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| 1 | 中国旅游目的地定位与品牌化仍很滞后显示文摘大约自1998年开始,西方国家的旅游学者与旅游市场营销从业人员对目的地品牌化表现出极大的兴趣。令人遗憾的是,中国大陆的目的地管理机构(destination management organizations,DMO)往往只提出目的地"口号"和"标识",而不愿开展专业化的目的地品牌化开发。 | Alastair Morrison 李菲菲 | 2013 | 旅游学刊2013，28，2： | 11 |
| 2 | 身份认同视角下中国背包客的目的地选择偏好研究显示文摘近年来,随着我国城市化、现代化进程的不断加快,背包旅行作为一种后现代的生活方式迅速流行起来。中国背包客在本土化的过程中也形成了独特的目的地选择偏好。文章试图从身份认同的视角切入,分析背包客与目的地之间的关系。研究首先以背包客对其群体身份的认同度为依据,通过因子一聚类分析将背包客群体分为了两类——经验型和业余型;再通过t检验和卡方检验发现他们在目的地的选择上存在着不同的行为模式。文章最后指出,背包客群体本身具有异质性,不同的群体成员对于背包客身份的认同程度不同,而身份认同则是理解背包客不同行为特征新的切入点。 | 刘鲁 张静儒 吴必虎 Alastair M. MORRISON | 2018 | 旅游学刊2018，33，4： | 11 |
| 3 | 法庭说话人识别语音数据库的构建显示文摘为建立具有代表性的法庭话者识别相关背景人群语音数据库,促进法庭语音数据的资源共享,从法庭话者识别的研究和实践出发,提出了一套基于汉语的法庭语音数据库构建方案,对语音数据的采集、处理和应用也提出了相关建议。这样的数据库更贴近典型案件条件,更适合法庭语音研究及应用,也适合其他自然口语语音研究。 | 张翠玲 Geoffrey Stewart Morrison | 2016 | 中国刑警学院学报2016，，4： | 9 |
| 4 | 法庭说话人识别新范式实证研究显示文摘目的通过对一起法庭说话人识别案例的实证研究,表明法庭语音证据评价新范式的核心内容及其在司法实践中的具体应用。新范式通过相关数据、定量测量和统计建模计算似然比,量化评价证据价值,并在反映该案实际条件下进行系统的有效性和可靠性验证。方法该案中,检材语音来源于两名嫌疑人之一。采集二人的样本语音,每人5段录音。提取每段录音的美尔频率倒谱系数(MFCC),使用典型线性判别函数进行降维和失配补偿。结果分别使用单变量t分布和正则化逻辑回归方法计算似然比,并对两种方法进行交叉验证。前者似然比在数百到数万之间,后者似然比在数百之内,方向都始终正确。正则化逻辑回归基于训练数据较少的考虑,得到的证据强度更为保守。结论似然比框架可以用于法庭语音证据的评价,其结果也可以在反映案件实际条件下进行验证。 | 张翠玲 Geoffrey Stewart Morrison Ewald Enzinger | 2018 | 中国人民公安大学学报(自然科学版)2018，24，3： | 6 |
| 5 | 目的地管理与目的地营销:打造优质旅游目的地平台显示文摘为进一步提高本刊的学术水平和国际影响力,本栏目2013年起进行了全新改版,特邀请相关领域的专家学者担任本栏目的特邀责任编辑,由这些特邀责任编辑约请各自领域国内外有一定影响力的专家学者参与讨论。 | Alastair Morrison 邵隽 陈映臻 | 2013 | 旅游学刊2013，，1： | 5 |
| 6 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 7 | 脑海绵状血管畸形临床诊疗指南概要:血管瘤联盟科学咨询委员会临床专家组基于系统文献评价的共识推荐显示文摘背景尽管脑海绵状血管畸形(cerebral cavernous malformation, CCM)的相关研究文献已相当丰富,但在诊断和治疗策略方面仍存在着争议。目的制订CCM诊疗指南。方法作为代表CCM患者和研究的患者支持团体,血管瘤联盟(www.angioma.org)召集了一个包括CCM临床专家在内的多学科写作组来帮助总结现有的CCM临床诊疗相关文献,重点关注5个主题:(1)流行病学和自然病程;(2)遗传检测和咨询;(3)诊断标准和影像学标准;(4)神经外科注意事项;(5)神经内科注意事项。写作组根据预定方案进行了文献回顾和证据评价,最终制定推荐意见,并且确立了共识、争议和知识空白。结果根据方法学标准从1983年1月1日至2014年9月31日期间公开发表的1 270篇文献中筛选出98篇,并确定了另外38篇近期或相关的文献。各主题作者利用这些文献总结了现有知识并形成了23项共识诊疗推荐,同时根据美国心脏协会/美国卒中协会标准进行了推荐强度(效应量)和证据水平(确定性估计)评级。其中,尚无A级证据(因为缺乏随机对照试验),B级证据11项(48%),C级证据12项(52%);Ⅰ级推荐8项(35%),Ⅱ级推荐10项(43%),Ⅲ级推荐5项(22%)。结论现有证据支持对CCM诊疗的推荐,但这些证据的级别和推荐强度普遍较低,因此需要进一步研究来帮助进行更好的临床实践并更新这些推荐。完整的推荐文档包括引用文献的纳入标准、关于各项推荐更详尽的评判标准以及各种争议和知识空白的总结,同样通过了同行评议并可在线获取(www.angioma.org/CCMGuidelines)。 | Amy Akers Rustam Al-Shahi Salman Issam A. Awad Kristen Dahlem Kelly Flemming Blaine Hart Helen Kim Ignacio Jusue-Torres Douglas Kondziolka Cornelia Lee Leslie Morrison Daniele Rigamonti Tania Rebeiz Elisabeth Toumier-Lasserve Darrel Waggoner Kevin Whitehead 鄂同舟 雷宇 倪伟 顾宇翔 | 2017 | 国际脑血管病杂志2017，25，7： | 4 |
