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| 1 | 海水中天然细菌对不同生源要素有机物的矿化作用显示文摘海洋异养细菌是微食物网中非常重要的一部分,它消耗海洋中的溶解有机物并进行细菌的二次生产。细菌对不同种类的溶解有机物分解速率不同,并且有机物的生物利用率影响细菌的生长。研究了含有不同生源要素的4种溶解有机物(DOM)在海洋异养细菌存在下的矿化作用及对细菌生长的影响。结果表明:添加不同生源要素的有机物,对海洋天然异养细菌的生长均有促进作用,其比生长速率(μ)的大小顺序为:N>C>P>S>对照组,说明含氮有机物更有助于细菌的生长;细菌生长效率(BGE)的大小顺序为:对照组>C>P>N>S,说明细菌的二次生产跟有机物的分解速率没有直接相关性;单个细菌对有机物的消耗速率I为:N>C>P>S>对照组,说明细菌生长速率与有机物消耗速率直接相关;有机物的生物可利用性顺序为:N>C>P>S>对照组,与有机物的消耗速率顺序一致。上述结果表明,具有相同结构但不同生源要素的有机物的矿化速率存在差异,含氮有机物最容易分解,其次是含碳有机物,然后是含磷有机物,含硫有机物分解最慢,说明细菌对含有不同生源要素有机物的分解利用存在差异。 | 谭丽菊 肖慧 Craig A.Carlson 王江涛 | 2016 | 生态学报2016，36，1： | 5 |
| 2 | Novel fibrin-fibronectin matrix accelerates mice skin wound healing显示文摘Plasma fibrinogen(F1)and fibronectin(pFN)polymerize to form a fibrin clot that is both a hemostatic and provisional matrix for wound healing.About 90%of plasma F1 has a homodimeric pair ofγchains(γγF1),and 10%has a heterodimeric pair ofγand more acidicγ′chains(γγ′F1).We have synthesized a novel fibrin matrix exclusively from a 1:1(molar ratio)complex ofγγ′F1 and pFN in the presence of highly active thrombin and recombinant Factor XIII(rFXIIIa).In this matrix,the fibrin nanofibers were decorated with pFN nanoclusters(termedγγ′F1:pFN fibrin).In contrast,fibrin made from 1:1 mixture ofγγF1 and pFN formed a sporadic distribution of“pFN droplets”(termedγγF1+pFN fibrin).Theγγ′F1:pFN fibrin enhanced the adhesion of primary human umbilical vein endothelium cells(HUVECs)relative to theγγF1+FN fibrin.Three dimensional(3D)culturing showed that theγγ′F1:pFN complex fibrin matrix enhanced the proliferation of both HUVECs and primary human fibroblasts.HUVECs in the 3Dγγ′F1:pFN fibrin exhibited a starkly enhanced vascular morphogenesis while an apoptotic growth profile was observed in theγγF1+pFN fibrin.Relative toγγF1+pFN fibrin,mouse dermal wounds that were sealed byγγ′F1:pFN fibrin exhibited accelerated and enhanced healing.This study suggests that a 3D pFN presentation on a fibrin matrix promotes wound healing. | Carlos Poblete Jara Ou Wang Thais Paulino do Prado Ayman Ismail Frank Marco Fabian Han Li Licio A.Velloso Mark A.Carlson William Burgess Yuguo Lei William H.Velander Eliana P.Araújo | 2020 | Bioactive Materials2020，5，4： | 5 |
| 3 | 查看详情显示文摘 | C.E.Valdivia E.Desfonds D.Masson S.Fafard A.Carlson J.Cook T.J.Hall and K.Hinzer | | 0，，： | 1 |
| 4 | Bioengineering strategies for the treatment of peripheral arterial disease显示文摘Peripheral arterial disease(PAD)is a progressive atherosclerotic disorder characterized by narrowing and occlusion of arteries supplying the lower extremities.Approximately 200 million people worldwide are affected by PAD.The current standard of operative care is open or endovascular revascularization in which blood flow restoration is the goal.However,many patients are not appropriate candidates for these treatments and are subject to continuous ischemia of their lower limbs.Current research in the therapy of PAD involves developing modalities that induce angiogenesis,but the results of simple cell transplantation or growth factor delivery have been found to be relatively poor mainly due to difficulties in stem cell retention and survival and rapid diffusion and enzymolysis of growth factors following injection of these agents in the affected tissues.Biomaterials,including hydrogels,have the capability to protect stem cells during injection and to support cell survival.Hydrogels can also provide a sustained release of growth factors at the injection site.This review will focus on biomaterial systems currently being investigated as carriers for cell and growth factor delivery,and will also discuss biomaterials as a potential stand-alone method for the treatment of PAD.Finally,the challenges of development and use of biomaterials systems for PAD treatment will be reviewed. | Cui Li Oliver Kitzerow Fujiao Nie Jingxuan Dai Xiaoyan Liu Mark A.Carlson George P.Casale Iraklis I.Pipinos Xiaowei Li | 2021 | Bioactive Materials2021，6，3： | 0 |
