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| 1 | 肠源性内毒素血症促使水肿型胰腺炎向坏死型胰腺炎转化显示文摘目的 探讨肠源性内毒素血症对急性坏死型胰腺炎 (ANP)的促成作用及其可能机制。方法 C5 7BL/ 6小鼠随机分成 4组 :Ⅰ组 ,急性水肿型胰腺炎 (AEP)组 (n =2 0 ) ;Ⅱ组 ,AEP +脂多糖 (LPS)处理组 (n =2 0 ) ;Ⅲ组 ,LPS组 (n =2 0 ) ;Ⅳ组 ,正常对照组 (n =5 )。腹腔内间隔 1h共 7次 ,注射 5 0 μg/kg体重雨蛙素诱导小鼠AEP。第 6小时胃管内灌入 5mg/kg体重LPS溶液。监测 12、2 4、48h和 5d血清淀粉酶、乳酸脱氢酶 (LDH)活性 ;胰组织髓过氧化物酶 (MPO)活性和组织变化 ;免疫组化观察胰组织Mac 1(CD11b/CD18)、E选择素、P选择素和细胞间黏附分子 (ICAM 1)表达 ;RT PCR和Southern印迹检测胰组织TNFα、IL 1β、IL 6和IFNγmRNA变化。 结果 雨蛙素诱导小鼠AEP。LPS单独并不引起胰组织明显病理变化和血清淀粉酶、LDH活性改变。然而 ,同剂量LPS则使小鼠AEP胰损伤加重 ,血清淀粉酶和LDH活性显著增加 ;胰组织Mac 1表达增强 ;MPO活性增加 ;E选择素、P选择素和ICAM 1表达增强 ;TNFα、IL 1β、IL 6和IFNγmRNA表达上调。 结论 肠源性内毒素血症可促使AEP转化为ANP ,黏附分子介导的中性粒细胞过度聚集和大量细胞因子释放 。 | 王兴鹏 王冰娴 徐选福 谢传高 徐敏 王国良 Adler G | 2001 | 中华消化杂志2001，21，2： | 24 |
| 2 | 核因子-κB促使水肿型胰腺炎向坏死型胰腺炎转化显示文摘目的 探讨核因子 κB (NF -κB)在肠源性内毒素血症促使急性水肿型胰腺炎 (AEP)向急性坏死型胰腺炎 (ANP)转化中的作用。方法 C5 7BL 6小鼠随机分 5组 :正常组 (n =5 )、脂多糖 (LPS)组(n =2 0 )、AEP组 (n =2 0 )、AEP +LPS组 (n =2 0 )、PDTC干预组 (AEP +LPS +PDTC)组 (n =2 0 )。腹腔内间隔 1h共 7次注射雨蛙素 (5 0 μg kg)诱导小鼠AEP。第 6h胃管内灌入LPS溶液 (5mg kg)。PDTC干预组于雨蛙素注射前腹腔内注射PDTC ,剂量为 10 0mg kg。监测 12h、 2 4h、 4 8h和 5d血清淀粉酶、乳酸脱氢酶 (LDH)活性 ;免疫组化观察胰组织Mac - 1(CD11b CD18)、E选择素、P选择素和ICAM - 1表达 ;Southern印迹检测胰组织TNF -α、IL - 1βmRNA变化。 结果 LPS单独并不引起胰组织明显病理变化和血清淀粉酶、LDH活性改变 ,但使小鼠AEP胰腺组织损伤加重 ,血清淀粉酶和LDH活性显著增加 ;胰腺组织Mac - 1表达增强 ;PDTC处理组血清淀粉酶和LDH活性显著降低 ,胰腺组织病理改善 ,细胞因子TNF -α、IL - 1βmRNA表达下调。 结论 肠源性内毒素血症可促使AEP转化为ANP。PDTC通过选择性抑制NF -κB阻断内毒素信号通路 ,抑制内毒素介导的高细胞因子反应及其继发的中性粒细胞活化 ,最终使胰腺炎程度减轻。提示NF -κB在肠源性? | 吴丽颖 王兴鹏 Adler G | 2004 | 中华急诊医学杂志2004，13，2： | 15 |
| 3 | Enteral stents for the management of malignant colorectal obstruction显示文摘Colorectal cancer(CRC) is the 3rd most common cancer in the United States with more than 10000 new cases diagnosed annually. Approximately 20% of patients with CRC will have distant metastasis at time of diagnosis, making them poor candidates for primary surgical resection. Similarly, 8%-25% of patients with CRC will present with bowel obstruction and will require palliative therapy. Emergent surgical decompression has a high mortality and morbidity, and often leads to a colostomy which impairs the patient's quality of life. In the last decade, there has been an increasing use of colonic stents for palliative therapy to relieve malignant colonic obstruction. Colonic stents have been shown to be effective and safe to treat obstruction from CRC, and are now the therapy of choice in this scenario. In the setting of an acute bowel obstruction in patients with potentially resectable colon cancer, stents may beused to delay surgery and thus allow for decompression, adequate bowel preparation, and optimization of the patient's condition for curative surgical intervention. An overall complication rate(major and minor) of up to 25% has been associated with the procedure. Long term failure of stents may result from stent migration and tumor ingrowth. In the majority of cases, repeat stenting or surgical intervention can successfully overcome these adverse effects. | Jeremy Kaplan Anna Strongin Douglas G Adler Ali A Siddiqui | 2014 | World Journal of Gastroenterology2014，20，37： | 13 |
| 4 | Osteoclastic and pleomorphic giant cell tumors of the pancreas:A review of clinical,endoscopic,and pathologic features显示文摘Giant cell tumors of the pancreas come in three varieties-osteoclastic,pleomorphic,and mixed histology.These tumors have distinctive endoscopic,clinical,and cytological features.Giant cell tumors have a controversial histogenesis,with some authors favoring an epithelial origin and others favoring a mesenchymal origin.The true origin of these lesions remains unclear at this time.These are also very rare tumors but proper identification and differentiation from more common pancreatic adenocarcinoma is important.The risk factors of these tumors and the prognosis may be different from those associated with standard pancreatic adenocarcinoma.Recognition of these differences can significantly affect patient care.These lesions have a unique appearance when imaged with endoscopic ultrasound(EUS),and these lesions can be diagnosed via EUS guided Fine Needle Aspiration(FNA).This manuscript will review the endoscopic,clinical,and pathologic features of these tumors. | Jill C Moore Joel S Bentz Kristen Hilden Douglas G Adler | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，1： | 7 |