| 8 | 早产治疗的临床证据显示文摘截止至2002年5月,现有早产治疗的临床证据如下: (1) 高危早产:在一些国家实施的RCT发现,在降低早产危险方面,加强产前保健与普通产前保健没有明显差异.包括5个RCT的1个系统评价发现,对有宫颈改变的妇女行宫颈环扎术有不同的结果,没有明确的结论.1个大样本的RCT发现,孕9~29周宫颈功能可能不全的妇女进行预防性宫颈环扎手术与不环扎相比,能明显降低早产(<33孕周),但也会明显增加产褥感染的危险.另外4篇较小样本的RCT发现,孕10~30周、具各种早产高危因素的妇女,进行预防性宫颈环扎手术与不环扎相比,并不能降低早产(<34孕周).1篇系统评价的2个RCT报告,对有宫颈改变的妇女进行环扎术有不同的结果,其中1个RCT发现其并不能明显降低早产(<34孕周),而另外1个较小样本的RCT却发现宫颈环扎手术加卧床休息与单纯卧床休息比较,能明显降低34周前的早产.没有1个RCT证实行环扎术加卧床休息与单纯卧床休息相比,能降低围生儿死亡率. (2) 胎膜早破:1个系统评价发现,对胎膜早破的妇女,抗生素较安慰剂能明显延长孕周、降低新生儿发病率的危险,如新生儿感染、出生后氧疗、脑部超声异常等.阿莫西林加克拉维酸治疗与新生儿坏死性小肠结肠炎的发生率明显增加有关.一个基于1个RCT的系统评价发现,没有充足的证据证实羊膜腔灌注与不灌注比较能改善胎膜早破后的新生儿结局. (3) 先兆早产的治疗:①β-肾上腺素兴奋剂:1个系统评价发现,β-肾上腺素兴奋剂与安慰剂或不治疗相比,并不能明显降低围生儿死亡率、呼吸窘迫综合征及低体重儿(<2 500 g)发生率,且与与安慰剂或不治疗相比,β-肾上腺素兴奋剂增加孕母副反应,如胸痛、心悸、呼吸困难、震颤、恶心、呕吐、头痛、高血糖、低钾血症.②钙离子通道拮抗剂: 没有关于钙离子通道拮抗剂与安慰剂比较的系统评价或RCT.1个系统评价发现,钙离子通道抑制剂与其它保胎药(主要是β-肾上腺受体兴奋剂)比较,能显著降低48 h内的早产分娩,减少因孕母副反应退出治疗和新生儿发病率.③硫酸镁:1个系统评价发现,硫酸镁与安慰剂比较,并不能明显降低孕36周前的早产率、围生儿死亡率、呼吸窘迫综合征的发生率.另一个系统评价发现,硫酸镁和其他宫缩抑制剂(β-肾上腺素兴奋剂、钙离子通道拮抗剂、前列腺素合成抑制剂、硝化甘油、酒精和葡萄糖注射剂)比较,并不能明显降低48 h内早产率(尽管结果没有差异).④垂体受体拮抗剂(阿托西班):1个系统评价纳入 2个RCT,对阿托西班和安慰剂治疗早产进行比较有不同的结果.较大样本的RCT发现,阿托西班较安慰剂能延长孕周,但阿托西班增加了孕28周以下的胎儿死亡率.另一个RCT发现,阿托西班增加了48 h内的早产.⑤前列腺素抑制剂(消炎痛):1个系统评价发现,消炎痛与安慰剂比较,能明显降低孕37周前的48 h和7天的早产率的证据有限.然而,同时发现消炎痛与安慰剂或不治疗相比,并不能明显降低围生儿死亡率、新生儿呼吸窘迫综合征、肺支气管发育不良、坏死性小肠结肠炎、新生儿败血症或低体重儿.但这个系统评价样本太小,尚不能发现有临床意义的差异. (4) 择期或非择期剖宫产对早产妇女治疗效果:1个系统评价结果发现,择期剖宫产较非择期剖宫产会增加孕母的发病率,却不能降低新生儿的发病率和死亡率.但尚不能证明此效果是否对新生儿有临床意义. (5) 改善早产妊娠结局的干预措施:①对早产者采用皮质类固醇:1个系统评价认为,对可能发生早产的妇女使用皮质激素较安慰剂或不处理能明显降低早产儿出生后呼吸窘迫综合征、新生儿死亡率和颅内出血的发生.②促甲状腺激素释放激素在早产中的运用:1个系统评价发现,在早产的高危妇女中,促甲状腺激素释放激素和类固醇激素联合应用与单用皮质类固醇激素比较,对新生儿结局的影响无明显差异,但会明显增加孕母和胎儿的不良反应.③抗生素:1个系统评价发现,抗生素与安慰剂比较,不能延长孕周、降低新生儿死亡率,但可降低孕母感染率. | Bridgette Byrne John Morrison 李蓉 | 2005 | 中国循证医学杂志2005，5，3： | 4 |
| 9 | 佛罗里达涉禽羽毛的汞浓度显示文摘1987~1990年,在美国佛罗里达州奥基乔比湖及其南边的湿地收集了92只涉禽(涉水鸟)的初级飞羽或尾羽。雏鸟羽毛中汞平均浓度检定结果:玫瑰琵鹭(Ajaia ajaja)为 2.0ppm,大蓝鹭(Ardea herodias)为 3.5ppm,大白鹭(Ardea herodias occidentalis)为4.7ppm,巨白鹭(Casmerodius albus)为7.1ppm。大白鹭羽毛中汞的浓度随年龄增长而升高,雏鸟为4.7ppm,幼鸟为6.7ppm,成鸟为8.2ppm。猎食大鱼的鸟类汞浓度最高。林鹳(Mycteriaamericana)羽毛中汞平均浓度为3.3ppm。佛罗里达南部涉禽羽毛中汞浓度比所报道的亚洲涉禽羽毛中的要高。已知25只涉禽肝脏和羽毛中汞浓度。肝脏(湿重)汞浓度(Y)与羽毛汞浓度(X)的回归方程是:log(Y)=1.52log(X)-0.722,相关系数为0.84。如果成鸟羽毛中平均汞浓度达9ppm,就会出现生殖失调,正如从一项已发表的绿头鸭(Anas platyrhynchos)实验室研究成果可以推断的那样,那么,佛罗里达南部汞浓度就高得足以减少涉禽种群的繁殖力。然而,在有把握地指定羽毛中最低中毒浓度以前,需要另外进行对照研究。 | W.Nelson Beyer Marilyn Spalding Doug Morrison 寒江 | 1997 | 人类环境杂志1997，26，2： | 4 |
