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| 1 | 肠源性内毒素血症促使水肿型胰腺炎向坏死型胰腺炎转化显示文摘目的 探讨肠源性内毒素血症对急性坏死型胰腺炎 (ANP)的促成作用及其可能机制。方法 C5 7BL/ 6小鼠随机分成 4组 :Ⅰ组 ,急性水肿型胰腺炎 (AEP)组 (n =2 0 ) ;Ⅱ组 ,AEP +脂多糖 (LPS)处理组 (n =2 0 ) ;Ⅲ组 ,LPS组 (n =2 0 ) ;Ⅳ组 ,正常对照组 (n =5 )。腹腔内间隔 1h共 7次 ,注射 5 0 μg/kg体重雨蛙素诱导小鼠AEP。第 6小时胃管内灌入 5mg/kg体重LPS溶液。监测 12、2 4、48h和 5d血清淀粉酶、乳酸脱氢酶 (LDH)活性 ;胰组织髓过氧化物酶 (MPO)活性和组织变化 ;免疫组化观察胰组织Mac 1(CD11b/CD18)、E选择素、P选择素和细胞间黏附分子 (ICAM 1)表达 ;RT PCR和Southern印迹检测胰组织TNFα、IL 1β、IL 6和IFNγmRNA变化。 结果 雨蛙素诱导小鼠AEP。LPS单独并不引起胰组织明显病理变化和血清淀粉酶、LDH活性改变。然而 ,同剂量LPS则使小鼠AEP胰损伤加重 ,血清淀粉酶和LDH活性显著增加 ;胰组织Mac 1表达增强 ;MPO活性增加 ;E选择素、P选择素和ICAM 1表达增强 ;TNFα、IL 1β、IL 6和IFNγmRNA表达上调。 结论 肠源性内毒素血症可促使AEP转化为ANP ,黏附分子介导的中性粒细胞过度聚集和大量细胞因子释放 。 | 王兴鹏 王冰娴 徐选福 谢传高 徐敏 王国良 Adler G | 2001 | 中华消化杂志2001，21，2： | 24 |
| 2 | Helicobacter pylori and oral pathology:Relationship with the gastric infection显示文摘Helicobacter pylori(H.pylori)has been found in the oral cavity and stomach,and its infection is one of the most frequent worldwide.We reviewed the literature and conducted a Topic Highlight,which identified studies reporting an association between H.pylori-infection in the oral cavity and H.pylori-positive stomach bacterium.This work was designed to determine whether H.pylori is the etiologic agent in periodontal disease,recurrent aphthous stomatitis(RAS),squamous cell carcinoma,burning and halitosis.Record selection focused on the highest quality studies and meta-analyses.We selected 48 articles reporting on the association between saliva and plaque and H.pylori-infection.In order to assess periodontal disease data,we included 12 clinical trials and 1 meta-analysis.We evaluated 13 published articles that addressed the potential association with RAS,and 6 with squamous cell carcinoma.Fourteen publications focused on our questions on burning and halitosis.There is a close relation between H.pylori infection in the oral cavity and the stomach.The mouth is the first extra-gastric reservoir.Regarding the role of H.pylori in the etiology of squamous cell carcinoma,no evidence is still available. | Isabel Adler Andrea Muio Silvia Aguas Laura Harada Mariana Diaz Adriana Lence Mario Labbrozzi Juan Manuel Muio Boris Elsner Alejandra Avagnina Valeria Denninghoff | 2014 | World Journal of Gastroenterology2014，20，29： | 21 |
| 3 | 交织混合型战略——一个多案例研究的发现显示文摘通过多案例研究方法,本文讨论了3家在中国本土创立并成长起来的饭店公司采取的业务层面战略的特征及其含义。论文主要回答了两个问题:这3家饭店公司如何成功地将低成本战略和差异化战略结合到了一起?为什么这种结合方式在我们的研究背景中是可行的?对于前者,我们指出,这3家经济型饭店公司密不可分地将低成本战略的要素与差异化战略的要素交织到了一起,而不仅仅是将两个方面的要素进行简单结合。对于后者,我们指出,我们的研究对象存在于'中国'及'饭店业'这两个具体的背景中。与其他背景相比,这两个背景的特殊性使得交织混合型战略表现出更好的可行性。在对两类背景进行了深入分析后,我们提出了3个命题及一个概念性模型。 | 秦宇 Liping A.Cai Howard Adler | 2010 | 管理世界2010，26，10： | 18 |
| 4 | 核因子-κB促使水肿型胰腺炎向坏死型胰腺炎转化显示文摘目的 探讨核因子 κB (NF -κB)在肠源性内毒素血症促使急性水肿型胰腺炎 (AEP)向急性坏死型胰腺炎 (ANP)转化中的作用。方法 C5 7BL 6小鼠随机分 5组 :正常组 (n =5 )、脂多糖 (LPS)组(n =2 0 )、AEP组 (n =2 0 )、AEP +LPS组 (n =2 0 )、PDTC干预组 (AEP +LPS +PDTC)组 (n =2 0 )。腹腔内间隔 1h共 7次注射雨蛙素 (5 0 μg kg)诱导小鼠AEP。第 6h胃管内灌入LPS溶液 (5mg kg)。PDTC干预组于雨蛙素注射前腹腔内注射PDTC ,剂量为 10 0mg kg。监测 12h、 2 4h、 4 8h和 5d血清淀粉酶、乳酸脱氢酶 (LDH)活性 ;免疫组化观察胰组织Mac - 1(CD11b CD18)、E选择素、P选择素和ICAM - 1表达 ;Southern印迹检测胰组织TNF -α、IL - 1βmRNA变化。 结果 LPS单独并不引起胰组织明显病理变化和血清淀粉酶、LDH活性改变 ,但使小鼠AEP胰腺组织损伤加重 ,血清淀粉酶和LDH活性显著增加 ;胰腺组织Mac - 1表达增强 ;PDTC处理组血清淀粉酶和LDH活性显著降低 ,胰腺组织病理改善 ,细胞因子TNF -α、IL - 1βmRNA表达下调。 结论 肠源性内毒素血症可促使AEP转化为ANP。PDTC通过选择性抑制NF -κB阻断内毒素信号通路 ,抑制内毒素介导的高细胞因子反应及其继发的中性粒细胞活化 ,最终使胰腺炎程度减轻。提示NF -κB在肠源性? | 吴丽颖 王兴鹏 Adler G | 2004 | 中华急诊医学杂志2004，13，2： | 15 |
