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| 1 | 保护动机理论在个体行为改变中的应用和发展显示文摘 | 王芸 肖霞 郑频频 Abu Abdullah 傅华 | 2009 | 中国健康教育2009，25，11： | 38 |
| 2 | CHARACTERIZATION OF POWDER FLOWABILITY USING MEASUREMENT OF ANGLE OF REPOSE显示文摘In response to the need in industry for a quick and reproducible method of measuring the flowability o powders in processes involving transport and storage, the apparently simple idea of measuring angle of repose has bee revived. The simple tester first used has evolved over a number of years into the present version which is shown to b capable of handling quite small samples of powders that are even slightly cohesive. Experimental data are presented an results shown to compare consistently with the better known Hausner ratio. | D. Geldart E. C. Abdullah A. Hassanpour L. C. Nwoke I. Wouters | 2006 | China Particuology2006，4，3： | 28 |
| 3 | Contrast-induced acute kidney injury:A review of practical points显示文摘Contrast-induced acute kidney injury(CI-AKI) is oneof the most common causes of AKI in clinical practice.CI-AKI has been found to be strongly associated with morbidity and mortality of the patients.Furthermore,CI-AKI may not be always reversible and it may be associated with the development of chronic kidney disease.Pathophysiology of CI-AKI is not exactly understood and there is no consensus on the preventive strategies.CI-AKI is an active research area thus clinicians should be updated periodically about this topic.In this review,we aimed to discuss the indications of contrastenhanced imaging,types of contrast media and their impact on nephrotoxicity,major pathophysiological mechanisms,risk factors and preventive strategies of CI-AKI and alternative non-contrast-enhanced imaging methods. | Sercin Ozkok Abdullah Ozkok | 2017 | World Journal of Nephrology2017，6，3： | 28 |
| 4 | Recent advances and perspectives of nucleic acid detection for coronavirus显示文摘The recent pneumonia outbreak caused by a novel coronavirus(SARS-CoV-2)is posing a great threat to global public health.Therefore,rapid and accurate identification of pathogenic viruses plays a vital role in selecting appropriate treatments,saving people's lives and preventing epidemics.It is important to establish a quick standard diagnostic test for the detection of the infectious disease(COVID-19)to prevent subsequent secondary spread.Polymerase chain reaction(PCR)is regarded as a gold standard test for the molecular diagnosis of viral and bacterial infections with high sensitivity and specificity.Isothermal nucleic acid amplification is considered to be a highly promising candidate method due to its fundamental advantage in quick procedure time at constant temperature without thermocycler opera-tion.A variety of improved or new approaches also have been developed.This review summarizes the currently available detection methods for coronavirus nucleic acid.It is anticipated that this will assist researchers and clinicians in developing better techniques for timely and effective detection of coro-navirus infection. | Minzhe Shen Ying Zhou Jiawei Ye Abdu Ahmed Abdullah AL-maskri Yu Kang Su Zeng Sheng Cai | 2020 | Journal of Pharmaceutical Analysis2020，10，2： | 27 |
| 5 | 农林废弃生物质吸附材料在水污染治理中的应用显示文摘环境污染问题已经成为人类社会可持续发展的巨大挑战之一,化工、冶炼及核燃料循环过程等排放的废水中含大量重金属离子、有机物及放射性核素等,若未经处理即排放会给环境带来了极大的危害。吸附法的效率高、操作简单、低成本且无副产物、可循环利用及无二次污染等优点使其成为废水处理的重要方法之一。由于农林废弃生物质成本低、来源丰富、绿色环保且可再生,以其为原料制备的吸附材料被广泛研究。本文主要针对以农林废弃生物质为原料制备的生物炭、纤维素及木质素为研究对象,综述了生物炭的制备及改性方法、天然纤维素及木质素的改性方法及其在水污染治理中的应用现状。从原材料、制备工艺、改性方法等方面总结分析了吸附材料的性能对水中污染物吸附的影响,提出了生物质基吸附材料在水污染治理应用中所存在的问题,并展望了未来的发展方向。 | 易锦馨 霍志鹏 Abdullah M.Asiri Khalid A.Alamry 李家星 | 2019 | 化学进展2019，31，5： | 22 |
