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| 1 | Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children显示文摘AIM:To investigate the safety and efficacy of a Hansenula-derived PEGylated(polyethylene glycol)interferon(IFN)-alpha-2a(Reiferon Retard)plus ribavirin customized regimen in treatment-na?ve and previously treated(non-responders and relapsers)Egyptian children with chronic hepatitis C infection.METHODS:Forty-six children with chronic hepatitis C virus(HCV)infection were selected from three tertiary pediatric hepatology centers.Clinical and laboratory evaluations were undertaken.Quantitative polymerase chain reaction(PCR)for HCV-RNA was performed before starting treatment,and again at 4,12,24,48,72wk during treatment and 6 mo after treatment cessation.All patients were assigned to receive a weekly subcutaneous injection of PEG-IFN-alpha-2a plus daily oral ribavirin for 12 wk.Thirty-four patients were treatment-na?ve and 12 had a previous treatment trial.Patients were then divided according to PCR results into two groups.GroupⅠincluded patients who continued treatment on a weekly basis(7-d schedule),while groupⅡincluded patients who continued treatment on a 5-d schedule.Patients from either group who were PCR-negative at week 48,but had at least one PCRpositive test during therapy,were assigned to have an extended treatment course up to 72 wk.The occurrence of adverse effects was assessed during treatment and follow up.The study was registered at www.ClinicalTrials.gov(NCT02027493).RESULTS:Only 11 out of 46(23.9%)patients showed a sustained virological response(SVR),two patients were responders at the end of treatment;however,they were lost to follow up at 6 mo post treatment.Breakthrough was seen in 18(39.1%)patients,one patient(2.17%)showed relapse and 14(30.4%)were non-responders.Male gender,short duration of infection,low viral load,mild activity,and mild fibrosis were the factors related to a better response.On the other hand,patients with high viral load and absence of fibrosis failed to respond to treatment.Before treatment,liver transaminases were elevated.After commencing treatment,they were normalized in all patients at week 4 and were maintained normal in responders till the end of treatment,while they increased again significantly in non-responders(P=0.007 and 0.003 at week 24 and 72 respectively).The 5-d schedule did not affect the response rate(1/17 had SVR).Treatment duration(whether 48 wk or extended course to 72 wk)gave similar response rates(9/36 vs 2/8 respectively;P=0.49).Type of previous treatment(short acting IFN vs PEG-IFN)did not affect the response to retreatment.On the other hand,SVR was significantly higher in previous relapsers than in previous non-responders(P=0.039).Only mild reversible adverse effects were observed and children tolerated the treatment well.CONCLUSION:Reiferon Retard plus ribavirin combined therapy was safe.Our customized regimen did not influence SVR rates.Further trials on larger numbers of patients are warranted. | Suzan El Naghi Tawhida Y Abdel-Ghaffar Hanaa El-Karaksy Elham F Abdel-Aty Mona S El-Raziky Aleef A Allam Heba Helmy Hanaa A El-Araby Behairy E Behairy Mohamed A El-Guindi Hatem El-Sebaie Aisha Y Abdel-Ghaffar Nermin A Ehsan Ahmed M El-Hennawy Mostafa M Sira | 2014 | World Journal of Gastroenterology2014，20，16： | 2 |
| 2 | Mutual compensation ofmobility and threshold voltage temperature effectswith applications in CMOS circuits显示文摘 | Filanovsky I M Allam A | 2001 | IEEE Trans-actions on Circuits and Systems I2001，48，7： | 1 |
| 3 | On the improvement of neural cryptography using erroneous transmitted information with error prediction显示文摘 | ALLAM A M ABBAS H M | 2010 | IEEE Trans on Neural Networks2010，21，12： | 1 |
| 4 | Effect of wetting and drying on shear strength 显示文摘 | Allam M M Sridharan S | 1981 | J Geotech Engrg Div ASCE1981，107，4： | 1 |
| 5 | Stress concentrations in a viscoelastic composite plate weak- ened by a triangular hole显示文摘 | Allam M N M Zenkour A M El-Mekawy H F | 2007 | Composite Structures2007，79，1： | 1 |
| 6 | Attenuated TGF-131 responsiveness of dendritic cells and their precursors in atopic dermatitis显示文摘 | PENG W M MAINTZ L ALLAM J P | 2013 | European Journal of immunology2013，43，5： | 1 |
| 7 | Stress concentrations in a viscoelastic composite plate weakened by a triangular hole显示文摘 | ALLAM M N M ZENKOUR A M EL-MEKAWY H F | 2007 | Composite Structures2007，79，1： | 1 |
| 8 | Effect of wetting and drying on shear strength 显示文摘 | ALLAM M M SRIDHARAM S | 1981 | Journal of Geotechnical Engineering1981，107，4： | 1 |
| 9 | The B-lynch and other uterine com- pression suture techniques 显示文摘 | Allam M S B-lynch C | 2005 | [nt Cynaecol obstet2005，89，3： | 1 |
| 10 | The B -Lynch and other uterine compression suture techniques显示文摘 | Allam M S B -Lynch C | 2007 | Int J Gynaccol Obstet2007，89，3： | 1 |
| 11 | Clinical value of im?munohistochemically detected lymphovascular space invasion in early stage cervical carcinoma显示文摘 | Lim CS Alexander-Sefre F Allam M | 2008 | Ann Surg Oncol2008，15，： | 1 |
| 12 | Incidence of bladder cancer in a one-stop clinic 显示文摘 | Yakasai A Allam M Thompson A J | 2011 | Ann Mr Med2011，10，2： | 1 |
| 13 | Mutual compensation of mobility and threshold voltage temperature effects with applications in CMOS circuits显示文摘 | Filanovsky I M Allam A | 2001 | IEEE Transactions on Circuits and Systems I:Fundamental Theory and Applications2001，48，7： | 1 |
| 14 | Long-term load forecasting and economical operation of wind farms for Egyptian electrical network显示文摘 | Abou A A El-zaftawy A A Allam S M | 2009 | Electric Power Systems Research2009，79，7： | 1 |
| 15 | Concise review of recent studies in vitiligo显示文摘 | Allam M Riad H | 2013 | Qatar Medical Journal2013，2013，2： | 1 |
| 16 | Mutual compensation of mobility and threshold voltage temperature effects with applications in CMOS circuits显示文摘 | Filanovsky I M Allam A | 2001 | IEEE Transactions on Circuits and Systems I:Fundamental Theory and Applications2001，48，7： | 1 |
| 17 | Dynamic current mode logic(DyCML):A new low-power high-performance logic style显示文摘 | Allam M W Elmasry M I | 2001 | IEEE Journal of Solid-State Circuits2001，36，3： | 1 |
| 18 | Analysis of cable-stayed bridges under multi-component random ground motion by response spectrum method显示文摘 | Allam S M Datta T K | 2000 | Engineering Structures2000，22，10： | 1 |
| 19 | Seismic response of a cablestayed bridge deck under multi-component non-stationary random ground motion 显示文摘 | Allam Said M Datta T K | 2004 | Earthquake Engineering and Structural Dynamics2004，33，3： | 1 |
| 20 | Association between total plasma homocysteine level and cognitive functions in elderly Egyptian subjects显示文摘 | Allam M Fahmy E Elatti SA | 2013 | J Neurol Sci2013，332，12： | 1 |
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