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| 1 | Does capsule endoscopy have an added value in patients with perianal disease and a negative work up for Crohn's disease?显示文摘AIM:To investigate the role of capsule endoscopy in patients with persistent perianal disease and negative conventional work up for Crohn's disease(CD).METHODS:Patients with perianal disease(abscesses,fistulas,recurrent fissures) were evaluated for underlying CD.Patients who had a negative work up,defined as a negative colonoscopy with a normal ileoscopy or a normal small bowel series or a normal CT/MR enterography,underwent a Pillcam study of the small bowel after signing informed consent.Patients using nonsteroidal anti-inflammatory drugs or who had a history of inflammatory bowel disease or rheumatic disease were excluded.RESULTS:We recruited 26 patients aged 21-61 years(average 35.6 years),17 males and 9 females.One case could not be evaluated since the capsule did not leave the stomach.In 6 of 25(24%) patients with a negative standard work up for Crohn's disease,capsuleendoscopy(CE) findings were consistent with Crohn's disease of the small bowel.Family history of CD,white blood cell,hemoglobin,erythrocyte sedimentation rate or C-reactive protein did not predict a diagnosis of CD.Capsule endoscopy findings led to a change in treatment.CONCLUSION:In patients with perianal disease and a negative conventional work up to exclude CD,CE leads to incremental diagnostic yield of 24%. | Samuel N Adler Metzger Yoav Scapa Eitan Chowers Yehuda Rami Eliakim | 2012 | World Journal of Gastrointestinal Endoscopy2012,4,5: | 4 |
| 2 | What we have learned and what to expect from capsule endoscopy显示文摘Capsule endoscopy was conceived by Gabriel Iddan and Paul Swain independently two decades ago. These applications include but are not limited to Crohn's disease of the small bowel, occult gastrointestinal bleeding, non steroidal anti inflammatory drug induced smallbowel disease, carcinoid tumors of the small bowel,gastro intestinal stromal tumors of the small bowel andother disease affecting the small bowel. Capsule endoscopy has been compared to traditional small bowelseries, computerized tomography studies and pushenteroscopy. The diagnostic yield of capsule endoscopyhas consistently been superior in the diagnosis of smallbowel disease compared to the competing methods(small bowel series, computerized tomography, pushenteroscopy) of diagnosis. For this reason capsule en-doscopy has enjoyed a meteoric success. Image qualityhas been improved with increased number of pixels,automatic light exposure adaptation and wider angle ofview. Further applications of capsule endoscopy of other areas of the digestive tract are being explored. Theincreased transmission rate of images per second hasmade capsule endoscopy of the esophagus a realisticpossibility. Technological advances that include a double imager capsule with a nearly panoramic view of the colon and a variable frame rate adjusted to the movement of the capsule in the colon have made capsuleendoscopy of the colon feasible. The diagnostic ratefor the identification of patients with polyps equal to orlarger than 6 mm is high. Future advances in technology and biotechnology will lead to further progress.Capsule endoscopy is following the successful moderntrend in medicine that replaces invasive tests with lessinvasive methodology. | Samuel N Adler Ingvar Bjarnason | 2012 | World Journal of Gastrointestinal Endoscopy2012,4,10: | 2 |
| 3 | Complexes of deoxyribonucleic acid with lysine-rich (f1) histone phosphorylated at two separate sites:circular dichroism studies显示文摘 | ADLER A J GREENFIELD N FASMAN G D | 1972 | Arch Biochem Biophys1972,153,2: | 1 |
| 4 | Effects of Cardiac Resynchronization on Disease Progression in Patients With Left Ventricular Systolic Dysfunction, an Indication for an Implantable Cardioverter-Defibrillator, and Mildly Symptomatic Chronic Heart Failure显示文摘 | William T. Abraham James B. Young Angel R. León Stuart Adler Alan J. Bank Shelley A. Hall Randy Lieberman L Bing Liem John B. O’Connell John S. Schroeder Kevin R. Wheelan | 2004 | Circulation2004,,18: | 1 |
| 5 | Mitral annulus calcification-a window to diffuse atherosclerosis of the vascular system显示文摘 | Adler Y Fink N Spector D | 2001 | Atherosclerosis2001,155,1: | 1 |
| 6 | Harvesting the lateralfemoral circumflex chimera free flap:guidelines for elevation显示文摘 | Adler N Dorafshar AH Agarwal JP | 2009 | Plast Reconstr Surg2009,123,3: | 1 |
| 7 | Detemlination of the degree of hydrolysis of food pro- tein hydrolysates by trinitrobenzenesulfonic acid显示文摘 | ADLER N J | 1979 | Journal of Agricul- tural and Food Chemistry1979,27,: | 1 |
| 8 | Association between mitral annulus calcification and aortic atheroma:a prospective transesophageal echocardiographic study显示文摘 | Adler Y Vaturi M Fink N | 2000 | Atherosclerosis2000,152,2: | 1 |
| 9 | Review of ranking methods in the data envelopment analysis eontext 显示文摘 | Adler N Friedman L Zilla SS | 2002 | European Journal of Operational Research2002,140,: | 1 |
| 10 | The predecessor attack:an analysis of a threat to anonymous communications systems显示文摘 | WRIGHT M ADLER M LEVINE B N | 2004 | ACM Transactions on Information and System Security2004,7,4: | 1 |
| 11 | A Simplex Algorithm Whose Average Number of Steps Is Bound Between Two Quadratic Functions of the Smaller Dimension显示文摘 | Adler I Megiddo N | 1985 | ACM1985,32,4: | 1 |
| 12 | Prognostic indices in lupus nephritis显示文摘 | Hechr B Siggel N Adler M | 1976 | Medicine1976,55,: | 1 |
| 13 | Parental imprinting on the mouse X chromosome:effects on the early development of X0,XXY and XXX embryos显示文摘 | Tada T Takagi N Adler ID | 1993 | Genet Res1993,62,2: | 1 |
| 14 | Strategy Implementation:a Comparison of Face-to-face Negotiations in the People's Republic of China and the United States显示文摘 | Brahm R Graham J L | 1992 | Strategic Management Journal1992,13,: | 1 |
| 15 | High-speed Rail and Air Transport Competition= Game Engineering as Tool for Cost-benefit Analysis显示文摘 | ADLER N PELS E NASH C | 2010 | Transportation Research Part B2010,44,7: | 1 |
| 16 | Postive coeliac se- rology in irritable bowel syndrome patients with normal duodenal diopsies: video capsule endoscopy findings and HLA - DQ typing may affect clinical management 显示文摘 | ADLER S N JACOB H MULDER C I | 2006 | J Gastrointestin Liver Dis2006,15,3: | 1 |
| 17 | A second GDP-L-galactose phosphorylase in Arabidopsis enroute to vitamin C显示文摘 | Linster C L Adler L N Webb K | 2008 | Journal of Biochem-istry2008,283,18: | 1 |
| 18 | The moleeularand cellular basis of pathogenesis inmelioidosis : how does Burkholderia pseudomallei cause disease显示文摘 | LAZAR ADLER N R GOVAN B CULLINANE M | 2009 | FEMS Microbiol Rev2009,33,: | 1 |
| 19 | Evaluation of deregulated airline networks us- ing data envelopment analysis combined withprineipal component analysis with an application to Western Europe显示文摘 | Adler N Golany B | 2001 | European Jour- nal of Operational Research2001,132,2: | 1 |
| 20 | The mechanism of threshold switching in amorphous alloys 显示文摘 | Adler D Heinz K H Mott N | 1978 | Reviews of Modern Physics1978,50,: | 1 |