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| 1 | Randomized trial in malignant biliary obstruction:Plastic vs partially covered metal stents显示文摘AIM:To compare efficacy and complications of par-tially covered self-expandable metal stent(pcSEMS)to plastic stent(PS)in patients treated for malignant,infrahilar biliary obstruction.METHODS:Multicenter prospective randomized clinical trial with treatment allocation to a pcWallstent(SEMS)or a 10 French PS.Palliative patients aged≥18,for infrahilar malignant biliary obstruction and a Karnofsky performance scale index>60%from 6 participating North American university centers.Primary endpoint was time to stent failure,with secondary outcomes of death,adverse events,Karnofsky performance score and short-form-36 scale administered on a three-monthly basis for up to 2 years.Survival analyses were performed for stent failure and death,with Cox proportional hazards regression models to determine significant predictive characteristics.RESULTS:Eighty-five patients were accrued over 37mo,42 were randomized to the SEMS group and 83patients were available for analyses.Time to stent failure was 385.3±52.5 d in the SEMS and 153.3±19.8 d in the PS group,P=0.006.Time to death did not differ between groups(192.3±23.4 d for SEMS vs211.5±28.0 d for PS,P=0.70).The only significant predictor was treatment allocation,relating to the time to stent failure(P=0.01).Amongst other measured outcomes,only cholangitis differed,being more common in the PS group(4.9%vs 24.5%,P=0.029).The small number of patients in follow-up limits longitudinal assessments of performance and quality of life.From an initially planned 120 patients,only 85 patients were recruited.CONCLUSION:Partially covered SEMS result in a longer duration till stent failure without increased complication rates,yet without accompanying measurable benefits in survival,performance,or quality of life. | Peter L Moses Khalid M AlNaamani Alan N Barkun Stuart R Gordon Roger D Mitty M Stanley Branch Thomas E Kowalski Myriam Martel Viviane Adam | 2013 | World Journal of Gastroenterology2013，19，46： | 6 |
| 2 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 3 | Multiple effects of an additional growth hormone gene in aduh sheep 显示文摘 | ADAMS N R BRIEGEL J R | 2005 | Journal of Animal Science2005，83，： | 1 |
| 4 | Effect of organic acids on aluminum toxicity in subsoils显示文摘 | Hue N V Craddock G R Adams F | 1986 | Soil Science Society of America Journal1986，50，： | 1 |
| 5 | Isolation of transmissible enteritis agent of turkeys in avian embryos 显示文摘 | Adams N R Hofstad M S | 1971 | Avian Dis1971，15，： | 1 |
| 6 | Effect of Poisson's ratio strains in adherends on stresses of an idealized lap joints显示文摘 | Adams R D Peppiatt N A | 1973 | J Strain Analysis1973，8，2： | 1 |
| 7 | Modeling and analysis of workflows using Petri nets 显示文摘 | Adam N R Atluri V Huang W K | 1998 | Journal of Intelligent Information Systems1998，10，2： | 1 |
| 8 | The concordance of tetraploid, ISSR and RAPD markers, and ITS sequence data sets among genotypes: an example from Juniperus显示文摘 | ADAMS R P SCHWARZBACH A E PANDEY R N | 2003 | Biochem Systematics and Ecol2003，31，： | 1 |
| 9 | Effect of Poisson's ratio strains in adherends on stresses of an idealized lap joints显示文摘 | Adams R D Peppiatt N A | 1973 | The Journal of Strain Analysis1973，8，2： | 1 |
| 10 | Microstrueture of dense thin sheets of γ-TiAl fabricated by hot isostatic pressing of tape-cast monotapes 显示文摘 | ADAMS A G RAHAMAN M N DUTTON R E | 2008 | Materials Science and Engineering2008，447，： | 1 |
| 11 | Security-control methods for statis- tical databases: a comparative study 显示文摘 | ADAM N R WORTHMANN J C | 1989 | ACM Computing Surveys (CSUR)1989，21，4： | 1 |
| 12 | Reburning using biomass for NO control 显示文摘 | Adams B R Harding N S | 1998 | Fuel ProcessingTechnology1998，54，3： | 1 |
| 13 | Organizational and activational effects of phytoestrogens on the reproductive tract of the ewe 显示文摘 | Adams N R | 1995 | Proceedings of the Society for Experimental Biology and Medicine1995，208，1： | 1 |
| 14 | Influence of cultivar nitrogen and frequency of insecticide application on vegetable leafminer (Diptera:Agromyzidae) population density and dispersion on snap beans显示文摘 | Hanna H Y Story R N Adams A J | 1987 | Journal of Economic Entomology1987，80，1： | 1 |
| 15 | Nitric oxide-mediated regulation of chemosensitivity in cancer cell显示文摘 | Matthews N E Adams M A Maxwell L R | 2001 | J Natl Cancer Inst2001，93，24： | 1 |
| 16 | The dynamic properties of carbon-glass fiber sandwich laminated composites,Theoretical,experimental and economic consideration显示文摘 | Ni R G Lin D N Adams R D | 1984 | Composites1984，15，4： | 1 |
| 17 | 23-gauge transconjunctival sutureless vitrectomy: a retrospective study of 164 consecutive cases显示文摘 | de Preobrajensky N Mrejen S Adam R | 2010 | J Fr Ophtalmol2010，33，2： | 1 |
| 18 | Detecting metabolic activities in single cells,with emphasis on rnanoSIMS显示文摘 | Musat N Foster R Vagner T Adam B Kuypers M M M | | 0，，02： | 1 |
| 19 | 显示文摘 | Adams N R | 1998 | Proc Aust Soci Anim Prod1998，22，： | 1 |
| 20 | Virus inactivation during disinfection of wastewater by chlorination and UV irradiation and the efficacy of F^+ bacteriophage a“viral indicator”显示文摘 | Tree J A Adams M R Lees D N | 1997 | Water Sci Technol1997，35，11： | 1 |
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