| 6 | Long Non-coding RNAs in the Cytoplasm显示文摘An enormous amount of long non-coding RNAs(lnc RNAs) transcribed from eukaryotic genome are important regulators in different aspects of cellular events. Cytoplasm is the residence and the site of action for many lncRNAs. The cytoplasmic lncRNAs play indispensable roles with multiple molecular mechanisms in animal and human cells. In this review, we mainly talk about functions and the underlying mechanisms of lncRNAs in the cytoplasm. We highlight relatively well-studied examples of cytoplasmic lncRNAs for their roles in modulating mRNA stability,regulating m RNA translation, serving as competing endogenous RNAs, functioning as precursors of microRNAs, and mediating protein modifications. We also elaborate the perspectives of cytoplasmic lncRNA studies. | Farooq Rashid Abdullah Shah Ge Shan | 2016 | Genomics, Proteomics & Bioinformatics2016，14，2： | 21 |
| 7 | Toxic tau: structural origins of tau aggregation in Alzheimer’s disease显示文摘Alzheimer’s disease is characterized by the extracellular accumulation of the amyloidβin the form of amyloid plaques and the intracellular deposition of the microtubule-associated protein tau in the form of neurofibrillary tangles.Most of the Alzheimer’s drugs targeting amyloidβhave been failed in clinical trials.Particularly,tau pathology connects greatly in the pathogenesis of Alzheimer’s disease.Tau protein enhances the stabilization of microtubules that leads to the appropriate function of the neuron.Changes in the quantity or the conformation of tau protein could affect its function as a microtubules stabilizer and some of the processes wherein it is involved.The molecular mechanisms leading to the accumulation of tau are principally signified by numerous posttranslational modifications that change its conformation and structural state.Therefore,aberrant phosphorylation,as well as truncation of tau protein,has come into focus as significant mechanisms that make tau protein in a pathological entity.Furthermore,the shape-shifting nature of tau advocates to comprehend the progression of Alzheimer’s disease precisely.In this review,we emphasize the recent studies about the toxic and shape-shifting nature of tau in the pathogenesis of Alzheimer’s disease. | Abdullah Al Mamun Md.Sahab Uddin Bijo Mathew Ghulam Md Ashraf | 2020 | Neural Regeneration Research2020，15，8： | 21 |
| 8 | Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats显示文摘AIM:To evaluate the ameliorative effect of naringenin(NG)during ulcerative colitis(UC)in rats.METHODS:Rats were treated with three different doses(25,50 and 100 mg/kg per day)of NG and a single dose of mesalazine(MES,300 mg/kg per day)for seven days prior to ulcerative colitis induction by4%acetic acid(AA).Twenty four hours after AA rectal administration,animals were scarified and the colonic tissues were dissected.Colonic mucus content was estimated using Alcian blue dye binding technique.In colon tissues,levels of total glutathione sulphadryls(T-GSH),non-protein sulphadryls(NP-SH)and thiobarbituric acid reactive substances(TBARS)were evaluated.The activities of the antioxidant enzymes,catalase(CAT)and superoxide dismutase(SOD)were measured.Concentrations of nucleic acids(DNA and RNA)and total protein were also estimated in colon tissues.Colonic levels of tumor necrosis factor-(TNF-),interleukin-1(IL-1),interleukin-6(IL-6),prostaglandin E2(PGE2)and nitric oxide(NO)were estimated.In cross section of colitis tissue the histopathological changes were observed.RESULTS:Colonic mucus content was decreased in AA compared to controls(587.09±65.59 mg/kg vs941.78±68.41 mg/kg,P<0.001).AA administration markedly reduced T-GSH(5.25±0.37 nmol/L vs 3.04±0.24 nmol/L,P<0.01),NP-SH(3.16±0.04 nmol/L vs 2.16±0.30 nmol/L,P<0.01),CAT(6.77±0.40 U/mg vs 3.04±0.2 U/mg,P<0.01)and SOD(3.10±0.11U/mg vs 1.77±0.18 U/mg,P<0.01)while TBARS,TNF-,IL-1,IL-6,PGE2 and NO levels(15.09±3.84nmol/L vs 59.90±16.34 nmol/L,P<0.01;113.56±1.91 pg/mg vs 134.24±4.77 pg/mg,P<0.01;209.20±36.38 