|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 离子通道、磷酸化和哺乳动物精子获能显示文摘有性生殖动物需要精子和卵子之间进行精心协调的交流才能产生新的个体。精子获能是发生在女性生殖系统中的生殖细胞成熟的一个复杂现象,让精子能够和卵子联结并融合,是哺乳动物生育的必要条件。精子获能过程包括了质膜重组、离子渗透调节、胆固醇减少和许多蛋白质磷酸化状态的变化。研究精子离子通道的新工具能用更好的时空解析度将细胞内的离子变化和蛋白图像化,这些工具正在一步步阐明离子运输和磷酸化状态中的一系列调节是如何引起获能的。最近的证据表明有两条平行的通路调节引起获能的磷酸化发生。其中一条通路要求蛋白激酶A活化,另一条通路需要丝氨酸/苏氨酸磷酸酶失活。本文综述了精子获能所要求的离子运输参与和磷酸化信号处理。理解导致生育的分子机制,对于人们应对男性不育率升高、开发安全的以雄性配子为基础的避孕药、通过辅助生殖策略保持生物多样性都至关重要。 | Pablo E Visconti Dario Krapf Jose Luis de la Vega-Beltran Juan Jose Acevedo Alberto Darszon | 2011 | Asian Journal of Andrology2011，13，3： | 19 |
| 2 | Hepatorenal syndrome:Update on diagnosis and therapy显示文摘Hepatorenal syndrome(HRS) is a manifestation of extreme circulatory dysfunction and entails high morbidity and mortality.A new definition has been recently recommended by the International Club of Ascites,according to which HRS diagnosis relies in serum creatinine changes instead that on a fixed high value.Moreover,new data on urinary biomarkers has been recently published.In this sense,the use of urinary neutrophil gelatinase-associated lipocalin seems useful to identify patients with acute tubular necrosis and should be employed in the diagnostic algorithm.Treatment with terlipressin and albumin is the current standard of care.Recent data show that terlipressin in intravenous continuous infusion is better tolerated than intravenous boluses and has the same efficacy.Terlipressin is effective in reversing HRS in only 40%-50% of patients.Serum bilirubin and creatinine levels along with the increase in blood pressure and the presence of systemic inflammatory response syndrome have been identified as predictors of response.Clearly,there is a need for further research in novel treatments.Other treatments have been assessed such as noradrenaline,dopamine,transjugular intrahepatic portosystemic shunt,renal and liver replacement therapy,etc.Among all of them,liver transplant is the only curative option and should be considered in all patients.HRS can be prevented with volume expansion with albumin during spontaneous bacterial peritonitis and after post large volume paracentesis,and with antibiotic prophylaxis in patients with advanced cirrhosis and low proteins in the ascitic fluid.This manuscript reviews the recent advances in the diagnosis and management of this life-threatening condition. | Juan G Acevedo Matthew E Cramp | 2017 | World Journal of Hepatology2017，9，6： | 8 |
| 3 | Respective indications for orbital rim, zygomatic arc and orbitao- zygomatic osteotomies in the surgical approach to central skull base lesions: Critical, retrospective review in 146 cases 显示文摘 | Sindou M Emery E Acevedo G | 2001 | Acta Neurochir (Wien)2001，143，8： | 1 |
| 4 | Glucoregutatory endocrine responses to intermittent exercise of different intensities显示文摘 | Kraemer R R Acevedo E O Synovitz L B | 2002 | Amylin Metablism2002，51，5： | 1 |
| 5 | 14-3-3s are potentialbiomarkers for HIV-related neurodegeneration显示文摘 | Morales D? Skoulakis E C Acevedo S F | 2012 | J Neurovir-oU2012，18，5： | 1 |
| 6 | Effect of drought on leaf gas exchange,carbon isotope discrimination,transpiration efficiency and productivity in field grown durum wheat genotypes显示文摘 | Monneveux P Rekika D Acevedo E | 2006 | Plant Science2006，170，： | 1 |
| 7 | Immediate and subsequent growth responses of maize leaves to changes in water stress显示文摘 | Acevedo E | 1971 | Plant Physiology1971，48，： | 1 |
| 8 | Thickness measurernent in composite materials using lamb waves viscoelastic effects 显示文摘 | Moreno E Acevedo P Castillo M | 2000 | Ultrasonics2000，37，8： | 1 |
| 9 | Selective increase in cardliac IGF-1 in a rat model of ventricular hypertrophy显示文摘 | Ebensperger R Acevedo E Melendez J | 1998 | Bioehem Biophys Res Commun1998，243，1： | 1 |
| 10 | Triggering ovulation with gonadotropin - releasing hormone agonists does not compromise embryo implantation rates 显示文摘 | Acevedo B Gomez - Palomares JL Ricciarelli E | 2006 | Fertil Steril2006，86，6： | 1 |
| 11 | Human papillomavirus DNA and protein in tissue samples of oesophageal cancer, Barrett's oesophagus and oesophagitis显示文摘 | Acevedo E Gonzalez Ojeda A Vazquez Camacho G | 2004 | Anticancer Res2004，24，2： | 1 |
| 12 | Immediate and subsequent growth responses of maize leaves to changes in water stress显示文摘 | Acevedo E | 1971 | Plant Physiol1971，48，： | 1 |
| 13 | Heat and mass transfer coefficients for natural convection in fruit packages显示文摘 | Sanchez E Young M E | 2007 | Journal of Food Engineering2007，80，2： | 1 |
| 14 | Regio- and stereoselectivity of P450-catalysed hydroxylation of steroids controlled by laboratory evolution 显示文摘 | KILLE S ZILLY F E ACEVEDO J P | 2011 | Nat Chem2011，3，9： | 1 |
| 15 | Triggering ovulation with gonadotropin-releasing hormone agonists does not comprom iseem bryo implantation rates显示文摘 | Acevedo B Gomez-Palomares JL Ricciarelli E | 2006 | Fertil Steril2006，86，6： | 1 |
| 16 | Depression and risk for Alzheimer disease:systematic review, meta-analysis, and metare- gression analysis显示文摘 | Ownby RL Croceo E Acevedo A | 2006 | Arch Gen Psychiatry2006，63，5： | 1 |
| 17 | Immediate and subsequent growth response of maize leaves in water stress显示文摘 | ACEVEDO E HSIAO T C HENDERSON D W | 1971 | Plant Physiol1971，48，： | 1 |
| 18 | Adaptation of barley to harsh Mediterranean environment显示文摘 | Van Oosterom E J Acevedo E | 1992 | Phytica1992，，62： | 1 |
| 19 | Immediate and subsequent growth responses of maize leaves to changes in water stress显示文摘 | Acevedo E Hsiao T C Henderson D W | 1971 | Plant Physiol1971，48，： | 1 |
| 20 | Glucoregutatory endocrine responses to Intermittent exer-cise of different Intensities Plasma changes in a Pancreatic beta cell peptide Amylin显示文摘 | KRAEMER R R ACEVEDO E O SYNOVITZ L B | 2002 | Metabolism2002，51，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员