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1篇 您的检索式：关键字=Synovial fibroblast

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		题名	作者	年代	出处	被引量
	1	Effect of Tongbiling (通痹灵) on the Synoviocyte Function in Adjuvant Arthritis Rats显示文摘Objective: To study the effect of Tongbiling (TBL) on the proliferation of synovial fibroblast and interleukin1 (IL1), tumor necrosis factor-α (TNF-α) and prostaglandin E 2 (PGE 2) secreted by synoviocytes in adjuvant arthritis (AA) rats. Methods: Synovial fibroblast was derived from culture of tissue piece. The effect of primary synoviocyte culture supernatants on the fibroblast proliferation were assayed and IL1, TNF-α bioactivity and PGE 2 content of supernatants of cultured synoviocytes were measured. Results: TBL could significantly inhibit the synovial fibroblast proliferation (P<0.001), and downregulate IL1, TNFα and PGE 2 productions (P<0.001); indomethacin could obviously promote the synovial fibroblast proliferation(P< 0.001 ). It significantly inhibited PGE 2 production, but further upregulated IL1 and TNFα secreted by synoviocytes (P<0.01). Conclusion: The therapeutical effect of TBL on AA might be associated with its downregulating the secretory function of synoviocyte, then restoring the abnormal proliferation of fibroblast to normal levels.	陈纪藩赵会芳沈晓燕李颂华李迎敏廖世煌黄仰模奥西秀树邱联群关彤方永奇刘晓玲	2000	Chinese Journal of Integrative Medicine2000，6，1：	0

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