pg/mg vs 422.19±31.47 pg/mg,P<0.01;250.83±25.09 pg/mg vs 638.58±115.9 pg/mg,P<0.01;248.19±36.98 pg/mg vs 541.74±58.34 pg/mg,P<0.01 and 81.26±2.98 mmol/g vs 101.90±10.73 mmol/g,P<0.001)were increased in colon of rats with UC compared controls respectively.Naringenin supplementation,significantly and dose dependently increased the colonic mucus content.The elevated TBARS levels were significantly decreased(39.35±5.86nmol/L,P<0.05;26.74±3.17 nmol/L,P<0.01 nmol/L and 17.74±2.69 nmol/L,P<0.01)compared to AA(59.90±16.34 nmol/L)group while the decreased levels of T-GSH and NP-SH and activities of CAT and SOD found increased by NG treatments in dose dependent manner.The decreased values of nucleic acids and total protein in AA group were also significantly(P<0.01)increased in all three NG supplemented groupsrespectively.NG pretreatment inhibited the TNF-levels(123.76±3.76 pg/mg,122.62±3.41 pg/mg and121.51±2.61 pg/mg vs 134.24±4.78 pg/mg,P<0.05)compared to AA group,respectively.Interleukins,IL-1 and IL-6 levels were also decreased in NG50+AA(314.37±16.31 pg/mg and 292.58±23.68 pg/mg,P<0.05)and NG100+AA(416.72±49.62 pg/mg and 407.96±43.87 pg/mg,P<0.05)when compared to AA(352.46±8.58 pg/mg and 638.58±115.98pg/mg)group.Similar decrease(P<0.05)was seen in PGE2and NO values when compared to AA group.The group pretreated with MES,as a reference drug,showed significant(P<0.01)protection against the changes induced in colon tissue by AA administration respectively.CONCLUSION:In present study,NG produced antioxidant and anti-inflammatory effects demonstrating protective effect in inflammatory bowel disease. | Salim S Al-Rejaie Hatem M Abuohashish Maher M Al-Enazi Abdullah H Al-Assaf Mihir Y Parmar Mohammed M Ahmed | 2013 | World Journal of Gastroenterology2013，19，34： | 20 |
| 9 | 外语能力磨蚀的性别差异初探显示文摘对300余名大学生进行了英语阅读和听力测试,并从中随机抽取男女生各50名进行了写作测试,得出如下结论:(1)外语磨蚀程度存在明显的性别差异;(2)男女生在深度阅读、短对话听力以及段落听力方面的磨蚀差异不显著;(3)女生在快速阅读能力方面的磨蚀程度明显超过男生;(4)女生写作能力在切题性、连贯性以及清楚性方面的磨蚀程度显著大于男生,而在语言的正确性方面的磨蚀没有明显超过男生。 | 于中根 Chan Swee Heng Ain Nadzimah Bt Abdullah Bahaman bin Abu Samah Yap Ngee Thai | 2010 | 南京邮电大学学报(社会科学版)2010，12，2： | 19 |
| 10 | Influence of ellagic acid on prostate cancer cell proliferation:A caspase-dependent pathway显示文摘Objective:To evaluate the effect of allagic acid treatment on the cell viability of human prostate cancer cells.Methods:Ellagic acid(10-100 mol/L) treatment(48 h) of human prostate carcinoma PC3 cells was found to result in a dose-dependent inhibition of cell growth and apoptosis of PC3 cells as assessed by MTT assay,western blotting.flow cytometry and confocal microscopy.Results:We observed that ellagic acid treatment of PC3 cells resulted in a dose dependent inhibition of cell growth/cell viability.This ellagic acid caused cell growth inhibition was found to be accompanied by induction of apoptosis,as assessed by the cleavage of poly (ADP-ribose) polymerase(PARP) and morphological changes.Further,induction of apoptosis accompanied a decrease in the levels of antiapoptotic protein Bcl-2 and increase in proapoptotic protein Bax.thus shifting the Bax:Bcl-2 ratio in favor of apoptosis.Ellagic acid treatment of PC3 cells was also found to result in significant activation of caspases,as shown by the dose dependent decrease in the protein expression of procaspase-3,-6.-8 and -9.This ellagic acid-mediated induction of apoptosis was significantly(80%-90%) inhibited by the caspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone(Z-VAD-FMK).Thus these data suggested an essential role of caspases in ellagic acid-mediated apoptosis of PC3 cells.Conclusions:It is tempting to suggest that consumption of tropical pigmented fruits and vegetables could be an effective strategy to combat prostate cancer. | Arshi Malik Sarah Afaq Mohammad Shahid Kafil Akhtar Abdullah Assiri | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，7： | 18 |