| 10 | Epidemiology of cancer of the small intestine显示文摘Cancer of the small intestine is very uncommon.There are 4 main histological subtypes:adenocarcinomas,carcinoid tumors,lymphoma and sarcoma.The incidence of small intestine cancer has increased over the past several decades with a four-fold increase for carcinoid tumors,less dramatic rises for adenocarcinoma and lymphoma and stable sarcoma rates.Very little is known about its etiology.An increased risk has been noted for individuals with Crohn's disease,celiac disease,adenoma,familial adenomatous polyposis and Peutz-Jeghers syndrome.Several behavioral risk factors including consumption of red or smoked meat,saturated fat,obesity and smoking have been suggested.The prognosis for carcinomas of the small intestine cancer is poor(5 years relative survival < 30%),better for lymphomas and sarcomas,and best for carcinoid tumors.There has been no signif icant change in longterm survival rates for any of the 4 histological subtypes.Currently,with the possible exceptions of obesity and cigarette smoking,there are no established modifiable risk factors which might provide the foundation for a prevention program aimed at reducing the incidence and mortality of cancers of the small intestine.More research with better quality and sufficient statistical power is needed to get better understanding of the etiology and biology of this cancer.In addition,more studies should be done to assess not only exposures of interest,but also host susceptibility. | Howard Morrison | 2011 | World Journal of Gastrointestinal Oncology2011，3，3： | 4 |
| 11 | Murine hepatocellular carcinoma derived stem cells reveal epithelial-to-mesenchymal plasticity显示文摘AIM To establish a model to enrich and characterize stemlike cells from murine normal liver and hepatocellular carcinoma(HCC) cell lines and to further investigate stem-like cell association with epithelial-to-mesenchymal transition(EMT).METHODS In this study,we utilized a stem cell conditioned serumfree medium to enrich stem-like cells from mouse HCC and normal liver cell lines,Hepa 1-6 and AML12,respectively.We isolated the 