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| 1 | Utility of flexible fiberoptic bronchoscopy for critically ill pediatric patients:A systematic review显示文摘AIM: To investigate the diagnostic yield, therapeutic efficacy, and rate of adverse events related to flexible fiberoptic bronchoscopy(FFB) in critically ill children. METHODS: We searched Pub Med, SCOPUS, OVID, and EMBASE databases through July 2014 for English language publications studying FFB performed in the intensive care unit in children < 18 years old. We identified 666 studies, of which 89 full-text studies were screened for further review. Two reviewers independently determined that 27 of these studies met inclusion criteria and extracted data. We examined the diagnostic yield of FFB among upper and lower airway evaluations, as well as the utility of bronchoalveolar lavage(BAL). RESULTS: We found that FFB led to a change in medical management in 28.9%(range 21.9%-69.2%) of critically ill children. The diagnostic yield of FFB was 82%(range 45.2%-100%). Infectious organisms were identified in 25.7%(17.6%-75%) of BALs performed, resulting in a change of antimicrobial management in 19.1%(range: 12.2%-75%). FFB successfully reexpanded atelectasis or removed mucus plugs in 60.3%(range: 23.8%-100%) of patients with atelectasis. Adverse events were reported in 12.9%(range: 0.5%-71.4%) of patients. The most common adverse effects of FFB were transient hypotension, hypoxia and/or bradycardia that resolved with minimal intervention, such as oxygen supplementation or removal of the bronchoscope. Serious adverse events were uncommon; 2.1% of adverse events required intervention such as bag-mask ventilation or intubation and atropine for hypoxia and bradycardia, normal saline boluses for hypotension, or lavage and suctioning for hemorrhage. CONCLUSION: FFB is safe and effective for diagnostic and therapeutic use in critically ill pediatric patients. | Aida Field-Ridley Viyeka Sethi Shweta Murthi Kiran Nandalike Su-Ting T Li | 2015 | World Journal of Critical Care Medicine2015，4，1： | 12 |
| 2 | 脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。 | Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 | 2018 | 神经损伤与功能重建2018，13，4： | 4 |
| 3 | Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project显示文摘AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated children.METHODS:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to < 10,10 to < 15 and ≥ 15 years respectively compared to those < 5 years and 1.1 among girls compared to boys with P < 0.01. HBs Ag was positive in 0.11% and breakthrough infection was 0.36% and 0.39% depending on positivity of anti-HBc and DNA detection respectively. The prevalence of HBV infection was significantly higher among children aged ≥ 7 years(0.59%) compared to 0.07% among younger children with odds ratio equal to 8.4(95%CI:1.1-64.2) and P < 0.01.The prevalence was higher among girls(0.48%) than boys(0.29%) with P > 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory. | Iman I Salama Samia M Sami Zeinab Nabil Ahmed Said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel Hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally | 2015 | World Journal of Hepatology2015，7，22： | 2 |
| 4 | One-dimensional nanostructures of molecular graphenes显示文摘 | Zhang W Fukushima T Aida T | 2012 | Supramolecular Chemistry:From molecules to nanomaterials2012，8，： | 1 |
| 5 | Isolation ofcDNA encoding a putative chitinase precursor in thekuruma prawn Penaeus japonicus 显示文摘 | Watanabe T Kono M Aida K | 1996 | MolecularMarine Biology and Biotechnology1996，5，4： | 1 |
| 6 | Genes involved in organ separation in Arobidopsis: an analysis of the cup-shaped cotyledon mutant显示文摘 | Aida M Ishida T Fukaki H | 1997 | The Plant cell1997，9，6： | 1 |
| 7 | Genes involved in organ separation in Arabidopsis: an analysis of the cup - shaped cotyledon mutant 显示文摘 | Aida M Ishida T Fukaki H | 1997 | Plant Cell1997，9，6： | 1 |
| 8 | Improving the superplastic properties of a two-phase Mg-8 % Li alloy through processing by ECAP显示文摘 | FURUI M XU C AIDA T | 2005 | Materials Science and Engineering2005，，： | 1 |
| 9 | Involvement of mortalin in cellular senescence from the perspective of its mitochondrial import, chaperone, and oxidative stress management functions 显示文摘 | Yaguchi T Aida S Kaul SC | 2007 | Ann N Y Acad Sci2007，1100，1： | 1 |
| 10 | Fundamental Research on Gear Noise and Vibration显示文摘 | H Fukuma T Furukawa and T Aida | 1973 | Bulletin of JSME1973，，： | 1 |
| 11 | 显示文摘 | Aida T Meijer E W Stupp S I | 2012 | Science2012，335，6070： | 1 |
| 12 | Congenital absence of the portal vein:clinical and radiologic findings显示文摘 | Niwa T Aida N Tachibana K | | 0，，05： | 1 |
| 13 | Genes involved in organ separation in Arabidopsis, analysis of the cupshaped cotyledon mutant显示文摘 | AIDA M ISHIDA T FUKAKI H FUJISAWA H TASAKA M | 1997 | The Plant Cell1997，9，： | 1 |
| 14 | Estimating the equivalent strain in the equal channel angular pressing 显示文摘 | Matsuki K Horita Z | 2001 | Scrip Mater2001，44，4： | 1 |
| 15 | Genes involved in organ separation in Arabidopsis : an analysis of the cup- shaped cotyledon mutant显示文摘 | Aida M Ishida T Fukaki H | 1997 | Plant Cell1997，9，： | 1 |
| 16 | Combustion of lean prevaporized fuel-air mixtures mixed with hot burned gas for low- NOx emissions over an extended range of fuel-air ratios显示文摘 | Aida N Nishijima T Hayashi S | 2005 | Proceedings of Combustion Institute2005，30，： | 1 |
| 17 | Textural properties of layered double hydroxides: effect of magnesium substitution by copper or iron 显示文摘 | Carja G Nakamura R Aida T | 2001 | Microporous and Mesoporous Materials2001，47，2： | 1 |
| 18 | Catalytical Conversion of Fructose and Glucose into 5-Hydroxymethylfurfural in Hot Compressed Water by Microwave Heating显示文摘 | QI X H WATANABE M AIDA T M | 2008 | Catalysis Communications2008，9，13： | 1 |
| 19 | Microscopic intraosseous extension of ostensarcoma:assessment on dynamic enhanced MRI显示文摘 | Iwasawa T Tanaka Y Aida N | 1997 | Skeletal Radiol1997，26，4： | 1 |
| 20 | Dehydration of d-glucose in high temperature water at pressures up to 80 MPa显示文摘 | Aida T M Sato Y Watanabe M | 2007 | The Journal of Supercritical Flu- ids2007，40，3： | 1 |
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