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| 1 | The effect of acute aerobic exercise on central arterial stiffness,wave reflections,and hemodynamics in adults with diabetes:A randomized cross-over design显示文摘Background:Individuals with diabetes have greater central arterial stiffness,wave reflections,and hemodynamics,all of which promote the accelerated cardiovascular pathology seen in this population.Acute aerobic exercise has been shown to be an effective strategy for reducing central arterial stiffness,wave reflections,and hemodynamics in healthy individuals;however,the effects of acute aerobic exercise in reducing these outcomes is not well established in people with diabetes.Recently,implementation of high-intensity interval exercise(HIIE)has shown superior improvements in cardiovascular health outcomes when compared to traditional aerobic exercise.Yet,the effect of HIIE on the aforementioned outcomes in people with diabetes is not known.The purpose of this study was to(i)describe the central arterial stiffness,wave reflections,and hemodynamic responses to a bout of HIIE and moderate-intensity continuous exercise(MICE)in adults with diabetes;and(ii)compare the effects of HIIE and MICE on the aforementioned outcomes.Methods:A total of 24 adult men and women(aged 29-59 years old)with type 1(n=12)and type 2(n=12)diabetes participated in a randomized cross-over study.All participants completed the following protocols:(i)HIIE:cycling for 4×4 min at 85%-95%of heart rate peak(HR_(peak)),interspersed with 3 min of active recovery at 60%-70%HR_(peak);(ii)MICE:33 min of continuous cycling at 60%-70%HR_(peak);and(iii)control(CON):lying quietly in a supine position for 30 min.Results:A significant group￡time effect was found for changes in central systolic blood pressure(F=3.20,p=0.01)with a transient reduction for the HIIE group but not for the MICE or CON groups.There was a significant group￡time effect for changes in augmentation index at a heart rate of 75 beats/min(F=2.32,p=0.04)with a decrease following for HIIE and MICE but not for CON.For all other measures of central arterial stiffness and hemodynamics,no significant changes were observed(p>0.05).Conclusion:A bout of HIIE appears to lead to a greater transient reduction in central systolic blood pressure than the reduction observed following MICE;however,both HIIE and MICE improved augmentation index at a heart rate of 75 beats/min in people with diabetes.There was no significant difference in response to HIIE and MICE in all outcomes.This provides preliminary evidence on the role of HIIE on such outcomes in people with diabetes. | Kimberley L.Way Angela S.Lee Stephen M.Twigg Nathan A.Johnson | 2021 | Journal of Sport and Health Science2021，10，4： | 4 |
| 2 | Effects of therapeutic horseback riding on post-traumatic stress disorder in military veterans显示文摘Background:Large numbers of post-deployment U.S.veterans are diagnosed with post-traumatic stress disorder(PTSD)and/or traumatic brain injury(TBI),leading to an urgent need for effective interventions to reduce symptoms and increase veterans’coping.PTSD includes anxiety,flashbacks,and emotional numbing.The symptoms increase health care costs for stress-related illnesses and can make veterans’civilian life difficult.Methods:We used a randomized wait-list controlled design with repeated measures of U.S.military veterans to address our specific aim to test the efficacy of a 6-week therapeutic horseback riding(THR)program for decreasing PTSD symptoms and increasing coping self-efficacy,emotion regulation,social and emotional loneliness.Fiftyseven participants were recruited and 29 enrolled in the randomized trial.They were randomly assigned to either the horse riding group(n=15)or a wait-list control group(n=14).The wait-list control group experienced a 6-week waiting period,while the horse riding group began THR.The wait-list control group began riding after 6 weeks of participating in the control