| 5 | Predicting global landslide spatiotemporal distribution:Integrating landslide susceptibility zoning techniques and real-time satellite rainfall estimates显示文摘Landslides triggered by rainfall can possibly be foreseen in real time by jointly using rainfall intensity-duration thresholds and information related to land surface susceptibility. However, no system exists at either a national or a global scale to monitor or detect rainfall conditions that may trigger landslides due to the lack of sufficient ground-based observing network in many parts of the world. Recent advances in satellite remote sensing technology and increasing availability of high-resolution geospatial products around the globe have provided an unprecedented opportunity for such a study. In this paper, a framework for developing a preliminary real-time prediction system to identify where rainfall-triggered landslides will occur is proposed by combining two necessary components: surface landslide susceptibility and a real-time space-based rainfall analysis system (http://gffzz393ea4fcb44c40b8hvo9xk9cbxwuc6qfb.ffgz.tsg.suse.edu.cn). First, a global landslide susceptibility map is derived from a combination of semi-static global surface characteristics (digital elevation topography, slope, soil types, soil texture, land cover classification, etc.) using a GIS weighted linear combination approach. Second, an adjusted empirical relationship between rainfall intensity-duration and landslide occurrence is used to assess landslide hazards at areas with high susceptibility. A major outcome of this work is the availability for the first time of a global assessment of landslide hazards, which is only possible because of the utilization of global satellite remote sensing products. This preliminary system can be updated continuously using the new satellite remote sensing products. This proposed system, if pursued through wide interdisciplinary efforts as recommended herein, bears the promise to grow many local landslide hazard analyses into a global decision-making support system for landslide disaster preparedness and mitigation activities across the world. | Yang HONG Robert F. ADLER | 2008 | International Journal of Sediment Research2008，23，3： | 13 |
| 6 | A Talk on the Translation of Volume V of Chairman Mao’s Selected Works显示文摘I should first mention the collective style of work in preparing the translation of VolumeV which was admirable.We all had only one objective which was to make the translationas good as possible,and everything was subordinated to that.The second point I would like to make is that every effort was made to correct andimprove at each stage right to the very end,right up to and including the page proofs.This is essential.Of course it is virtually impossible to eliminate all errors;the fairly obviousones should have been disposed of before the two final corrections,and the process ismuch more difficult where it is not a question of eliminating errors but of choosing bet- | Sol Adler | 1980 | 中国翻译1980，，1： | 13 |
| 7 | Enteral stents for the management of malignant colorectal obstruction显示文摘Colorectal cancer(CRC) is the 3rd most common cancer in the United States with more than 10000 new cases diagnosed annually. Approximately 20% of patients with CRC will have distant metastasis at time of diagnosis, making them poor candidates for primary surgical resection. Similarly, 8%-25% of patients with CRC will present with bowel obstruction and will require palliative therapy. Emergent surgical decompression has a high mortality and morbidity, and often