| 5 | Research highlights from the Status report for step it up! The surgeon general's call to action to promote walking and walkable communities显示文摘In September 2015,the Office of the Surgeon General,U.S.Department of Health and Human Services,released Step it up!The surgeon general’s call to action to promote walking and walkable communities(Call to Action)to increase walking among people across the USA.1The Call to Action also recognized that walkable communities can accommodate wheelchair rolling and are inclusive of persons with disabilities.The Status Report for the Call to Action was released in 2017。 | David R.Brown Susan A.Carlson Gayathri S.Kumar Janet E.Fulton | 2018 | Journal of Sport and Health Science2018，7，1： | 0 |
| 6 | Genetic diseases conferring resistance to infectious diseases显示文摘This review considers available evidence for mechanisms of conferred adaptive advantages in the face of specific infectious diseases.In short,we explore a number of genetic conditions,which carry some benefits in adverse circumstances including exposure to infectious agents.The examples discussed are conditions known to result in resistance to a specific infectious disease,or have been proposed as being associated with resistance to various infectious diseases.These infectious diseasedgenetic disorder pairings include malaria and hemoglobinopathies,cholera and cystic fibrosis,tuberculosis and Tay-Sachs disease,mycotic abortions and phenylketonuria,infection by enveloped viruses and disorders of glycosylation,infection by filoviruses and NiemannePick C1 disease,as well as rabies and myasthenia gravis.We also discuss two genetic conditions that lead to infectious disease hypersusceptibility,although we did not cover the large number of immunologic defects leading to infectious disease hypersusceptibilities.Four of the resistance-associated pairings(malaria/hemogloginopathies,cholera/cystic fibrosis,tuberculosis/Tay-Sachs,and mycotic abortions/phenylketonuria)appear to be a result of selection pressures in geographic regions in which the specific infectious agent is endemic.The other pairings do not appear to be based on selection pressure and instead may be serendipitous.Nonetheless,research investigating these relationships may lead to treatment options for the aforementioned diseases by exploiting established mechanisms between genetically affected cells and infectious organisms.This may prove invaluable as a starting point for research in the case of diseases that currently have no reliably curative treatments,e.g.,HIV,rabies,and Ebola. | Isabelle C.Withrock Stephen J.Anderson Matthew A.Jefferson Garrett R.McCormack Gregory S.A.Mlynarczyk Aron Nakama Jennifer K.Lange Carrie A.Berg Sreemoyee Acharya Matthew L.Stock Melissa S.Lind K.C.Luna Naveen C.Kondru Sireesha Manne Bhavika B.Patel Bierlein Mde la Rosa Kuei-Pin Huang Shaunik Sharma Hilary Z.Hu Sri Harsha Kanuri Steve A.Carlson | 2015 | Genes & Diseases2015，2，3： | 0 |
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