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| 1 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 2 | Cervical inlet patch-optical coherence tomography imaging and clinical significance显示文摘AIM:To demonstrate the feasibility of optical coherence tomography(OCT)imaging in differentiating cervical inlet patch(CIP)from normal esophagus,Barrett'sesophagus(BE),normal stomach and duodenum. METHODS:This study was conducted at the Veterans Affairs Boston Healthcare System(VABHS).Patients undergoing standard esophagogastroduodenoscopy at VABHS,including one patient with CIP,one representative patient with BE and three representative normal subjects were included.White light video endoscopy was performed and endoscopic 3D-OCT images were obtained in each patient using a prototype OCT system.The OCT imaging probe passes through the working channel of the endoscope to enable simultaneous video endoscopy and 3D-OCT examination of the human gastrointestinal(GI)tract.Standard hematoxylin and eosin(H and E)histology was performed on biopsy or endoscopic mucosal resection specimens in order to compare and validate the 3D-OCT data. RESULTS:CIP was observed from a 68-year old male with gastroesophageal reflux disease.The CIP region appeared as a pink circular lesion in the upper esophagus under white light endoscopy.OCT imaging over the CIP region showed columnar epithelium structure,which clearly contrasted the squamous epithelium structure from adjacent normal esophagus.3D-OCT images obtained from other representative patients demonstrated distinctive patterns of the normal esophagus,BE,normal stomach,and normal duodenum bulb.Microstructures,such as squamous epithelium,lamina propria, muscularis mucosa,muscularis propria,esophageal glands,Barrett's glands,gastric mucosa,gastric glands, and intestinal mucosal villi were clearly observed with OCT and matched with H and E histology.These results demonstrated the feasibility of using OCT to evaluate GI tissue morphology in situ and in real-time. CONCLUSION:We demonstrate in situ evaluation of CIP microstructures using 3D-OCT,which may be a useful tool for future diagnosis and follow-up of patients with CIP. | Chao Zhou Tejas Kirtane Tsung-Han Tsai Hsiang-Chieh Lee Desmond C Adler Joseph M Schmitt Qin Huang James G Fujimoto Hiroshi Mashimo | 2012 | World Journal of Gastroenterology2012，18，20： | 3 |
| 3 | Doppler ultrasound color flow imaging in the study of breast cancer: preliminary findings显示文摘 | Adler D D Carson P L Rubin J M | 1990 | Ultrasound MedBiol1990，16，6： | 1 |
| 4 | Association of systolic blood pressure with macrovascular and microvascular complications on type 2 diabetes (UKPDS 36 ): prospective observational study 显示文摘 | ADLER A I STRATrON I M NEIL H A | 2000 | BMJ2000，321，： | 1 |
| 5 | Association of glycaemia with macrovascular and micro-vascular complications of type 2 diabetes (UKPDS 35): prospective observational study 显示文摘 | Stratton I M Adler A I Neil H A | 2000 | BMJ2000，321，： | 1 |
| 6 | 显示文摘 | Adler J Baldwin P M Melia C D | 1994 | Starch1994，46，7： | 1 |
| 7 | Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease显示文摘 | Vasa M Fichtlscherer S Adler K | 2001 | Circulation2001，103，24： | 1 |
| 8 | Prevention of chronic fibrillation by pacing in the region of bachmann's bundle:Results of a multicenter randomized trial显示文摘 | Bailin SJ Adler S Giudici M | 2001 | J Cardivasc Electrophys2001，12，8： | 1 |
| 9 | Flow in simulated porous media显示文摘 | Adler P M Jacquin C G Quiblier J A | 1990 | International Journal of Multiphase Flow1990，16，： | 1 |
| 10 | Persistent and pro- gressive pulmonary fibrotic changes in a model of fat embol- ism显示文摘 | Poisner A M Adler F Uhal B | 2012 | J Trauma Acute Care Surg2012，72，4： | 1 |
| 11 | Prognosis of idiopathic recurrent peri-carditis as determined from previously published reports显示文摘 | Imazio M Brucato A Adler Y Brambilla G Artom G Cecchi E | 2007 | Am J Cardiol2007，100，： | 1 |
| 12 | A prospective comparison of capsule endoscopy and push enteroscopy in patients with GI bleeding of obscure origin显示文摘 | Adler DG Knipschield M Gostout C | 2004 | Gastrointestinal Endoscopy2004，59，4： | 1 |
| 13 | Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes(UKPDS 35):prospective observational study显示文摘 | Stratton I M Adler A I Neil H A | | 0，，7258： | 1 |
| 14 | Differential diagnosis of benign tumors and tumor - like lesions in the spine: Own cases and review of the literature 显示文摘 | Knoeller SM Uhl M Adler CP | 2004 | Neoplasam2004，51，2： | 1 |
| 15 | Fractal porous media IV: three-dimensional stokes flow through random media and regular fractals显示文摘 | Lemaitre R Adler P M | 1990 | Tra -nsport in porous media1990，5，： | 1 |
| 16 | Immuno-PCR: High sensitivity detection of proteins by nucleic acid amplification 显示文摘 | Niemeyer C M Adler M Wacker R | 2005 | Trends Biotechnol2005，23，4： | 1 |
| 17 | Solution structure of kistrin, a potent platelet aggregation inhibitor and GPⅡbⅢa antagonist 显示文摘 | Adler M Lazarus RA Dennis MS Wagner G | 1991 | Science1991，253，5018： | 1 |
| 18 | Possible participation of nitric oxide in the increase of norepinephrine release caused by angiotensin peptides in rat atria显示文摘 | HIRONACCI M M LOVENZO P S ADLER GRASCHINSKY E | 1997 | Hypertension1997，29，6： | 1 |
| 19 | A novel family of mammalian taste receptors显示文摘 | Adler E Hoon M A Mueller K L | 2000 | Cell2000，100，： | 1 |
| 20 | COMT inhibition:a new treatment strategy for Parkinson's disease显示文摘 | Kurth M C Adler C H | 1998 | Neurology1998，50，5： | 1 |
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