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| 1 | Androgen synthesis inhibitors in the treatment of castration-resistant prostate cancer显示文摘gonadal 睾丸激素合成的抑制首先代表标准为变形前列腺癌症的治疗的线治疗。在得阉割抵抗的前列腺癌症(CRPC ) 的病人的多数,然而,通过自己在肾上腺或在肿瘤以内生产的雄激素检测雄激素受体(AR ) 的坚持的激活是可能的。Abiraterone 醋酸盐作为 17 α 与活动作为双功能的细胞色素 P450 酶 CYP17 的一个不可逆的禁止者被开发; -hydroxylase 和 17,20-lyase。CYP17 为从胆固醇的 nongonadal 雄激素的生产是必要的。基于与 abiraterone 和泼尼松对泼尼松在全面幸存(OS ) 显示出重要改进的阶段 III 试用,在 2011 的 abiraterone 的规章的赞同代表了指向 AR 为与 CRPC 在人改进结果是必要的原则的证明。 17 α 的抑制;由 abiraterone 的 -hydroxylase 由于垂体的调停皮质醇的抑制的损失导致在上游的 mineralocorticoids 的累积促肾上腺皮质的荷尔蒙( ACTH ),为 17,20-lyase 为 CYP17 禁止者的开发向一个基本原理提供增加的特性( orteronel , galeterone 和 VT-464 )没有外长的 corticosteroids ,那能潜在地被管理。在这篇文章,我们考察 abiraterone 和另外的 CYP17 禁止者的发展;有 abiraterone 的最近的研究在 quality-of-life,反应的潜在的早预言者,并且关于另外的代理人的 abiraterone 的最佳的定序上通知我们的理解象药效果那样的临床的参数;并且提供卓见进抵抗机制给导致临床的试用,药联合设计了延长 abiraterone 利益或恢复 abiraterone 活动的 CYP17 禁止者的翻译研究结果。 | Mark N Stein | 2014 | Asian Journal of Andrology2014，16，3： | 3 |
| 2 | Impaired swallowing mechanics of post radiation therapy head and neck cancer patients: A retrospective videofluoroscopic study显示文摘AIM: To determine swallowing outcomes and hyolaryngeal mechanics associated with post radiation therapy head and neck cancer(rt HNC) patients using videofluoroscopic swallow studies. METHODS: In this retrospective cohort study, video-fluoroscopic images of rt HNC patients(n = 21) were compared with age and gender matched controls(n = 21). Penetration-aspiration of the bolus and bolus residue were measured as swallowing outcome variables. Timing and displacement measurements of the anterior and posterior muscular slings elevating the hyolaryngeal complex were acquired. Coordinate data of anatomical landmarks mapping the action of the anterior muscles(suprahyoid muscles) and posterior muscles(long pharyngeal muscles) were used to calculate the distance measurements, and slice numbers were used to calculate time intervals. Canonical variate analysis with post-hoc discriminant function analysis was performed on coordinate data to determine multivariate mechanics of swallowing associated with treatment. Pharyngeal constriction ratio(PCR) was also measured to determine if weak pharyngeal constriction is associated with post radiation therapy.RESULTS: The rt HNC group was characterized by poor swallowing outcomes compared to the control group in regards to: Penetration-aspiration scale(P < 0.0001), normalized residue ratio scale(NRRS) for the valleculae(P = 0.002) and NRRS for the piriform sinuses(P = 0.003). Timing and distance measurements of the anterior muscular sling were not significantly different in the two groups, whereas for the PMS time of displacement was abbreviated(P = 0.002) and distance of excursion was reduced(P = 0.02) in the rt HNC group. A canonical variate analysis shows a significant reduction in pharyngeal mechanics in the rt HNC group(P < 0.0001). The PCR was significantly higher in the test group than the control group(P = 0.0001) indicating reduced efficiency in pharyngeal clearance. CONCLUSION: Using videofluoroscopy, this study shows rt HNC patients have worse swallowing outcomes associated with reduced hyolaryngeal mechanics and pharyngeal constriction compared with controls. | William G Pearson Jr Alisa A Davidoff Zachary M Smith Dorothy E Adams Susan E Langmore | 2016 | World Journal of Radiology2016，8，2： | 2 |
