维普中文期刊产品整合服务

Biological regulation on synovial fibroblast and the treatment of rheumatoid arthritis by nobiletin-loaded tetrahedral framework nucleic acids cargo tank

查看全文 作　　者：Yuting [1]Wen;Mei [1]Zhang;Yangxue [1]Yao;Yang [1]Gao;Xiaolin [1]Zhang;Yunfeng [1]Lin;Xiaoxiao [1]Cai 高影响力作者 机构地区：[1]State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China高影响力机构 出　　处：《Chinese Chemical Letters》索引2023年第34卷第2期,共6页高影响力期刊 基　　金：supported by the National Key R&D Program of China (No. 2019YFA0110600);National Natural Science Foundation of China (Nos. 82171006, 81970986);Sichuan Province Youth Science and Technology Innovation Team (No. 2022JDTD0021)。 摘　　要：The hyperplasia and destruction of synovial tissue have an important impact on the development of rheumatoid arthritis(RA), the abnormal proliferation and migration of synovial fibroblast in synovial tissue is similar to tumor cells. Targeting anomalous synovial fibroblast and designing a high bioavailability nano drug delivery system can reduce the dosage for the treatment of rheumatoid arthritis and it is of great significance to reduce toxic and side effects and improve curative effect. In this experiment, the nobiletin-loaded tetrahedral framework nucleic acids cargo tank was established, carrying antiinflammatory small molecule monomer drug nobiletin with minimal bioavailability. Both in vitro cell experiments and in vivo animal studies proved the nano cargo tank enhance the role of nobiletin in reducing the invasiveness of pathological synovial fibroblast and promote their apoptosis, effectively alleviate the disease development of rheumatoid arthritis. 关 键 词：Tetrahedral framework nucleic acids NOBILETIN Rheumatoid arthritis Synovial fibroblast APOPTOSIS
相关文献

参考文献(32)

引证文献(1)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费