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| 1 | Interrelationship between chromosome 8 aneuploidy,C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma显示文摘AIM: To investigate chromosome 8 numerical aberra- tions, C-MYC oncogene alterations and its expression in gastric cancer and to correlate these findings with histo- pathological characteristics of gastric tumors. METHODS: Specimens were collected surgically from seven patients with gastric adenocarcinomas. Immu- nostaining for C-MYC and dual-color fluorescence in situ hybridization (FISH) for C-MYC gene and chromosome 8 centromere were performed. RESULTS: All the cases showed chromosome 8 aneu- ploidy and C-MYC amplification, in both the diffuse and intestinal histopathological types of Lauren. No significant difference (P < 0.05) was observed between the level ofchromosome 8 ploidy and the site, stage or histological type of the adenocarcinomas. C-MYC high amplification, like homogeneously stained regions (HSRs) and double minutes (DMs), was observed only in the intestinal-type. Structural rearrangement of C-MYC, like translocation, was observed only in the diffuse type. Regarding C-MYC gene, a significant difference (P < 0.05) was observed between the two histological types. The C-MYC protein was expressed in all the studied cases. In the intestinal- type the C-MYC immunoreactivity was localized only in the nucleus and in the diffuse type in the nucleus and cytoplasm. CONCLUSION: Distinct patterns of alterations between intestinal and diffuse types of gastric tumors support the hypothesis that these types follow different genetic path- ways. | Danielle Queiroz Calcagno Mariana Ferreira Leal Aline Damaceno Seabra Andre Salim Khayat Elizabeth Suchi Chen Samia Demachki Paulo Pimentel Assumpcao Mario Henrique Girao Faria Silvia Helena Barem Rabenhorst Márcia Valéria Pitombeira Ferreira Marília de Arruda Cardoso Smith Rommel Rodríguez Burbano | 2006 | World Journal of Gastroenterology2006，12，38： | 9 |
| 2 | Percutaneous radiofrequency ablation for early hepatocellular carcinoma: Risk factors for survival显示文摘AIM: To evaluate outcomes of radiofrequency ablation(RFA) therapy for early hepatocellular carcinoma(HCC) and identify survival- and recurrence-related factors. METHODS: Consecutive patients diagnosed with early HCC by computed tomography(CT) or magnetic resonance imaging(MRI)(single nodule of ≤ 5 cm, or multi-(up to 3) nodules of ≤ 3 cm each) and who underwent RFA treatment with curative intent between January 2010 and August 2011 at the Instituto do Cancer do Estado de S o Paulo, Brazil were enrolled in the study. RFA of the liver tumors(with 1.0 cm ablative margin) was carried out under CT-fluoro scan and ultrasonic image guidance of the percutaneous ablation probes. Procedure-related complications were recorded. At 1-mo post-RFA and 3-mo intervals thereafter, CT and MRI were performed to assess outcomes of complete response(absence of enhancing tissue at the tumor site) or incomplete response(enhancing tissue remaining at the tumor site). Overall survival and diseasefree survival rates were estimated by the Kaplan-Meier method and compared by the log rank test or simple Cox regression. The effect of risk factors on survival was assessed by the Cox proportional hazard model. RESULTS: A total of 38 RFA sessions were performed during the study period on 34 patients(age in years: mean, 63 and range, 49-84). The mean follow-up time was 22 mo(range, 1-33). The study population showed predominance of male sex(76%), less severe liver disease(Child-Pugh A, n = 26; Child-Pugh B, n = 8), and single tumor(65%). The maximum tumor diameters ranged from 10 to 50 mm(median, 26 mm). The initial(immediately post-procedure) rate of RFAinduced complete tumor necrosis was 90%. The probability of achieving complete response was significantly greater in patients with a single nodule(vs patients with multi-nodules, P = 0.04). Two patients experienced major complications, including acute pulmonary edema(resolved with intervention) and intestinal perforation(led to death). The 1- and 2-year overall survival rates were 82% and 71%, respectively. Sex, tumor size, initial response, and recurrence status influenced survival, but