| 5 | Endoscopic retrograde cholangiopancreatography in cirrhosis-a systematic review and meta-analysis focused on adverse events显示文摘AIM To investigate indications and outcomes of endoscopic retrograde cholangiopancreatography(ERCP) in cirrhotics, especially adverse events. Patients with cirrhosis undergoing ERCP are believed to have increased risk. However, there is a paucity of literature describing the indications and outcomes of ERCP procedures in patients with cirrhosis, especially focusing on adverse events.METHODS We performed a systematic appraisal of major literature databases, including PubMed and EMBASE, with a manual search of literature from their inception until April 2017.RESULTS A total of 6,505 patients from 15 studies were analyzed(male ratio 59%, mean age 59 years), 11% with alcoholic and 89% with non-alcoholic cirrhosis, with 56.2% Child-Pugh class A, and 43.8% class B or C. Indications for ERCP included choledocholithiasis 60.9%, biliary strictures 26.2%, gallstone pancreatitis 21.1% and cholangitis 15.5%. Types of interventions included endoscopic sphincterotomy 52.7%, biliary stenting 16.7% and biliary dilation 4.6%. Individual adverse events included hemorrhage in 4.58%(95%CI: 2.77-6.75%, I^2 = 85.9%), post-ERCP pancreatitis(PEP) in 3.68%(95%CI: 1.83-6.00%, I^2 = 89.5%), cholangitis in 1.93%(95%CI: 0.63-3.71%, I^2 = 87.1%) and perforation in 0.00%(95%CI: 0.00-0.23%, I^2 = 37.8%). Six studies were used for comparison of ERCPrelated complications in cirrhosis vs non-cirrhosis, which showed higher overall rates of complications in cirrhosis patients with pooled OR of 1.63(95%CI: 1.27-2.09, I2 = 65%): higher rates of hemorrhage with OR of 2.05(95%CI: 1.62-2.58, I^2 = 2.1%) and PEP with OR of 1.33(95%CI: 1.04-1.70, I2=65%), but similar cholangitis rates with OR of 1.23(95%CI: 0.67-2.26, I^2 = 44.3%).CONCLUSION There is an overall higher rate of adverse events related to ERCP in patients with cirrhosis, especially hemorrhage and PEP. A thorough risk/benefit assessment should be performed prior to undertaking ERCP in patients with cirrhosis. | Shailender Singh Mashiana Amaninder Singh Dhaliwal Harlan Sayles Banreet Dhindsa Ji Won Yoo Qing Wu shailender singh Ali A Siddiqui Gordon Ohning Mohit Girotra Douglas G Adler | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，11： | 6 |
| 6 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 7 | Cervical inlet patch-optical coherence tomography imaging and clinical significance显示文摘AIM:To demonstrate the feasibility of optical coherence tomography(OCT)imaging in differentiating cervical inlet patch(CIP)from normal esophagus,Barrett'sesophagus(BE),normal stomach and duodenum. METHODS:This study was conducted at the Veterans Affairs Boston Healthcare System(VABHS).Patients undergoing standard esophagogastroduodenoscopy at VABHS,including one patient with CIP,one representative patient with BE and three representative normal subjects were included.White light video endoscopy was performed and endoscopic 3D-OCT images were obtained in each patient using a prototype OCT system.The OCT imaging probe passes through the working channel of the endoscope to enable simultaneous video endoscopy and 3D-OCT examination of the human gastrointestinal(GI)tract.Standard