Circular dichroism spectroscopic studies on structures formed by telomeric DNA sequences in vitro

查看全文 作　　者：ZHANG [1]Xiaoyan;CAO [1]Enhua;SUN [1]Xueguang;BAI [2]Chunli

机构地区：[1]Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;[2]Institute of Chemistry,Chinese Academy of Sciences,Beijing 100101,China

出　　处：《Chinese Science Bulletin》索引2000年第45卷第21期,共5页

摘　　要：Telomere plays an important role in cellular processes, such as cell aging, death and carcinogenisis. Having special sequences, it can form quadrupiex structure in vitro. Circular dichroism (CD) spectroscopic studies show that TTAGGG, (TTAGGG)2 and (TTAGGG)4 can all form quadrupiex in vitro and exist mainly as parallel quadrupiex without metal ions. Both K+ and Na+ can stabilize the tetrameric structure and facilitate the forming of anti-parallel conformation. Furthermore, the conformations of quadrupiex can also be affected by sequence length, the nature and concentration of metal ions. 关键词：human TELOMERE QUADRUPLEX CONFORMATION CD spectrum K+ Na+ CATION concentration.

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Circular dichroism spectroscopic studies on structures formed by telomeric DNA sequences in vitro

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