did not reach the threshold of statistical significance. Child-Pugh class and the model for end-stage liver disease score were identified as predictors of survival by simple Cox regression, but only Child-Pugh class showed a statistically significant association to survival in multiple Cox regression analysis(HR = 15; 95%CI: 3-76 mo; P = 0.001). The 1-and 2-year cumulative disease-free survival rates were 65% and 36%, respectively. CONCLUSION: RFA is an effective therapy for local tumor control of early HCC, and patients with preserved liver function are the best candidates. | Luciana Kikuchi Marcos Menezes Aline L Chagas Claudia M Tani Regiane SSM Alencar Marcio A Diniz Venncio AF Alves Luiz Augusto Carneiro D’Albuquerque Flair José Carrilho | 2014 | World Journal of Gastroenterology2014，20，6： | 5 |
| 3 | Personalized medicine in gastric cancer:Where are we andwhere are we going?显示文摘Despite improvements in adjuvant therapies for gastric cancer in recent years, the disease is characterized by high recurrence rates and a dismal prognosis. The major improvement in the treatment of recurrent or metastatic gastric cancer in recent years has been the incorporation of trastuzumab, a monoclonal antibody that inhibits human epidermal growth factor receptor 2(HER2) heterodimerization, after the demonstrated predictive value of the overexpression and/or amplification of this receptor. Beyond HER2, other genetic abnormalities have been identified, and these mutations may be targetable by tyrosine kinase inhibitors or monoclonal antibodies. The demonstration of four distinct molecular subtypes of gastric cancer by the Cancer Genome Atlas study highlight the enormous heterogeneity of the disease and its complex interplay between genetic and epigenetic alterations and provide a roadmap to implement genome-guided personalized therapy in gastric cancer. In the present review, we aim to discuss, from a clinical point of view, the genomic landscape of gastric cancer described in recent studies, the therapeutic insights derived from these findings, and the clinical trials that have been conducted and those in progress that take into account tailored therapies for gastric cancer. | Alexandre A Jácome Anelisa K Coutinho Enaldo M Lima Aline C Andrade JoséSebastião dos Santos | 2016 | World Journal of Gastroenterology2016，22，3： | 2 |
| 4 | Energetic-protein supplementation in the last 60 days of gestation improves performance of beef cows grazing tropical pastures显示文摘Background: Nutrition is one of the most important factors that affect animal performance, and it therefore also impacts on financial results in beef systems. In this way, finding the best strategy for feeding supplements is of paramount importance. Aiming to evaluate the effect of supplement feeding strategies for beef cows in the last third of gestation, two experiments were conducted. In Experiment 1, 35 pregnant Nellore cows were assigned to a completely randomized design with four treatments: control, which received no supplement; supplementation for the last 30 d of gestation(30-d; 3.0 kg/d); supplementation for the last 60 d of gestation(60-d; 1.5 kg/d); or supplementation for the last 90 d of gestation(90-d; 1.0 kg/d). All supplemented treatments received the same total amount of supplement throughout the experiment: 90 kg(20% of crude protein). A second experiment(Experiment 2) was delineated to evaluate the effects of the amounts offered in Experiment 1 on intake and metabolism. Four multiparous pregnant Nellore cows were assigned to a 4 × 4 Latin square design, with periods of15 d each.Results: There was a linear effect of the number of days of supplementation on calving body weight(BW; P < 0.05)and a quadratic effect on BW change from parturition to d 31 post-calving(P < 0.05), with cows on the 60-d strategy losing less BW post-calving. No difference was found in offspring birth BW(P > 0.10). A significant linear effect on interval from parturition to conception(P < 0.05) was observed, with the highest calving to conception interval being observed in the 90-d strategy. The level of supplementation did not affect forage intake or neutral detergent fiber digestibility(P > 0.10). Nitrogen excreted through urine