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| 1 | Bitter components related to alleviating intestinal obstruction in traditional Mongolian medicine显示文摘Intestinal obstruction is a blockage that keeps digesta from passing through upper or lower intestine.Traditional Mongolian medicine(TMM)has been proven to be efficacious in the clinical treatment of intestinal obstruction.However,the mechanism of its treatment has not been studied.The bitter taste receptors(T2Rs)are highly expressed in the extra-oral digestive system,such as gastrointestinal tract,which can regulate gastrointestinal peristalsis and contraction of gastrointestinal smooth muscle.In the respiratory system,T2Rs can relax the airway smooth muscle and effectively alleviate asthma symptoms.In this review,the theory and clinical applications of bitter herbs in TMM were discussed and the functional expression of T2Rs and bitter taste signal transduction pathway were analyzed to investigate whether bitter Mongolian medicine may play an effective role in promoting gastrointestinal peristalsis.Therefore,the scientific connotation of the theory of bitter medicinal property of TMM was interpreted by combining T2Rs research and application of modern technology.This new research approach may enrich and improve the basic theory and accelerate the modernization of TMM. | Hong-Zhen Yu Li-Sha A Xiao-Ping Ji Sung-Bo Cho Gen-Na Ba Peng-Fei Han Ming-Hai Fu | 2020 | TMR Theory and Hypothesis2020，3，2： | 3 |
| 2 | The inheritance path research of the processing of Chinese materia medica in Anguo herbs market显示文摘Anguo,known as Qizhou in ancient time,its herbs industry began in Song Dynasty,boomed in Ming,and flourished in Qing.During the development of Qizhou herbs industry,a number of special processing techniques of Chinese Materia Medicine were produced.'Qizhou's Four Uniqueness',of which,the most representative medicine includes'Hundred pieces areca','Cicada feather of Qingxia','Yunpian deer antler'and'Pound Rhinoceros unicornis L'.To investigate the present inheritance situation of the traditional processing technology of Chinese Materia Medicine in Anguo herbs market,we will consult literature including the ancient books and records,Anguo local chronicles and visit the inheritors of the traditional processing technology in Anguo,and research the processing technology historical origin.This study aims to create the Anguo herbs cultural card,and enrich the cultural heritage of Chinese medicine industry of Anguo country even Hebei province. | Ying Chen Li-Na Zhang Yu-Hui Ma Miao-Miao Lin Xing Zhang Yu Wang Guo-Wei Zhang | 2019 | TMR Theory and Hypothesis2019，2，1： | 2 |
| 3 | Application value of tongue coating microflora in integration of traditional Chinese medicine and modern medicine显示文摘Observation of tongue coating is the characteristic content of traditional Chinese medicine syndrome differentiation and treatment. The microflora is the important component of tongue coating besides the desquamated epithelial cells. Tongue coating microflora might be an important linkage between the modern medical research and the classic traditional Chinese medicine theory. Therefore, the present paper summarised the application value of tongue coating microflora in health and disease to enrich the scienti fic connotation of traditional Chinese medicine tongue diagnosis and promote the development of integration of traditional Chinese medicine and modern medicine. | Juan Wu Jun Qian Li-Yun Shi Zhen Zhan Jun-Feng Zhang | 2019 | TMR Theory and Hypothesis2019，2，4： | 2 |
