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| 1 | Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease显示文摘 | A.Ansari C.Hassan J.Duley A.Marinaki E. ‐M.Shobowale‐Bakre P.Seed J.Meenan A.Yim J.Sanderson | 2002 | Alimentary Pharmacology & Therapeutics2002，，10： | 1 |
| 2 | Treatment with a JAK1/2 inhibitor ameliorates murine autoimmune cholangitis induced by IFN overexpression显示文摘The interferon(IFN)signaling pathways are major immunological checkpoints with clinical significance in the pathogenesis of autoimmunity.We have generated a unique murine model named ARE-Del,with chronic overexpression of IFNγ,by altering IFNγmetabolism.Importantly,these mice develop an immunologic and clinical profile similar to patients with primary biliary cholangitis,including high titers of autoantibodies and portal inflammation.We hypothesized that the downregulation of IFN signaling pathways with a JAK1/2 inhibitor would inhibit the development and progression of cholangitis.To study this hypothesis,ARE-Del^(+/−)mice were treated with the JAK1/2 inhibitor ruxolitinib and serially studied.JAK inhibition resulted in a significant reduction in portal inflammation and bile duct damage,associated with a significant reduction in splenic and hepatic CD4^(+)T cells and CD8^(+)T cells.Functionally,ruxolitinib inhibited the secretion of the proinflammatory cytokines IFNγand TNF from splenic CD4^(+)T cells.Additionally,ruxolitinib treatment also decreased the frequencies of germinal center B(GC B)cells and T follicular helper(Tfh)cells and led to lower serological AMA levels.Of note,liver and peritoneal macrophages were sharply decreased and polarized from M1 to M2 with a higher level of IRF4 expression after ruxolitinib treatment.Mechanistically,ruxolitinib inhibited the secretion of IL-6,TNF and MCP1 and the expression of STAT1 but promoted the expression of STAT6 in macrophages in vitro,indicating that M1 macrophage polarization to M2 occurred through activation of the STAT6-IRF4 pathway.Our data highlight the significance,both immunologically and clinically,of the JAK/STAT signaling pathway in autoimmune cholangitis. | Tihong Shao Patrick S.C.Leung Weici Zhang Koichi Tsuneyama William M.Ridgway Howard A.Young Zongwen Shuai Aftab A.Ansari M.Eric Gershwi | 2022 | Cellular & Molecular Immunology2022，19，10： | 1 |
| 3 | The multi‐hit hypothesis of primary biliary cirrhosis: polyinosinic‐polycytidylic acid (poly I:C) and murine autoimmune cholangitis显示文摘 | Y. M.Ambrosini G.‐X.Yang W.Zhang M.Tsuda S.Shu K.Tsuneyama P. S. C.Leung A. A.Ansari R. L.Coppel M. E.Gershwin | 2011 | Clinical & Experimental Immunology2011，，1： | 1 |
| 4 | The Love of Money and Pay Level Satisfaction: Measurement and Functional Equivalence in 29 Geopolitical Entities around the World显示文摘 | Thomas Li‐PingTang TotoSutarso AdebowaleAkande Michael W.Allen Abdulgawi SalimAlzubaidi Mahfooz A.Ansari FernandoArias‐Galicia Mark G.Borg LuiginaCanova BrigitteCharles‐Pauvers Bor‐ShiuanCheng Randy K.Chiu LinzhiDu IlyaGarber Consuelo Garcia De LaTorre Ro | 2006 | Management and Organization Review2006，，3： | 1 |
| 5 | Optical and electrical properties of electrochemically deposited polyaniline/CeO2 hybrid nanocomposite film显示文摘This paper reports the optical and electrical properties of electrochemically deposited polyaniline (PANI)/cerium oxide(CeO2) hybrid nano-composite film onto indium-tin-oxide(ITO) glass substrate.UV-visible spectroscopy andⅠ-Ⅴcharacteristic were performed to study the optical and electrical parameters of the electrochemically deposited film.The film exhibited a strong absorption below 400 nm(3.10 eV) with a well defined absorbance peak at around 285 nm(4.35 eV).The estimated band gap of the CeO2 sample was 3.44 eV,higher than bulk CeO2 powder(Eg = 3.19 eV) due to the quantum confinement effect.Optical and electrochemical characteristics indicated that the electrical properties of PANI/CeO2 hybrid nanocomposite film arc dominated by PANI doping. | Anees A.Ansari M.A.M.Khan M.Naziruddin Khan Salman A.Alrokayan M.Alhoshan M.S.Alsalhi | 2011 | Journal of Semiconductors2011，32，4： | 1 |
| 6 | Optical and structural properties of sol-gel derived nanostructured CeO_2 film显示文摘Sol-gel derived nanostructured CeO_2 film was deposited on glass substrate using by dip-coating technique with annealing at 650℃.X-ray diffraction(XRD),scanning electron microscopy(SEM),Fourier transform infrared (FTIR),UV/vis and photoluminescence(PL) spectroscopy studies were employed to analyze the structural and optical properties of the sol-gel derived nanostructured CeO_2 film.The average crystallite size was estimated from the XRD pattern using by Scherrer equation as about 3-4 nm.An SEM micrograph shows that the film was porous in nature and crack free.The UV-visible absorption spectroscopic measurement results showed that the products had conspicuous quantum size effects.The absorption spectrum indicates that the sol-gel derived nanostructured CeO_2 film has a direct bandgap of 3.23 eV and the photoluminescence spectra of the film show a strong band at 378 nm:it may have a promising application as an optoelectronic material. | Anees A.Ansari | 2010 | Journal of Semiconductors2010，31，5： | 1 |
