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| 1 | 北美神经内分泌肿瘤学会和核医学与分子影像学会有关177Lu-DOTATATE肽受体放射性核素治疗患者选择和合理应用共识显示文摘随着177Lu-1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸-D-苯丙氨酸1-酪氨酸3-苏氨酸8-奥曲肽(DOTATATE)肽受体放射性核素治疗(PRRT)的日益普及,有关患者合理选择的问题日益增多。该文回顾了有关177Lu-DOTATATE在不同原发性神经内分泌肿瘤(NETs)中的应用文献,讨论了一些有争议的问题,并回顾了治疗的潜在禁忌证。此共识是由北美神经内分泌肿瘤学会(NANETS)和核医学与分子影像学会(SNMMI)共同制定的。NANETS是成立于2005年的北美多学科神经内分泌专家专业学会,目的在于通过增加研究和教育机会改善对NETs的管理。NANETS致力于多学科研究,由NETs涉及的不同专业的医师和科学家组成。SNMMI成立于1954年,旨在促进核医学科学、技术和实践应用的国际性科学专业组织,除了出版期刊、时事通讯和书籍外,还主办提高核医学从业人员能力和促进核医学科学新发展的国际会议及讲习班。 | 邓艳(译) 张伟(审校) Thomas A.Hope Lisa Bodei Jennifer A.Chan Ghassan El-Haddad Nicholas Fidelman Pamela L.Kunz Josh Mailman Yusuf Menda David C.Metz Erik S.Mittra Daniel A.Pryma Diane L.Reidy-Lagunes Simron Singh Jonathan R.Strosberg | 2020 | 中华核医学与分子影像杂志2020，40，11： | 11 |
| 2 | Knowledge exchange behaviors of science park firms:the innovation hub case显示文摘 | Kai-Ying A.Chan Leon A.G.Oerlemans Marthinus W.Pretorius | | 0，，02： | 1 |
| 3 | The role of land use on the local climate and air quality during calm inter-monsoon in a tropical city显示文摘The modification of land use is known to be a major climate change driver to the local warming and air quality in cities. Despite the reduction of NOx over the years, the Selangor state has captured a higher level of O_3 in year 2011. The measurement result has shown that the surge in O_3 level was attributed to the reduction of NO_x/NMHC ratio. This paper hence attempted to identify the role of land use change from 1999 to 2011 on the ground ozone air quality in the tropical urban conurbation, Greater Kuala Lumpur(GKL), Selangor, Malaysia. With the state-of-the-art chemical weather prediction tool, WRFChem, the external synoptic factors and emission inventory were controlled when comparing the chronological land use changes. The results showed that the urban-induced temperature and wind bias in the tropical region has induced stronger wind to disperse the NO_x and carries the TVOC from the suburban to the downwind urban region. The reduction of NO_x/TVOC has gradually shifted towards the optimum O_3 formation regime in 2011. The formation of highly concentrated ozone becomes more sensitive to the increment of TVOC as the NO_x level reduces in the urban. This highlights the essential involvement of TVOC in the ozone formation in lieu of the NOx reduction in the tropical city, a region with growing emitter of reactive biogenic ozone precursors. | M.C.G.Ooi A.Chan M.J.Ashfold M.Y.Oozeer K.I.Morris S.S.K.Kong | 2019 | Geoscience Frontiers2019，10，2： | 1 |
| 4 | On measuring the change in size of pulmonary nodules显示文摘 | A.Reeves A.Chan D.Yankelevitz | | 0，，25： | 1 |
| 5 | Unraveling the molecular genetics of head and neck cancer through genome-wide approaches显示文摘The past decade has seen an unprecedented increase in our understanding of the biology and etiology of head and neck squamous cell carcinomas(HNSCC).Genome-wide sequencing projects have identified a number of recurrently mutated genes,including unexpected alterations in the NOTCH pathway and chromatin related genes.Gene-expression profiling has identified 4 distinct genetic subtypes which show some parallels to lung squamous cell carcinoma biology.The identification of the human papilloma virus as one causative agent in a subset of oropharyngeal cancers and their association with a favorable prognosis has opened up avenues for new therapeutic strategies.The expanding knowledge of the underlying molecular abnormalities in this once very poorly understood cancer should allow for increasingly rational clinical trial design and improved patient outcomes. | Nadeem Riaz Luc G.Morris William Lee Timothy A.Chan | 2014 | Genes & Diseases2014，1，1： | 1 |