| 4 | Evidence - based Librarianship 显示文摘 | Eldredge JD | 1997 | Hypothesis1997，11，3： | 1 |
| 5 | Dairy products and breast cancer: the IGF- Ⅰ , estrogen, and bGH hypothesis 显示文摘 | Nicholson A Barnard N | 1997 | Medical Hypothesis1997，48，6： | 1 |
| 6 | Melatonin and abeta, macular degeneration and alzheimers disease: same disease, different outcomes显示文摘 | Vladan B Panfoli I | 2012 | Med Hypothesis Discov Innov Ophthalmol2012，1，2： | 1 |
| 7 | Pathophysiological factors underlying heatstroke显示文摘 | Yah Y F Zhao Y Q Wang H | 2006 | Mcd Hypothesis2006，67，3： | 1 |
| 8 | The Number of Components in a Mixture Determines Whether Synergistic and Antagonistic or Additive Toxicity Predominat显示文摘 | MICHAEL S J DARRYL W H | 1995 | The Funnel Hypothesis Ecotoxicology and Environ Safety1995，31，： | 1 |
| 9 | Uremic anorexia: a cortsequence of persistently high brain semtonin levels显示文摘 | Aguilera A Selgas R Codoceo R | 2000 | The tryptophan/semtonin disorder hypothesis Petit Dial Int2000，20，6： | 1 |
| 10 | Oncogenic retroviruses of cattle,chicken and turkeys: potential infectivity oncogenetic for humans显示文摘 | Johnson E S Griswold C M | 1996 | Med Hypothesis1996，46，4： | 1 |
| 11 | 系统复杂性的中医证候规范化研究探析[J]显示文摘 | 孟庆刚 王永炎 戴汝为 | 1995 | hypothesis1995，，： | 1 |
| 12 | ERK5 mediated signalling in diabetic retinopathy显示文摘 | Wu Y Chakrabarti S | 2015 | Med Hypothesis Discov Innov Ophthalmol2015，4，1： | 1 |
| 13 | Diabetic retinopathy and ehrlichia: the pos- sible relationship显示文摘 | A Kallick C | 2012 | Med Hypothesis Discov Innov Oph- thalmol2012，1，2： | 1 |
| 14 | Geographical variations in clutch-size among passerine birds显示文摘 | Ricklefs R E | 1980 | Ashmole'' s hypothesis1980，97，： | 1 |
| 15 | Polyphenol-mediated inhibition of AP-1 transactivating activity may show cancer growth by impeding angiogenesis and tumor invasiveness显示文摘 | McCarty MF | 1998 | Med Hypothesis1998，50，6： | 1 |
| 16 | Developing Evidence Based Librarianship in Canada: Six Aspects for Consideration显示文摘 | Crumley E | 2001 | Hypothesis2001，，3： | 1 |
| 17 | Aspirin and Age Related Macular Degeneration; the Possible Relationship 显示文摘 | Wu Y Zhu W Li YH | 2013 | Med Hypothesis Discov Innov Ophthalmol2013，2，3： | 1 |
| 18 | Effects of yiqi yangyin huoxue therapy on IgA nephropathy: a systematic review and meta-analysis of randomized controlled trials显示文摘评估益气养阴活血法治疗IgA肾病的疗效和安全性。方法:2018年2月检索关于益气养阴活血法治疗IgA肾病的数据库文献。以益气养阴活血法单独或联合西药作为实验干预,以西药作为对照的随机对照试验。Cochrane协作工具用于评估偏倚风险,以评估方法学质量。应用RevMan5.3软件对纳入的试验数据进行分析。结果:共纳入21项研究,涉及1473例患者。Meta分析结果显示,单用益气养阴活血法或益气养阴活血法联合西药较单独西药治疗蛋白尿[MD=-0.41,95%CI(-0.53,-0.29),P<0.00001]及尿红细胞[MD=-7.46,95%CI(-9.28,-5.64),P<0.00001]疗效更加显著,临床总有效率也有所提高[OR=2.78,95%CI(2.14,3.61),P<0.00001]。其中一些试验没有报告不良反应。结论:目前研究表明益气养阴活血法能降低蛋白尿和尿红细胞,提高总有效率。由于一些实验的质量和出版偏倚很差,需要更多的循证医学研究来明确益气养阴活血法在治疗IgA肾病中的作用。 | Jing Gan Jiao-Ying Ou Yan-Sheng Wu Wei-Wei Liu Jian-Dong Gao | 2018 | TMR Theory and Hypothesis2018，1，4： | 1 |
| 19 | Harvey with a modern twist: how and why conducting arteries amplify the pressure wave originating from the heart 显示文摘 | Schaafsma A | 2014 | Medical Hypothesis2014，82，5： | 1 |
| 20 | Evidence - Based Librarianship: A Commentary for Hypothesis显示文摘 | Eldredge J | 1997 | Hypothesis1997，11，3： | 1 |
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