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| 1 | Hepatitis B genotypes: Relation to clinical outcome in patients with chronic hepatitis B in Saudi Arabia显示文摘AIM: To identify the most common hepatitis B virus (HBV) genotype in Saudi Arabia, and correlate the prevailing genotypes with the clinical outcome of patients. METHODS: Patients were consecutively recruited from the hepatology clinics of two tertiary care referral cen- ters. Patients were categorized into 4 different groups: group 1, patients with hepatitis B and normal liver en- zymes; group 2, patients with hepatitis B and abnormal liver enzymes but without cirrhosis; group 3, patients with hepatitis B and liver cirrhosis; group 4, patients with hepatitis B and hepatocellular carcinoma. All patients had a positive hepatitis B surface antigen (HBsAg). Ge- notyping of HBV was performed by nested PCR-mediated amplification of the target sequence and hybridization with sequence-specific oligonucleotides. RESULTS: Seventy patients were enrolled in this study. They were predominantly male (72.9%) in their mid- forty’s (mean age 47 years). Forty-nine (70%) patients were hepatitis B envelope antigen (HBeAg) negative. The majority of patients (64%) acquired HBV through unknown risk factors. Hepatitis B genotyping revealed that 57 patients (81.4%) were genotype D, 1 patient (1.4%) had genotype A, 1 patient (1.4%) had geno- type C, and 4 patients (5.7%) had genotype E, while 7 patients (10%) had mixed genotype (4 patients ADG, 1 patient DE, 1 patient DF, and 1 patient ADFG). Based on univariate analysis of genotype D patients, significant predictors of advanced liver disease were age, gender, aspartate transaminase, alanine transaminase, albumin,bilirubin, and alkaline phosphatase (all P < 0.001). In multivariate analysis decreased hemoglobin (r = -0.05; 95% CI: -0.08 to -0.03; P = 0.001) and albumin levels (r = -0.004; 95% CI: -0.007 to -0.001; P = 0.002) were highly significant predictors of advanced liver disease. In patients with HBV genotype D, HBeAg negativity was found to increase across advancing stages of liver dis- ease (P = 0.024). CONCLUSION: This study highlights that the vast ma- jority of Saudi patients with chronic hepatitis B have genotype D. No correlation could be observed between the different genotypes and epidemiological or clinical factors. The relationship between genotype D and HBeAg status in terms of disease severity needs to be further elucidated in larger longitudinal studies. | Ayman A Abdo Badr M Al-Jarallah Faisal M Sanai Ahmad S Hersi Khalid Al-Swat Nahla A Azzam Manal Al-Dukhayil Amira Al-Maarik Faleh Z Al-Faleh | 2006 | World Journal of Gastroenterology2006，12，43： | 7 |
| 2 | Diferences in the composi-tion of vaginal microbial communities found in healthy Cauca-sian and black women显示文摘 | Zhou X Brown CJ Abdo Z | 2007 | ISME J2007，1，2： | 1 |
| 3 | Vaginal microbiome of reproduc- tive-age women显示文摘 | Ravel J Gajer P Abdo Z | 2011 | Proc Nat Acad Sci U S A2011，108，1： | 1 |
| 4 | A step toward barcoding life a model based, decision theoretic method to assign genes to preexisting species groups显示文摘 | ABDO Z GOLD1NG G B | 2007 | Syst Bio12007，56，1： | 1 |
| 5 | Advances in the use of terminal restriction fragment length polymorphism (T-RFLP) analysis of 16S rRNA genes to characterize microbial communities 显示文摘 | Sch ti tte Ursel M E Abdo Z Bent St J | 2008 | Applied Microbiology and Biotechnology2008，80，3： | 1 |
| 6 | Minimally invasive, nonendoscopic thyroid surgery 显示文摘 | Ferzli GS Sayad P Abdo Z | 2001 | J Am Coll Surg2001，192，5： | 1 |
| 7 | Advances in the use of terminal restriction fragment length polymorphism (T-RFLP) analysis of 16S rRNA genes to characterize microbial communities 显示文摘 | Schtitte U M E Abdo Z Bent S J | 2008 | Applied Microbiology and Bio- technology2008，80，3： | 1 |
| 8 | Contrasting codon usage patterns and purifying selection at the mating locus in putatively asexual Alternaria fungal species 显示文摘 | Stewart J E Kawabe M Abdo Z | 2011 | PLoS One2011，6，20： | 1 |
| 9 | Minimally invasive,nonendoscopic thyroid surgery显示文摘 | Ferzli GS Sayad P Abdo Z | 2001 | J Am Coll Surg2001，192，5： | 1 |
| 10 | Vaginal microbiome of reproductive-age women显示文摘 | Ravel J Gajer P Abdo Z | 2011 | Proc Natl Acad Sci U S A2011，108，1： | 1 |
| 11 | Advances in the use of terminal restriction fragment length polymorphism (T-RFLP) analysis of 16S rRNA genes to characterize microbial communities显示文摘 | Schütte U E Abdo Z Bent S J | 2008 | Applied Microbiology and Biotechnology2008，80，3： | 1 |
| 12 | Advances in the use of terminal restriction fragment length polymorphism (T-RFLP) analysis of 16S rRNA genes to characterize microbial communities显示文摘 | Schiitte UME Abdo Z Bent S J | 2008 | Applied Microbiology and Biotechnology2008，80，3： | 1 |
| 13 | Differences inthe composition of vaginal microbial community healthyfound in Caucasian and black woman显示文摘 | ZHOU X BROWN C J ABDO Z | 2007 | ISME Journal2007，1，2： | 1 |
| 14 | Efficient use of animal manure on cropland economic analysis显示文摘 | ARAJI A A ABDO Z O JOYCE P | 2001 | Bioresource Technology2001，79，： | 1 |
| 15 | Vaginal microbiome of repro- ductive-age women显示文摘 | Ravel J Gajer P Abdo Z | 2011 | Proc Natl Acad Sci U S A2011，，： | 1 |
| 16 | Vaginal microbiome of reproductive- age women 显示文摘 | Ravel J Gajer P Abdo Z | 2011 | Proc Natl Acad Sci U S A2011，108，1： | 1 |
| 17 | Vaginal mierobiome of repro- duetive-age women显示文摘 | Ravel J Gajer P Abdo Z | 2011 | Proc Natl Acad Sci U S A2011，108，1： | 1 |
| 18 | Effect of a commercial housing system on egg quality during extended storage显示文摘 | JONES D R KARCHER D M ABDO Z | 2014 | Poultry Science2014，，5： | 1 |
| 19 | A step toward barcoding life: a model-based, decision theoretic method to assign genes to pre - existing species groups显示文摘 | ABDO Z GOLDING G B | 2007 | Systematic Biology2007，56，： | 1 |
| 20 | Differences in the composition of vaginal microbial communities found in healthy Caucasian and black women显示文摘 | Zhou X Brown C J Abdo Z | 2007 | ISME J2007，1，2： | 1 |
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