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| 1 | Cytokine profile in Egyptian hepatitis C virus genotype-4 in relation to liver disease progression显示文摘AIM: To observe the imbalance between T helper cell Th1 and Th2 cytokines in several chronic hepatitis disease at different stages of disease progression.METHODS: We measured the cytokine levels of Th1 (IL-2 and IL-2R), Th2 (IL-10) and the pro-inflammatory cytokines (IL-6 and IL-6R and TNF and TNF-RⅠ and Ⅱ)by the ELISA technique in the sera of 33 hepatocellular carcinoma (HCC) patients and 20 chronic liver disease (CLD) patients. In addition, 20 asymptomatic hepatitis C virus carriers and 20 healthy subjects negative for hepatitis C virus(HCV) markers served as controls.RESULTS: Anti-HCV antibodies were found to be positive in 94% of HCC cases and 75% of CLD cases.On the other hand, HCV viremia was detected using RTPCR in 67% of HCC cases and 65% of CLD cases. HBsAg was positive in 9% of HCC cases and 30% of CLD cases.Also bilharzial-Ab was positive in 55% of HCC cases,65% of CLD cases and in 70% of asymptomatic carriers (ASC). HCC patients had significantly higher values of IL-2R, TNF-RⅡ (P<0.001), and TNF-RⅠ (P>0.05), but lower TNFα (P<0.001) and IL-6 (P = 0.032) in comparison to ASC. But, in comparison to non-cancer controls, HCC patients had higher values of IL-2R, IL-6R, TNF-RⅠ and TNF-RⅡ, but lower TNF-α (P<0.001). CLD patients had higher IL-2R, TNF-RⅠ, and TNF-RⅡ (P<0.001) than ASC. But, in comparison to non-cancer controls, CLD patients had higher values of IL-2R, TNF-RⅠ and TNF-RⅡ, but lower TNF-α (P<0.001). IL-10 was higher (though not significantly) in HCC and CLD patients than in symptomatic carriers and non-cancer controls.CONCLUSION: Liver disease progression from CLD to HCC due to HCV genotype-4 infection is associated with an imbalance between Th1 and Th2 cytokines. IL-2R,TNF-RⅠ, and TNF-RⅡ could be used as potential markers. | Abdel-Rahman N Zekri Mohammed S El-Din Ashour Ahmed Hassan Hanaa M Alam El-Din Amal MR El-Shehaby Maha A Abu-Shady | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 2 | Dynamic modeling, design and simulation of a wind/fucl cell/ultra-capacitor-based hybrid power generation system显示文摘 | Onar O C Uzunoglu M Alam M S | 2006 | Journal of Power Sources2006，，161： | 1 |
| 3 | MHD free and forced convection boundary layer flow along a vertical porous plate显示文摘 | Hossaln M A Alam K C A Rees D A S | 1997 | Appl Mech Engrg1997，2，1： | 1 |
| 4 | Extraction of rhodium from other platinum group metals with Kelex 100 from chloride media containing tin显示文摘 | Alam M S Inoe K | 1997 | Hydrometallurgy1997，46，3： | 1 |
| 5 | Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications显示文摘 | Ryter S W Alam J Choi A M K | 2006 | Physiological Reviews2006，86，： | 1 |
| 6 | Influence of common purslane aqueous extracts on germination and seedling growth of rice显示文摘 | Alam S M Khan M A Mujtaba S M | 2004 | Pakistan Journal of Scientific and Industrial Research2004，47，4： | 1 |
| 7 | Two atypical fibroxanthomas of the ear显示文摘 | Alam M Goldberg LH | 2003 | Dermatol Surg2003，29，4： | 1 |
| 8 | New soluble n-type conjugated copolymer for light-emitting diodes显示文摘 | Tonzola C J Alam M M Jenekhe S A | 2002 | Adv Mater2002，14，： | 1 |
| 9 | Invariant Object Tracking Using Fringe-adjusted Joint Transform Correlator显示文摘 | Chye-Hwa Loo Alam M S | 2004 | Optical Engineering2004，43，9： | 1 |
| 10 | Efficacy and safety of Saccharo- myces boulardii in acute childhood diarrhea: A double blind ran- domised controlled trial 显示文摘 | Riaz M Alam S Malik A | 2012 | Indian J Pediatr2012，79，4： | 1 |
| 11 | Chromiumremoval through biosorption and bioaccumulation by bacteria from tannery effluents contaminatedsoil显示文摘 | Alam M Z Ahmad S | 2011 | Clean-Soil Air Water2011，39，3： | 1 |
| 12 | Pregnenolone derivatives as potential anticancer agents 显示文摘 | CHOUDHARY M I ALAM M S RAHMAN A | 2011 | Steroids2011，76，14： | 1 |
| 13 | Analysis of active and reactive power control of a stand alone PEM fuel cell power plant显示文摘 | El-Sharkh M Y Rahman A Alam M S | 2004 | IEEE Transactions on Power Systems2004，19，4： | 1 |
| 14 | Extraction of arsenic in a synthetic arsenic-contaminated soil using phosphate显示文摘 | ALAM M G M TOKUNAGA S MAEKAWA T | 2001 | Chemosphere2001，43，8： | 1 |
| 15 | Effects of supplementation of coated crystalline amino acids on growth performance and body composition of juvenile kuruma shrimp Marsupenaeus japonicus显示文摘 | ALAM M S TESHIMA S KOSHIO S | 2004 | Aquaculture Nutrition2004，10，： | 1 |
| 16 | Enteric protein loss and intestinal permeability changes in children during acute shigellosis and after recovery:effect of zinc supplementation显示文摘 | Alam A N Sarker S A Wahed M A | 1994 | Gut1994，35，12： | 1 |
| 17 | Mechanism of control of plant-parasitic nematodes as a result of the application of organic amendments to the soil Ⅳ Role of formaldehyde and acetone显示文摘 | Alam M M Khan A M Saxena S K | | 0，，： | 1 |
| 18 | Optical implementation of reference phase-encoded fringe-adjusted joint transform correlation显示文摘 | M S Alam E Horache | 2005 | SPIE2005，59，085908： | 1 |
| 19 | Experimental investigation on the seismic behavior of beam-column joints reinforced with superelastic shape memory alloys 显示文摘 | Youssef M A Alam M S Nehdi M | 2008 | Journal of Earthquake Engineering2008，12，7： | 1 |
| 20 | Arithmetic processing with a joint-transform correlator 显示文摘 | Alam M S Karim M A | 1992 | Appl Opt1992，31，23： | 1 |
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