| 11 | Salivary proteins and microbiota as biomarkers for early childhood caries risk assessment显示文摘Early childhood caries(ECC) is a term used to describe dental caries in children aged 6 years or younger. Oral streptococci, such as Streptococcus mutans and Streptococcus sorbrinus, are considered to be the main etiological agents of tooth decay in children. Other bacteria, such as Prevotella spp. and Lactobacillus spp., and fungus, that is, Candida albicans, are related to the development and progression of ECC. Biomolecules in saliva, mainly proteins, affect the survival of oral microorganisms by multiple innate defensive mechanisms, thus modulating the oral microflora. Therefore, the protein composition of saliva can be a sensitive indicator for dental health. Resistance or susceptibility to caries may be significantly correlated with alterations in salivary protein components. Some oral microorganisms and saliva proteins may serve as useful biomarkers in predicting the risk and prognosis of caries. Current research has generated abundant information that contributes to a better understanding of the roles of microorganisms and salivary proteins in ECC occurrence and prevention. This review summarizes the microorganisms that cause caries and tooth-protective salivary proteins with their potential as functional biomarkers for ECC risk assessment. The identification of biomarkers for children at high risk of ECC is not only critical for early diagnosis but also important for preventing and treating the disease. | abdullah s hemadi rui-jie huang yuan zhou jing zou | 2017 | International Journal of Oral Science2017，9，4： | 18 |
| 12 | Effects of melatonin on lipid peroxidation and antioxidant enzymes in streptozotocin-induced diabetic rat testis显示文摘瞄准:为了在 streptozotocin (STZ ) 的阴囊的组织每氧化(LPO ) 和抗氧化剂酶的活动在类脂化合物上检验 melatonin 治疗的效果,导致了糖尿病的老鼠。方法:26 只雄的老鼠随机如下被划分成三个组:组我,控制,非糖尿病的老鼠(n = 9 ) ;组 II,导致 STZ 的、未经治疗的糖尿病的老鼠(n = 8 ) ;组 III,导致 STZ,对待 melatonin (10 mg/kg 的剂量。白天) 糖尿病的老鼠(n = 9 ) 。后面的 8 星期的 melatonin 处理,所有老鼠被使麻木然后被打死把睾丸从阴囊移开。结果:作为与组相比我,在老鼠组 II 的阴囊的纸巾, malondialdehyde ( MDA )的增加的层次( P <
0.01 )并且超级氧化物歧化酶(草皮)( P <
0.01 )象过氧化氢酶(猫)的减少的层次一样( P <
0.01 )并且谷胱甘肽过氧化物酶( GSH-Px )( P >
0.05 )被发现。相反作为与组 II 相比,在老鼠组 III 的阴囊的纸巾, MDA 的层次减少了(但是这减少不是重要的, P >
0.05 ) 并且草皮(P <
0.01 ) 象猫一样(P <
0.05 ) 增加。GSH-Px 没被任何处理影响。Melatonin 显著地没影响糖尿病的组的提高的葡萄糖集中。在学习的结束,借助于身体和阴囊的重量在对待 melatonin 的组和未经治疗的组之间没有有效差量。结论:糖尿病增加氧化应力, melatonin 每氧化和力量禁止类脂化合物调整糖尿病的老鼠睾丸的抗氧化剂酶的活动。 | Abdullah Armagan EfkanUz H.RamazanYilmaz SedatSoyupek TaylanOksay Nurten Ozcelik | 2006 | Asian Journal of Andrology2006，8，5： | 17 |
| 13 | Ampullary carcinoma:Effect of preoperative biliary drainage on surgical outcome显示文摘AIM: To evaluate the influence of preoperative biliary drainage on morbidity and mortality after surgical resection for ampullary carcinoma. METHODS: We analyzed retrospectively data for 82 patients who underwent potentially curative surgery for ampullary carcinoma between September 1993 and July 2007 at the Singapore General Hospital, a tertiary referral hospital. Diagnosis of ampullary carcinoma was confirmed histologically. Thirty-five patients underwent preoperative biliary drainage (PBD group), and 47 were not drained (non-PBD group). The mode of biliary drainage was endoscopic retrograde cholangiopancreatography (n = 33) or percutaneous biliary drainage (n = 2). The following parameters were analyzed: wound infection, intra-abdominal abscess, intra-abdominal or gastrointestinal bleeding, septicemia, biliary or pancreatic leakage, pancreatitis, gastroparesis, and re-operation rate. Mortality was assessed at 30 d (hospital mortality) and also longterm. The statistical endpoint of this study was patient survival after surgery. RESULTS: The groups were well matched for demographic