leads to a colostomy which impairs the patient's quality of life. In the last decade, there has been an increasing use of colonic stents for palliative therapy to relieve malignant colonic obstruction. Colonic stents have been shown to be effective and safe to treat obstruction from CRC, and are now the therapy of choice in this scenario. In the setting of an acute bowel obstruction in patients with potentially resectable colon cancer, stents may beused to delay surgery and thus allow for decompression, adequate bowel preparation, and optimization of the patient's condition for curative surgical intervention. An overall complication rate(major and minor) of up to 25% has been associated with the procedure. Long term failure of stents may result from stent migration and tumor ingrowth. In the majority of cases, repeat stenting or surgical intervention can successfully overcome these adverse effects. | Jeremy Kaplan Anna Strongin Douglas G Adler Ali A Siddiqui | 2014 | World Journal of Gastroenterology2014，20，37： | 13 |
| 8 | 点燃思维之火:开放教育,长尾理论和学习2.0显示文摘高等教育需求和服务供给的矛盾为基于新技术的学习模式提供了空间。基于实践社区支持,强调参与、建构和兴趣驱动的社会化学习等非正式学习开始从边缘走向中心。本文讨论技术支持下的学习模式变革,强调整合社区支持和资源共享的重要性,从学习知识(Learn about)向学会生存(Learn to be)转变,并指出以资源共享为主的开放教育资源在社区支持方面的薄弱。开放教育资源的价值在学习的长尾中得到了揭示和体现,而建立社区与共享资源同样重要。通过建立参与性学习生态系统,推动从Web2.0发展到Learning2.0。 | John Seely Brown Richard P. Adler 王龙(译) | 2009 | 现代远程教育研究2009，21，3： | 12 |
| 9 | Intrahepatic natural killer T cell populations are increased in human hepatic steatosis显示文摘AIM: To determine if natural killer T cell (NKT) populations are affected in nonalcoholic fatty liver disease (NAFLD). METHODS: Patients undergoing bariatric surgery underwent liver biopsy and blood sampling during surgery. The biopsy was assessed for steatosis and immunocyte infiltration. Intrahepatic lymphocytes (IHLs) were isolated from the remainder of the liver biopsy, and peripheral blood mononuclear cells (PBMCs) were isolated from the blood. Expression of surface proteins on both IHLs and PBMCs were quantified using flow cytometry. RESULTS: Twenty-seven subjects participated in thisstudy. Subjects with moderate or severe steatosis had a higher percentage of intrahepatic CD3+/CD56+ NKT cells (38.6%) than did patients with mild steatosis (24.1%, P = 0.05) or those without steatosis (21.5%, P = 0.03). Patients with moderate to severe steatosis also had a higher percentage of NKT cells in the blood (12.3%) as compared to patients with mild steatosis (2.5% P = 0.02) and those without steatosis (5.1%, P = 0.05). CONCLUSION: NKT cells are significantly increased in the liver and blood of patients with moderate to severe steatosis and support the role of NKT cells in NAFLD. | Michael Adler Sarah Taylor Kamalu Okebugwu Herman Yee Christine Fielding George Fielding Michael Poles | 2011 | World Journal of Gastroenterology2011，17，13： | 10 |
| 10 | 中国小鲵100年显示文摘 | 赵尔宓 Kraig Adler | 1989 | 四川动物1989，8，2： | 10 |
| 11 | Osteoclastic and pleomorphic giant cell tumors of the pancreas:A review of clinical,endoscopic,and pathologic features显示文摘Giant cell tumors of the pancreas come in three varieties-osteoclastic,pleomorphic,and mixed histology.These tumors have distinctive endoscopic,clinical,and cytological features.Giant cell tumors have a controversial histogenesis,with some authors favoring an epithelial origin and others favoring a mesenchymal origin.The true origin of these lesions remains unclear at this time.These are also very rare tumors but proper identification and differentiation from more