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| 1 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 2 | Condensed tannin biosynthesis genes are regulated separately from other flavonoid biosynthesis genes in apple fruit skin显示文摘 | Adam M T Benjamin E U Robinson S P | 2006 | Plant Science2006，170，： | 1 |
| 3 | Use of a whole genome approach to identify vaccine molecules affording protection against topneumococcal bacteremia infection显示文摘 | Wizemann T M Heinrichs J H Adamou J E | | 0，，03： | 1 |
| 4 | Evaluation of hemispherical photography for determining plant area index and geometry of a forest stand显示文摘 | Chen J M Black T A Adams R S | 1991 | Agricultural and Forest Meteorology1991，56，1： | 1 |
| 5 | A genome-wide, endsequenced 129Sv BAC library resource for targeting vector construetion显示文摘 | Adams D J Quail M A Cox T | 2005 | Genomies2005，86，6： | 1 |
| 6 | Dietary restriction reduces the rate of estradiol clearance in sheep 显示文摘 | Requist B J Adams T E Adams B M | 2010 | J Anim Sci2010，86，： | 1 |
| 7 | A novel Pd/MgAlOx catalyst for NOX storage-reduction显示文摘 | SILLETTI B A ADAMS R T SIGMON S M NIKOLOPOULOS A SPIVEY J J LAMB H H | 2006 | Catal Today2006，114，1： | 1 |
| 8 | Healthy, Wealthy, and Wise? Tests for Direct Causal Paths Between Health and Socioeconomic Status 显示文摘 | ADAMS P HURD M MCFADDEN D MERRILL A RIBEI- RO T | 2003 | Journal of Econometrics2003，112，： | 1 |
| 9 | Variability in root production, phenology, and turnover rate among 12 temperate tree species 显示文摘 | MCCORMACK M L ADAMS T S SMITHWICK E A | 2014 | Ecology2014，95，8： | 1 |
| 10 | Particle analysis with digital holography 显示文摘 | Adams M Kreis T Juptner W | 2000 | Proceeding of the SPIE(S0277-786X)2000，4101，： | 1 |
| 11 | Evaluation of hemispherical photography for determining plant area index and geometry of a forest stand显示文摘 | Chen J M Black T A Adams R S | 1991 | Agricultural and Forest Meteorology1991，56，： | 1 |
| 12 | Betahistine inhibits food intake in rats显示文摘 | Magorzata T Anna M | 2001 | J Pharmacol2001，53，10： | 1 |
| 13 | Heart disease and stroke statistics-2010 update:A report from the American Heart Association显示文摘 | Lloyd-Jones D Adams R J Brown T M | | 0，，7： | 1 |
| 14 | The effects of Fenton's reagent pretreatment on the biodegradability of nonionic surfactants 显示文摘 | Kitis M Adams C D Daigger G T | 1999 | Water Research1999，33，11： | 1 |
| 15 | An experimental investication of single-phase forced convection in microchannels 显示文摘 | ADAMS T M ABDEL-KHALIK S I JETER S M | 1998 | Int J Heat and Mass Transfer1998，41，67： | 1 |
| 16 | Streamlining the Drug Discovery Process by Integrating Miniaturization, High Throughput Screening, High Content Screening, and Autination on the Cell ChipTM System显示文摘 | Kapur R Giuliano K A Adams T Campana M | 1999 | Biomedical Microdevices1999，2，2： | 1 |
| 17 | Crystallography & NMR system: A new software suite for maeromoleeular structure determination显示文摘 | Brunger A T Adams P D Clore G M | 1998 | Aeta Crystallogr D Biol Crystallogr1998，54，5： | 1 |
| 18 | Executive summary:heart disease and stroke statistics:2010 update:a report from the American Heart Association显示文摘 | LLOYD-JONES D ADAMS R J BROWN T M | 2010 | Circulation2010，121，： | 1 |
| 19 | An antibody- and synthetic peptide-defined rubella virus E1 glycoprotein neutraliza- tiondomain显示文摘 | Wolinsky J S Sukholutsky E Moore W T Lovett A McCarthy M Adame B | 1993 | J Virol1993，67，2： | 1 |
| 20 | Bayesian estimation of follower and leader vehicle poses with a virtual trailer link model显示文摘 | Ng T C Adams M Ibanez-Guzman J | 2008 | International Journal of Robotics Research2008，27，1： | 1 |
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