-effi cacy increased from pre- to post-scenario: noticing the event increased from 80% to 96%;interpreting as a problem increased from 86% to 97%;taking responsibility increased from 56% to 93%;possessing necessary skills increased from 47% to 63%(P<0.001). CONCLUSION: Self-efficacy to respond to an SCA event increased pre- to post-scenario. Bystanders who reported feeling comfortable “taking responsibility to intervene” during an emergency were more likely to take action during a simulated emergency. | David G. Buckler Alfredo Almodovar Jr Paul Snobelen Benjamin S. Abella Audrey Blewer Marion Leary | 2019 | World Journal of Emergency Medicine2019，10，3： | 2 |
| 3 | Role and therapeutic potential of VEGF in the nervous system显示文摘 | Ruiz de Almodovar C Lambrechts D Mazzone M | 2009 | Physiol Rev2009，89，2： | 1 |
| 4 | Initial radiation-induced DNA damage in human turnour cell lines: a correlation with intrinsic cellular radiosensitivity显示文摘 | Ruiz de Almodovar JM Nunez MI McMillan TJ | 1994 | Br J Cancer1994，69，3： | 1 |
| 5 | The upregulation of human caspase 8 by interferon-gamma in breast tumor cells requires the induction and action of the transcription factor interferon regulatory factor-1 显示文摘 | Ruiz-Ruz C Ruiz de Almodovar C Rodriguez A | 2004 | J Biol Chem2004，279，19： | 1 |
| 6 | The responses to surface wettability gradients induced by chitosan nanofilms on microtextured titanium mediated by specific integrin receptors显示文摘 | PARK J H WASILEWSKI C E ALMODOVAR N | 2012 | Biomaterials2012，33，30： | 1 |
| 7 | An SDF-1 Trap for Myeloid Cells Stimulates Angiogenesis显示文摘 | Carmen Ruiz de Almodovar Aernout Luttun Peter Carmeliet | 2006 | Cell2006，，1： | 1 |
| 8 | Surgery for coaretation of the aorta in infants weighing less than 2 kg显示文摘 | Bacha EA Almodovar M Wessel DL | 2001 | 71(4) : 1260-12642001，71，4： | 1 |
| 9 | Association of biomarkers of inflammation, cartilage and bone turnover with gender, disease activity, radiological damage and sacroiliitis by magnetic resonance imaging in patients with early spondyloarthritis 显示文摘 | Almodovar R Rios V Ocafia S | 2014 | Clin Rheumatol2014，33，2： | 1 |
| 10 | Effects of temperature on the embryonic development of Willowsia jacobsoni(brner)(Collembola:Entomobryidae)显示文摘 | Mari Mutt J A Reyes Almodovar R G Diez I R | 1984 | Caribbean Journal of Sciences1984，20，12： | 1 |
| 11 | High-Bandwidth Scanned Wavelength Modulation Spec- troscopy Sensors for Temperature and H2O in a Rotating Detonation Engine 显示文摘 | Goldenstein C S Almodovar C A Jeffries J B | 2014 | Measurement Science and Tech- nology2014，25，： | 1 |
| 12 | Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis 显示文摘 | Garnacho- Montero J Garcia- Garmendia JL Barrero- Almodovar A | 2003 | Crit Care Med2003，31，12： | 1 |
| 13 | 显示文摘 | Leccabue F Salviati G Almodovar N S | 1988 | IEEE Trans Magn1988，，： | 1 |
| 14 | Integrated Coastal Zone Management (ICZM): a review of progress in Portuguese implementation显示文摘 | F. L. Alves L. P. Sousa M. Almodovar M. R. Phillips | 2013 | Regional Environmental Change2013，，5： | 1 |
| 15 | Enhancing atrazine activity with addtions of mineral and vegetable oils 显示文摘 | Almodovar B L | 1970 | Journal of Agric Univ of Porto Rico1970，54，4： | 1 |
| 16 | Neutron diffraction refinement of CaWO4 显示文摘 | M Kay B Frazer I Almodovar | 1964 | J Chem Phys1964，40，2： | 1 |
| 17 | An SDF- 1 trap for myeloid cells stimulates angiogenesis 显示文摘 | Ruiz de Almodovar C Luttun A and Carmeliet P | 2006 | Cell2006，124，1： | 1 |
| 18 | The usefulness of calculated attenuation correction in the evaluation of metallic artifacts on brain PET/CT imaging显示文摘 | Almodovar S White SL Modarresifar H | 2006 | Clin Nucl Med2006，31，9： | 1 |
| 19 | A new mouse model to study acquired lymphedema显示文摘 | Schneider M Ny A Ruiz de Almodovar C | 2006 | PLoS Med2006，3，7： | 1 |
| 20 | Adsorption kinetics of deamidated antibody variants on macroporous and dextran-grafted cation exchangers (Ⅲ): Microscopic studies 显示文摘 | TAO Y ALMODOVAR E X P CARTA G | 2011 | Journal of Chromatography A2011，1218，44： | 1 |
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