common pancreatic adenocarcinoma is important.The risk factors of these tumors and the prognosis may be different from those associated with standard pancreatic adenocarcinoma.Recognition of these differences can significantly affect patient care.These lesions have a unique appearance when imaged with endoscopic ultrasound(EUS),and these lesions can be diagnosed via EUS guided Fine Needle Aspiration(FNA).This manuscript will review the endoscopic,clinical,and pathologic features of these tumors. | Jill C Moore Joel S Bentz Kristen Hilden Douglas G Adler | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，1： | 7 |
| 12 | Endoscopic retrograde cholangiopancreatography in cirrhosis-a systematic review and meta-analysis focused on adverse events显示文摘AIM To investigate indications and outcomes of endoscopic retrograde cholangiopancreatography(ERCP) in cirrhotics, especially adverse events. Patients with cirrhosis undergoing ERCP are believed to have increased risk. However, there is a paucity of literature describing the indications and outcomes of ERCP procedures in patients with cirrhosis, especially focusing on adverse events.METHODS We performed a systematic appraisal of major literature databases, including PubMed and EMBASE, with a manual search of literature from their inception until April 2017.RESULTS A total of 6,505 patients from 15 studies were analyzed(male ratio 59%, mean age 59 years), 11% with alcoholic and 89% with non-alcoholic cirrhosis, with 56.2% Child-Pugh class A, and 43.8% class B or C. Indications for ERCP included choledocholithiasis 60.9%, biliary strictures 26.2%, gallstone pancreatitis 21.1% and cholangitis 15.5%. Types of interventions included endoscopic sphincterotomy 52.7%, biliary stenting 16.7% and biliary dilation 4.6%. Individual adverse events included hemorrhage in 4.58%(95%CI: 2.77-6.75%, I^2 = 85.9%), post-ERCP pancreatitis(PEP) in 3.68%(95%CI: 1.83-6.00%, I^2 = 89.5%), cholangitis in 1.93%(95%CI: 0.63-3.71%, I^2 = 87.1%) and perforation in 0.00%(95%CI: 0.00-0.23%, I^2 = 37.8%). Six studies were used for comparison of ERCPrelated complications in cirrhosis vs non-cirrhosis, which showed higher overall rates of complications in cirrhosis patients with pooled OR of 1.63(95%CI: 1.27-2.09, I2 = 65%): higher rates of hemorrhage with OR of 2.05(95%CI: 1.62-2.58, I^2 = 2.1%) and PEP with OR of 1.33(95%CI: 1.04-1.70, I2=65%), but similar cholangitis rates with OR of 1.23(95%CI: 0.67-2.26, I^2 = 44.3%).CONCLUSION There is an overall higher rate of adverse events related to ERCP in patients with cirrhosis, especially hemorrhage and PEP. A thorough risk/benefit assessment should be performed prior to undertaking ERCP in patients with cirrhosis. | Shailender Singh Mashiana Amaninder Singh Dhaliwal Harlan Sayles Banreet Dhindsa Ji Won Yoo Qing Wu shailender singh Ali A Siddiqui Gordon Ohning Mohit Girotra Douglas G Adler | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，11： | 6 |
| 13 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 14 | Fluid and electrolyte overload in critically ill patients: An overview显示文摘Fluids are considered the cornerstone of therapy for many shock states, particularly states that are associated with relative or absolute hypovolemia. Fluids are also commonly used for many other purposes, such as renalprotection from endogenous and exogenous substances, for the safe dilution of medications and as 'maintenance' fluids. However, a large amount of evidence from the last decade has shown that fluids