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| 1 | Application of neurotrophic and proangiogenic factors as therapy after peripheral nervous system injury显示文摘The intrinsic ability of peripheral nerves to regenerate after injury is extremely limited,especially in case of severe injury.This often leads to poor motor function and permanent disability.Existing approaches for the treatment of injured nerves do not provide appropriate conditions to support survival and growth of nerve cells.This drawback can be compensated by the use of gene therapy and cell therapy-based drugs that locally provide an increase in the key regulators of nerve growth,including neurotrophic factors and extracellular matrix proteins.Each growth factor plays its own specific angiotrophic or neurotrophic role.Currently,growth factors are widely studied as accelerators of nerve regeneration.Particularly noteworthy is synergy between various growth factors,that is essential for both angiogenesis and neurogenesis.Fibroblast growth factor 2 and vascular endothelial growth factor are widely known for their proangiogenic effects.At the same time,fibroblast growth factor 2 and vascular endothelial growth factor stimulate neural cell growth and play an important role in neurodegenerative diseases of the peripheral nervous system.Taken together,their neurotrophic and angiogenic properties have positive effect on the regeneration process.In this review we provide an in-depth overview of the role of fibroblast growth factor 2 and vascular endothelial growth factor in the regeneration of peripheral nerves,thus demonstrating their neurotherapeutic efficacy in improving neuron survival in the peripheral nervous system. | Kamilla Faritovna Idrisova Alina Kazymovna Zeinalova Galina Andreevna Masgutova Alexey Andreevich Bogov Jr. Cinzia Allegrucci Valeriia Yurievna Syromiatnikova Ilnur Ildusovich Salafutdinov Ekaterna Evgenievna Garanina Dina Ivanovna Andreeva Adilet Abdullaatovich Kadyrov Albert Anatolevich Rizvanov Ruslan Faridovich Masgutov | 2022 | Neural Regeneration Research2022，17，6： | 6 |
| 2 | DNA methylation,insulin resistance, and blood pressure in offspring determined by mater- nal periconceptional B vitamin and methionine status显示文摘 | SINCLAIR K D ALLEGRUCCI C SINGH R | 2007 | Proc Nail Acad Sci USA2007，104，19： | 1 |
| 3 | Overcomingdrug resistance and treating advanced prostate cancer 显示文摘 | Semenas J Allegrucci C Boorjian SA | 2012 | Curr Drug Targets2012，13，10： | 1 |
| 4 | Epigenetic marks in somatic chromatin are remodelled to resem- ble pluripotent nuclei by amphibian oocyte extracts 显示文摘 | Bian Y Alberio R Allegrucci C | 2009 | Epigenetics2009，4，： | 1 |
| 5 | DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine statue显示文摘 | Sinclair K D Allegrucci C Singh R et ol | 2007 | P Natl Acad Sci USA2007，104，19： | 1 |
| 6 | Modulation of plu- ripotency in the porcine embryo and iPS cells显示文摘 | RODRIGUEZ A ALLEGRUCCI C ALBERIO R | 2012 | PLoS One2012，7，49： | 1 |
| 7 | Epigenetic marks in so matie chromatin are remodelled to resemble pluripotent nuclei by amphibian oocyte extracts 显示文摘 | Bian Y Alberio R Allegrucci C | 2009 | Epigenetics2009，4，： | 1 |
| 8 | Phenotypic characterization of Streptococcus pneumortiae biofilm development显示文摘 | Allegrucci M Hu F Z Shen K | 2006 | J Bacteriol2006，188，： | 1 |
| 9 | Epigenetics and the germline显示文摘 | Allegrucci C Thurston A Lucas E | 2005 | Reproduction2005，129，2： | 1 |
| 10 | Pig epiblast stem cells depend on activin/nodal signaling for pluripotency and selfrenewal显示文摘 | Alberio R Croxall N Allegrucci C | 2010 | Stem Cells Dev2010，19，10： | 1 |
| 11 | Fatigue fracture of a aircraft canopy lever reverse显示文摘 | Allegrucci L Amura M Bagnoli F | 2009 | Eng Fail Anal2009，16，： | 1 |
| 12 | Differences between human embryonic stem cell lines显示文摘 | ALLEGRUCCI C YOUNG L | | 0，，02： | 1 |
| 13 | DNA methylation, insulin resistance, and blood pres- sure in offspring determined by maternal periconcep- tional B vitamin and methionine status 显示文摘 | SINCLAIR K D ALLEGRUCCI C SINGH R | 2007 | Proceed- ings of the National Academy of Sciences of the Unit- ed States of America2007，104，19： | 1 |
| 14 | Differences between human embryonic stem cell lines 显示文摘 | Allegrucci C Young LE | 2007 | Hum Reprod Update2007，13，： | 1 |
| 15 | Clinnical implications of secondary impingement of the shoulder in freesyle swimmers显示文摘 | Allegrucci M Whitney SL Irrgang JJ | 1994 | J Orthop Sports Phys Ther1994，20，： | 1 |
| 16 | Shoulder kinesthesia in healthy unilateral athletes participating in upper extremity sports显示文摘 | Allegrucci M Whitney SL Lephart SM | 1996 | JOSPT1996，21，4： | 1 |
| 17 | Patterns of gene flow and genetic structure in cave-dwelling crickets of the Tuscan endemic显示文摘 | Allegrucci G Maria G M Valerie S | 1997 | Dolichopoda Schiavazzii Heredity1997，78，6： | 1 |
| 18 | Region-specific DNA methylation in the preimplantation embryo as a target for genomic plasticity显示文摘 | Thurston A Lucas ES Allegrucci C Steele W Young LE | 2007 | Theriogenology2007，68，1： | 1 |
| 19 | Clinnical implications of secondary impingement of the shoulder in freesyle swimmers显示文摘 | Allegrucci M Whitney S L Irrgang J J | 1994 | J Orthop Sports Phys Ther1994，20，： | 1 |
| 20 | Fatigue Fracture of a Aircratt Canopy Lever Reverse显示文摘 | Allegrucci L Amura M Bagnoli F | 2009 | Engi neering Failure Analysis2009，16，： | 1 |
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