3-dimensional spheres and assessed their stemness characteristics by evaluating theRNA levels of stemness genes and a cell surface stem cell marker by quantitative reverse transcriptase-PCR(q RTPCR).Next,we examined the relationship between stem cells and EMT using q RT-PCR.RESULTS Three-dimensional spheres were enriched by culturing murine HCC and normal hepatocyte cell lines in stem cell conditioned serum-free medium supplemented with epidermal growth factor,basic fibroblast growth factor and heparin sulfate.The 3-dimensional spheres had enhanced stemness markers such as Klf4 and Bmi1 and hepatic cancer stem cell(CSC) marker Cd44 compared to parental cells grown as adherent cultures.We report that epithelial markers E-cadherin and ZO-1 were downregulated,while mesenchymal markers Vimentin and Fibronectin were upregulated in 3-dimensional spheres.The 3-dimensional spheres also exhibited changes in expression of Snai,Zeb and Twist family of EMT transcription factors.CONCLUSION Our novel method successfully enriched stem-like cells which possessed an EMT phenotype.The isolation and characterization of murine hepatic CSCs could establish a precise target for the development of more effective therapies for HCC. | Aparna Jayachandran Ritu Shrestha Bijay Dhungel I-Tao Huang Marianna Yumi Kawashima Vasconcelos Brian J Morrison Charmaine A Ramlogan-Steel Jason C Steel | 2017 | World Journal of Stem Cells2017，9，9： | 4 |
| 12 | Ultra-high suppression microwave photonic bandstop filters显示文摘A bandstop radio frequency(RF)filter can enhance the capabilities of RF communication systems by removing unwanted signal components such as distortion,or interference.In modern cognitive radio systems,frequency agile filters are desired to block interferers with dynamically changing frequencies and powers.These filters should be tunable over a broad frequency range,and they should be capable of suppressing very strong signals with a high resolution.To simultaneously meet these requirements with traditional RF filters are highly challenging.Microwave photonic(MWP),a technology that primary deals with the generation,distribution,and processing of high speed RF signals using photonic techniques and components,is promising for creating frequency agile RF filters.However,traditional MWP filters are lacking the high resolution and peak suppression exhibited by state-ofthe-art