can have deleterious effects on several organ functions, both from excessive amounts of fluids and from their non-physiological electrolyte composition. Additionally, fluid prescription is more common in patients with systemic inflammatory response syndrome whose kidneys may have impaired mechanisms of electrolyte and free water excretion. These processes have been studied as separate entities(hypernatremia, hyperchloremic acidosis and progressive fluid accumulation) leading to worse outcomes in many clinical scenarios, including but not limited to acute kidney injury, worsening respiratory function, higher mortality and higher hospital and intensive care unit lengthof-stays. In this review, we synthesize this evidence and describe this phenomenon as fluid and electrolyte overload with potentially deleterious effects. Finally, we propose a strategy to safely use fluids and thereafter wean patients from fluids, along with other caveats to be considered when dealing with fluids in the intensive care unit. | Bruno Adler Maccagnan Pinheiro Besen André Luiz Nunes Gobatto Lívia Maria Garcia Melro Alexandre Toledo Maciel Marcelo Park | 2015 | World Journal of Critical Care Medicine2015，4，2： | 5 |
| 15 | 弹性波在两种液体饱和多孔介质界面上的反射和透射(英文)显示文摘Biot理论用来研究弹性波在两种液体饱和多孔介质界面上的反射和透射,考虑到斜入射时模式转换的一般情况,对相当普遍的一组边界条件计算了能量反射和透射系数与入射角的关系。给出了一个数值解的例子。 | 吴昆裕 薛强 Laszlo Adler | 1992 | 中国科学技术大学学报1992，22，1： | 4 |
| 16 | Osteoporosis in men: a review显示文摘Osteoporosis and consequent fracture are not limited to postmenopausal women. There is increasing attention being paid to osteoporosis in older men. Men suffer osteoporotic fractures about 10 years later in life than women, but life expectancy is increasing faster in men than women. Thus, men are living long enough to fracture, and when they do the consequences are greater than in women, with men having about twice the1-year fatality rate after hip fracture, compared to women. Men at high risk for fracture include those men who have already had a fragility fracture, men on oral glucocorticoids or those men being treated for prostate cancer with androgen deprivation therapy. Beyond these high risk men, there are many other risk factors and secondary causes of osteoporosis in men. Evaluation includes careful history and physical examination to reveal potential secondary causes, including many medications, a short list of laboratory tests, and bone mineral density testing by dual energy X-ray absorptiometry(DXA) of spine and hip. Recently, international organizations have advocated a single normative database for interpreting DXA testing in men and women.The consequences of this change need to be determined. There are several choices of therapy for osteoporosis in men, with most fracture reduction estimation based on studies in women. | Robert A Adler | 2014 | Bone Research2014，2，1： | 4 |
| 17 | Does capsule endoscopy have an added value in patients with perianal disease and a negative work up for Crohn's disease?显示文摘AIM:To investigate the role of capsule endoscopy in patients with persistent perianal disease and negative conventional work up for Crohn's disease(CD).METHODS:Patients with perianal disease(abscesses,fistulas,recurrent fissures) were evaluated for underlying CD.Patients who had a negative work up,defined as a negative colonoscopy with a normal ileoscopy or a normal small bowel series or a normal CT/MR enterography,underwent a Pillcam study of the small bowel after signing informed consent.Patients using nonsteroidal anti-inflammatory