tended to increase linearly with the level of supplementation(P < 0.10).Conclusion: Providing 1.5 kg of supplement during the last 60 d of gestation improves cow performance after calving, reducing the magnitude of BW lost, and reduces the number of days from calving to re-conception in the following breeding season compared to the usually recommended period of supplementation of 90 d pre-partum. | Aline Gomes da Silva Mário Fonseca Paulino Edenio Detmann Henrique Jorge Fernandes Lincoln da Silva Amorim Román Enrique Maza Ortega Victor Valério de Carvalho Josilaine Aparecida da Costa Lima Felipe Henrique de Moura Mariana Benevides Monteiro Jéssika Almeida Bitencourt | 2018 | Journal of Animal Science and Biotechnology2018，9，1： | 2 |
| 5 | Migration from PolycarbonatePackaging to Food Simulants During Microwave Heating显示文摘 | ALIN J HAKKARAINEN M | 2012 | Polymer Degradation and Stability2012，97，8： | 1 |
| 6 | Determi- nation of the total phenolic, flavonoid and proline contents in Burkina Fasan honey, as well as their radical scavenging activity显示文摘 | LAMIEN-MEDA ALINE LAMIEN C E ROMITO M | 2005 | Food Chem2005，91，3： | 1 |
| 7 | Photocatalytic degradation of lignin and lignin models, using titanium dioxide: the role of the hydroxyl radical显示文摘 | Antonio Eduardo H Machadoa Aline M Furuyamaa Sandra Z Falone | 2000 | Chemosphere2000，，40： | 1 |
| 8 | DetermlnaUon of the total phenolic, flavonoid and proline contents in Burkina Fasan honey, as well as their radical scavenging activity显示文摘 | ALINE M CHARLES E L MARCO R | 2005 | Food Chemistry2005，91，3： | 1 |
| 9 | Hepatic Lesions Observed in Hepatitis C Virus Transgenic Mice Infected by H elicobacter hepaticus显示文摘 | Emilie Roux‐Goglin Pierre Dubus Corinne Asencio Marthe‐Aline Jutand Jean Rosenbaum Francis Mégraud | 2012 | Helicobacter2012，，1： | 1 |
| 10 | Pharmacokinetics(PK) and dose-response relationship of esomeprazole显示文摘 | Andersson T Rohss K Hassan Alin M | 2000 | Gastroentemlogy2000，118，： | 1 |
| 11 | FDG-PET/CT imaging biomarkers in head and neck squamous cell carcinoma显示文摘 | Vasavi Paidpally Alin Chirindel Stella Lam Nishant Agrawal Harry Quon Rathan M Subramaniam | 2012 | Imaging Med2012，，6： | 1 |
| 12 | Frequent deletions and down regulation of micro-RNA genes miR15 and miR16 at 13ql4 in chronic lymphocytic leukemia 显示文摘 | ALIN G A DUMITRU C D SHIMIZU M | 2002 | Proc Natl Acad Sci USA2002，99，15： | 1 |
| 13 | The effete of auc and cmax of esomeprazole on acid secretion and intragastric PH显示文摘 | Junghard o hassan Alin M hasselgren G | 2000 | Gastroenterology2000，118，： | 1 |
| 14 | Pharmackinettics and dose reponse realationship of esomeprazole显示文摘 | Andersson T Rohss K Hassan Alin M | 2000 | Gastroenterology2000，118，： | 1 |
| 15 | Binding and uptake of liposomes containing a poly( ethylene glycol) derivative of cholesterol (stealth liposomes) by the macrophage cell line J77: influence of PEG content and its molecular weight 显示文摘 | Aline VD Hideki I Koichiro M | 1996 | Biochim Biophys Acta1996，1278，： | 1 |
| 16 | Method development for the determination of cadmium in fertilizer samples using high-resolution continuum source graphite furnace atomic absorption spectrometry and slurry sampling 显示文摘 | ALINE R B EMILENE M B CI~LINE L | 2011 | Spectrochimica Acta Part B2011，66，7： | 1 |
| 17 | Pharmacokinetic study of csomeprazolc of the oral and intravenous administration of single and repeated doses to healthy subjects显示文摘 | Hassa - Alin M Andersson T Brelberg E | 2000 | Eur J Clin Phar- macol2000，56，9210： | 1 |
| 18 | Salivary Gland Tumor: A Review of 599 Cases in a Brazilian Population显示文摘 | Flávia Aparecida Oliveira Eliza Carla Barroso Duarte Cláudia Teixeira Taveira Aline Abreu Máximo érica Carvalho Aquino Rita de Cássia Alencar Eneida Franco Vencio | 2009 | Head and Neck Pathology2009，，4： | 1 |
| 19 | Occupational Exposure of Farm Workers to Pesticides:Biochemical Parameters and Evaluation of Genotoxicity显示文摘 | ALINE P R ALVES M JANE M B | | 0，，： | 1 |
| 20 | Determination of the total phenolic, flavonoid and proline contents in Burkina Fasan honey, as well as their radical scavenging activity显示文摘 | ALINE M CHARLES E L MARCO R | 2005 | Food Chemistry2005，91，： | 1 |
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