criteria, clinical presentation and operative characteristics, except for lower hemoglobin in the non-PBD group (10.9 ± 1.6 vs 11.8 ± 1.6 in the PBD group).Of the parameters assessing postoperative morbidity, incidence of wound infection was signif icantly less in the PBD than the non-PBD group [1 (2.9%) vs 12 (25.5%)]. However, the rest of the parameters did not differ signif icantly between the groups, i.e. sepsis [10 (28.6%) vs 14 (29.8%)], intra-abdominal bleeding [1 (2.9%) vs 5 (10.6%)], intra-abdominal abscess [1 (2.9%) vs 8 (17%)], gastrointestinal bleeding [3 (8.6%) vs 5 (10.6%)], pancreatic leakage [2 (5.7%) vs 3 (6.4%)], biliary leakage [2 (5.7%) vs 3 (6.4%)], pancreatitis [2 (5.7%) vs 2 (4.3%)], gastroparesis [6 (17.1%) vs 10 (21.3%)], need for blood transfusion [10 (28.6%) vs 17 (36.2%)] and re-operation rate [1 (2.9%) vs 5 (10.6%)]. There was no early mortality in either group. Median survival was 44 mo (95% CI: 34.2-53.8) in the PBD group and 41 mo (95% CI: 27.7-54.3; P = 0.86) in the non-PBD group. CONCLUSION: Biliary drainage before surgery for ampullary cancer significantly reduced postoperative wound infection. Overall mortality was not influenced by preoperative drainage. | Sheikh Anwar Abdullah Tarun Gupta Khairul Azhar Jaafar Yaw Fui Alexander Chung London Lucien Peng Jin Ooi Steven Joseph Mesenas | 2009 | World Journal of Gastroenterology2009，15，23： | 16 |
| 14 | Aetiology and risk factors of ischaemic cholangiopathy after liver transplantation显示文摘Liver transplantation(LT)is the best treatment for endstage hepatic failure,with an excellent survival rates over the last decade.Biliary complications after LT pose a major challenge especially with the increasing number of procured organs after circulatory death.Ischaemic cholangiopathy(IC)is a set of disorders characterized by multiple diffuse strictures affecting the graft biliary system in the absence of hepatic artery thrombosis or stenosis.It commonly presents with cholestasis and cholangitis resulting in higher readmission rates,longer length of stay,repeated therapeutic interventions,and eventually re-transplantation with consequent effects on the patient’s quality of life and increased health care costs.The pathogenesis of IC is unclear and exhibits a higher prevalence with prolonged ischaemia time,donation after circulatory death(DCD),rejection,and cytomegalovirus infection.The majority of IC occurs within 12 mo after LT.Prolonged warm ischaemic times predispose to a profound injury with a subsequently higher prevalence of IC.Biliary complications and IC rates are between 16%and 29%in DCD grafts com-pared to between 3%and 17%in donation after brain death(DBD)grafts.The majority of ischaemic biliary lesions occur within 30 d in DCD compared to 90 d in DBD grafts following transplantation.However,there are many other risk factors for IC that should be considered.The benefits of DCD in expanding the donor pool are hindered by the higher incidence of IC with increased rates of re-transplantation.Careful donor selection and procurement might help to optimize the utilization of DCD grafts. | Moustafa Mabrouk Mourad Abdullah Algarni Christos Liossis Simon R Bramhall | 2014 | World Journal of Gastroenterology2014，20，20： | 16 |
| 15 | Kinetic adsorption of application of carbon nanotubes for Pb(Ⅱ) removal from aqueous solution显示文摘The capability of carbon nanotubes (CNTs) to adsorb lead (Pb) in aqueous solution was investigated. Batch mode adsorption experiment was conducted to determine the effects of pH, agitation speed, CNTs dosage and contact time. The removal of Pb(Ⅱ) reached maximum value 85% or 83% at pH 5 or 40 mg/L of CNTs, respectively. Higher correlation coeffcients from Langmuir isotherm model indicates the strong adsorptions of Pb(Ⅱ) on the surface of CNTs (adsorption capacity Xm = 102.04 mg/g). The results indicates that the highest percentage removal of Pb (96.03%) can be achieved at pH 5, 40 mg/L of CNTs, contact time 80 min, and agitation speed 50 r/min. | Nassereldeen A Kabbashi Muataz A Atieh Abdullah Al-Mamun Mohamed E S Mirghami MD Z Alam Noorahayu Yahya | 2009 | Journal of Environmental Sciences2009，21，4： | 15 |