group.Demographic and health history information was obtained from all the participants.PTSD symptoms were measured using the standardized PTSD Checklist-Military Version(PCL-M).The PCL-M as well as other instruments including,The Coping Self Efficacy Scale(CSES),The Difficulties in Emotion Regulation Scale(DERS)and The Social and Emotional Loneliness Scale for Adults-short version(SELSA)were used to access different aspects of individual well-being and the PTSD symptoms.Results:Participants had a statistically significant decrease in PTSD scores after 3 weeks of THR(P≤0.01)as well as a statistically and clinically significant decrease after 6 weeks of THR(P≤0.01).Logistic regression showed that participants had a 66.7%likelihood of having lower PTSD scores at 3 weeks and 87.5%likelihood at 6 weeks.Under the generalized linear model(GLM),our ANOVA findings for the coping self-efficacy,emotion regulation,and social and emotional loneliness did not reach statistical significance.The results for coping self-efficacy and emotion regulation trended in the predicted direction.Results for emotional loneliness were opposite the predicted direction.Logistic regression provided validation that outcome effects were caused by riding longer.Conclusion:The findings suggest that THR may be a clinically effective intervention for alleviating PTSD symptoms in military veterans. | Rebecca A.Johnson David L.Albright James R.Marzolf Jessica L.Bibbo Hayley D.Yaglom Sandra M.Crowder Gretchen K.Carlisle Amy Willard Cynthia L.Russell Karen Grindler Steven Osterlind Marita Wassman Nathan Harms | 2018 | Military Medical Research2018，5，1： | 3 |
| 3 | Functional roles of ornithine decarboxylase and arginine decarboxylase during the peri-implantation period of pregnancy in sheep显示文摘Background: Polyamines stimulate DNA transcription and m RNA translation for protein synthesis in trophectoderm cells, as well as proliferation and migration of cells; therefore, they are essential for development and survival of conceptuses(embryo/fetus and placenta). The ovine conceptus produces polyamines via classical and non-classical pathways. In the classical pathway, arginine(Arg) is transformed into ornithine, which is then decarboxylated by ornithine decarboxylase(ODC1) to produce putrescine which is the substrate for the production of spermidine and spermine. In the non-classical pathway, Arg is converted to agmatine(Agm) by arginine decarboxylase(ADC), and Agm is converted to putrescine by agmatinase(AGMAT).Methods: Morpholino antisense oligonucleotides(MAOs) were designed and synthesized to inhibit translational initiation of the m RNAs for ODC1 and ADC, in ovine conceptuses.Results: The morphologies of MAO control, MAO-ODC1, and MAO-ADC conceptuses were normal. Double knockdown of ODC1 and ADC(MAO-ODC1:ADC) resulted in two phenotypes of conceptuses; 33% of conceptuses appeared to be morphological y and functional y normal(phenotype a) and 67% of the conceptuses presented an abnormal morphology and functionality(phenotype b). Furthermore, MAO-ODC1:ADC(a) conceptuses had greater tissue concentrations of Agm,putrescine, and spermidine than MAO control conceptuses, while MAO-ODC1:ADC(b) conceptuses only had greater tissue concentrations of Agm. Uterine flushes from ewes with MAO-ODC1:ADC(a) had greater amounts of arginine, aspartate, tyrosine, citrulline, lysine, phenylalanine, isoleucine, leucine, and glutamine, while uterine flushes of ewes with MAO-ODC1:ADC(b) conceptuses had lower amount of putrescine, spermidine, spermine, alanine, aspartate,glutamine, tyrosine, phenylalanine, isoleucine, leucine, and lysine.Conclusions: The double-knockdown of translation of ODC1 and ADC m RNAs was most detrimental to conceptus development and their production of interferon tau(IFNT). Agm, polyamines, amino acids, and adequate secretion of IFNT are critical for establishment and maintenance of pregnancy during the peri-implantation period of gestation in sheep. | Yasser Y.Lenis Gregory A.Johnson Xiaoqiu Wang Wendy W.Tang Kathrin A.Dunlap M.Carey Satterfield Guoyao Wu Thomas R.Hansen Fuller W.Bazer | 2018 | Journal of Animal Science and Biotechnology2018，9，2： | 3 |