| 6 | Multimodal single-cell omics analysis identifies epithelium-immune cell interactions and immune vulnerability associated with sex differences in COVID-19显示文摘Sex differences in the susceptibility of SARS-CoV-2 infection and severity have been controversial,and the underlying mechanisms of COVID-19 in a sex-specific manner remain understudied.Here we inspected sex differences in SARS-CoV-2 infection,hospitalization,admission to the intensive care unit(ICU),sera inflammatory biomarker profiling,and single-cell RNA-sequencing(scRNA-seq)profiles across nasal,bronchoalveolar lavage fluid(BALF),and peripheral blood mononuclear cells(PBMCs)from COVID-19 patients with varying degrees of disease severities.Our propensity score-matching observations revealed that male individuals have a 29%elevated likelihood of SARS-CoV-2 positivity,with a hazard ratio(HR)1.32(95%confidence interval[Cl]1.18-1.48)for hospitalization and HR 1.51(95%Cl 1.24-1.84)for admission to ICU.Sera from male patients at hospital admission had elevated neutrophil-lymphocyte ratio and elevated expression of inflammatory markers(C-reactive protein and procalcitonin).We found that SARS-CoV-2 entry factors,including ACE2,TMPRSS2,FURIN,and NRP1,have elevated expression in nasal squamous cells from male individuals with moderate and severe COVID-19.We observed male-biased transcriptional activation in SARS-CoV-2-infected macrophages from BALF and sputum samples,which offers potential molecular mechanism for sex-biased susceptibility to viral infection.Cell-cell interaction network analysis reveals potential epithelium-immune cell interactions and immune vulnerability underlying male-elevated disease severity and mortality in COVID-19.Mechanistically,monocyte-elevated expression of Toll-like receptor 7{TLR7)and Bruton tyrosine kinase{BTK)is associated with severe outcomes in males with COVID-19.In summary,these findings provide basis to decipher immune responses underlying sex differences and designing sex-specific targeted interventions and patient care for COVID-19. | Yuan Hou Yadi Zhou Michaela U.Gack Justin D.Lathia Asha Kallianpur Reena Mehra Timothy A.Chan Jae U.Jung Lara Jehi Charis Eng Feixiong Cheng | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 0 |
| 7 | 舍二求一,任重道远——专访法拉帝集团亚太区代表陈钢显示文摘2008年1月10日.法拉帝游艇公司(Ferretti Yachts)在上海宣布:和记行(集团)有限公司旗下的坚荣控股有限公司正式成为法拉帝豪华游艇中国区总代理.之前该公司在内地南北区各设一个代理商的情况将不复存在。法拉帝游艇公司亚太区总经理Giuseppe Zecchin先生与和记行主席李文辉先生共同表示.双方将紧密合作,为中国客户打造最完美的游艇之梦。本刊记者就此专访了法拉帝集团亚太区代表陈钢.以求解开该公司在内地代理商“舍二求一”的真正原因。 | A.Chan(采编) 陈钢(图) | 2008 | 游艇业2008，，1： | 0 |
| 8 | 应对钻井挑战的先进技术和解决方案——为应对钻井产业相关的服务、设备、工具和材料成本的显著提高,必须采用先进高效的技术提高钻井效率显示文摘随着钻进速度的大幅提升,与钻井产业相关的服务、设备、工具和材料成本也显著提高,但现有油气井和油气藏产量却在不断下降,因此必须采用先进高效的技术在可控成本下提高钻井效率。从第三代双台肩接头、深水钻井对座放管柱的高抗拉性能要求、深水钻井井下摩擦生热造成的钻杆破坏以及酸性环境下全套抗SSC钻柱系统(包括摩擦焊缝)的研究等方面介绍了钻井技术的最新进展,解决了与深水钻井钻柱相关的实际问题,井指出深水钻井中大位移、大斜度和深层油气藏钻井的挑战趋势将持续增加,还需要不断改进和提高钻杆和钴柱构件的性能,并持续探索创新型解决方案以克服油气工业面临的各种挑战。 | M. J. Jellison A.Chan | 2016 | 世界石油工业2016，0，3： | 0 |
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