| 16 | Periodontopathogen profile of healthy and oral lichen planus patients with gingivitis or periodontitis显示文摘Oral lichen planus (OLP) is a chronic inflammatory disease that is frequently detected in oral tissues. The aim of our study was to identify the prevalence of the detection of periodontopathogenic microorganisms (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia and Treponema denticola in OLP patients and to compare with this prevalence of periodontopathogenic microorganisms in healthy non-OLP patients. Our study included 27 (18 chronic periodontitis (OLPP) and 9 gingivitis (OLPG)) patients diagnosed with OLP along with 26 (13 chronic periodontitis (HP) and 13 gingivitis (HG)) healthy non-OLP patients. The multiplex polymerase chain reaction (PCR) with subsequent reverse hybridization method (micro-IDent) was used for identifying periodontopathogenic microorganisms present in subgingival plaque samples. The percentages of detection for A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia and T. denticola in subgingival plaque samples taken from OLP patients (OLPG and OLPP) were 18.5%, 85.1%, 81.4%, 88.8% and 74%, respectively. Meanwhile, in the non-OLP patients (HG and HP), these values were 7.6%, 50%, 46.1%, 73% and 57.7%, respectively. Thus, comparing the non-OLP groups with the OLP groups, the periodontopathogens' percentages of detection in the OLP groups were higher than those in the non-OLP groups. According to our study results, OLP patients have higher levels of infection with A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia and T. denticola than non-OLP patients. We argue that the high percentages in patients with OLP may help identify the importance of periodontopathogenic microorganisms in the progress of periodontal diseases of OLP. | Abdullah Seckin Ertugrul Ugur Arslan Recep Dursun Sema Sezgin Hakki | 2013 | International Journal of Oral Science2013，5，2： | 15 |
| 17 | CeO_2-TiO_2 as a visible light active catalyst for the photoreduction of CO_2 to methanol显示文摘The performance of CeO2-TiO2 photocatalyst for the photocatalytic reduction of CO2 into methanol was studied under visible light irradiation. The as-prepared catalysts were characterized for their structural, textural and optical properties using X-ray diffraction(XRD), field emission scanning electron microscopy(FESEM), X-ray photoelectron spectroscopy(XPS), nitrogen physisorption analysis, UV-vis spectroscopy and photoluminescence(PL) spectroscopy. The characterization results indicated that the presence of CeO2 stabilized the anatase phase of TiO2, decreased its crystallite size, increased the surface area, reduced the band gap energy and lowered the rate of electron-hole pair recombination. The CeO2-TiO2 photocatalyst showed an increased methanol yield of 18.6 μmol/g under visible light irradiation, compared to the bare TiO2(6.0 μmol/g). | Hamidah Abdullah Maksudur R.Khan Manoj Pudukudy Zahira Yaakob Nur Aminatulmimi Ismail | 2015 | Journal of Rare Earths2015，33，11： | 15 |
| 18 | Big data storage technologies: a survey显示文摘对于容量快速增长、日趋多元化的大数据,业界亟需开发可行性更好的存储工具。为满足大数据存储需求,存储机制已经形成从传统数据管理系统到No SQL技术的结构化转移。然而,目前可用的大数据存储技术无法为持续增长的异构数据提供一致、可扩展和可用的解决方案。在科学实验、医疗保健、社交网络和电子商务等实际应用中,存储是大数据分析的第一步。截至目前,亚马逊、谷歌和阿帕奇等公司形成了大数据存储方案的行业标准,但尚未有关于大数据存储技术性能和容量提升的深入调查和文献报告。本文旨在对目前可用于大数据的最先进的存储技术进行全面调查,提供了一个明确的大数据存储技术分类方法,以帮助数据分析师和研究人员了解和选择更适合其需求的存储机制。我们使用布鲁尔的CAP定理比较和分析了现有存储方法,评估了不同存储架构的性能,讨论了存储技术的意义、应用及其对其他类别数据的支持。为了加快部署可靠和可扩展的存储系统,文中还突出了未来研究面临的几个挑战。 | Aisha SIDDIQA Ahmad KARIM Abdullah GANI | 2017 | Frontiers of Information Technology & Electronic Engineering2017，18，8： | 15 |