| 4 | 加拿大档案馆社交媒体利用研究显示文摘通过对加拿大档案馆运用社交媒体的调查发现:利用社交媒体吸引档案用户的档案馆较少。该调查分析了648个档案馆在2011年11月11日至2012年1月10日期间使用社交媒体的情况,并记录了用户对于各类社交媒体的利用程度。此次调研表明:社交媒体在增加用户和档案馆之间互动的同时,促使档案馆更加民主化,也更加有利于馆藏资源的优化和档案事业的发展。 | Wendy M.Duff Catherine A.Johnson Joan M.Cherry 沈春会 刘彩云 蔡娜 | 2014 | 档案2014，，6： | 2 |
| 5 | 世界猪人工授精技术研究和应用现状显示文摘1948年伊藤、丹羽等首先报道利用新鲜猪精液的实际应用技术,而后1956年 Polge 也作了报道。但是打开猪冷冻精液商品化利用之路乃是1971年的事。1971年 Graham 等、Crabro 和 Einarsson 以及 Pursel 和 Johnson 同时报道,将冻精经子宫颈管道输入,成功产下仔猪。1975年发明了简便的冷冻及解冻方法后冷冻精液作为商品使用。 | 陶永辉 Beltsville Lawrence A.Johnson | 1991 | 国外畜牧学(猪与禽)1991，，2： | 2 |
| 6 | 岩石中的非线性弹性和应力引起的各向异性:实验结果分析显示文摘由应力—应变曲线不符合虎克定律所表示的岩石的非线性弹性特性归因于存在着的机械损害(断裂、微裂缝、晶粒节理……),这是一个经典的答案。本文的目的是将非线性与波的应力效应,亦即P波各向异性及S波双折射联系起来。并根据有关文献中关于均匀岩石的为数不多的实验数据,对非线性弹性常数或Murnaghan系数进行了量化。与“完整”的(没有机械损害的材料)均匀固体相反,岩石都能够呈现由弱到强的非线性并总是以同样的方式(即模量随压力的增加而增加)。因此,应力引起的P波各向异性和S波双折射可能是广泛存在的。对多种岩石所做的实验表明:在施加的压力较低的情况下,这种因果律可得到充分证实。 | Paul A.Johnson 王德琪 | 1994 | 石油物探译丛1994，，6： | 2 |
| 7 | Select nutrients and their effects on conceptus development in mammals显示文摘The dialogue between the mammalian conceptus(embryo/fetus and associated membranes) involves signaling for pregnancy recognition and maintenance of pregnancy during the critical peri-implantation period of pregnancy when the stage is set for implantation and placentation that precedes fetal development. Uterine epithelial cells secrete and/or transport a wide range of molecules, including nutrients,collectively referred to as histotroph that are transported into the fetal-placental vascular system to support growth and development of the conceptus. The availability of uterine-derived histotroph has long-term consequences for the health and well-being of the fetus and the prevention of adult onset of metabolic diseases. Histotroph includes numerous amino acids, but arginine plays a particularly important role as a source of nitric oxide and polyamines required for fetal-placental development in rodents, swine and humans through mechanisms that remain to be fully elucidated. Mechanisms whereby arginine regulates expression of genes via the mechanistic target of rapamycin cell signaling pathways critical to conceptus development, implantation and placentation are discussed in detail in this review. | Fuller W.Bazer Xiaoqiu Wang Greg A.Johnson Guoyao Wu | 2015 | Animal Nutrition2015，，3： | 2 |
| 8 | Urbanization,Industrialization,and Crime in Imperial Germany:Part Ⅰ显示文摘 | Vincent E.McHale Eric A.Johnson | | 0，，01： | 1 |
| 9 | Intestinal fibrosis is reduced by early elimination of inflammation in a mouse model of IBD: Impact of a “Top‐Down” approach to intestinal fibrosis in mice显示文摘 | Laura A.Johnson AmyLuke KaySauder David S.Moons Jeffrey C.Horowitz Peter D.R.Higgins | 2012 | Inflamm Bowel Dis2012，，3： | 1 |
| 10 | 猪精子性别分离技术的最新进展显示文摘前言预选后代家畜性别,可提高畜牧生产的效益。其中两个主要好处是加速遗传进展和改善猪群的经营管理。Lush从1925年就开始研究分离X和Y精子。此后,大量试验在授精前分离带X和Y染色体的精子,以改变后代的性比例,但是都没有取得明显进展(见Amann,1989综述)。最近Johnson(1989;1991)报道了家免和猪性别预选精子授精的试验结果。用DNA作标记成功的关键是通过重新分析DNA含量来评价分离的X和Y精子群,用于证实分离的X和Y精子比例,以便预选后代的性别。最后将预选的性别和后代的实际性别作相关计算。 | Lawrence A.Johnson 张雨 | 1993 | 国外畜牧科技1993，20，2： | 1 |
| 11 | Functional Properties of Improved Glycinin and β‐nglycinin Fractions显示文摘 | D. A.Rickert L. A.Johnson P. A.Murphy | 2006 | Journal of Food Science2006，，4： | 1 |
| 12 | 小麦族多年生根茎类禾草的生态地理分布及利用显示文摘分析了小麦族各属根茎类禾草在我国和世界的种数分布、主要种的生态类型及生境特征、建群种或优势种群落的植物组成生态类群和地理分布 。 | 谷安琳 易津 Douglas A.Johnson | 2000 | 中国草地2000，22，6： | 1 |
| 13 | The Nrf2–ARE Pathway显示文摘 | Jeffrey A.Johnson Delinda A.Johnson Andrew D.Kraft Marcus J.Calkins Rebekah J.Jakel Marcelo R.Vargas Pei‐ChunChen | 2008 | Annals of the New York Academy of Sciences2008，，1： | 1 |
| 14 | Selective reduction in complicated monochorionic pregnancies: radiofrequency ablation vs. bipolar cord coagulation显示文摘 | A.Roman R.Papanna A.Johnson S. S.Hassan J.Moldenhauer S.Molina K. J.Moise | 2010 | Ultrasound Obstet Gynecol2010，，1： | 1 |
