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| 1 | Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children显示文摘AIM:To investigate the safety and efficacy of a Hansenula-derived PEGylated(polyethylene glycol)interferon(IFN)-alpha-2a(Reiferon Retard)plus ribavirin customized regimen in treatment-na?ve and previously treated(non-responders and relapsers)Egyptian children with chronic hepatitis C infection.METHODS:Forty-six children with chronic hepatitis C virus(HCV)infection were selected from three tertiary pediatric hepatology centers.Clinical and laboratory evaluations were undertaken.Quantitative polymerase chain reaction(PCR)for HCV-RNA was performed before starting treatment,and again at 4,12,24,48,72wk during treatment and 6 mo after treatment cessation.All patients were assigned to receive a weekly subcutaneous injection of PEG-IFN-alpha-2a plus daily oral ribavirin for 12 wk.Thirty-four patients were treatment-na?ve and 12 had a previous treatment trial.Patients were then divided according to PCR results into two groups.GroupⅠincluded patients who continued treatment on a weekly basis(7-d schedule),while groupⅡincluded patients who continued treatment on a 5-d schedule.Patients from either group who were PCR-negative at week 48,but had at least one PCRpositive test during therapy,were assigned to have an extended treatment course up to 72 wk.The occurrence of adverse effects was assessed during treatment and follow up.The study was registered at www.ClinicalTrials.gov(NCT02027493).RESULTS:Only 11 out of 46(23.9%)patients showed a sustained virological response(SVR),two patients were responders at the end of treatment;however,they were lost to follow up at 6 mo post treatment.Breakthrough was seen in 18(39.1%)patients,one patient(2.17%)showed relapse and 14(30.4%)were non-responders.Male gender,short duration of infection,low viral load,mild activity,and mild fibrosis were the factors related to a better response.On the other hand,patients with high viral load and absence of fibrosis failed to respond to treatment.Before treatment,liver transaminases were elevated.After commencing treatment,they were normalized in all patients at week 4 and were maintained normal in responders till the end of treatment,while they increased again significantly in non-responders(P=0.007 and 0.003 at week 24 and 72 respectively).The 5-d schedule did not affect the response rate(1/17 had SVR).Treatment duration(whether 48 wk or extended course to 72 wk)gave similar response rates(9/36 vs 2/8 respectively;P=0.49).Type of previous treatment(short acting IFN vs PEG-IFN)did not affect the response to retreatment.On the other hand,SVR was significantly higher in previous relapsers than in previous non-responders(P=0.039).Only mild reversible adverse effects were observed and children tolerated the treatment well.CONCLUSION:Reiferon Retard plus ribavirin combined therapy was safe.Our customized regimen did not influence SVR rates.Further trials on larger numbers of patients are warranted. | Suzan El Naghi Tawhida Y Abdel-Ghaffar Hanaa El-Karaksy Elham F Abdel-Aty Mona S El-Raziky Aleef A Allam Heba Helmy Hanaa A El-Araby Behairy E Behairy Mohamed A El-Guindi Hatem El-Sebaie Aisha Y Abdel-Ghaffar Nermin A Ehsan Ahmed M El-Hennawy Mostafa M Sira | 2014 | World Journal of Gastroenterology2014，20，16： | 2 |
| 2 | Polyene macrolide antifungal drugs trigger interleukin-ll3 secre- tion by activating the NLRP3 inflammasome 显示文摘 | Darisipudi MN Allam R Rupanagudi KV et a/ | 2011 | PLoS One2011，6，19： | 1 |
| 3 | Application of prepared waterborne polyurethane extended with chitosan to impart antibacterial properties to acrylic fabrics显示文摘 | Atef E1-Sayed A E1 Gabry L K Allam 0 G | 2010 | Journal of Materials Science : Materials in Medicine2010，21，2： | 1 |
| 4 | Analyzing microarray data of Alzheimer's using cluster analysis to identify the biomarker genes显示文摘 | Guttula SV Allam A Gumpemy RS | 2012 | J Atzheimer''s Dis2012，2012，64： | 1 |
| 5 | Mutual compensation ofmobility and threshold voltage temperature effectswith applications in CMOS circuits显示文摘 | Filanovsky I M Allam A | 2001 | IEEE Trans-actions on Circuits and Systems I2001，48，7： | 1 |
| 6 | On the improvement of neural cryptography using erroneous transmitted information with error prediction显示文摘 | ALLAM A M ABBAS H M | 2010 | IEEE Trans on Neural Networks2010，21，12： | 1 |
| 7 | Crystal engineering of energetic materials:cocrystals of CL-20显示文摘 | Millar D I A Maynard-Caely H E Allam D R | 2012 | Cryst Eng Comm2012，14，10： | 1 |
| 8 | Stress concentrations in a viscoelastic composite plate weak- ened by a triangular hole显示文摘 | Allam M N M Zenkour A M El-Mekawy H F | 2007 | Composite Structures2007，79，1： | 1 |
| 9 | Optical coherence tomography findings in autoimmune retinopathy显示文摘 | Abazari A Allam SS Adamus G | 2012 | Am J Ophthalmol2012，153，： | 1 |
| 10 | Stress concentrations in a viscoelastic composite plate weakened by a triangular hole显示文摘 | ALLAM M N M ZENKOUR A M EL-MEKAWY H F | 2007 | Composite Structures2007，79，1： | 1 |
| 11 | Isolation of the pathogen Vibrio tapetis and defense parameters in brown ring diseased Manila clams Rutitapes philippinarum cultivated in England 显示文摘 | Allam B Paillard C Howard A | 2000 | Viseases of Aquatic Organisms2000，41，2： | 1 |
| 12 | Effects of benzotriazole on the corrosion of Cu10Ni alloy in sulfide-polluted salt water显示文摘 | N K Allam E A Ashour H S Hegazy | 2005 | Corrosion Science2005，47，： | 1 |
| 13 | SOMA: A method for developing service-oriented solutions显示文摘 | Arsanjani A Ghosh S Allam A | 2008 | IBM SystemsJournal2008，47，3： | 1 |
| 14 | Flow cytometric comparison of haemocytes from three species of bivalve mollusks显示文摘 | Allam B Ashton-Alcox K A Ford S E | 2002 | Fish & Shellfish Immunology2002，13，： | 1 |
| 15 | Incidence of bladder cancer in a one-stop clinic 显示文摘 | Yakasai A Allam M Thompson A J | 2011 | Ann Mr Med2011，10，2： | 1 |
| 16 | Mutual compensation of mobility and threshold voltage temperature effects with applications in CMOS circuits显示文摘 | Filanovsky I M Allam A | 2001 | IEEE Transactions on Circuits and Systems I:Fundamental Theory and Applications2001，48，7： | 1 |
| 17 | Long-term load forecasting and economical operation of wind farms for Egyptian electrical network显示文摘 | Abou A A El-zaftawy A A Allam S M | 2009 | Electric Power Systems Research2009，79，7： | 1 |
| 18 | Malignant fibrous histiocytoma:a retrospective study of 109 cases 显示文摘 | Belal A Kandil A Allam A | 2002 | Am J Clin Oncol2002，25，： | 1 |
| 19 | Mutual compensation of mobility and threshold voltage temperature effects with applications in CMOS circuits显示文摘 | Filanovsky I M Allam A | 2001 | IEEE Transactions on Circuits and Systems I:Fundamental Theory and Applications2001，48，7： | 1 |
| 20 | An exploration of the potential for studying the usage of investor relations information through the analysis of web server logs显示文摘 | Rowhottom N Allam A and Lymer A | 2005 | International Journal of Accounting Information Systems2005，6，1： | 1 |
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