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| 1 | Acute pancreatitis in aging animals:Loss of pancreatitis-associated protein protection?显示文摘AIM:To investigate the effect of age on severity of acute pancreatitis(AP) using biochemical markers,histology and expression of the protective pancreatitisassociated proteins(PAPs).METHODS:AP was induced via intraductal injection of 4% sodium taurocholate in young and old rats.Sera and pancreata were assayed at 24 h for the parameters listed above;we also employed a novel molecular technique to assess bacterial infiltration using polymerase chain reaction to measure bacterial genomic ribosomal RNA.RESULTS:At 24 h after induction of AP,the pancreata of older animals had less edema(mean ± SE histologic score of young vs old:3.11 ± 0.16 vs 2.50 ±-0.11,P < 0.05),decreased local inflammatory response(histologic score of stromal infiltrate:3.11 ± 0.27 vs 2.00 ± 0.17,P < 0.05) and increased bacterial infiltration(174% ± 52% increase from sham vs 377% ± 4%,P < 0.05).A decreased expression of PAP1 and PAP2 was demonstrated by Western blotting analysis and immunohistochemical staining.There were no differences in serum amylase and lipase activity,or tissue myeloperoxidase or monocyte chemotactic protein-1 levels.However,in the most-aged group,serum C-reactive protein levels were higher(young vs old:0.249 ± 0.04 mg/dL vs 2.45 ± 0.68 mg/dL,P < 0.05).CONCLUSION:In older animals,there is depressed PAP expression related to a blunted inflammatory response in AP which is associated with worsened bacterial infiltration and higher C-reactive protein level;this may explain the more aggressive clinical course. | Sophia Fu Albert Stanek Cathy M Mueller Nefertti A Brown Chongmin Huan Martin H Bluth Michael E Zenilman | 2012 | World Journal of Gastroenterology2012，18，26： | 5 |
| 2 | Correlation of expression of BP1,a homeobox gene,with estrogen receptor status in breast cancer 显示文摘 | Fu SW Schwartz A Stevenson H | 2003 | Breast Cancer Res2003，5，4： | 1 |
| 3 | nonsense mutation of the MASS1 gene in a family with febrile and afebrile seizures显示文摘 | Nakayama J Fu Y H Clark A M | 2002 | Ann Neurol2002，52，5： | 1 |
| 4 | Resveratrol-caused apop- tosis of human prostate carcinoma LNCaP ceils is mediated via modulation of Phosphatidylinositol 3 '-kinase/Akt pathway and Bcl- 2 family proteins显示文摘 | Moammir H A Nihal M Fu V X | 2006 | Mol Cancer Ther2006，5，5： | 1 |
| 5 | Recovery of soianesol from tobacco as a value- added byproduct for alternative applications显示文摘 | MACHADO P A FU H KRATOCHVIL R J | 2010 | Bioresource technology2010，101，3： | 1 |
| 6 | Protective effect of N-acetyl-L-cysteine on amyloid beta-peptide-induced learning and memory deficits in mice显示文摘 | Fu A L Dong Z H Sun M J | 2006 | Brain Res2006，1109，1： | 1 |
| 7 | Effect of seiencing of HER2/neu gene in anti-BPDE-transformed cells 显示文摘 | Jiang Y Fu J Greenlee A R Shen YoDuan H Chen X | 2009 | Toxicol In Vitro2009，23，： | 1 |
| 8 | Recycling Steel from Grinding Swarf 显示文摘 | Fu H Matthews M A Langdon S W | 1998 | Waste Management1998，18，5： | 1 |
| 9 | Ge- netic diversity and drug resistance among newly diagnosed and antiretroviral treatment-naive HIV-infected individuals in western Yunnan: a hot area of viral recombination in China 显示文摘 | Chen M Ma Y Duan S Xing H Yao S Su Y Luo H Yang L Chen H Fu L Qu A Ou CY Jia M Lu L | 2012 | BMC Infect Dis2012，12，： | 1 |
| 10 | Phase I clinical trials in patients≥ 80 显示文摘 | GADDIPATI H FU P DOWLATI A | 2011 | J Geriatriconcology2011，2，2： | 1 |
| 11 | Effect of functional group type of anion- exchange layers on I-V curves of bipolar membranes 显示文摘 | Xu T W Fu R Q Yang W H Fundamental studies on a novel series of bipolar membranes pre- pared from poly (2 6-dimethyl-1 4-phenylene oxide) (PPO) (Ⅱ) | 2006 | J Membr Sci2006，279，： | 1 |
| 12 | Azoxystrobin, a mito- chondrial complex Ⅲ Qo site inhibitor, exerts beneficial metabolic effects in vivo and in vitro显示文摘 | GAO A H FU Y Y ZHANG K Z | 2014 | Biochimica et Biophys- ica Acta (BBA)-Bioenergetics2014，1840，7： | 1 |
| 13 | Comparison between Supercritical Carbon Dioxide Extraction and Aqueous Surfactant Washing of an Oily Machining Waste显示文摘 | Fu H Matthews M A | 1999 | Journal of Hazardous Materials1999，，67： | 1 |
| 14 | Differential protective effects of volatile anesthetics against renal ischemia-reperfusion injury in viro显示文摘 | Lee H T Ota-Setlik A Fu Y | 2004 | Anesthesiology2004，101，6： | 1 |
| 15 | The application of surface visibility and moldabifity to parting line generation显示文摘 | FU M W NEE A Y C FUH J Y H | 2002 | Computer-Aided Design2002，34，34： | 1 |
| 16 | Genome-wide analysis of the AP2/ERF gene family in Populus trichocarpa 显示文摘 | Zhuang J Cai B Peng R H Zhu B Jin X F Xue Y Gao F Fu X Y Tian Y S Zhao W Qiao Y S Zhang Z Xiong A S Yao Q H | 2008 | Biochem Biophys Res Commun2008，371，： | 1 |
| 17 | Preparation of cellulose based microspheres by combining spray coagulating with spray drying显示文摘 | Wang Q Fu A Li H | 2014 | Carbohydrate Polymers2014，111，： | 1 |
| 18 | Synthesis of pyrene-1-earbaldehyde nanorods and emission tuning by the fluorescent ratiometric change显示文摘 | SHENG X H PENG A D FU H B | 2007 | Physicochemical Eng Aspects2007，308，： | 1 |
| 19 | Generalized Vector Equilibrium Problems with Set-valued Mappings显示文摘 | Fu J Y and Wan A H | 2002 | Mathematical Methods of Operations Research2002，56，： | 1 |
| 20 | Non-destructive evaluation of plasma sprayed functionally graded thermal barrier coatings显示文摘 | Fu L Khor K A Ng H W | 2000 | Surface and Coatings Technology2000，130，23： | 1 |
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