| 3 | Unmasking of α-fetoprotein-specific CD4+ T cell responses in hepatocellular carcinoma patients undergoing embolization 显示文摘 | AYARU L PEREIRA SP ALISA A | 2007 | J Immunol2007，178，3： | 1 |
| 4 | Human CD4+ T cells recognize an epitope within α-fetoprotein sequence and develop into TGF-β-producing CD4+ T cells 显示文摘 | ALISA A BOSWELL S PATHAN AA | 2008 | J Immunol2008，180，7： | 1 |
| 5 | Human CD4 (+) T cells recognize an epitope within alpha-fetoprotein sequence and develop into TGF-beta-producing CD4 (+) T cells显示文摘 | Alisa A Boswell S Pathan AA | 2008 | J Immunol2008，180，7： | 1 |
| 6 | Alpha-fetoprotein impairs APC function and induces their apoptosis显示文摘 | Um SH Mulhall C Alisa A | 2004 | J Immunol2004，173，3： | 1 |
| 7 | a-Fetoprotein Impairs APC Function and Induces Their Apoptosis显示文摘 | Um S H MulhaU C Alisa A | 2004 | J lmmunol2004，173，3： | 1 |
| 8 | Expansion of anti-AFP Th1 and Tcl responses in hepatocellular carcinoma occur in different stages of disease显示文摘 | Behboudi S Alisa A Boswell S et a1 | 2010 | Br J Cancer2010，102，4： | 1 |
| 9 | Treatment of noncompliance using parent child interaction therapy: a data-dfived approach显示文摘 | Alisa B Bahl Scott A Spaulding Cheryl B McNeil | 1999 | Education & Treatment of Children1999，22，2： | 1 |
| 10 | α -fetoprotein impairs APC function and induces their apoptosis 显示文摘 | Um SH Mulhall C Alisa A | 2004 | J Immunol2004，173，3： | 1 |
| 11 | Increased Intracellular,Cell Surface,and Secreted Inducible Heat Shock Protein 70 Responses Are Triggered during the Monocyte to Dendritic Cell (DC) Transition by Cytokines Independently of Heat Stress and Infection and May Positively Regulate DC Growth显示文摘 | Carla A Martin Danielle L Kurkowski Alisa M Valentino Frances Santiago-Sehwarz | 2009 | Immunol2009，183，： | 1 |
| 12 | α-fetoprotein impairs APC function and induces their apoptosis 显示文摘 | UM SH MULHALL C ALISA A | 2004 | J Immunol2004，173，3： | 1 |
| 13 | Analysis of CD4+ T-cell responses to a novel (-fetoprotein-derived epitope in hepatocellular carcinoma patients 显示文摘 | ALISA A IVES A PATHAN AA | 2005 | Clin Cancer Res2005，11，18： | 1 |
| 14 | Alpha-fetoprotein impairs APC function and induces their apoptosis 显示文摘 | Um SH Mulhall C Alisa A | 2004 | J Immunol2004，173，3： | 1 |
| 15 | Alpha-fetoprotein impairs APC function and induces their apoptosis 显示文摘 | Um S H Mulhall C Alisa A | 2004 | J Immunol2004，173，3： | 1 |
| 16 | Increased intracellular,cell surface,and secreted inducible heat shock protein 70 responses are triggered during the monocyte to dendritic cell (DC) transition by cytokines independently of heat stress and infection and may positively regulate DC growth显示文摘 | Carla A Danielle L Alisa M | 2009 | J Immunol2009，183，1： | 1 |
| 17 | Alpha-fetoprotein impairs APC function and induces their apoptosis显示文摘 | Um SH Mulhall C Alisa A | 2004 | J Immunol2004，173，3： | 1 |
| 18 | Adsorption of micelle forming and non-micelle forming surfactants on the adsorbents of different nature显示文摘 | Alisa V Sineva Aksana M Parfenova Anna A Fedorova | | 0，，306： | 1 |
| 19 | Adsorption of micelle forming and non-micelle forming surfactants on the adsorbents of different nature 显示文摘 | Alisa V S Aksana M P Anna A F | 2007 | Colloids Surf A: Physicoehem Eng Aspects2007，306，： | 1 |
| 20 | Alpha-fetoProtein impairs APC function and induces their apoptosis 显示文摘 | Um SH Mulhall C Alisa A | 2004 | Immunol2004，173，3： | 1 |
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