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		题名	作者	年代	出处	被引量
	1	Molecular mechanisms of liver preconditioning显示文摘Ischemia/reperfusion (I/R) injury still represents an important cause of morbidity following hepatic surgery and limits the use of marginal livers in hepatic transplantation. Transient blood flow interruption followed by reperfusion protects tissues against damage induced by subsequent I/R. This process known as ischemic pre-conditioning (IP) depends upon intrinsic cytoprotective systems whose activation can inhibit the progression of irreversible tissue damage. Compared to other organs,liver IP has additional features as it reduces inflammation and promotes hepatic regeneration. Our present understanding of the molecular mechanisms involved in liver IP is still largely incomplete. Experimental studies have shown that the protective effects of liver IP are triggered by the release of adenosine and nitric oxide and the subsequent activation of signal networks involving protein kinases such as phosphatidylinositol 3-kinase,protein kinase C δ/ε and p38 MAP kinase,and transcription factors such as signal transducer and activator of transcription 3,nuclear factor-κB and hypoxia-inducible factor 1. This article offers an overview of the molecular events underlying the preconditioning effects in the liver and points to the possibility of developing pharmacological approaches aimed at activating the intrinsic protective systems in patients undergoing liver surgery.	Elisa Alchera Caterina Dal Ponte Chiara Imarisio Emanuele Albano Rita Carini	2010	World Journal of Gastroenterology2010，16，48：	3
	2	Adenosine A2a receptor-mediated,normoxic induction of HIF-1 through PKC and PI-3K-dependent pathways in macrophages 显示文摘	Deponti C Carini R Alchera E	2007	J Leukoc Biol2007，82，2：	1
	3	Purinergic P2Y2 receptors promote hepato cyte resistance to hypoxia显示文摘	Carini R Alchera E De Cesaris M G Splendore R Piranda D Baldanzi G	2006	J Hepatol2006，45，：	1
	4	Purinergic P2Y2 receptors promote hepatoeyte resistance to hypoxia 显示文摘	Carini R Alchera E De Cesaris MG	2006	Journal of hepatology2006，45，2：	1
	5	Adenosine-dependent activa-tion of hypoxia-inducible factor-1 induces late preconditioning in livercells显示文摘	Alchera E Tacchini L Imarisio C	2008	Hepatology2008，48，：	1
	6	Purinergie P2Y2 receptors promote hepatocyte resistance to hypoxia显示文摘	Carini R Alchera E De Cesaris MG etal	2006	J Hepatol2006，45，2：	1
	7	Adenosine dependent activation of hypoxia-inducible factor-1 induces late preconditioning in liver cells显示文摘	ALCHERA E TACCHINI L IMARISIO C		0，，01：	1
	8	Purinergic P2Y2 receptors promote hepatocyte resistance to hypoxia 显示文摘	Carini R Alchera E De Cesaris MG	2006	J Hepatol2006，45，2：	1

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