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| 1 | Clinical-pathological and molecular characterization of long-term survivors with advanced non-small cell lung cancer显示文摘Objective:Long-term survivors(LS)of non-small cell lung cancer(NSCLC)without driver alterations,displaying an overall survival(OS)of more than 3 years,comprise around 10%of cases in several series treated with chemotherapy.There are classical prognosis factors for these cases[stage,Eastern Cooperative Oncology Group(ECOG),etc.],but more data are required in the literature.In this multi-center study,we focused on LS of advanced NSCLC with OS above 36 months to perform a clinical-pathological and molecular characterization.Methods:In the first step,we conducted a clinical-pathological characterization of the patients.Afterwards,we carried out a genetic analysis by comparing LS to a sample of short-term survivors(SS)(with an OS less than 9 months).We initially used whole-genome RNA-seq to identify differentiating profiles of LS and SS,and later confirmed these with reverse transcription-polymerase chain reaction(RT-PCR)for the rest of the samples.Results:A total of 94 patients were included,who were mainly men,former smokers,having adenocarcinoma(AC)-type NSCLC with an ECOG of 0-1.We obtained an initial differential transcriptome expression,displaying 5 over-and 33 under-expressed genes involved in different pathways:namely,the secretin receptor,surfactant protein,trefoil factor 1(T FF1),serpin,Ca-channels,and Tolllike receptor(TLRs)families.Finally,RT-PCR analysis of 40(20 LS/20 SS)samples confirmed that four genes(surfactant proteins and SFTP)were significantly down-regulated in SS compared to LS by using an analysis of covariance(ANCOVA)model:SFTPA1(P=0.023),SFTPA2(P=0.027),SFTPB{P=0.02),and SFT PC(P=0.047).Conclusions:We present a sequential genetic analysis of a sample of NSCLCLS with no driver alterations,obtaining a differential RNA-seq/RT-PCR profile showing an abnormal expression of SF genes. | Juan Moreno-Rubio Santiago Ponce Rosa Alvarez Maria Eugenia Olmedo Sandra Falagan Xabier Mielgo Fatima Navarro Patricia Cruz Luis Cabezon-Gutierrez Carlos Aguado Gonzalo Colmenarejo Marta Munoz-Fernandez de Leglaria Ana Belen Enguita Maria Cebollero Amparo Benito Isabel Alemany Carolina del Castillo Ricardo Ramos Ana Ramirez de Molina Enrique Casado Maria Sereno | 2020 | Cancer Biology & Medicine2020，17，2： | 4 |
| 2 | Plasma refining process to provide solar-grade silicon 显示文摘 | Delannoy Y Alemany C Li K I | 2002 | Solar Energy Materials & Solar Ceils2002，72，： | 1 |
| 3 | Reactivity and physieochemical characterization of V205-WO3/TiO2 De- NOx catalysts 显示文摘 | Alemany L J Lietti L Ferlazzo N | 1995 | Journalof Catalysis1995，155，1： | 1 |
| 4 | Human papillomavirus types in invasive cervical cancer specimens from Turkey显示文摘 | Usubutttn A Alemany L Ktltlkali T | 2009 | Int J GynecolPathol2009，28，6： | 1 |
| 5 | A new approach to the functionalization of single-walled carbon nanotubes with both alkyl and carboxyl groups 显示文摘 | Peng H Q Alemany L B Margrave J L | 2003 | J Am Chem Soc2003，125，15： | 1 |
| 6 | Esophageal verruciform xanthoma following radiotherapy显示文摘 | Salamanca J Alemany I Sosa G | 2012 | Gastroenterol Hepatol2012，35，5： | 1 |
| 7 | Human pap-illomavirus genotype attribution in invasive cervical can-cer:a retrospective cross-sectional worldwide study显示文摘 | de Sanjose S Quint WG Alemany L | | 0，，11： | 1 |
| 8 | Anterior maxillary and mandibular biotype : relationship between gingival thickness and width with respect to underlying bone thickness 显示文摘 | La Rocca AP Alemany AS Levis P Jr | 2012 | Implant Dent2012，21，6： | 1 |
| 9 | Reactivity and physicochemical characterization of V2O5-WO3/TiO2 De- NOx catalysts显示文摘 | ALEMANY L J LIETTI L FERLAZZO N | 1995 | Journal of Catalysis1995，155，1： | 1 |
| 10 | Refining of metallurgical-grade silicon by inductive plasma 显示文摘 | Alemany C Trassy C Pateyron B | 2002 | Solar Energy Materials & Solar Cells2002，72，14： | 1 |
| 11 | Replicative adenoviruses for cancer therapy显示文摘 | Alemany R Balague C Curiel DT | 2000 | Nat Biotechnol2000，18，： | 1 |
| 12 | Oxidation of sulfur dioxide to sulfur trioxide over denoxing catalysts 显示文摘 | Svachula J Alemany L J Ferlazzo N | 1993 | Ind Eng Chem Res1993，32，： | 1 |
| 13 | Microbial transformation of 10-deacetylbaccatin III (10-DAB) by Curvularia lunata and Trametes hirsuta显示文摘 | Alberto Arnone Adriana Bava Stefano Alemani Gianluca Nasini Ezio Bombardelli Gabriele Fontana | 2006 | Journal of Molecular Catalysis B Enzymatic2006，，3： | 1 |
| 14 | Reactivity of V205-WO3/ TiO2 catalysts in the selective catalytic reduction of nitric oxide by ammonia显示文摘 | Lietti L Alemany J L Forzatti P | 1996 | Catalysis Today1996，29，1234： | 1 |
| 15 | Human papillo- mavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study显示文摘 | de Sanjose S Quint WG Alemany L | 2010 | Lancet On- col2010，11，11： | 1 |
| 16 | Diet, Body Composition, and Physical Fitness Influences on IGF - 1 Bioac- tivity in Women 显示文摘 | KARL J P ALEMANY J A KOENIG C | 2009 | Growtr Horm IGF Res2009，19，6： | 1 |
| 17 | Plasma-refining process to provide solar-grade silicon 显示文摘 | Delannoy Y Alemany C Li K-I | 2002 | Solar Energy Materials & Solar Cells2002，72，14： | 1 |
| 18 | 查看详情显示文摘 | Gao W Alemany L.B Ci L Ajayan P.M | | 0，，： | 1 |
| 19 | Human papillo- mavirus genotype attribution in invasive cervical cancer: a ret- rospective cross-sectional worldwide study 显示文摘 | de Sanjose S Quint WG Alemany L | 2010 | Lancet On- col2010，11，11： | 1 |
| 20 | Density-functional calculations of the structures, binding energies, and magnetic moments of Fe clusters with 2 to 17 atoms显示文摘 | Di e guez O Alemany M M G Rey C | 2001 | Phys Rev B2001，63，： | 1 |
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