hematoxylin and eosin(H and E)histology was performed on biopsy or endoscopic mucosal resection specimens in order to compare and validate the 3D-OCT data. RESULTS:CIP was observed from a 68-year old male with gastroesophageal reflux disease.The CIP region appeared as a pink circular lesion in the upper esophagus under white light endoscopy.OCT imaging over the CIP region showed columnar epithelium structure,which clearly contrasted the squamous epithelium structure from adjacent normal esophagus.3D-OCT images obtained from other representative patients demonstrated distinctive patterns of the normal esophagus,BE,normal stomach,and normal duodenum bulb.Microstructures,such as squamous epithelium,lamina propria, muscularis mucosa,muscularis propria,esophageal glands,Barrett's glands,gastric mucosa,gastric glands, and intestinal mucosal villi were clearly observed with OCT and matched with H and E histology.These results demonstrated the feasibility of using OCT to evaluate GI tissue morphology in situ and in real-time. CONCLUSION:We demonstrate in situ evaluation of CIP microstructures using 3D-OCT,which may be a useful tool for future diagnosis and follow-up of patients with CIP. | Chao Zhou Tejas Kirtane Tsung-Han Tsai Hsiang-Chieh Lee Desmond C Adler Joseph M Schmitt Qin Huang James G Fujimoto Hiroshi Mashimo | 2012 | World Journal of Gastroenterology2012，18，20： | 3 |
| 8 | Experimental animal model of acute pancreatitis显示文摘 | Lerch MM Adler G | 1994 | Inter J Pancreat1994，15，： | 2 |
| 9 | Innovative ceramic materials for porous medium burners I显示文摘 | Pickenacker O Pickenacker K Wawrzinek K Trimis D Pritzkow W E C Miiller C Goedtke P Papenburg U Adler J Standke G Heymer H Tauscher W Jansen F | 1999 | Interceram:International Ceramic Review1999，48，5： | 1 |
| 10 | Complexes of deoxyribonucleic acid with lysine-rich (f1) histone phosphorylated at two separate sites:circular dichroism studies显示文摘 | ADLER A J GREENFIELD N FASMAN G D | 1972 | Arch Biochem Biophys1972，153，2： | 1 |
| 11 | Flow in simulated porous media显示文摘 | Adler P M Jacquin C G Quiblier J A | 1990 | International Journal of Multiphase Flow1990，16，： | 1 |
| 12 | Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B显示文摘 | Wahl C Liptay S Adler G | | 0，，： | 1 |
| 13 | A proposed Tropical Rainfall Measuring Mission (TRMM) satellite显示文摘 | SIMPSON J ADLER R F NORTH G R | 1988 | Bull Amer Meteor Soc1988，69，3： | 1 |
| 14 | Prognosis of idiopathic recurrent peri-carditis as determined from previously published reports显示文摘 | Imazio M Brucato A Adler Y Brambilla G Artom G Cecchi E | 2007 | Am J Cardiol2007，100，： | 1 |
| 15 | Recent advances in the prevention and treatment of congenital cytomegalovirus infections显示文摘 | Adler SP Nigro G Pereira L | | 0，，： | 1 |
| 16 | Pheochromocytoma: current approaches and future directions 显示文摘 | Adler J T Rochow G Y Chen H | 2008 | Oncolo - gist2008，13，7： | 1 |
| 17 | Passive immunization during pregnancy for congenital cytomegalovirus infection显示文摘 | Nigro G Adler SP La Torre R | 2005 | N Engl J Med2005，353，13： | 1 |
| 18 | Solution structure of kistrin, a potent platelet aggregation inhibitor and GPⅡbⅢa antagonist 显示文摘 | Adler M Lazarus RA Dennis MS Wagner G | 1991 | Science1991，253，5018： | 1 |
| 19 | Innovative ceramic materials for porous medium burners Ⅱ显示文摘 | Pickenacker O Pickenacker K Wawrzinek K Trimis D Pritzkow W E C Muller C Goedtke P Papenburg U Adler J Standke G Heymer H Tauscher W Jansen F | 1999 | Interceram:International Ceramic Review1999，48，6： | 1 |
| 20 | The TRMM Multi-satellite Precipitation Analysis (TM- PA) : Quasi-global, Multi-year, Combined-sensor precipitation at Fine Scales显示文摘 | Huffman G J Adler R F Bolvin D T | 2007 | Hydrometeorology2007，，8： | 1 |
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