| 19 | Hepatitis E virus: Epidemiology, diagnosis, clinical manifestations, and treatment显示文摘The hepatitis E virus(HEV)is the fifth known form of viral hepatitis and was first recognized as the cause of an epidemic of unexplained acute hepatitis in the early 1980s.Globally,it is one of the most frequent causes of acute viral hepatitis.The majority of HEV infections are asymptomatic and lead to the spontaneous clearance of the virus.Among the eight different genotypes identified to date,HEV genotype 1(HEV1),HEV2,HEV3,and HEV4 are the most frequent genotypes causing infections in humans.HEV1 and HEV2 are prevalent in developing regions and able to result in large-scale outbreaks originating from contaminated water supplies.They are also responsible for severe hepatitis in pregnant patients and infants.In contrast,HEV3 and HEV4 are zoonotic,and the transmission of these genotypes to humans occurs mainly through the fecal contamination of water and consumption of contaminated meat from infected animals.Their main reservoir is the pig,and they are mostly encountered in developed countries.The major risk groups for HEV infection and its ensuing adverse consequences are pregnant women,infants,older people,immunocompromised individuals,patients with underlying chronic liver diseases,and workers that come into close contact with HEV-infected animals.In the clinical perspective,HEV infections have diverse clinical manifestations including acute and self-limiting hepatitis,acute-on-chronic liver disease,chronic hepatitis,cirrhosis,and liver failure.Although HEV mainly results in acute selflimiting infection,chronic HEV infection may occur among immunocompromised patients(e.g.,solid-organ transplant recipients).Additionally,HEV-associated extrahepatic manifestations involving various organs have been reported in the last decade,although the causal link for many of them still needs to be proven.Ribavirin and interferon-alpha are the most widely used agents for the treatment of HEV infections with a certain level of success.However,ribavirin is contraindicated in pregnant patients,and interferon-alpha cannot be used in most transplant recipients.Therefore,there is an urgent need for novel antiviral compounds that are safe and effective particularly for patients having contraindications for ribavirin or interferon-alpha and infected by the ribavirinresistant HEV.In this review article,a literature search using PubMed and MEDLINE databases was performed,up to March 2020.Only the articles published in English were reviewed. | Abdullah Tarık Aslan Hatice Yasemin Balaban | 2020 | World Journal of Gastroenterology2020，26，37： | 15 |
| 20 | Understanding mechanisms of the pathogenesis of nonalcoholic fatty liver disease显示文摘A central issue in the understanding of the pathogenesis of nonalcoholic fatty liver disease is the problem of the underlying mechanisms which are not fully understood.In the setting of excessive central adiposity,insulin resistance is the major underlying cause of fat accumulation in hepatocytes.Because of the difficulties with human trials,several animal models have been developed for this purpose mainly characterized as follows:genetically disturbed or murine fatty liver,methionine-choline deficient diet fed or murine steatohepatitis,and high-fat or sucrose diet fed models.Although these animal models have provided useful information,none of them accurately reflect genetic,metabolic and biochemical characteristics of the human disease. | Metin Basaranoglu Serra Kayacetin Nevin Yilmaz Ertugrul Kayacetin Orhan Tarcin Abdullah Sonsuz | 2010 | World Journal of Gastroenterology2010，16，18： | 14 |
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