| 7 | Nanoporous characteristics of sol-gel-derived ZnO thin film显示文摘Sol-gel-derived nanoporous ZnO film has been successfully deposited on glass substrate at 200℃and subsequently annealed at different temperatures of 300,400 and 600℃.Atomic force micrographs demonstrated that the film was crack-free,and that granular nanoparticles were homogenously distributed on the film surface. The average grain size of the nanoparticles and RMS roughness of the scanned surface area was 10 nm and 13.6 nm,respectively,which is due to the high porosity of the film.Photoluminescence(PL) spectra of the nanoporous ZnO film at room temperature show a diffused band,which might be due to an increased amount of oxygen vacancies on the lattice surface.The observed results of the nanoporous ZnO film indicates a promising application in the development of electrochemical biosensors due to the porosity of film enhancing the higher loading of biomacromolecules (enzyme and proteins). | Anees A.Ansari M.A.M.Khan M.Alhoshan S.A.Alrokayan M.S.Alsalhi | 2012 | Journal of Semiconductors2012，33，4： | 0 |
| 8 | Impact of surface coating on morphological, optical and photoluminescence properties of YF3:Tb^3+ nanoparticles显示文摘A simple polyol and sol–gel Stober process were employed for synthesis of YF_3:Tb^+(core), YF_3:Tb^+@LaF_3(core/shell) and YF_3:Tb^+@LaF_3@SiO_2(core/shell/SiO_2) nanoparticles(NPs). The phase purity, crystalinity,morphology, optical and photoluminescence properties were investigated and discussed with the help of various analytical techniques including X-ray diffraction pattern,FE-transmission electron microscopy(TEM),FTIR, UV/vis absorption, energy band gap and emission spectra. XRD andFE-TEM studies indicate the formation of core/shell nanostructure and ~10 nm thick amorphous silica surface coating surrounding the core-NPs, which is also confirmed byFTIR spectral results. The surface modifications of core-NPs significantly affect the optical features in the form of energy band gap, which were correlated with particle size of the nanomaterials. The comparative emission spectral results show that after inert layer coating the luminescent core-NPs display stronger emission intensity in respect to core and silica coated core/shell/SiO_2-NPs. The solubility character along with colloidal stability was improved after silica surface modification, whereas luminescent intensity was suppressed causing the surface functionalized with high energy silanol(Si-OH) molecules. These novel luminescent nanomaterials with enhanced emission intensity and excellent solubility in aqueous solvents would be potentially useful for fluorescence bioimaging/optical bio-probe etc. | Anees A.Ansari | 2017 | Chinese Chemical Letters2017，28，3： | 0 |
| 9 | Impact of environmental factors on COVID-19 cases and mortalities in major cities of Pakistan显示文摘Introduction:Climate factors play an important role in the transmission of viruses,such as influenza viruses,MERS-CoV,and SARS-CoV-1.This study aimed to determine the relationship between changes in temperature,humidity,rainfall,and SARS-CoV-2 contagion.Five ecologically and climatically distinct regions were considered—Karachi,Lahore,Islamabad,Peshawar,and Gilgit-Baltistan.Method:Data on daily COVID-19 cases and deaths were retrieved from government officials,while meteorological information was collected from Pakistan Meteorological Department.Statistical analysis was performed using SPSS version 20 and the Spearman rank correlation test was used to analyze the correlation between the meteorological factors and COVID-19 cases and deaths.Result:Positive correlation of COVID-19 incidence was observed with all the temperature ranges(maximum,minimum and average)and negative correlation was seen with humidity,DTR and rainfall.COVID-19 deaths were positively associated with temperature and were negatively associated only with humidity.Linear regression showed that for every unit increase in humidity,there was a3.345 daily signifi-cant decrease in COVID-19 cases,while in Karachi for every unit increase in humidity,there remained a 10.104 daily significant increase in cases.In Gilgit-Baltistan,for every unit increase in average temperature and rainfall respectively,significant increases of 0.534 and 1.286 in daily cases were found.Conclusion:This study signifies the effect of climate factors on COVID-19 incidence and mortality rate,but climate factors are not the only variable and several other interlinked factors enhance the spread of COVID-19.Hence,effective mitigation policies,enhancing testing capacities,and developing public attitudes toward adopting precautionary measures are important to overcome this overwhelming pandemic. | Rabia Basray Amber Malik Wajiha Waqar Ambreen Chaudhry Muhammad Wasif Malik Mumtaz Ali Khan Jamil A.Ansari Aamir Ikram | 2021 | Journal of Biosafety and Biosecurity2021，3，1： | 0 |
| 10 | Synthesis,Structural and Optical Properties of Mn-Doped Ceria Nanoparticles:A Promising Catalytic Material显示文摘The structure,the morphology and the thermal,optical and the surface properties of nanocrystalline CeO_2 doped with Mn have been studied by X-ray diffraction(XRD),field-emission transmission electron microscopy(FE-TEM),energy-dispersive X-ray analysis,thermogravimetric analysis,UV–Vis absorption spectroscopy and Fourier transform infrared spectroscopy.The XRD results confirmed the successful incorporation of Mn into the CeO_2 lattice through the formation of nanoscale face-centered cubic solid solution.The FE-TEM observations supported the nanocrystalline nature of the solid solutions.The presence of structural defects and their role on the band gap have been discussed on the basis of absorption spectral studies.The structural differences correlate with results from temperature-programmed reaction(TPR)experiments with H_2 consumption.The TPR measurements showed an enhanced bulk reduction at much lower temperatures,indicating increased oxygen mobility in the samples,which enable to enhanced oxygen diffusion at lower temperatures. | Anees A.Ansari Joselito P.Labis Manawwer Alam Shahid M.Ramay Naushad Ahmad Asif Mahmood | 2016 | Acta Metallurgica Sinica(English Letters)2016，29，3： | 0 |
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