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| 1 | A Combination of Midazolam and Ketamine for Procedural Sedation and Analgesia in Adult Emergency Department Patients显示文摘 | Carl R.Chudnofsky James E.Weber Peter J.Stoyanoff Pino D.Colone Mark D.Wilkerson Diane L.Hallinen F. MichaelJaggi Michael E.Boczar Marcia A.Perry | 2008 | Academic Emergency Medicine2008，，3： | 1 |
| 2 | The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration显示文摘Diet-induced obesity has previously been shown to occur with the concomitant rise in the expression of proin-flammatory cytokines and increases in collagen deposition.While it has been known that the regenerative process of skeletal muscle is altered in obese mice following an acute muscle injury,we sought to examine differences in the expression of various markers of extracellular matrix remodeling and repair.Our laboratory has previously reported an impaired inflammatory and protein synthetic signaling in these mice that may contribute negatively to the muscle regenerative process.To expand upon this previous investigation,tissues from these animals un-derwent further analysis to determine the extent of changes to the regenerative response within the extracellular matrix,including transcriptional changes in CollagenⅠ,CollagenⅢ,and Fibronectin.Here,we show that the expression of CollagenⅢ:Ⅰis significantly increased at 3-days post-injury in obese injured animals compared to lean injured animals(p=0.0338),and by 28-days the obese injured animals exhibit a significantly lower CollagenⅢ:Ⅰthan their lean injured counterparts(p=0.0035).We demonstrate an impaired response to an acute muscle injury in obese mice when compared with lean counterparts.However,further studies are required to elucidate translational consequences of these changes,as well as to determine any causative mechanisms that may be driving this effect. | J.William Deaver Eleanor R.Schrems Lemuel A.Brown Wesley A.Haynie Richard A.Perry Jr. Megan E.Rosa-Caldwell Michelle A.Tedrowe Nicholas P.Greene Tyrone A.Washington | 2021 | Sports Medicine and Health Science2021，3，4： | 0 |
| 3 | Effects of PGC-1αoverexpression on the myogenic response during skeletal muscle regeneration显示文摘The ability of skeletal muscle to regenerate from injury is crucial for locomotion,metabolic health,and quality of life.Peroxisome proliferator-activated receptor-γcoactivator-1α(PGC1A)is a transcriptional coactivator required for mitochondrial biogenesis.Increased mitochondrial biogenesis is associated with improved muscle cell differentiation,however PGC1A's role in skeletal muscle regeneration following damage requires further investigation.The purpose of this study was to investigate the role of skeletal muscle-specific PGC1A overexpression during regeneration following damage.22 C57BL/6J(WT)and 26 PGC1A muscle transgenic(A1)mice were injected with either phosphate-buffered saline(PBS,uninjured control)or Bupivacaine(MAR,injured)into their tibialis anterior(TA)muscle to induce skeletal muscle damage.TA muscles were extracted 3-or 28-days postinjury and analyzed for markers of regenerative myogenesis and protein turnover.Pgc1a mRNA was~10–20 fold greater in A1 mice.Markers of protein synthesis,AKT and 4EBP1,displayed decreases in A1 mice compared to WT at both timepoints indicating a decreased protein synthetic response.Myod mRNA was~75%lower compared to WT 3 days post-injection.WT mice exhibited decreased cross-sectional area of the TA muscle at 28 days post-injection with bupivacaine compared to all other groups.PGC1A overexpression modifies the myogenic response during regeneration. | Tyrone A.Washington Wesley S.Haynie Eleanor R.Schrems Richard A.Perry Jr. Lemuel A.Brown Breanna M.Williams Megan E.Rosa-Caldwell David E.Lee Jacob L.Brown | 2022 | Sports Medicine and Health Science2022，4，3： | 0 |
| 4 | 先进的前道CMP设备及整合解决方法显示文摘概述了未来IC器件可采用的前道CMP设备及整合解决方法的巨大进展。为提高设备的可用性和生产线的运作效率,在一台设备上采用多用途的整合解决方法。而且,对这些方法与下一代无磨料网膜抛光设备的能力进行了比较。未来数代器件要求的CMP工艺技术包括先进的抛光头、先进的现场终点系统、多平台、多抛光头结构。与下一代消耗品(单独硬抛光垫、高平面性磨料、无磨料抛光等)结合,能使直接抛光浅沟槽隔离(STI)工艺方法满足0.18μm乃至更小特征尺寸的器件要求。采用新型多步工艺进行了多晶硅CMP。先进的多晶硅金属介质(PMD)抛光工艺展示了更长寿命的抛光垫和更高的金刚石盘片生产效率和更强的设备可用性。这些工艺技术已全部成功地使用在生产线,并正在生产中进行测试。 | Raymond R.Jin Sen-Hou Ko Benjamin A.Bonner Shijian Li Thomas H.Osterheld Kathleen A.Perry | 2003 | 电子工业专用设备2003，32，6： | 0 |
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