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| 1 | Tumor-stroma ratio as prognostic factor for survival in rectal adenocarcinoma: A retrospective cohort study显示文摘AIM To evaluate the prognostic value of the tumor-stroma ratio(TSR) in rectal cancer.METHODS TSR was determined on hematoxylin and eosin stained histological sections of 154 patients treated for rectal adenocarcinoma without prior neoadjuvant treatment in the period 1996-2006 by two observers to assessreproducibility. Patients were categorized into three categories: TSR-high [carcinoma percentage(CP) ≥ 70%], TSR-intermediate(CP 40%, 50% and 60%) and TSR-low(CP ≤ 30%). The relation between categorized TSR and survival was analyzed using Cox proportional hazards model.RESULTS Thirty-six(23.4%) patients were scored as TSR-low, 70(45.4%) as TSR-intermediate and 48(31.2%) as TSRhigh. TSR had a good interobserver agreement(κ = 0.724, concordance 82.5%). Overall survival(OS) and disease free survival(DFS) were significantly better for patients with a high TSR(P = 0.01 and P = 0.02, respectively). A similar association existed for disease specific survival(P = 0.06). In multivariate analysis, patients without lymph node metastasis and an intermediate TSR had a higher risk of dying from rectal cancer(HR = 5.27, 95%CI: 1.54-18.10), compared to lymph node metastasis negative patients with a high TSR. This group also had a worse DFS(HR = 6.41, 95%CI: 1.84-22.28). An identical association was seen for OS. These relations were not seen in lymph node metastasis positive patients. CONCLUSION The TSR has potential as a prognostic factor for survival in surgically treated rectal cancer patients, especially in lymph node negative cases. | René Scheer Alexi Baidoshvili Shorena Zoidze Marloes AG Elferink Annefleur EM Berkel Joost M Klaase Paul J van Diest | 2017 | World Journal of Gastrointestinal Oncology2017，9，12： | 3 |
| 2 | Targeting head and neck tumoral stem cells: From biologicalaspects to therapeutic perspectives显示文摘Head and neck squamous cell cancer(HNSCC) is the sixth most common cancer in the world. Effective therapeutic modalities such as surgery, radiation, chemotherapy and combinations of each are used in the management of the disease. In most cases, treatment fails to obtain total cancer cure. In recent years, it appears that one of the key determinants of treatment failure may be the presence of cancer stem cells(CSCs) that escape currently available therapies. CSCs form a small portion of the total tumor burden but may play a disproportionately important role in determining outcomes. CSCs have stem features such as self-renewal, high migration capacity, drug resistance, high proliferation abilities. A large body of evidence points to the fact that CSCs are particularly resistant to radiotherapy and chemotherapy. In HNSCC, CSCs have been increasingly shown to have an integral role in tumor initiation, disease progression, metastasis and treatment resistance. In the light of such observations, the present review summarizes biological characteristics of CSCs in HNSCC, outlines targeted strategies for the successful eradication of CSCs in HNSCC including targeting the self-renewal controlling pathways, blocking epithelial mesenchymal transition, niche targeting, immunotherapy approaches and highlights the need to better understand CSCs biology for new treatments modalities. | Benoîte Méry Jean-Baptiste Guy Sophie Espenel Anne-Sophie Wozny Stéphanie Simonet Alexis Vallard Gersende Alphonse Dominique Ardail Claire Rodriguez-Lafrasse Nicolas Magné | 2016 | World Journal of Stem Cells2016，8，1： | 3 |
