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| 1 | The human olfactory system in two proteinopathies: Alzheimer’s and Parkinson’s diseases显示文摘Alzheimer’s and Parkinson’s diseases are the most prevalent neurodegenerative disorders.Their etiologies are idiopathic,and treatments are symptomatic and orientated towards cognitive or motor deficits.Neuropathologically,both are proteinopathies with pathological aggregates(plaques of amyloid-β peptide and neurofibrillary tangles of tau protein in Alzheimer’s disease,and Lewy bodies mostly composed of α-synuclein in Parkinson’s disease).These deposits appear in the nervous system in a predictable and accumulative sequence with six neuropathological stages.Both disorders present a long prodromal period,characterized by preclinical signs including hyposmia.Interestingly,the olfactory system,particularly the anterior olfactory nucleus,is initially and preferentially affected by the pathology.Cerebral atrophy revealed by magnetic resonance imaging must be complemented by histological analyses to ascertain whether neuronal and/or glial loss or neuropil remodeling are responsible for volumetric changes.It has been proposed that these proteinopathies could act in a prion-like manner in which a misfolded protein would be able to force native proteins into pathogenic folding(seeding),which then propagates through neurons and glia(spreading).Existing data have been examined to establish why some neuronal populations are vulnerable while others are resistant to pathology and to what extent glia prevent and/or facilitate proteinopathy spreading.Connectomic approaches reveal a number of hubs in the olfactory system(anterior olfactory nucleus,olfactory entorhinal cortex and cortical amygdala)that are key interconnectors with the main hubs(the entorhinal–hippocampal–cortical and amygdala–dorsal motor vagal nucleus)of network dysfunction in Alzheimer’s and Parkinson’s diseases. | Isabel Ubeda-Bañon Daniel Saiz-Sanchez Alicia Flores-Cuadrado Ernesto Rioja-Corroto Melania Gonzalez-Rodriguez Sandra Villar-Conde Veronica Astillero-Lopez Juan Pablo Cabello-de la Rosa Maria Jose Gallardo-Alcañiz Julia Vaamonde-Gamo Fernanda Relea-Calatayud Lucia Gonzalez-Lopez Alicia Mohedano-Moriano Alberto Rabano Alino Martinez-Marcos | 2020 | Translational Neurodegeneration2020，9，2： | 4 |
| 2 | Efficacy of stellate ganglion block in the treatment of anxiety symptoms from combat-related post-traumatic stress disorder: a case series 显示文摘 | Alino J Kosatka D McLean B | 2013 | Mil Med2013，178，4： | 1 |
| 3 | Characterisation of pile salting with sodium replaced mixtures of salts in dry-cured loin manufacture显示文摘 | ALINO M GRAU R | | 0，，3： | 1 |
| 4 | Long-term therapeutic levels of human alpha-1 antitrypsin in plasma after hydrodynamic injection of nonviral DNA显示文摘 | Alino SF Crespo A Dasi F | 2003 | Gene Ther2003，10，19： | 1 |
| 5 | Influence of sodium replacement on the salting kinetics of pork loin显示文摘 | ALINO M GRAU R BAIGTS D | | 0，，4： | 1 |
| 6 | Efficacy of tran- scranial magnetic stimulation ( TMS)in depression: natural- istic study 显示文摘 | Alino J J Jim6nez JL Flores SC | 2010 | Actas Esp Psiquiatr2010，38，2： | 1 |
| 7 | Laminin surface binding sites and metastatic potential of 3LL tumor cell increased by indomethancin 显示文摘 | Alino SF Unda FJ Perez-Yarza G | 1990 | Biochem Biophys Res Common1990，167，2： | 1 |
| 8 | Physicochemical properties and microbiology of dry-cured loins obtained by partial sodium replacement with potassium, calcium and magnesium显示文摘 | ALINO M GRAU R TOLDRA F | 2010 | Meat Science2010，85，3： | 1 |
| 9 | Influence of sodium replacement on the salting kinetics ofpork loin显示文摘 | ALINO M GRAU R BAIGTS D | 2009 | Journal of Food Engineering2009，95，4： | 1 |
| 10 | Influence of low-sodium mixtures of salts on the post-salting stage of dry-dured ham progress显示文摘 | ALINO M GRAU R FUENTES A | 2010 | Journal of Food Engineering2010，99，2： | 1 |
| 11 | Physicochemical properties and microbiology of dry-crued loins obtained by partial sodium replacement with potassium, calcium and magnesium显示文摘 | ALINO M GRAU R TOLDRA F | 2010 | Meat Science2010，85，： | 1 |
| 12 | Influence of sodium replacement on physicochemical properties of dry-cured loin显示文摘 | ALINO M GRAU R BARATA J M | 2009 | Meat Science2009，83，3： | 1 |
| 13 | Efficacy of stellate ganglion block in the treatment of anxiety symptoms from combat-related post-traumatic stress disorder: a case series显示文摘 | ALINO J KOSATKA D MCLEAN B | 2013 | Mil Med2013，178，4： | 1 |
| 14 | Development of a low-sodium ready-to-eat desalted cod显示文摘 | ALINO M FUENTES A FERNANDEZ S I | 2011 | Journal of Food Engineering2011，107，34： | 1 |
| 15 | Stabilization of liposomes with collagen Int显示文摘 | Iruarrizaga A Alfaro J | 1991 | Pharm1991，77，： | 1 |
| 16 | Structure and function of the vomcronasal system:an update显示文摘 | ALINO MART'YNEZ-MARCOS | 2003 | Progress in Neurobiology2003，70，： | 1 |
| 17 | Long-term therapeutic levels of human alpha-1 antitrypsin in plasma after hydrodynamic injection of nonviral DNA显示文摘 | Alino S F Crespo A Dasi F | 2003 | Gene Ther2003，10，19： | 1 |
| 18 | The South China Sea -Revisting the Large Marine Ecosystem Approach 显示文摘 | ALINO Porfirio M | 2009 | National Geographic2009，，2： | 1 |
| 19 | On the interaction between intragastric pH andelectrical vagal stimulation in causing gastric acid secretion and intraluminal release ofgastrin and somatostatin in anesthetized rats显示文摘 | Alino SF Garcia D Uvnas-Moberg K | 1983 | Acta Physiol Scand1983，117，： | 1 |
| 20 | Efficacy of transcranial magnetic stimulation (TMS) in depression:naturalistic study显示文摘 | Alino JJ Jimenez JL Flores SC | 2010 | Actas Esp psiquiatr2010，38，： | 1 |
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