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| 1 | Juvenile polyposis syndrome显示文摘Juvenile polyposis syndrome is a rare autosomal dominant syndrome characterized by multiple distinct juvenile polyps in the gastrointestinal tract and an increased risk of colorectal cancer.The cumulative life-time risk of colorectal cancer is 39% and the relative risk is 34.Juvenile polyps have a distinctive histology characterized by an abundance of edematous lamina propria with inflammatory cells and cystically dilated glands lined by cuboidal to columnar epithelium with reactive changes.Clinically,juvenile polyposis syndrome is defined by the presence of 5 or more juvenile polyps in the colorectum,juvenile polyps throughout the gastrointestinal tract or any number of juvenile polyps and a positive family history of juvenile polyposis.In about 50%-60% of patients diagnosed with juvenile polyposis syndrome a germline mutation in the SMAD4 or BMPR1A gene is found.Both genes play a role in the BMP/TGF-beta signalling pathway.It has been suggested that cancer in juvenile polyposis may develop through the socalled 'landscaper mechanism' where an abnormal stromal environment leads to neoplastic transformation of the adjacent epithelium and in the end invasive carcinoma.Recognition of this rare disorder is important for patients and their families with regard to treatment,follow-up and screening of at risk individuals.Each clinician confronted with the diagnosis of a juvenile polyp should therefore consider the possibility of juvenile polyposis syndrome.In addition,juvenile polyposis syndrome provides a unique model to study colorectal cancer pathogenesis in general and gives insight in the molecular genetic basis of cancer.This review discusses clinical manifestations,genetics,pathogenesis and management of juvenile polyposis syndrome. | Lodewijk AA Brosens Danielle Langeveld W Arnout van Hattem Francis M Giardiello G Johan A Offerhaus | 2011 | World Journal of Gastroenterology2011，17，44： | 7 |
| 2 | 血压变异性预测自发性脑出血患者的院内不良预后显示文摘越来越多的证据表明,较高的收缩压变异性(systolicblood pressure variability ,SBPV)可能与脑出血患者的不良预后相关。该研究探讨了 SB PV 与院内脑出血预后之间的关系。研究者在2个医疗系统中收集了10年的自发性脑出血患者的连续数据。记录人口统计学、病史、实验室测试、计算机断层扫描数据、院内治疗情况以及神经和功能评估。在入院后24h内获取血压记录。 | 刘青 叶鹏 Divani AA Liu X Di Napoli M Lattanzi S Ziai W James ML Jafarli A Jafari M Saver JL Hemphill JC Vespa PM Mayer SA Petersen A | 2019 | 中华高血压杂志2019，27，8： | 6 |
| 3 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 4 | GAP-43 expression is upregulated in retinal ganglion ceils after ischemia/reperfusion-induced damage 显示文摘 | Dijk F Bergen AA Kamphuis W | 2007 | Exp Eye Res2007，84，： | 1 |
| 5 | Tensile strength of the medial patellofemoral ligament before and after repair or recon- struction显示文摘 | Mountney J Senavongse W Amis AA | 2005 | J Bone Joint Surg Br2005，87，1： | 1 |
| 6 | GAP-43 expression is upregulated in retinal ganglion cells after ischemia/reperfusioninduced damage显示文摘 | Dijk F Bergen AA Kamphuis W | 2007 | Exp Eye Res2007，84，： | 1 |
| 7 | Computed tomography of the nasopharyhx:Normal and variantsof normal显示文摘 | Mancuso AA Bohman L Hanafee W | 1980 | Radiology1980，137，2： | 1 |
| 8 | Experimental verification of the i- dentity of variant-specific surface proteins in Giardia lamblia trophozoites显示文摘 | Li W Saraiya AA Wang CC | 2015 | Am Soc Microbiol2015，4，00： | 1 |
| 9 | Targeting Hedgehog-a cancer stem cell pathway显示文摘 | Merchant AA Matsui W | 2010 | Clin Cancer Res2010，16，12： | 1 |
| 10 | A microRNA derived from an ap- parent canonical biogenesis pathway regulates variant surface pro- tein gene expression in Giardia lamblia显示文摘 | Saraiya AA Li W Wang CC | 2011 | RNA2011，17，12： | 1 |
| 11 | Discorvery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2(SGLT2) inhibitor for the treatment of type 2 diabetes显示文摘 | Meng W Ellsworth BA Nirschl AA | 2008 | J Med Chem2008，51，5： | 1 |
| 12 | The cellular response to protein misfolding in the endoplasmic reticulum显示文摘 | Wehllnda AA Tirasophon W Kaufinan R | 1999 | Gene Expr1999，7，46： | 1 |
| 13 | Thrombolysis for ischemic stroke in the United States:data fromNationa l Hospital Discharge Survey 1999-2001显示文摘 | Suri MF Nasar A He W Kirmani JF Divani AA PrestiqiacomoCJ Low RB | 2005 | Neurosurgery2005，57，65： | 1 |
| 14 | Discovery of dapagliflozin:a potent,selective renal sodium-dependent glucose cotransporter 2 (SGLT2)inhibitor for the treatment of type 2 diabetes显示文摘 | Meng W Ellsworth BA Nirschl AA | 2008 | J Med Chem2008，51，5： | 1 |
| 15 | A stress response pathway from the endoplas-mic reticulum to the nucleus requires a novel bifunctional protein kinase! endoribonuclease (Irelp) in mammalian cells显示文摘 | Tirasophon W Welihinda AA Kaufman RJ | 1998 | Genes Dev1998，2，： | 1 |
| 16 | Urban material flow analysis:An approach for Bogotá,Colombia显示文摘 | Piaa W H A Martínezb C I P | 2014 | Ecological Indicators2014，42，： | 1 |
| 17 | Gene regulation in Giardia lam- bia involves a putative microRNA derived from a small nucleolar RNA显示文摘 | Li W Saraiya AA Wang CC | 2011 | PLoS Negl Trop Dis2011，5，10： | 1 |
| 18 | Haemodynamic and catechol- amine stress responses to the Laryngeal Tube Suction Airway and the Proseal Laryngeal Mask Airway显示文摘 | Dahaba AA Prax N Gaube W | 2006 | Aneasthesia2006，61，4： | 1 |
| 19 | C-peptide prevents nociceptive sensory neuropathy in type 1 diabetes显示文摘 | Kamiya H Zhang W Sima AA | 2004 | Ann Neurol2004，56，6： | 1 |
| 20 | The tumor suppressor PP2A Abeta regulates the RalA GTPase显示文摘 | Sablina AA Chen W Arroyo JD | 2007 | Cell2007，129，5： | 1 |
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