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1Does capsule endoscopy have an added value in patients with perianal disease and a negative work up for Crohn's disease?显示文摘AIM:To investigate the role of capsule endoscopy in patients with persistent perianal disease and negative conventional work up for Crohn's disease(CD).METHODS:Patients with perianal disease(abscesses,fistulas,recurrent fissures) were evaluated for underlying CD.Patients who had a negative work up,defined as a negative colonoscopy with a normal ileoscopy or a normal small bowel series or a normal CT/MR enterography,underwent a Pillcam study of the small bowel after signing informed consent.Patients using nonsteroidal anti-inflammatory drugs or who had a history of inflammatory bowel disease or rheumatic disease were excluded.RESULTS:We recruited 26 patients aged 21-61 years(average 35.6 years),17 males and 9 females.One case could not be evaluated since the capsule did not leave the stomach.In 6 of 25(24%) patients with a negative standard work up for Crohn's disease,capsuleendoscopy(CE) findings were consistent with Crohn's disease of the small bowel.Family history of CD,white blood cell,hemoglobin,erythrocyte sedimentation rate or C-reactive protein did not predict a diagnosis of CD.Capsule endoscopy findings led to a change in treatment.CONCLUSION:In patients with perianal disease and a negative conventional work up to exclude CD,CE leads to incremental diagnostic yield of 24%.Samuel N Adler Metzger Yoav Scapa Eitan Chowers Yehuda Rami Eliakim 2012World Journal of Gastrointestinal Endoscopy2012,4,5:4
2What we have learned and what to expect from capsule endoscopy显示文摘Capsule endoscopy was conceived by Gabriel Iddan and Paul Swain independently two decades ago. These applications include but are not limited to Crohn's disease of the small bowel, occult gastrointestinal bleeding, non steroidal anti inflammatory drug induced smallbowel disease, carcinoid tumors of the small bowel,gastro intestinal stromal tumors of the small bowel andother disease affecting the small bowel. Capsule endoscopy has been compared to traditional small bowelseries, computerized tomography studies and pushenteroscopy. The diagnostic yield of capsule endoscopyhas consistently been superior in the diagnosis of smallbowel disease compared to the competing methods(small bowel series, computerized tomography, pushenteroscopy) of diagnosis. For this reason capsule en-doscopy has enjoyed a meteoric success. Image qualityhas been improved with increased number of pixels,automatic light exposure adaptation and wider angle ofview. Further applications of capsule endoscopy of other areas of the digestive tract are being explored. Theincreased transmission rate of images per second hasmade capsule endoscopy of the esophagus a realisticpossibility. Technological advances that include a double imager capsule with a nearly panoramic view of the colon and a variable frame rate adjusted to the movement of the capsule in the colon have made capsuleendoscopy of the colon feasible. The diagnostic ratefor the identification of patients with polyps equal to orlarger than 6 mm is high. Future advances in technology and biotechnology will lead to further progress.Capsule endoscopy is following the successful moderntrend in medicine that replaces invasive tests with lessinvasive methodology.Samuel N Adler Ingvar Bjarnason 2012World Journal of Gastrointestinal Endoscopy2012,4,10:2
3Complexes of deoxyribonucleic acid with lysine-rich (f1) histone phosphorylated at two separate sites:circular dichroism studies显示文摘ADLER A J GREENFIELD N FASMAN G D 1972Arch Biochem Biophys1972,153,2:1
4Effects of Cardiac Resynchronization on Disease Progression in Patients With Left Ventricular Systolic Dysfunction, an Indication for an Implantable Cardioverter-Defibrillator, and Mildly Symptomatic Chronic Heart Failure显示文摘William T. Abraham James B. Young Angel R. León Stuart Adler Alan J. Bank Shelley A. Hall Randy Lieberman L Bing Liem John B. O’Connell John S. Schroeder Kevin R. Wheelan 2004Circulation2004,,18:1
5Mitral annulus calcification-a window to diffuse atherosclerosis of the vascular system显示文摘Adler Y Fink N Spector D 2001Atherosclerosis2001,155,1:1
6Harvesting the lateralfemoral circumflex chimera free flap:guidelines for elevation显示文摘Adler N Dorafshar AH Agarwal JP 2009Plast Reconstr Surg2009,123,3:1
7Detemlination of the degree of hydrolysis of food pro- tein hydrolysates by trinitrobenzenesulfonic acid显示文摘ADLER N J 1979Journal of Agricul- tural and Food Chemistry1979,27,:1
8Association between mitral annulus calcification and aortic atheroma:a prospective transesophageal echocardiographic study显示文摘Adler Y Vaturi M Fink N 2000Atherosclerosis2000,152,2:1
9Review of ranking methods in the data envelopment analysis eontext 显示文摘Adler N Friedman L Zilla SS 2002European Journal of Operational Research2002,140,:1
10The predecessor attack:an analysis of a threat to anonymous communications systems显示文摘WRIGHT M ADLER M LEVINE B N 2004ACM Transactions on Information and System Security2004,7,4:1
11A Simplex Algorithm Whose Average Number of Steps Is Bound Between Two Quadratic Functions of the Smaller Dimension显示文摘Adler I Megiddo N 1985ACM1985,32,4:1
12Prognostic indices in lupus nephritis显示文摘Hechr B Siggel N Adler M 1976Medicine1976,55,:1
13Parental imprinting on the mouse X chromosome:effects on the early development of X0,XXY and XXX embryos显示文摘Tada T Takagi N Adler ID 1993Genet Res1993,62,2:1
14Strategy Implementation:a Comparison of Face-to-face Negotiations in the People's Republic of China and the United States显示文摘 Brahm R Graham J L 1992Strategic Management Journal1992,13,:1
15High-speed Rail and Air Transport Competition= Game Engineering as Tool for Cost-benefit Analysis显示文摘ADLER N PELS E NASH C 2010Transportation Research Part B2010,44,7:1
16Postive coeliac se- rology in irritable bowel syndrome patients with normal duodenal diopsies: video capsule endoscopy findings and HLA - DQ typing may affect clinical management 显示文摘ADLER S N JACOB H MULDER C I 2006J Gastrointestin Liver Dis2006,15,3:1
17A second GDP-L-galactose phosphorylase in Arabidopsis enroute to vitamin C显示文摘Linster C L Adler L N Webb K 2008Journal of Biochem-istry2008,283,18:1
18The moleeularand cellular basis of pathogenesis inmelioidosis : how does Burkholderia pseudomallei cause disease显示文摘LAZAR ADLER N R GOVAN B CULLINANE M 2009FEMS Microbiol Rev2009,33,:1
19Evaluation of deregulated airline networks us- ing data envelopment analysis combined withprineipal component analysis with an application to Western Europe显示文摘Adler N Golany B 2001European Jour- nal of Operational Research2001,132,2:1
20The mechanism of threshold switching in amorphous alloys 显示文摘Adler D Heinz K H Mott N 1978Reviews of Modern Physics1978,50,:1
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