drugs or who had a history of inflammatory bowel disease or rheumatic disease were excluded.RESULTS:We recruited 26 patients aged 21-61 years(average 35.6 years),17 males and 9 females.One case could not be evaluated since the capsule did not leave the stomach.In 6 of 25(24%) patients with a negative standard work up for Crohn's disease,capsuleendoscopy(CE) findings were consistent with Crohn's disease of the small bowel.Family history of CD,white blood cell,hemoglobin,erythrocyte sedimentation rate or C-reactive protein did not predict a diagnosis of CD.Capsule endoscopy findings led to a change in treatment.CONCLUSION:In patients with perianal disease and a negative conventional work up to exclude CD,CE leads to incremental diagnostic yield of 24%. | Samuel N Adler Metzger Yoav Scapa Eitan Chowers Yehuda Rami Eliakim | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，5： | 4 |
| 18 | 慢性阻塞性肺疾病中黏液高分泌的潜在疗法显示文摘 | Jin-Ah Park Kenneth B Adler | 2006 | 中华医学杂志2006，86，41： | 4 |
| 19 | Flexibility Versus Efficiency? A Case Study of Model Changeovers in the Toyota Production System显示文摘 | Paul S. Adler Barbara Goldoftas David I. Levine | 1999 | Organization Science1999，，1： | 3 |
| 20 | Cervical inlet patch-optical coherence tomography imaging and clinical significance显示文摘AIM:To demonstrate the feasibility of optical coherence tomography(OCT)imaging in differentiating cervical inlet patch(CIP)from normal esophagus,Barrett'sesophagus(BE),normal stomach and duodenum. METHODS:This study was conducted at the Veterans Affairs Boston Healthcare System(VABHS).Patients undergoing standard esophagogastroduodenoscopy at VABHS,including one patient with CIP,one representative patient with BE and three representative normal subjects were included.White light video endoscopy was performed and endoscopic 3D-OCT images were obtained in each patient using a prototype OCT system.The OCT imaging probe passes through the working channel of the endoscope to enable simultaneous video endoscopy and 3D-OCT examination of the human gastrointestinal(GI)tract.Standard hematoxylin and eosin(H and E)histology was performed on biopsy or endoscopic mucosal resection specimens in order to compare and validate the 3D-OCT data. RESULTS:CIP was observed from a 68-year old male with gastroesophageal reflux disease.The CIP region appeared as a pink circular lesion in the upper esophagus under white light endoscopy.OCT imaging over the CIP region showed columnar epithelium structure,which clearly contrasted the squamous epithelium structure from adjacent normal esophagus.3D-OCT images obtained from other representative patients demonstrated distinctive patterns of the normal esophagus,BE,normal stomach,and normal duodenum bulb.Microstructures,such as squamous epithelium,lamina propria, muscularis mucosa,muscularis propria,esophageal glands,Barrett's glands,gastric mucosa,gastric glands, and intestinal mucosal villi were clearly observed with OCT and matched with H and E histology.These results demonstrated the feasibility of using OCT to evaluate GI tissue morphology in situ and in real-time. CONCLUSION:We demonstrate in situ evaluation of CIP microstructures using 3D-OCT,which may be a useful tool for future diagnosis and follow-up of patients with CIP. | Chao Zhou Tejas Kirtane Tsung-Han Tsai Hsiang-Chieh Lee Desmond C Adler Joseph M Schmitt Qin Huang James G Fujimoto Hiroshi Mashimo | 2012 | World Journal of Gastroenterology2012，18，20： | 3 |
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