| 3 | Impacts and challenges of United States medical students during the COVID-19 pandemic显示文摘The delivery of medical student education has changed rapidly during the coronavirus disease 2019(COVID-19)pandemic.Students in their pre-clinical years have transitioned to online courses and examinations.Students in their clinical years are not permitted on clinical rotations,and face uncertainties in career exploration and the residency application process.Medical students in all stages of training are volunteering and helping their communities.The future presence of COVID-19 throughout the United States is unknown,and medical students are eager to return to their training.This paper outlines current challenges in medical student education and the various responses that have been adopted.We also discuss possible future directions for students through involvement in telemedicine,outpatient clinic visits,and non-respiratory inpatient care tasks as adequate personal protective equipment,COVID-19 testing,and resources become more widely available. | Stacey Rolak Alexis M Keefe Emily L Davidson Prabesh Aryal Sandesh Parajuli | 2020 | World Journal of Clinical Cases2020，8，15： | 2 |
| 4 | Low dose airborne endotoxin exposure enhances bronchial responsiveness to inhaled allergen in atopic asthmatics 显示文摘 | Boehlecke B Hazucha M Alexis NE | 2003 | J Allergy Clin Immunol2003，112，： | 1 |
| 5 | Repair of tetralogy of Fallot in infancy with a transventricular or a transatrial approach 显示文摘 | Alexiou C Chen Q Galogavrou M | 2002 | Eur J Cardio Thorac Surg2002，22，2： | 1 |
| 6 | Doing competencies well:best practics in competency modeling显示文摘 | Michael A Campion Alexis A Fink Brian J Ruggeberg Linda Carr Geneva M Phillips Ronald B Odman | 2011 | Personnel Psychology2011，，22： | 1 |
| 7 | Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons显示文摘 | Alexis M S Thiruma V A Roy G C | 2008 | Nat Neurosci2008，11，： | 1 |
| 8 | Black carbon contribution to soil organic matter composition in tropical sloping land under slash and burn agricul- ture显示文摘 | Rumpel C Alexis M Chabbi A | 2006 | Geoderma2006，130，12： | 1 |
| 9 | Superconducting Materials for Large Scale Applications显示文摘 | Ronald M Alexis P David C | 2004 | Appl Supercond2004，92，10： | 1 |
| 10 | Magnesium and its alloys as orthopedic biomaterials: A review 显示文摘 | MARK P S ALEXIS M P JERAWALA H | 2006 | Biomaterials2006，27，9： | 1 |
| 11 | Differ ential estrogen receptor subtype modulators: assessment of estrogen receptor subtype-binding selectivity and transcription-regulating properties of new cycloalkyl pyrazoles显示文摘 | Alexi X Kasiotis K M Fokialakis N | 2009 | J Steroid Biochem Mol Biol2009，117，45： | 1 |
| 12 | The genetic basis of craniofacial and dental abnormalities显示文摘 | Kouskoura T Fragou N Alexiou M | 2011 | Schweiz Monatsschr Zahn- med2011，121，78： | 1 |
| 13 | Modeling diurnal and seasonal patterns of maize pollen emission in relation to meteo- rological factors显示文摘 | ALEXIS M Benjamin L Bruno A | 2011 | Agricultural and Forest Meteorology2011，151，1： | 1 |
| 14 | Aldose reductase enzyme and its implication to major health problems of the 21st century显示文摘 | Alexiou P Pegklidou K Chatzopoulou M | | 0，，06： | 1 |
| 15 | Modeling of a DC Electric Arc Furnace-Heat Transfer From the Arc 显示文摘 | Alexis J Ramirez M Trapaga G | 2000 | ISIJ International2000，40，11： | 1 |
| 16 | Effect of density on growth rate and production of rainbow trout (Salmo gairdneri) over a full rearing period显示文摘 | Papoutsoglou S E Papaparaskeva-Papoutsoglou E Alexis M N | 1987 | Aquac1987，66，： | 1 |
| 17 | Poly (vinyl alcohol) stabilization in thermoplastic processing 显示文摘 | ALEXY P KACHOVA D KRSIAK M | 2002 | Polym Degrad Stab2002，78，： | 1 |
| 18 | Black carbon contribution to soil organic matter composition in tropical sloping land under slash and burn agriculture显示文摘 | Rumpel C Alexis M Chabbi A | 2006 | Geoderma2006，130，： | 1 |
| 19 | Mag-nesium and its alloys as orthopedic biomateriahs: a review显示文摘 | Staiger Mark P Pietak Alexis M Jerawala H * | 2006 | Biomaterials2006，27，9： | 1 |
| 20 | Investigation to determine digestibility coefficients of various raw materials in diets for gilthead sea bream, Sparus auratns L显示文摘 | Nengas I Alexis M N Davies S J | 1995 | Aquaculture Research1995，26，： | 1 |
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