RF electrical filters.We recently introduced a new class of MWP notch filter which is free from this limitation.This scheme allowed the creation of anomalously high suppression MWP notch filter from virtually any kind of optical resonance,irrespective of its type(gain or absorption),or its magnitude.This enabled,for the first time,simultaneous optimization of the MWP filter resolution,peak attenuation,and frequency tuning range.In this paper,we present the analysis of notch filter response creation using the novel sideband processing technique.We thenshow the applicability of this technique to a wide range of optical filters.We compare simulated and experimental results of the notch filter response created using three types of optical filter commonly used in MWP signal processing,namely stimulated Brillouin scattering(SBS),an integrated optical ring resonator(ORR),and a phase-shifted fiber Bragg-grating(FBG). | David Marpaung Blair Morrison Mattia Pagani Ravi Pant Benjamin J.Eggleton | 2014 | Chinese Science Bulletin2014，59，22： | 3 |
| 13 | Destination image representation on the web: Content analysis of Macau travel related websites显示文摘 | Soojin Choi Xinran Y. Lehto Alastair M. Morrison | 2006 | Tourism Management2006，，1： | 3 |
| 14 | 治疗肺动脉高压药物赛乐西帕显示文摘1研制背景花生四烯酸(AA)代谢产物中的一个重要成分是前列环素(1,PGl2),主要在血管内皮细胞中生成。PGI:具有多种生理功能,可强效地舒张血管,抑制血小板聚集,还抑制血管平滑肌细胞分化、增殖和迁移。PGl2的这些功能是通过与血管平滑肌细胞、血小板或其他细胞膜上的PGl2受体结合而产生的。PGl2途径的下调可引起一些血管性疾病,例如肺动脉高压。 | 郭宗儒 asaki t kuwano k morrison k | 2018 | 药学学报2018，53，12： | 3 |
| 15 | Target coverage for head and neck cancers treated with IMRT: review of clinical experiences显示文摘 | Adam S Garden William H Morrison David I Rosenthal K.S.Clifford Chao K.Kian Ang | 2004 | Seminars in Radiation Oncology2004，，： | 2 |
| 16 | Stem cells,cancer,and cancer stem cells显示文摘 | Reya T Morrison SJ Clarke MF | | 0，，6859： | 2 |
| 17 | A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study显示文摘 | Michael J. Proctor David S. Morrison Dinesh Talwar Steven M. Balmer Colin D. Fletcher Denis St.J. O’Reilly Alan K. Foulis Paul G. Horgan Donald C. McMillan | 2011 | European Journal of Cancer2011，，17： | 2 |
| 18 | Prospective identification, isolation by flow cytometry, and in vivo self-renewal ofmultipotent mammalian neural crest stem cells显示文摘 | Morrison SJ White PM Zock C | | 0，，： | 2 |
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