| 15 | LBY135, a novel anti‐DR5 agonistic antibody induces tumor cell–specific cytotoxic activity in human colon tumor cell lines and xenografts显示文摘 | JingLi Deborah A.Knee YouzhenWang QingxiuZhang Jennifer A.Johnson JaneCheng HelenHe ChristineMiller ZhifangLi ColleenKowal JosephEckman BettyTang JingYuan LiqingChen QuinnDeveraux Marc S.Nasoff DavidStover | 2008 | Drug Dev Res2008，，2： | 1 |
| 16 | Prognostic significance of secondary cytogenetic alterations in follicular lymphomas显示文摘 | Nathalie A.Johnson AbdulAl‐Tourah Carolyn. J.Brown Joseph M.Connors Randy D.Gascoyne Douglas E.Horsman | 2008 | Genes Chromosom. Cancer2008，，12： | 1 |
| 17 | Systematic review: the burden of disruptive gastro‐oesophageal reflux disease on health‐related quality of life显示文摘 | A.Becher D. A.Johnson | 2012 | Aliment Pharmacol Ther2012，，11： | 1 |
| 18 | 在人数多的外语教学班级中使用交际法来评估交际能力显示文摘很多国家中,一个把英语作为外语教学的口语班级里往往有三十到五十甚至更多的学生,他们是通过语法翻译法来学习外语的,因此,听和说的能力都很差。学习外语的传统方法——重复和记忆使这些学生有较大的词汇量,并且通晓不同程度的语法规则。然而他们学到的词汇常常和实际生活中的情景脱节,也通常不会在语法正确的句子中使用那些即使是最基本的词汇。 | Judith A.Johnson 朱钟毅 | 1991 | 外语教学理论与实践1991，，3： | 1 |
| 19 | Pre-implantation exogenous progesterone and pregnancy in sheep.II.Effects on fetalplacental development and nutrient transporters in late pregnancy显示文摘Background:Administration of progesterone(P4)to ewes during the first 9 to 12 days of pregnancy accelerates blastocyst development by day 12 of pregnancy,likely due to P4-induced up-regulation of key genes in uterine epithelia responsible for secretion and transport of components of histotroph into the uterine lumen.This study determined if acceleration of blastocyst development induced by exogenous P4 during the pre-implantation period affects fetal-placental development on day 125 of pregnancy.Suffolk ewes(n=35)were mated to fertile rams and assigned randomly to receive daily intramuscular injections of either corn oil vehicle(CO,n=18)or 25 mg progesterone in CO(P4,n=17)for the first 8 days of pregnancy.All ewes were hysterectomized on day 125 of pregnancy and:1)fetal and placental weights and measurements were recorded;2)endometrial and placental tissues were analyzed for the expression of candidate mRNAs involved in nutrient transport and arginine metabolism;and 3)maternal plasma,fetal plasma,allantoic fluid,and amniotic fluid were analyzed for amino acids,agmatine,polyamines,glucose,and fructose.Results:Treatment of ewes with exogenous P4 did not alter fetal or placental growth,but increased amounts of aspartate and arginine in allantoic fluid and amniotic fluid,respectively.Ewes that received exogenous P4 had greater expression of mRNAs for SLC7A1,SLC7A2,SLC2A1,AGMAT,and ODC1 in endometria,as well as SLC1A4,SLC2A5,SLC2A8 and ODC1 in placentomes.In addition,AZIN2 protein was immunolocalized to uterine luminal and glandular epithelia in P4-treated ewes,whereas AZIN2 localized only to uterine luminal epithelia in CO-treated ewes.Conclusions:This study revealed that exogenous P4 administered in early pregnancy influenced expression of selected genes for nutrient transporters and the expression of a protein involved in polyamine synthesis on day 125 of pregnancy,suggesting a‘programming’effect of P4 on gene expression that affected the composition of nutrients in fetal-placental fluids. | Katherine M.Halloran Emily C.Hoskins Claire Stenhouse Robyn M.Moses Kathrin A.Dunlap M.Carey Satterfield Heewon Seo Gregory A.Johnson Guoyao Wu Fuller W.Bazer | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 1 |
| 20 | Inhibitory Effects of 7‐Carboxymethyloxy‐3′,4′,5‐Trimethoxy Flavone (DA‐6034) on Helicobacter pylori‐Induced NF‐κB Activation and iNOS Expression in AGS Cells显示文摘 | JEONG‐SANGLEE HYUN‐SOOKIM KI‐BAIKHAHM MI‐WONSOHN MOOHIYOO JEFFREY A.JOHNSON YOUNG‐JOONSURH | 2007 | Annals of the New York Academy of Sciences2007，，1： | 1 |
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